Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Lithospermum erythrorhizon
Species name
Lithospermum erythrorhizon is a species of eudicot in the family Boraginaceae (borage family).
Species info
Gene sequence info
Lithospermum_erythrorhizon.4CL.fa
Download
>rna-gnl|WGS:JADFUC|Leryth_026699-t1
MTMPNPHPSHRSHHNNQRMEKSGYGRDGVLRSLRPKLILPKDPNLNIVSFLFRNVSSYPQNPALIDSQTGQIVTFSQLYSLVCTFSHSLKTKLAISKNDVVLIFAPNSIHYPICFFSVVGIGAIATTVNPLYTVAELSKQIKDCKPKLIITVKDLVNKVDSFDLPVLLLGENNGEELFKRYHFIDLANSKMSVDLRLSDVWSAKQNDTAALLYSSGTTGMSKGVVLTHRNFIASALMVTCDQEMLGVMQNVFLCVLPMFHVFGLALIMNAQLQRGNAVVSMSKFELGMILMAIEKYKITHLWVVPPIILALAKNSVVKKYDLSSLREIGSGAAPLGKELMAECARNFPQAVVVQGYGMTETCGIVSLENPSLGPRHSGSAGILVPGVESQIVSVDKLKPLPLGQLGEICVRGPNMMEGYFNNKQATKLSIDKQGWVHTGDLGYFDEVGQLYVVDRIKELIKYKGYQVAPAELEGLLVSHHEILDAVVIPFPDAEAGEVPIAFVVRSPNSSLTEEDVKKFIADQVAPFKRLRKVTFVNSVPKSTAGKILRRELIEKVRSKL
>rna-gnl|WGS:JADFUC|Leryth_004695-t1
MFSSGTTGACKGVVLTHRNFISMVALFVRFESSQYSFTPSKNVYIAVLPMFHIFGLAQFVTGLLSLGTTVVVMKKFNPDEMVKAIAKYGVTHFPVVPPLMTALTKKAKSMDVKKGNFLRSLKQVSSGAAPLTTKLIQELVQALPHVDFIQGYGMTETTAVATRGYNTKDLKNYTSVGLLAPNSEAKVVDFVSGATMPPGGVGELWLRSPGVMNGYLNNIKETMSTVDTEGWLHTGDIVYFDQDGYLYVIDRLKEVIKYKGFQISPADLESVLMSHPEVADAAVTAVTDEEAGEIPVAFVVRKKGSELSEESLMDFVATKVSPYKKVRKVCFTNSVPRSAAGKIIRRELKMILPSRL
>rna-gnl|WGS:JADFUC|Leryth_004634-t1
MLSVASPETQKPELSSIAAPPSSTPQNQSSISGDNNSNETIIFRSKLPDIPISNNLPLHTYCFQNASEYPNRTCIIDSKTGKQYTFSETDSICRKVAAGLSNLGIQKGDVIMVLLQNCAEFVFTFMGASIIGAVITTANPFYTTAEIFKQVNVSNTKLIITQSNYVDKLRNTTINESDNKYPKLGEDFKVITIDTPPENCLPFSLLIENTQENQVTSVSIDSNDPVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGDNPNLYLKHDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLIMQKFEIGALLELIQSHRVSVAAVVPPLVLALAKNPMVDKYDLSSIRVVLSGAAPLGRELELALLNRVPHAIFGQGYGMTEAGPVLSMSPSFAKHPYPAKSGSCGTVVRNADLKVIDPETGSSLGRNQPGEICIRGEQIMKGYLNDPEATARTVDIEGWLHTGDIGYVDDDDEVFIVDRVKELIKFKGFQVPPAELEALLISHPNIADAAVVPQKDAAAGEVPVAFVVPSNDGFELTEEAVKEFISKQVVFYKRLHKVYFIHSIPKSPSGKILRKDLRAKLAAAASSCIKVIIAMYYG
>rna-gnl|WGS:JADFUC|Leryth_000245-t1
MLSVASPEPQKPELSSIVTPPSSTPQTQSSISGDVNSNETIIFRSKFPDIPISNHLPLHTYCFQNASEDPNRTCLIDGKTGKQYSFAETDSICRKVGHNLSNLGIQKGDVIMVLLQNCPEFVFSFMGASIIGAITTTANPFYTCTEIFKQIILSNTKLIITQSNYVDKLNTTSFIDADKYPKFGQDFKVITIDSPPENCLPFSLLSETSQENELSPISIDSNDPVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLYLTKDDVVLCVLPLFHIYSLNSVLLCSLRAGATVLIMHKFEIGALLELIQSHRVTVAAVVPPLVLALAKNPMVDKFDLSSIRVVLSGAAPLGKELELALLSRVPHAIFGQGYGMTEAGPVLSMSPSFAKKPYPTKSGSCGTVVRNADLKVIDPETGSSLGRNQPGEICIRGEQIMKGYLNDPEATARTIDIEGWLHTGDIGYVDDDDQVFIVDRVKELIKFKGFQVPPAELEALLISHNNIADAAVVSQKDDDAGEVPVAFVVPSTDGFELTEEAVKEFISKQVVFYKRLHKVYFVHSIPKSPSGKILRKDLRAKLAANASS
>rna-gnl|WGS:JADFUC|Leryth_000173-t1
MGVKQGDVVLISLPNSIIFPIIFLGVLSIGAIVAPMNPVSNPLEIKKQTKDCKVKFAFTTPEKVDQVSKALNLQAIPVSENITPGSIFHKIISSDPNLAPKPRINQEDTAAIMFSSGTTGACKAQFVTGLLSLGTTIVVMKKFHPDEMVKAISRFGVTHFPVVPPLMTALTKKAKSEDVKNANFLRSLKQVSSGAAPLTTKLIQEFVQALPHVDFIQGYGMTETTAVATRGYNTEELKNYTSVGLLAPNSQAKVIDFVSGAAVPPGGVGELWLRSPGVMKGYLNNIKETMSTVDTEGWLHTGDIVYFDQEGYLYIIDRLKEVIKYKGFQISPADLESVLMSHPEVADAAVTAVTDEEAGEIPVAFVVRKKGSELSEESLMDFVATKVSPYKKVRKVCFTSSVPRSAAGKIIRRELKMILPSRL
>rna-gnl|WGS:JADFUC|Leryth_022862-t1
METKEIQEFIFKSPLPDITLKNHLPLHTYIFQNISQFRSSECLINSVTGEIFTYDDVEVATKKVATGFRNKLGIQKGDVIMILLHNSL
>rna-gnl|WGS:JADFUC|Leryth_022863-t1
MLTHKNLVSSVSVLVDGENPNMNFHKEDSIICVLPLFHIYCLNSVFLTALRVGATLVIMQKFDINNCMEVVEKYKVTITPFVPPILLAIIKSELADKYDLSSIRMVQSGGAPLGKELEDAIRTKLPSAVLGQGCGMTEAGPLAMCPMFAKEPASDAKSGSCGKVVRNIEMKIVDIQTGASLPRNQSGEICIRGDQVMKGYLDDPENTARAIDKEGWMHSGDIGYVDDDGDVFIVDRLKEIIKYKGFQVAPAELESLLVAHPSISEAVVVPMKDEAAGEVPVAFVVKANGSQVTEEEIKNYIAQQVIYYKKIKRVFFVDAIPKAPSGKLLRKEVRTKLLAGLA
>rna-gnl|WGS:JADFUC|Leryth_012845-t1
MGTVAQSLKQDEHIFRSKYPAIQVPDDLTLPEFVLQNAEAHSDKVAFVEAVTGKRYTYGQVSRDVKRFANALRSLGIRKGRVVVVILPNVAEYAILALGIMSAGGVFSGANPSAHESEVKKQVETSEAKLIVTDASTFNKVKGLDVPAILLGEERVEGTIQFDELLEAAERANTDHVKEKILQTDLCALPFSSGTTGLSKGVMLTHRNIVANLSSSLFSVGPDMIGKVTILGLIPFFHIYGLVGICCATIKNKGTVVVMPRYELRALLNALIVHEVNFAPIVPPVILALVKNPIVDEFDLRKLKLNSIMSAAAPLAPETLSEFHRKFPGVEVLEAYGMTEHSCITITHGDPRKGHQTAKKNSVGFILPNLEVKFVDPETGLSLPKNTPGEICVRSQCVMKGYYKNQHETDLTIDKAGWLHSGDIGYIDDDGDVFIVDRIKELIKYKGFQVAPAELEGILLSHSSVDDAAVVGLADEEAGEVPAAWVVINPAAKEREQDIMNYVASNVANYKRVRVLQFVDSIPKSSSGKTMRRLIKDKMMESLKIKTNASPKMQI
>rna-gnl|WGS:JADFUC|Leryth_011976-t1
MDTQTKTDQKDIIFKSKLPDIFIPKHLPLHSYCFQNISDFNTRPCLINGSNNQIYTYSQVELISRKVASGLHKHGIKKNETIMILLPNCPEFVFAFLGASYIGAVSTTANPFFTSSEIIKQAKASKTKLIITEATNVPKFKDFSQENDVKIMCIDKQIEGCLHFSSDLENSDETTLPDVEIHPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNPNLYMHKEDVVMCTLPLFHIYSMNSILLCGLRVGATILLMHKFEIVTFLELIQRFKVTIGPFVPPIVLAIAKSPVVDQFDLSSVRTVMSGAAPLGKELEDAVRAKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFPIKSGACGTVVRNAHMKIVDVETGASLPRNQSGEICIRGDQIMKGYLNDPEATERTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLVTHPQIFDAAVVPMKDEGAGEVPVAFVVTSSGFTTTEDEIKKFISKQVIFYKRINRVFFVDSIPKSPSGKILRKDLRAKLADMYPNGPTTKVVPNDVTTKDVPNSVSMEGLIIANGGVAGDEIANGAPTNAPDGVAN
>rna-gnl|WGS:JADFUC|Leryth_016914-t1
MDTQTKTDQKDIIFRSKLPDIYIPKHLPLHSYCFENISQFSSRPCLINGSNDREYTYAEVEITSRKVAAGLHKHGIKQTETIMLLLPNCPEFVFAFLGASYIGAVSTTANPFFTSSEIIKQAKASKTKLIITVSTNVPKLKDFSQENHVKIMCIDDKIDGCLHFSSDLENSDETTLPDVEIRPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNANLYMHHEDVVMCTLPLFHIYSMNSILLCGLRVGAAILLMHKFEIVTFLELIQRYKVTIGPFVPPIVLAIAKSNVVDQYDLSTVRTVMSGAAPLGSELEDAVRAKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFEIKSGACGTVVRNSEMKIIDTETGASLPRNQSGEICIRGDQIMKGYLNDPEATERTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLVTHPNVSDAAVVSMKDEGAGEVPVAFVVRSNGSTTTEDEIKQFVSKQVIFYKRINRVFFVDSIPKSPSGKILRKDLRAKLAARFLNGPTTNGVPNGGNVAKDNVPNGVSNGVSKANGGVAKEGVANGVPADGNYGVATKGVANGISNGVYKQVSNGVVSNGVANGVVSNGIANGVHN
MTMPNPHPSHRSHHNNQRMEKSGYGRDGVLRSLRPKLILPKDPNLNIVSFLFRNVSSYPQNPALIDSQTGQIVTFSQLYSLVCTFSHSLKTKLAISKNDVVLIFAPNSIHYPICFFSVVGIGAIATTVNPLYTVAELSKQIKDCKPKLIITVKDLVNKVDSFDLPVLLLGENNGEELFKRYHFIDLANSKMSVDLRLSDVWSAKQNDTAALLYSSGTTGMSKGVVLTHRNFIASALMVTCDQEMLGVMQNVFLCVLPMFHVFGLALIMNAQLQRGNAVVSMSKFELGMILMAIEKYKITHLWVVPPIILALAKNSVVKKYDLSSLREIGSGAAPLGKELMAECARNFPQAVVVQGYGMTETCGIVSLENPSLGPRHSGSAGILVPGVESQIVSVDKLKPLPLGQLGEICVRGPNMMEGYFNNKQATKLSIDKQGWVHTGDLGYFDEVGQLYVVDRIKELIKYKGYQVAPAELEGLLVSHHEILDAVVIPFPDAEAGEVPIAFVVRSPNSSLTEEDVKKFIADQVAPFKRLRKVTFVNSVPKSTAGKILRRELIEKVRSKL
>rna-gnl|WGS:JADFUC|Leryth_004695-t1
MFSSGTTGACKGVVLTHRNFISMVALFVRFESSQYSFTPSKNVYIAVLPMFHIFGLAQFVTGLLSLGTTVVVMKKFNPDEMVKAIAKYGVTHFPVVPPLMTALTKKAKSMDVKKGNFLRSLKQVSSGAAPLTTKLIQELVQALPHVDFIQGYGMTETTAVATRGYNTKDLKNYTSVGLLAPNSEAKVVDFVSGATMPPGGVGELWLRSPGVMNGYLNNIKETMSTVDTEGWLHTGDIVYFDQDGYLYVIDRLKEVIKYKGFQISPADLESVLMSHPEVADAAVTAVTDEEAGEIPVAFVVRKKGSELSEESLMDFVATKVSPYKKVRKVCFTNSVPRSAAGKIIRRELKMILPSRL
>rna-gnl|WGS:JADFUC|Leryth_004634-t1
MLSVASPETQKPELSSIAAPPSSTPQNQSSISGDNNSNETIIFRSKLPDIPISNNLPLHTYCFQNASEYPNRTCIIDSKTGKQYTFSETDSICRKVAAGLSNLGIQKGDVIMVLLQNCAEFVFTFMGASIIGAVITTANPFYTTAEIFKQVNVSNTKLIITQSNYVDKLRNTTINESDNKYPKLGEDFKVITIDTPPENCLPFSLLIENTQENQVTSVSIDSNDPVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGDNPNLYLKHDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLIMQKFEIGALLELIQSHRVSVAAVVPPLVLALAKNPMVDKYDLSSIRVVLSGAAPLGRELELALLNRVPHAIFGQGYGMTEAGPVLSMSPSFAKHPYPAKSGSCGTVVRNADLKVIDPETGSSLGRNQPGEICIRGEQIMKGYLNDPEATARTVDIEGWLHTGDIGYVDDDDEVFIVDRVKELIKFKGFQVPPAELEALLISHPNIADAAVVPQKDAAAGEVPVAFVVPSNDGFELTEEAVKEFISKQVVFYKRLHKVYFIHSIPKSPSGKILRKDLRAKLAAAASSCIKVIIAMYYG
>rna-gnl|WGS:JADFUC|Leryth_000245-t1
MLSVASPEPQKPELSSIVTPPSSTPQTQSSISGDVNSNETIIFRSKFPDIPISNHLPLHTYCFQNASEDPNRTCLIDGKTGKQYSFAETDSICRKVGHNLSNLGIQKGDVIMVLLQNCPEFVFSFMGASIIGAITTTANPFYTCTEIFKQIILSNTKLIITQSNYVDKLNTTSFIDADKYPKFGQDFKVITIDSPPENCLPFSLLSETSQENELSPISIDSNDPVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLYLTKDDVVLCVLPLFHIYSLNSVLLCSLRAGATVLIMHKFEIGALLELIQSHRVTVAAVVPPLVLALAKNPMVDKFDLSSIRVVLSGAAPLGKELELALLSRVPHAIFGQGYGMTEAGPVLSMSPSFAKKPYPTKSGSCGTVVRNADLKVIDPETGSSLGRNQPGEICIRGEQIMKGYLNDPEATARTIDIEGWLHTGDIGYVDDDDQVFIVDRVKELIKFKGFQVPPAELEALLISHNNIADAAVVSQKDDDAGEVPVAFVVPSTDGFELTEEAVKEFISKQVVFYKRLHKVYFVHSIPKSPSGKILRKDLRAKLAANASS
>rna-gnl|WGS:JADFUC|Leryth_000173-t1
MGVKQGDVVLISLPNSIIFPIIFLGVLSIGAIVAPMNPVSNPLEIKKQTKDCKVKFAFTTPEKVDQVSKALNLQAIPVSENITPGSIFHKIISSDPNLAPKPRINQEDTAAIMFSSGTTGACKAQFVTGLLSLGTTIVVMKKFHPDEMVKAISRFGVTHFPVVPPLMTALTKKAKSEDVKNANFLRSLKQVSSGAAPLTTKLIQEFVQALPHVDFIQGYGMTETTAVATRGYNTEELKNYTSVGLLAPNSQAKVIDFVSGAAVPPGGVGELWLRSPGVMKGYLNNIKETMSTVDTEGWLHTGDIVYFDQEGYLYIIDRLKEVIKYKGFQISPADLESVLMSHPEVADAAVTAVTDEEAGEIPVAFVVRKKGSELSEESLMDFVATKVSPYKKVRKVCFTSSVPRSAAGKIIRRELKMILPSRL
>rna-gnl|WGS:JADFUC|Leryth_022862-t1
METKEIQEFIFKSPLPDITLKNHLPLHTYIFQNISQFRSSECLINSVTGEIFTYDDVEVATKKVATGFRNKLGIQKGDVIMILLHNSL
>rna-gnl|WGS:JADFUC|Leryth_022863-t1
MLTHKNLVSSVSVLVDGENPNMNFHKEDSIICVLPLFHIYCLNSVFLTALRVGATLVIMQKFDINNCMEVVEKYKVTITPFVPPILLAIIKSELADKYDLSSIRMVQSGGAPLGKELEDAIRTKLPSAVLGQGCGMTEAGPLAMCPMFAKEPASDAKSGSCGKVVRNIEMKIVDIQTGASLPRNQSGEICIRGDQVMKGYLDDPENTARAIDKEGWMHSGDIGYVDDDGDVFIVDRLKEIIKYKGFQVAPAELESLLVAHPSISEAVVVPMKDEAAGEVPVAFVVKANGSQVTEEEIKNYIAQQVIYYKKIKRVFFVDAIPKAPSGKLLRKEVRTKLLAGLA
>rna-gnl|WGS:JADFUC|Leryth_012845-t1
MGTVAQSLKQDEHIFRSKYPAIQVPDDLTLPEFVLQNAEAHSDKVAFVEAVTGKRYTYGQVSRDVKRFANALRSLGIRKGRVVVVILPNVAEYAILALGIMSAGGVFSGANPSAHESEVKKQVETSEAKLIVTDASTFNKVKGLDVPAILLGEERVEGTIQFDELLEAAERANTDHVKEKILQTDLCALPFSSGTTGLSKGVMLTHRNIVANLSSSLFSVGPDMIGKVTILGLIPFFHIYGLVGICCATIKNKGTVVVMPRYELRALLNALIVHEVNFAPIVPPVILALVKNPIVDEFDLRKLKLNSIMSAAAPLAPETLSEFHRKFPGVEVLEAYGMTEHSCITITHGDPRKGHQTAKKNSVGFILPNLEVKFVDPETGLSLPKNTPGEICVRSQCVMKGYYKNQHETDLTIDKAGWLHSGDIGYIDDDGDVFIVDRIKELIKYKGFQVAPAELEGILLSHSSVDDAAVVGLADEEAGEVPAAWVVINPAAKEREQDIMNYVASNVANYKRVRVLQFVDSIPKSSSGKTMRRLIKDKMMESLKIKTNASPKMQI
>rna-gnl|WGS:JADFUC|Leryth_011976-t1
MDTQTKTDQKDIIFKSKLPDIFIPKHLPLHSYCFQNISDFNTRPCLINGSNNQIYTYSQVELISRKVASGLHKHGIKKNETIMILLPNCPEFVFAFLGASYIGAVSTTANPFFTSSEIIKQAKASKTKLIITEATNVPKFKDFSQENDVKIMCIDKQIEGCLHFSSDLENSDETTLPDVEIHPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNPNLYMHKEDVVMCTLPLFHIYSMNSILLCGLRVGATILLMHKFEIVTFLELIQRFKVTIGPFVPPIVLAIAKSPVVDQFDLSSVRTVMSGAAPLGKELEDAVRAKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFPIKSGACGTVVRNAHMKIVDVETGASLPRNQSGEICIRGDQIMKGYLNDPEATERTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLVTHPQIFDAAVVPMKDEGAGEVPVAFVVTSSGFTTTEDEIKKFISKQVIFYKRINRVFFVDSIPKSPSGKILRKDLRAKLADMYPNGPTTKVVPNDVTTKDVPNSVSMEGLIIANGGVAGDEIANGAPTNAPDGVAN
>rna-gnl|WGS:JADFUC|Leryth_016914-t1
MDTQTKTDQKDIIFRSKLPDIYIPKHLPLHSYCFENISQFSSRPCLINGSNDREYTYAEVEITSRKVAAGLHKHGIKQTETIMLLLPNCPEFVFAFLGASYIGAVSTTANPFFTSSEIIKQAKASKTKLIITVSTNVPKLKDFSQENHVKIMCIDDKIDGCLHFSSDLENSDETTLPDVEIRPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNANLYMHHEDVVMCTLPLFHIYSMNSILLCGLRVGAAILLMHKFEIVTFLELIQRYKVTIGPFVPPIVLAIAKSNVVDQYDLSTVRTVMSGAAPLGSELEDAVRAKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFEIKSGACGTVVRNSEMKIIDTETGASLPRNQSGEICIRGDQIMKGYLNDPEATERTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLVTHPNVSDAAVVSMKDEGAGEVPVAFVVRSNGSTTTEDEIKQFVSKQVIFYKRINRVFFVDSIPKSPSGKILRKDLRAKLAARFLNGPTTNGVPNGGNVAKDNVPNGVSNGVSKANGGVAKEGVANGVPADGNYGVATKGVANGISNGVYKQVSNGVVSNGVANGVVSNGIANGVHN
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University