Enzyme

Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.

HIDH

Enzyme

2-hydroxyisoflavanone dehydratase

Enzyme name

EC:4.2.1.105

Entry

Lyases;Carbon-oxygen lyases;Hydro-lyases

Class

2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)

Sysname

(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O

Reaction

daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]

Product

Species information

Lithospermum erythrorhizon

Species name

Lithospermum erythrorhizon is a species of eudicot in the family Boraginaceae (borage family).

Species info

Gene sequence info

Lithospermum_erythrorhizon.HIDH.fa

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>rna-gnl|WGS:JADFUC|Leryth_003751-t1
MSVSKIKHDVDIVWEYKPRFRLYKDGSYERNDFPKVPPSLDDPITGVSSKDITISKEISARLYLPKLNSPNQKLPILVYIHGGAFCFETAFEAYYHDYMNALVKEANVVVVSVEYRLAPEHPLPAAYEDAWNALQWVASHSDNEAKIEKEPWLINHGDFEKFFMNGDSAGANIVHNMIMRVGTEKLHGDVNISGAILAFPFFWSSNPIGSMSTENNMQSYFCNIWGFIYPLAPGGIDCPLVNPMANNAPSLAKIGCSKMLVVTGKLDVLRQRGFEYVEAVKKSEWKGEVELVDVEGGDHCFQMEHLHSQKARDLIKRMAYFIMN
>rna-gnl|WGS:JADFUC|Leryth_003752-t1
MSVSNSKHDGEILLECKPRFTLYKDGSYERNDFPKVPPSLDDPITGVSSKDITISKEISARLYHPKLNSPNQKLPILVYIHGGAFCFETAFEAYYHDYMNALVKEANVVVVSVEYRLAPEHPLPAAYEDSWNALQWVASHSDNETKIEKEAWLINHGDFDKFFINGDSAGANIVNNMVMRAGTEKLHGDVIISGAILAFPYFWGSKPIGSMSSESNMQSPSYKIWEFVYPLAPGGIDCALINPMADGAPSLAQIRCSKMLVVTGELDEVRERGIQYVEAVKKSEWKGEIELVDVEGEDHCFQMEHLQSEKARDLIKRLAYFINK
>rna-gnl|WGS:JADFUC|Leryth_012324-t1
MEASSNMEEVLYEFLPYGRVYKNGIVERLIDTDSIPALTDIETGVSSKDVSNIIPDSEVYVRLYLPNDLIVSAAKKLPVLVYFHGGAFIIATPSCSKYHNYLNALVAEAQVVAVSVHYRRPPEHPLPIAYEDSLAALQWVASHQNGNGPEAWLNDHADFDHVFLAGDSAGANIAHNLALSAGNVDFLPPGVNILGIALIHPYFWGSEAIGSESLEKEKKDYLDKLWPLVCPSDPDRDHPWINPVAEDAPSLAGLNCKRVLVCVAEKDILKDRGWLYYQILSKSGWLGVAEIQETEGEAHCFHLSDLKCENATNLMRRLAGFFNRDKPYL
>rna-gnl|WGS:JADFUC|Leryth_002294-t1
MASSNPSNENEVVIDISPIIKVYKDGKVERLMGDPQVPPSPEDPKTGVCSKDVSILENKISARFFIPKIKDDQKLPILIYFHGGGFCFQSAFSGSHHRFLNSLVKESNALAVSVEYRLAPESPLPIAYEDCWTALKWVLSHFDDEAKDIEKDPWLTKHGDFGRVFLGGDSAGGNIVHNMVMKFGTEKYHGGVEGRTQDSNMGYSVPRGVEIVGAILGFPYFWGSNPPGSMTIQENEESVPYRIWELVYPSAPGGIDNPMLNPFVDNAPSLENLGCSKVLVYTGEKDLLREKAIEYVEALKNSGWKGEVEYIEVEGEDHCFQIDFPDENLEKTNGLIKQMGDFIMLKNV
>rna-gnl|WGS:JADFUC|Leryth_002295-t1
MASSTKEIQLDLSPAIIIYKNSQIQRLWGSPPAPPSHPDPKTLVSSKDITISPQVSARLYLPTLQIPNQKLPILVYYHWGGFVAGSPFQEQEHCYLNILVSEANVVVVSVDYRLAPEHPLPAAYQDSWTALQWVASHADENMTKKDQWLVDHGDFGKLFIAGDSAGGNITHNMAMRAGREKLNADVTILGAIIAFPYFWGSKTILDMSNESNMKTLEYRLWEFVYPSADNGERDVMRARAIQYMEALRKSGWVGEVEFVDVERKNHCFQIVNPNSEKARDLIKSFACFINQ
>rna-gnl|WGS:JADFUC|Leryth_004327-t1
MQLLLAWPPQSPQSHIDKSLQFQLDHIEQKWLQTPSTEIVFEHFPLIRVFKDGHVHRFIEANFVQSSIDPLNNILSKDIILSQENNVSVHSWSALKWIVSNAEKNHGSDSEPWLRDHADFSRVFLAGDSTGANIAHNMMVRASTEDSGSFEREVNVMGMALIHPFFGNGQPDKLWDFLCKDREYRLDDPRLNPEVHPKLLKDFYYEGIKNSAWSGEVDIVDTEGEDHVFHLWNPGCDNAAILLKKVAAFMN
>rna-gnl|WGS:JADFUC|Leryth_004325-t1
MNPSSTEIVADFKSFFRVYKDGHVERYVEADFVPPSEDPETGVISKDVKIPPENDVIVRLYLPKNTNKKLPLLIYIHGGGFCIESALSSWYHPYLSRLVAEANVIALSIEYRLAPEFPIPICYDDCWSVFKWLENGKDSEPWLRDHADFSRTFLAGDSAGANISHEMMVRASNESNGGFEKTGMNLEGVVLIHPFFGDDFFNDLWLYLGKESNIGLDDPRLNPTLHPGILSKIVCKKILICTAEIDTVRHCGWSYYEAIKNSGWGGEVEIVEAEGEDHVFHLVNPGCDKADILMKKMTSFFN
>rna-gnl|WGS:JADFUC|Leryth_004326-t1
MASNSTEIVFEHFPLIRVFKDGHVHRFIEANFVHPSEDPLNNVLSKDIIISQENNVSVRLYMPNNHHDNNQKLPLLIYFHGGGFCIESACSSFYHSYLNKLVAEANVVAVSVEYRLAPEHPVTTCYEDSWSAFKWVVSNGEKTEGSDSEPWLRDHADFSRVFLAGDSAGANIAHNMMVKASDEESLLFETGVKVIGMALIHPYFGDGQREADKLWDFICKDGNSSLDDPRFNAAVHAKLLEKHVCKKILICVAEKDFLRERGVIYYEAIKNSAWSGEVDIFYTEGEEHVFHLKNPGCDNAAILMKQVAAFMK
>rna-gnl|WGS:JADFUC|Leryth_011566-t1
MQHSQEMPSNSTEILFESFPFIKVFKDGHVHRFLETDFVPPSEDPQNKVQSKDIIISQETNVSVRLYLPNNINYDNKKLPLLIYIHGGAFCIASASSSVYHSFLNKLVDEANVIAVSVEYRLAPEHPIPACYDDSWSAFKWVVSNGDNNSGSDSESWLRDYADFSKIFLAGDSAGANIAHDMMVRASDEASGFVETEVKLVGMALIHPFFGDDQPDVLWNFLCKDLNSRLDDPRFNPAVHSILLEKLVCKKILICIAEKDFLRQRGWSYYEAIKNSGWGGEVELEETEGEDHVFHLENPGSPKADIFIKKMATFFK
>rna-gnl|WGS:JADFUC|Leryth_011565-t1
MDSADQVVFEFMPFIKAYKSGRIERLFGTDFVPPTLNSENGVSSKDVVIDPQTGVSARVFIPTNKIKPGQNLPVLVYFHGGAFCLCSPFCAMYHSYLTTLVAKANVIAVSVDYRLAPEHPLPAAYEDSWNALKYVASHSAGNGPESWLNDHADFERVFLAGDSAGANISHNITLRAGIDGLMGMNINGVCIIHPDFVGREGSLNIAWNFICPDTCGESDTRVNPAIDSRLGNTGCSKMLVCVAEKDEFRDAGWIYYEAVKNSEWKGHVEITETTGEDHIFHLFNPANEKAAIFLDKVVSFISTGAQLKGLSSEVPASDVRKRERSSPEFKISV
>rna-gnl|WGS:JADFUC|Leryth_002685-t1
MASQEDEVLFDFSAELKVYKSGKFERGPKKFVPTNEDKETGVSSKDFTISQHASVRIYLPKLKSNEKQKFPVLIYYHGGGFCAGSAFQQEVHCYMNIIASQANVLVVSVEYRLAPDYPMPASYEDSWNALLWIASNSDKNSKIEKEPWLLNHGDFGKVFITGDSAGANIVHIMVMKAGAEKLPGDMKLFGAILCFPYFWSSEIEEKMKTPDANSFYYNLWNLAYPNAPGGIDCVLFSPWAKDAPGLHILGCSKMLVILAEKDILRGAGLQYVEEVKKSGFKGKVEMYEILEVDHCFQLVNLDTEKSKELIKRQVDFIKA
>rna-gnl|WGS:JADFUC|Leryth_002687-t1
MDSHSNEVVVDLSPVLKIYKDGRIERLWITPRVPPSLEDPTTGISSKDIIISPNVSARLYLPNQLLENQEAKLPIFVYCHGGGFRAESAFEELEHNFMNILTSEASVLAVAVEYRLAPEHPLPAAYEDLWTALQWVFSHADNNGQHFGTQMDAWLIHHGDFGKVILGGDSAGANLVHNIAVRAAIHYVEAVKKSGWNGEVELVDVEGEMHCFQIIDPSTSKAKELIKKIVAFILE
>rna-gnl|WGS:JADFUC|Leryth_002686-t1
MASEDNELIFAFPEFKVYKNGKFERGPTPTVPACMEDQETGVSSKDVSISSKFSARMYLPKLKSKDEKLRILIYIHGGGYCVGSAFQQEVHRYMNILASQAHCVGVSVEYRLAPEHPMPASYEDSWNAVQWVASHADNKSKIEKEPWLANHGDFSKVFINGDSAGGNIVHAMVMKAGDEKLPGDVKLLGAIYAFPYFWSSEIEEKVKTNDAPTFYYNLWKLVYPSAPGGIDCPLLNPWAKNAPSLTVLGCSKILVVVGSKDPLKVGAVKYLEEVKKSGWKGKTDFLDIEGEDHCFQLVNLDLEKSKIVVKRMVDFIRQ
>rna-gnl|WGS:JADFUC|Leryth_002683-t1
MVGNIVHVVAMRAGTEKLPGDVKLSGVIAAFPYFWSSEIEANRETLYYHLWKFLYPSIPGGIDNPLLNPWAKDAPSLTGLGCSKMLVVVGELDPLRIAGIQYVDEVKKSGWKGEKSRFRKG
>rna-gnl|WGS:JADFUC|Leryth_014103-t1
MDLMEPIDAEVVFQFETFIKVYKSGKVERLIGTDIVPPTSYSVNNVASKDVTISPEKPVSARLYLPTNIKKDEKLPLLIYFHGRAFCLCSPFCALYHNYLKETLVLNDVWKFTCPESSGVDDVRVNPALDPRLPSLGCTKILVAVVEKDEFEFRDSGWIYYEAIKKSGWNGEVEFHEGQDFHIFNPAIRTHTH
>rna-gnl|WGS:JADFUC|Leryth_014102-t1
MDQNKAEIAKDFPPFFRVHKNGLIDRYIHTDFIPPSQHPQTLVQSKDVIISQQNKLSARIYLPKSAFSNNHTRKFPLLIYIHGGAFSVQSPFSSIYHTYLNNLVSESEVIAVSVDYRLAPENPLPACYDDAWSVFNWVFSHSGKKIQDFPGPGKPEKPEPWLSDHVDYTRVFLAGDSAGANIAHDLLVRASSKNLKLEGMILIHPFFGNGKKADKLWEYIYPGTSGVHDPRLNPAAHVNLLKKLACKRIMICVAEEDELRKRGWYYYESVKRSGWNGEVEIVETKGESHVFHLLDPCCENAGIFMKQVASFINKIGFSAL
>rna-gnl|WGS:JADFUC|Leryth_014104-t1
MALIETIYDEVIFEYQPFIKVYKSGKIERFVGTDIVPATLNSPNNVSSKDVTISPEKHISARLYLPTNIKKDEKLPLLIYFHGGAFCLCSPFCALYHNYLTSLVSKANVVAVSVDYRLAPENPLPAAYEDSWDALLWVVSHSSCHGPESWLNDHVDFGRVFVGGDSAGANISHNIAQRAGIEKLEGLELNGACVIHPDFVGEEGSLNEVWKFICPGSFGEEDLRINPAIDPRLGSLGCTKMFVCVAEKDEFRDAGWIYYEAIKKSGWKGEVLFHETFGEAHVFHIFNPASKNAEPFMEKMACFINGTIAST
>rna-gnl|WGS:JADFUC|Leryth_020568-t1
MFVCTAENDLLRGRALYYVESVKKSGWNGQIELVDVQGEGHCFQIYDLDTSPGKAKELISRIVQFIMQC
>rna-gnl|WGS:JADFUC|Leryth_020567-t1
GYLYIPPSHDPDSVSSITISPNVSARLYLPNIKSNETKLPILVYYHAGAFCLGSVFSQDHHSYLNTLASEANCLAASLEYRLAPEHPLPAAFEDSWTALQWVASHAVQDIAEGGQKDPWLIKHGDFGRLLIGGDSAGGNIVHNIALKAGTEGLHGGVKILGAILAFPYFGGSKRLETESVETFEKSLSKELWDLVYPTAPGGVDCP
>rna-gnl|WGS:JADFUC|Leryth_020569-t1
MASSSTNDIVLHIPSIIKVYKDGKVERFWGTTHVPPSHDPTTGVSSKDITISPHVSARVYLPKVKSNETKLPVLVYYHAGGFCLGSAFSVDHHRYLNTLASEANCLAVSVEYRLAPEHLLPAAFEDSWTALQWVASHVVQDLTEGEEKDPWLIKHGDFERFFIGGDSAGGNIVHNTALKAGTEGLHGGVKILGAIFAFPYFWGSKPVGSESVETFEKGLSKELWNLVYPTAPGGVDCPLFNPFVDGAPTLNRLACSKIFVCAAENDELRGRALYYVESVKRSGWNGEIELVDVEGEGHCFQIYNLDTSLEKAKELISRIVHFIMQ
>rna-gnl|WGS:JADFUC|Leryth_018527-t1
MVTTFSVEKTQNLQISKNNYQHGGGFVVDEIPGLLKVYHNGHVERPQIVPNVPPNVPSELGIISRDIVIQSSSNIWARIYLPTQRRANKLPLLVYFHGGGFCVGSASWKCYHDFLAELASKSGCVIMSVNYRLAPENRLPAAYEDGINVVMWLNNQARNGCSGEHNWWLSHCTLSSIFLAGDSAGANIAYHVATRLESNPKAIRAKGIILIQPFTGGETRTNSEKQSIQPYYSALTLSASDAYWRLALPPGADRDHPWCNPLSRLTRLPRAMICISELDIMRDRNLDFCAALASSGTKVEKVVFQGVGHAFQILHNYPLSQQRTQQMMHYLKVFINS
>rna-gnl|WGS:JADFUC|Leryth_012524-t1
MATFTFDPTLLGTQDSQEHKQQRDVNVVEEIEGLIKVFEDGQVERPQIVPNVTPALPQNLGVKSRDVSIDKFSNIWARFYVPTCPNGKLPLLIYFHGGGFCVGSASWSCYHEFLARLSAKANCVIMSINYRLAPENPLPAAFDDGLKTLAWLQHQFLNGENEWITSKCNFSSIYLGGDSAGANIAHNVALKLGSNKSTTCDNYFNLLPLRLNGTILIQPFFGGEVRTNSEKYMAQSPRSALTLAASDCYWRLALPEGANRDHPWCNPMAKGGIKLEDFRLMDSMVCVAEMDILKDRNLEFCNALARGGNNVEHVMCKGVGHAFQILSKSPVAQKRTVELIYHIKKFITR

Gene tree

Gene tree

Sheng jun & Dong yang Teams, Yunnan agriculture University