Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Laqenaria siceraria
Species name
White-flowered gourd (Lagenaria siceraria) is a species of eudicot in the family Cucurbitaceae (cucumber family).
Species info
Gene sequence info
Laqenaria_siceraria.CHS.fa
Download
>Lsi05G004350.1
MTKKRHMYLTEEILRENPNMCAYMAPSLDTRQKIAAVEVPKLGKDAAVKAIEEWGQPKSKITHLIFYTSSDVDMPNANYQLLKLLDLRPSVKRYMMCQQGCFAGGTVLRLAKDLAENNRGARILVVCSETIATIFLGPSETHLDSMVGQALFAEGAAAVIIGSDPDMLMEQPLYELVLTEAMVVPDSEGAIGGQLKEVGLTFYLHKHVPDLISKNIEHCLKEAFTPLGISDWKSIFWIAHPGGPAILDQVEAKLGLKKEKMRATREVLSEYGNMWSPCVLFIMDQMRRNSMEEGHSTTGEGLEWGVLFRFGPGITVETVVLRSVDIKDTTVKVASH
>Lsi05G007240.1
MGKGKRLELLPEKLTASWQALIGYGNASGNTIMYVLEYMVEESLKLKMDGEEIEERNDLFVVIGKRMRMKEEEEEEEEKEKGMPVEVDAG
>Lsi05G021960.1
MAAISSSKDRATALFKRQSLSSYRRLPALRCYSSRLTKTETKSSTKTKKARGMAQMINSKPWSSDLESSLASLSPSLSKTTVLQTLGFLRDPSKALQFFNWAQEMGYAHTEQSYFSMLEILGRNRHLNTARNFLFSIEKRSRGVVKLEARFFNSLMRNFSRAGLFQESIKLFTIMKSHGVSPSVVTFNSLLTILLKRGRTNMAKNVYDEMLSTYGVTPDTFTFNILIRGFCMNGMVDEGFRIFKDLSRFGCEPDVITYNTLVDGLCRAGKVTVAYNVVKGMGKKSVDLNPNVVTYTTLVRGYCAKREIDKALAAFEEMANQGLKANNITYNTLIKGLCEAQKFEKIKEILETTAGDGTFSPDTCTFNTLMHCHCHAGNLDDALRVFERMTELKIRPDSATYSVLVRSLCQGGHYEKAEDLLDKLLERKILLSGDGCKPLAAAYNPIFKYLCENGKTKKAEKVFRQLMRRGTQDPPSYKTLIMGHCNEGTFESGYELLVLMLRKDFLPDLEIYESLINGLVHKDKPLLALQSLEKMLRSSHLPKSSTFHSILAKLLEQGSASESASLIQLMLDKNIRQNLSFSTGCVRLLFGARMNDKAFLIVRLLYENGYSVKMEELIHYLCHCKKVIEASKMLLFSLESHQSVDMDVCNTVIFRLCEINKLPEAFSLYYKLVEMGVHQQLSCQNQLKVSLEAGEKLEEAEFVSKRMELVEMGVHQQLSCQNQLKVSLEAGGKLEEAEFISKRREQQLKFKNSIPRVQNSSEKSRNILQSSVQDLSQSECWHGMWTFGGVDEIWDHYTSKRQERCVLKDLENGNFKNEIAAPENKDNLRCFIQIFTEKAINILLKLPNMSKMSCEGSAMLDHARARRVPTPGKATILALGKAFPSQLVPQECLVEGYIRDTKCIDATIKEKLERLCKTTTVKTRYTVMCKEILDKYPELVTEGSPTIRQRLEIANPAVVEMATEASKACIEEWGRSIEDITHIVYVSSSEIRLPGGDLYIANQLGLKNDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRILLTTSETTILGFRPPNNARPYDLVGAALFGDGAAAVIIGADPVPGQESPFMELNYAVQQFLPDTHNVIDGRLSEEGINFKLGRDLPQRIDDNIEDFCRKLMGKGNLVDFNDLFWAVHPGGPAILNKLESTLRLKSDKLECSRKALMDYGNVSSNTIFYVIENMRENLKREDGEEWGLALAFGPGITFEGILIRSL
>Lsi05G004340.1
FFLFHFASLIKKKKKKTLPISMASVLAEIRKAQRADGPATVLAISTATPPHSVLQSDYPDYYFRITNSEHMTHLKEKFTRIKRHMYLTEEILRENPNMCAYMAPSLDARQDIVVVEVPKLGKDAAAKAIKEWGQPKSKITHLIFCTTSGVDMPGADYQLLKLLGLRPSVKRYMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSETHLDSMVGQALFGDGAAAVIIGSDPDLSVERPLYELVWTGATVVPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLKEAFTPLGISDWNSIFWIAHPGGPAILDQVEAKLGLKEEKMRATREVLSEYGNMSSACVLFIMDQMRKNSMEEGNLTTGEGLEWGVLFGFGPGLTVETVVLHSVDINETTAKAASH
>Lsi05G004380.1
MSGGKIRSKGREDESNSESEYGNMSSVCVLFIMDQMRKNSMQEGNSTTGEGLEWGVLFGFGLGITVETVVLHSVDIKETTLKAASL
>Lsi05G004330.1
MASVLAEIRKAQRADGPATVLAISTATPPHSVLQSDYPDYYFRITNSEHMTHLKEKFTRMCEKSMIRKRHMYLTEEILRENPNMCAYMAPSLDARQDIVVVEVPKLGKDAAAKAIKEWGQPKSKITHLIFCTTSGVDMPGADYQLLKLLGLRPSVKRYMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSETHLDSMVGQALFGDGAAAVIIGSDPDLSVERPLYELVWTGATVVPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLKEAFTPLGISDWNSIFWIAHPGGPAILDQVEAKLGLKEEKMRATREVLSEYGNMSSACVLFIMDQMRKNSMEEGNLTTGEGLEWGVLFGFGPGLTVETVVLHSVDINETTAKAASH
>Lsi05G004370.1
MASVMAEICKAQRADGPATVLAIGTATPPHSVLQSDYPDYYFRITNSEHMTYLKEKFTRICEKSMIRKRQMYLMEEILRENPNICAYMAPSLDTRQDIVVVEVPKLGKDAAAKAIEEWSQPKSKITHLIFCTTSGVDMLGADYQLRKLLGLRPSVKRYMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEINAIKFRGPSETHLDSMVGQTLFGDGARAVIIGSDIDLSVERPLYELVWTGATVLSESEGAINGHLREVGLTYHLHKDVPSLIFKNIEQCLKEAFTLLEISDWNSIF
>Lsi08G004730.1
MGQPISNITHLIFCTSSTNSIPGPDCHLSNLLGLNHSTKKFMLYQQGCFVAGTALRLAKDLVENNVGARVLVVCVDITTICFHGPSENRFDILVGQALFSDGAAVMVTPLALISC
>Lsi08G004720.1
MASQALLPNTEDGIKVNIKEMGLVYQLSRNLPKYVGENIEKCLSDASPSGIISHEYNNSLFYAIHPGGRAILDEIEQKLGLEKGKLEVSREVLREYGNMIGPTVIFVLDEMRKRSIREGKSTTGEGLQCGVVVTIGPGVTMETLMLESVPIMFEKGEGNERNEERATILGLAPPSHPTLLEDEFASTNECNKLTSSVTAARALRCLSTISALVVGQNIVKMSKRDNRNINSIVEPSLTFVICSSSASSSRKKFKYLMDSNVEILGSRGAKH
>Lsi08G004740.1
MVIKMSSEMFEKLEDNNQSHQSRATILGIGTAVPPNCFYQNQYPDFYFGVTNSQHMTHSKRKFELSSKKIGVTLITPTY
>Lsi09G011580.1
MHVPTKSTKMPYVTSINPTPNSLSPPISLCSAAAPLAGAVEAAKKMSAVDEIFKAQKAEGVASILAIGTAVPSNCIEQSKYPDFYFRITNNEHKTELKQKFKRMCEKSKIEKRYMLLTEEILKENPEICAYEAPSLDTRQDIAVVEVPKLGKQAAVNALRQWGRPTADITHLIFCTSSGIDMPGADYRITNLLGLRPSVKRFMIYQQGCFAGATVLRLLKDLAENNRSARVLAVCSEITAVTFRGPSDSHLDSLVGQALFGDGASAIIVGSDPIPGLERPIFEIISAAQTILPHSDGAIDGHLREVGLTFHLLKDVPGLVSNNIRGILLEAFEPLGLSTDWNSIFWIAHPGGPAILDQIEMELGLGPEKLRASRHVLKEYGNMSSACVLFILDEMRKKSIQNGLKTTGEGLEWGVLFGFGPGLTVETVILRSKPI
>Lsi11G011760.1
MKEMENSNGVQGASKGKANPGKATILALGKALPPQLVLQDYLVDGYFKDTSCDDIDLKQKLTRLCKTTTVKTRYVVMSEEILKKYPELAMEGQATIKQRLEICNKAVTDMAIEASQAAINNWSRPVSDITHLVYVSSSEARLPGGDLFLARGLELSPHTQRVMLYFMGCSGGAMLIGTDPVLGIERPLFELHTATQKFIPDTQNIIDGKLSEEGISFTIARELPQIIEDNIESFCETFLQTLGLQEKEYNKMFWAVHPGGPAILNRLEKRLELLPEKLTASRRALMDYGNASSNTIVYVLEYMVEESLKMKMGGGEIEEWGLILAFGPGISFEGILARNLAV
MTKKRHMYLTEEILRENPNMCAYMAPSLDTRQKIAAVEVPKLGKDAAVKAIEEWGQPKSKITHLIFYTSSDVDMPNANYQLLKLLDLRPSVKRYMMCQQGCFAGGTVLRLAKDLAENNRGARILVVCSETIATIFLGPSETHLDSMVGQALFAEGAAAVIIGSDPDMLMEQPLYELVLTEAMVVPDSEGAIGGQLKEVGLTFYLHKHVPDLISKNIEHCLKEAFTPLGISDWKSIFWIAHPGGPAILDQVEAKLGLKKEKMRATREVLSEYGNMWSPCVLFIMDQMRRNSMEEGHSTTGEGLEWGVLFRFGPGITVETVVLRSVDIKDTTVKVASH
>Lsi05G007240.1
MGKGKRLELLPEKLTASWQALIGYGNASGNTIMYVLEYMVEESLKLKMDGEEIEERNDLFVVIGKRMRMKEEEEEEEEKEKGMPVEVDAG
>Lsi05G021960.1
MAAISSSKDRATALFKRQSLSSYRRLPALRCYSSRLTKTETKSSTKTKKARGMAQMINSKPWSSDLESSLASLSPSLSKTTVLQTLGFLRDPSKALQFFNWAQEMGYAHTEQSYFSMLEILGRNRHLNTARNFLFSIEKRSRGVVKLEARFFNSLMRNFSRAGLFQESIKLFTIMKSHGVSPSVVTFNSLLTILLKRGRTNMAKNVYDEMLSTYGVTPDTFTFNILIRGFCMNGMVDEGFRIFKDLSRFGCEPDVITYNTLVDGLCRAGKVTVAYNVVKGMGKKSVDLNPNVVTYTTLVRGYCAKREIDKALAAFEEMANQGLKANNITYNTLIKGLCEAQKFEKIKEILETTAGDGTFSPDTCTFNTLMHCHCHAGNLDDALRVFERMTELKIRPDSATYSVLVRSLCQGGHYEKAEDLLDKLLERKILLSGDGCKPLAAAYNPIFKYLCENGKTKKAEKVFRQLMRRGTQDPPSYKTLIMGHCNEGTFESGYELLVLMLRKDFLPDLEIYESLINGLVHKDKPLLALQSLEKMLRSSHLPKSSTFHSILAKLLEQGSASESASLIQLMLDKNIRQNLSFSTGCVRLLFGARMNDKAFLIVRLLYENGYSVKMEELIHYLCHCKKVIEASKMLLFSLESHQSVDMDVCNTVIFRLCEINKLPEAFSLYYKLVEMGVHQQLSCQNQLKVSLEAGEKLEEAEFVSKRMELVEMGVHQQLSCQNQLKVSLEAGGKLEEAEFISKRREQQLKFKNSIPRVQNSSEKSRNILQSSVQDLSQSECWHGMWTFGGVDEIWDHYTSKRQERCVLKDLENGNFKNEIAAPENKDNLRCFIQIFTEKAINILLKLPNMSKMSCEGSAMLDHARARRVPTPGKATILALGKAFPSQLVPQECLVEGYIRDTKCIDATIKEKLERLCKTTTVKTRYTVMCKEILDKYPELVTEGSPTIRQRLEIANPAVVEMATEASKACIEEWGRSIEDITHIVYVSSSEIRLPGGDLYIANQLGLKNDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRILLTTSETTILGFRPPNNARPYDLVGAALFGDGAAAVIIGADPVPGQESPFMELNYAVQQFLPDTHNVIDGRLSEEGINFKLGRDLPQRIDDNIEDFCRKLMGKGNLVDFNDLFWAVHPGGPAILNKLESTLRLKSDKLECSRKALMDYGNVSSNTIFYVIENMRENLKREDGEEWGLALAFGPGITFEGILIRSL
>Lsi05G004340.1
FFLFHFASLIKKKKKKTLPISMASVLAEIRKAQRADGPATVLAISTATPPHSVLQSDYPDYYFRITNSEHMTHLKEKFTRIKRHMYLTEEILRENPNMCAYMAPSLDARQDIVVVEVPKLGKDAAAKAIKEWGQPKSKITHLIFCTTSGVDMPGADYQLLKLLGLRPSVKRYMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSETHLDSMVGQALFGDGAAAVIIGSDPDLSVERPLYELVWTGATVVPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLKEAFTPLGISDWNSIFWIAHPGGPAILDQVEAKLGLKEEKMRATREVLSEYGNMSSACVLFIMDQMRKNSMEEGNLTTGEGLEWGVLFGFGPGLTVETVVLHSVDINETTAKAASH
>Lsi05G004380.1
MSGGKIRSKGREDESNSESEYGNMSSVCVLFIMDQMRKNSMQEGNSTTGEGLEWGVLFGFGLGITVETVVLHSVDIKETTLKAASL
>Lsi05G004330.1
MASVLAEIRKAQRADGPATVLAISTATPPHSVLQSDYPDYYFRITNSEHMTHLKEKFTRMCEKSMIRKRHMYLTEEILRENPNMCAYMAPSLDARQDIVVVEVPKLGKDAAAKAIKEWGQPKSKITHLIFCTTSGVDMPGADYQLLKLLGLRPSVKRYMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSETHLDSMVGQALFGDGAAAVIIGSDPDLSVERPLYELVWTGATVVPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLKEAFTPLGISDWNSIFWIAHPGGPAILDQVEAKLGLKEEKMRATREVLSEYGNMSSACVLFIMDQMRKNSMEEGNLTTGEGLEWGVLFGFGPGLTVETVVLHSVDINETTAKAASH
>Lsi05G004370.1
MASVMAEICKAQRADGPATVLAIGTATPPHSVLQSDYPDYYFRITNSEHMTYLKEKFTRICEKSMIRKRQMYLMEEILRENPNICAYMAPSLDTRQDIVVVEVPKLGKDAAAKAIEEWSQPKSKITHLIFCTTSGVDMLGADYQLRKLLGLRPSVKRYMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEINAIKFRGPSETHLDSMVGQTLFGDGARAVIIGSDIDLSVERPLYELVWTGATVLSESEGAINGHLREVGLTYHLHKDVPSLIFKNIEQCLKEAFTLLEISDWNSIF
>Lsi08G004730.1
MGQPISNITHLIFCTSSTNSIPGPDCHLSNLLGLNHSTKKFMLYQQGCFVAGTALRLAKDLVENNVGARVLVVCVDITTICFHGPSENRFDILVGQALFSDGAAVMVTPLALISC
>Lsi08G004720.1
MASQALLPNTEDGIKVNIKEMGLVYQLSRNLPKYVGENIEKCLSDASPSGIISHEYNNSLFYAIHPGGRAILDEIEQKLGLEKGKLEVSREVLREYGNMIGPTVIFVLDEMRKRSIREGKSTTGEGLQCGVVVTIGPGVTMETLMLESVPIMFEKGEGNERNEERATILGLAPPSHPTLLEDEFASTNECNKLTSSVTAARALRCLSTISALVVGQNIVKMSKRDNRNINSIVEPSLTFVICSSSASSSRKKFKYLMDSNVEILGSRGAKH
>Lsi08G004740.1
MVIKMSSEMFEKLEDNNQSHQSRATILGIGTAVPPNCFYQNQYPDFYFGVTNSQHMTHSKRKFELSSKKIGVTLITPTY
>Lsi09G011580.1
MHVPTKSTKMPYVTSINPTPNSLSPPISLCSAAAPLAGAVEAAKKMSAVDEIFKAQKAEGVASILAIGTAVPSNCIEQSKYPDFYFRITNNEHKTELKQKFKRMCEKSKIEKRYMLLTEEILKENPEICAYEAPSLDTRQDIAVVEVPKLGKQAAVNALRQWGRPTADITHLIFCTSSGIDMPGADYRITNLLGLRPSVKRFMIYQQGCFAGATVLRLLKDLAENNRSARVLAVCSEITAVTFRGPSDSHLDSLVGQALFGDGASAIIVGSDPIPGLERPIFEIISAAQTILPHSDGAIDGHLREVGLTFHLLKDVPGLVSNNIRGILLEAFEPLGLSTDWNSIFWIAHPGGPAILDQIEMELGLGPEKLRASRHVLKEYGNMSSACVLFILDEMRKKSIQNGLKTTGEGLEWGVLFGFGPGLTVETVILRSKPI
>Lsi11G011760.1
MKEMENSNGVQGASKGKANPGKATILALGKALPPQLVLQDYLVDGYFKDTSCDDIDLKQKLTRLCKTTTVKTRYVVMSEEILKKYPELAMEGQATIKQRLEICNKAVTDMAIEASQAAINNWSRPVSDITHLVYVSSSEARLPGGDLFLARGLELSPHTQRVMLYFMGCSGGAMLIGTDPVLGIERPLFELHTATQKFIPDTQNIIDGKLSEEGISFTIARELPQIIEDNIESFCETFLQTLGLQEKEYNKMFWAVHPGGPAILNRLEKRLELLPEKLTASRRALMDYGNASSNTIVYVLEYMVEESLKMKMGGGEIEEWGLILAFGPGISFEGILARNLAV
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University