Enzyme
Found in hops (Humulus lupulus). The enzyme can also methylate xanthogalenol.
OMT
Enzyme
Xanthohumol 4-O-methyltransferase
Enzyme name
EC:2.1.1.338
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:desmethylxanthohumol 6'-O-methyltransferase
Sysname
S-adenosyl-L-methionine + desmethylxanthohumol = S-adenosyl-L-homocysteine + xanthohumol [RN:R08004]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];xanthohumol [CPD:C16417]
Product
Species information
Lithospermum erythrorhizon
Species name
Lithospermum erythrorhizon is a species of eudicot in the family Boraginaceae (borage family).
Species info
Gene sequence info
Lithospermum_erythrorhizon.OMT.fa
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>rna-gnl|WGS:JADFUC|Leryth_016466-t1
MYAITLKHILHDWGDEDCIKILKNCRDAITKEIGKVIIVEEILRENKKGNEGHFGNIDVIQDLTMLVHTVGGKERTEIEFKNILEEAGFSRYKIINFNYFPSLIEAYPK
>rna-gnl|WGS:JADFUC|Leryth_016467-t1
MLVRMKIFTTQKLDTETHKSSDDDVLHGLTPFSSMLLHDADITLAPYVLMENYPALSSPWHYLSDVVKEGGSGFKKANGVEVFEMAGKDPGLKKVITDFISCTTKILFKGMFSNNGRNILLERADEDCTKILKNCRNAINKETGKVIIIGKILKEDEEGNEGHFGNIDVIQDLTMMVHTVGGKQRTENEWKKILKEAGFSRYNVIELNYLYSLIEAYPK
>rna-gnl|WGS:JADFUC|Leryth_016464-t1
MNTSNEELHELADITKCTFSFVDSMVLKCAVELRIADIIRSHGKSITLSQIASSIDSPSVNLGNLKRVMRMLVRMKIFTTQKLDTETHKSSDDVLYGLTPFSSMLVHDVDITLAPFVLMENYPMMAIPWHYLSDVVKEGGSGFKKANGVELFEMARKDPELNKIFNNAMRCITKIFFKGMFSTNNRDVFNGVNSVVDVGGGMGQFIGEIVKEFPNIKGVNLDLPHVVKMAPEIDGVTHVAGDMFKEIPNADAITLKNILLDWGDEDCIKILKNCRNAITKEIGKVVIVGETLKEDEEGNEGHFGNIDVIQDLTMMVHTVEGKQRTEIEWKKILEEAGFSRYKIIKLNYFSSLIEAYPK
>rna-gnl|WGS:JADFUC|Leryth_003288-t1
MDQLYVQNGSLKKSSMMANGSPHTRLSMLKHSYGTTPSNTIHKHGRPISISELAEALPMKKSKADSLSRLMRMLTNSGFFLKSKIVSETEEQVEAEGYSLSLAGRMLIKDDPCSMSKYVLALLDPITTDPFHQLCNWFKNDLTTPFETTHGKALWDCGDGHESHLVVAAHNFNAIMATDSLFVSGLIVNDDCRHIFEG
>rna-gnl|WGS:JADFUC|Leryth_002098-t1
MVALFVLESSPVMLAPWHELISSRVLINVASAFEGVHGEDVWKYAAKNPGHSKLINGKRARLSVPAIIEHCPEVFQGVRTLVDVGGGNGTTLSALVKAFPWIHGINFDLPHVVSTVGKCDHVVGIAGDMFKSIPKADAIFIKV
>rna-gnl|WGS:JADFUC|Leryth_001480-t3
MRTEDIITNTKFTEAEEAKAETEIWKYIFGFTEMAVVKCAVEMGIPDVLETQEHPITLEELSSLLGCHALSPLHRIMRFLSHRGLFKEEIKGNQEGHIYYTQTPLSRLLVKKGNKSMAALFLLESSPVMLAPWHQLSNRVLIHGAGAFEGAHGEDLWQYVASNPEHSKLFNDAMACDASLSVSAIIKQCPEVFEGVGTLVDVGGGNGTTLGTLVKACPWIHGINFDLAHVVETAKNCEGVERVAGDMFKSIPKGDAIFLKWTLHDWADEECIQILKNCREAIPSNNGKVIIVEAVIDLDEEGKSKELAQVGLMMDMVMLAHTTKGKERTSKEWTYVLNAAGFNRIVFKNNIQAIQSVIIGYP
>rna-gnl|WGS:JADFUC|Leryth_018368-t1
MGGQSQTKTKFTKEEEAQAEIDVWKYVFGFADMAIVKCAIELGIADVLETHDEPVTLEDLSSLLGCHTSPLHRIMRFLTHRGIFKEDVTTEEGGGHICYTQTPMSRLLRRGGDKSLAAFVLLESSPPMLAPWHELSSRVMIKGSSAFEGAHGEDVWTYAAKNPTHSKLINDAMSSHARISVPVIIEHCPEVFEGVNSLVDVGGGDGTTLQMLVKAFPWIHGINFDLPHVISTTTNYEGLENVGGDMFVSIPKADAIYIMWVLHDWGDDECIRILKNCRESIPKDTGKVIMAEAVIDLEEEKCKQLADVSLMLDMVMLAHTTNGKERTTKQWASILNAAGFSSYTFKRIQAVQSLIIAYP
>rna-gnl|WGS:JADFUC|Leryth_012293-t1
MVVDQERKLDEVETQLFYDMHLMMLNNGKERNEKEWAKLFFDAGFTYYKITHKLGVRSMIELFLFKRLQPVVVVVIRMRR
>rna-gnl|WGS:JADFUC|Leryth_012294-t1
MAFTNGNKQIIGDELLNAQTFIWKHMLNFINSFSLKCALQLGIPDVIHKHDNPMPLAVLVEALAINKTKADSLHHLMRLLVHSGFFIEMPEGYVLTPASHLLLKDNPFSISPPYRNHT
>rna-gnl|WGS:JADFUC|Leryth_012295-t1
MASDSRLMSSLVISECKEVFEGVDSLVDIAGGTGTMAKGIAKAFPNMSCIVLDLPHVIEGLKGSNNLSFVAGDMFAPLPTTNAILLKWILHDWNDDKCVEILKRCKEALTSKGKVIIIDMVVDQETKLDEVETQLFYDMHLMMLNNGKERNEKEWAKLFFDAGFTYYKITHKLGVRSMIEKNLCNKFSIPDVIHKHGKPMPLSNLVEALSINKAKAGCLQRLMRLLIHSGFFVQMPEGYALTLASRLLLKDNPFSVAPVFETMLDPIVTQPWKDGIILANGSKLMDMMFRYSRAFIGAHSGNLLEKNQSLTILLTNLWLPTLDVFEGLDSLVDVGGGTGTMAKVIANAFPNTSCIVLDLPHVIEGLKGRSNLSFVVGDMFLSLPKTDAILLKWILHDWTDDKYLEILERCKESLTSKCKVIIIDMVVDQGRKCDEVETQIFYDMHLMTLNNGKERNEKEWAKLFFDAGFTYYKITHKLGVRSLIEVYL
>rna-gnl|WGS:JADFUC|Leryth_012292-t1
MPLAVLVEALAINKTKADSLHHLMRLLVHSGFFIEMPEGYVLTPASHLLLKDNPFSISPHIETILDPTITQPWNQFSNWFKTDGHASLFESFHGSPLWQIASKDQEFNHSFNEAMASDSRLVSSLVVSEYKDVFEGVDSLVDIAGGTGTMAKGIAKAFPNMSCIVLDLPHVIEGLKGSNNLSFVGGDNLS
>rna-gnl|WGS:JADFUC|Leryth_011634-t1
MGWDIKFVHMWILHDWSDERCVEILRNCKEAIQNKKIDGKVIIIDMVVDKQKKDNHVETMLFFDMLMMVVTPGRERTEKDWANLF
>rna-gnl|WGS:JADFUC|Leryth_015394-t1
MSLSELVNALPIPKEKVNCVYSLMRLLIQSGFFLEILEGCVFAPAAHLFLKDNPFCLTPVILSMLDPVLTEPWHHLSNWLGIEPPTTPFESFHGKAMYEFASREPKFNPTFNEAMSCDARLLSSVVLRDCKDVFKGVDVLVDIGGGTGAMAKAIADAFPDISCMVLELPHVVDGLQGSSNLSFVAGDMFDSVPPADAILLKWILHNWDDDKCVEIIKNCREALLSKGGKGKVIILDMAIDTKRENTDVETLLLVLV
MYAITLKHILHDWGDEDCIKILKNCRDAITKEIGKVIIVEEILRENKKGNEGHFGNIDVIQDLTMLVHTVGGKERTEIEFKNILEEAGFSRYKIINFNYFPSLIEAYPK
>rna-gnl|WGS:JADFUC|Leryth_016467-t1
MLVRMKIFTTQKLDTETHKSSDDDVLHGLTPFSSMLLHDADITLAPYVLMENYPALSSPWHYLSDVVKEGGSGFKKANGVEVFEMAGKDPGLKKVITDFISCTTKILFKGMFSNNGRNILLERADEDCTKILKNCRNAINKETGKVIIIGKILKEDEEGNEGHFGNIDVIQDLTMMVHTVGGKQRTENEWKKILKEAGFSRYNVIELNYLYSLIEAYPK
>rna-gnl|WGS:JADFUC|Leryth_016464-t1
MNTSNEELHELADITKCTFSFVDSMVLKCAVELRIADIIRSHGKSITLSQIASSIDSPSVNLGNLKRVMRMLVRMKIFTTQKLDTETHKSSDDVLYGLTPFSSMLVHDVDITLAPFVLMENYPMMAIPWHYLSDVVKEGGSGFKKANGVELFEMARKDPELNKIFNNAMRCITKIFFKGMFSTNNRDVFNGVNSVVDVGGGMGQFIGEIVKEFPNIKGVNLDLPHVVKMAPEIDGVTHVAGDMFKEIPNADAITLKNILLDWGDEDCIKILKNCRNAITKEIGKVVIVGETLKEDEEGNEGHFGNIDVIQDLTMMVHTVEGKQRTEIEWKKILEEAGFSRYKIIKLNYFSSLIEAYPK
>rna-gnl|WGS:JADFUC|Leryth_003288-t1
MDQLYVQNGSLKKSSMMANGSPHTRLSMLKHSYGTTPSNTIHKHGRPISISELAEALPMKKSKADSLSRLMRMLTNSGFFLKSKIVSETEEQVEAEGYSLSLAGRMLIKDDPCSMSKYVLALLDPITTDPFHQLCNWFKNDLTTPFETTHGKALWDCGDGHESHLVVAAHNFNAIMATDSLFVSGLIVNDDCRHIFEG
>rna-gnl|WGS:JADFUC|Leryth_002098-t1
MVALFVLESSPVMLAPWHELISSRVLINVASAFEGVHGEDVWKYAAKNPGHSKLINGKRARLSVPAIIEHCPEVFQGVRTLVDVGGGNGTTLSALVKAFPWIHGINFDLPHVVSTVGKCDHVVGIAGDMFKSIPKADAIFIKV
>rna-gnl|WGS:JADFUC|Leryth_001480-t3
MRTEDIITNTKFTEAEEAKAETEIWKYIFGFTEMAVVKCAVEMGIPDVLETQEHPITLEELSSLLGCHALSPLHRIMRFLSHRGLFKEEIKGNQEGHIYYTQTPLSRLLVKKGNKSMAALFLLESSPVMLAPWHQLSNRVLIHGAGAFEGAHGEDLWQYVASNPEHSKLFNDAMACDASLSVSAIIKQCPEVFEGVGTLVDVGGGNGTTLGTLVKACPWIHGINFDLAHVVETAKNCEGVERVAGDMFKSIPKGDAIFLKWTLHDWADEECIQILKNCREAIPSNNGKVIIVEAVIDLDEEGKSKELAQVGLMMDMVMLAHTTKGKERTSKEWTYVLNAAGFNRIVFKNNIQAIQSVIIGYP
>rna-gnl|WGS:JADFUC|Leryth_018368-t1
MGGQSQTKTKFTKEEEAQAEIDVWKYVFGFADMAIVKCAIELGIADVLETHDEPVTLEDLSSLLGCHTSPLHRIMRFLTHRGIFKEDVTTEEGGGHICYTQTPMSRLLRRGGDKSLAAFVLLESSPPMLAPWHELSSRVMIKGSSAFEGAHGEDVWTYAAKNPTHSKLINDAMSSHARISVPVIIEHCPEVFEGVNSLVDVGGGDGTTLQMLVKAFPWIHGINFDLPHVISTTTNYEGLENVGGDMFVSIPKADAIYIMWVLHDWGDDECIRILKNCRESIPKDTGKVIMAEAVIDLEEEKCKQLADVSLMLDMVMLAHTTNGKERTTKQWASILNAAGFSSYTFKRIQAVQSLIIAYP
>rna-gnl|WGS:JADFUC|Leryth_012293-t1
MVVDQERKLDEVETQLFYDMHLMMLNNGKERNEKEWAKLFFDAGFTYYKITHKLGVRSMIELFLFKRLQPVVVVVIRMRR
>rna-gnl|WGS:JADFUC|Leryth_012294-t1
MAFTNGNKQIIGDELLNAQTFIWKHMLNFINSFSLKCALQLGIPDVIHKHDNPMPLAVLVEALAINKTKADSLHHLMRLLVHSGFFIEMPEGYVLTPASHLLLKDNPFSISPPYRNHT
>rna-gnl|WGS:JADFUC|Leryth_012295-t1
MASDSRLMSSLVISECKEVFEGVDSLVDIAGGTGTMAKGIAKAFPNMSCIVLDLPHVIEGLKGSNNLSFVAGDMFAPLPTTNAILLKWILHDWNDDKCVEILKRCKEALTSKGKVIIIDMVVDQETKLDEVETQLFYDMHLMMLNNGKERNEKEWAKLFFDAGFTYYKITHKLGVRSMIEKNLCNKFSIPDVIHKHGKPMPLSNLVEALSINKAKAGCLQRLMRLLIHSGFFVQMPEGYALTLASRLLLKDNPFSVAPVFETMLDPIVTQPWKDGIILANGSKLMDMMFRYSRAFIGAHSGNLLEKNQSLTILLTNLWLPTLDVFEGLDSLVDVGGGTGTMAKVIANAFPNTSCIVLDLPHVIEGLKGRSNLSFVVGDMFLSLPKTDAILLKWILHDWTDDKYLEILERCKESLTSKCKVIIIDMVVDQGRKCDEVETQIFYDMHLMTLNNGKERNEKEWAKLFFDAGFTYYKITHKLGVRSLIEVYL
>rna-gnl|WGS:JADFUC|Leryth_012292-t1
MPLAVLVEALAINKTKADSLHHLMRLLVHSGFFIEMPEGYVLTPASHLLLKDNPFSISPHIETILDPTITQPWNQFSNWFKTDGHASLFESFHGSPLWQIASKDQEFNHSFNEAMASDSRLVSSLVVSEYKDVFEGVDSLVDIAGGTGTMAKGIAKAFPNMSCIVLDLPHVIEGLKGSNNLSFVGGDNLS
>rna-gnl|WGS:JADFUC|Leryth_011634-t1
MGWDIKFVHMWILHDWSDERCVEILRNCKEAIQNKKIDGKVIIIDMVVDKQKKDNHVETMLFFDMLMMVVTPGRERTEKDWANLF
>rna-gnl|WGS:JADFUC|Leryth_015394-t1
MSLSELVNALPIPKEKVNCVYSLMRLLIQSGFFLEILEGCVFAPAAHLFLKDNPFCLTPVILSMLDPVLTEPWHHLSNWLGIEPPTTPFESFHGKAMYEFASREPKFNPTFNEAMSCDARLLSSVVLRDCKDVFKGVDVLVDIGGGTGAMAKAIADAFPDISCMVLELPHVVDGLQGSSNLSFVAGDMFDSVPPADAILLKWILHNWDDDKCVEIIKNCREALLSKGGKGKVIILDMAIDTKRENTDVETLLLVLV
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University