Polyphenols their derivatives exhibit a wide array of biological activities, including antioxidant, anti-inflammatory, and anticancer properties. They play pivotal roles in plant defense mechanisms and have attracted significant attention for their potential therapeutic applications in humans, such as cardiovascular protection and cancer prevention.

Our database is a comprehensive resource that focuses on the biosynthesis of polyphenols and their derivatives, the secondary metabolites known for their diverse biological activities and potential health benefits. It comprises detailed information on 64 enzymes involved in the biosynthetic pathways, along with data from 284 species representing a wide range of taxonomic groups, encompassing details about the enzymatic reactions, intermediates, and regulatory mechanisms. This wealth of knowledge allows researchers to unravel the complex network of biosynthesis and identify key enzymes and regulatory elements for further investigation. Furthermore, the database incorporates a comprehensive phylogenetic tree that encompasses the 284 species included in the dataset. This phylogenetic tree offers a systematic framework to explore the evolutionary relationships and distribution of species across taxonomic groups. It facilitates comparative studies, enables the identification of evolutionary adaptations, and provides insights into the phylogenetic patterns of polyphenols and their derivatives biosynthesis across the tree of life.