Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Laqenaria siceraria
Species name
White-flowered gourd (Lagenaria siceraria) is a species of eudicot in the family Cucurbitaceae (cucumber family).
Species info
Gene sequence info
Laqenaria_siceraria.4CL.fa
Download
>Lsi02G026370.1
MAVESNQTNEFIFRSKLPDIHIPNHLPLHDYVFQNLSKFASRPCLINGATGDVYSYNDVQITARRVAAGLHKLGIKKGDVIMNLLPNSPEFVFTFLGASYRGAIMTAANPFYTAVEIAKQAKAANAKLIVTMACFYDRVKDLAENGVKIVCVDFAVEGCSHFSVLSGADESSLPPVEFSPDDVVALPYSSGTTGLPKGVMLTHKGLITSVAQQMDGQNPNLHYHSDDVILCVLPFFHIYSLNSILLCGLRVGAAIMIMQKFDIVSLLQLIEKHRISIMPIVPPIFVAIAKSPDFEKYDVSSVRVLKSGGAPLGKELEDAVREKFPAAVLGQGYGMTEAGPVLSMSLAFAKEPFQVKAGACGTVVRNAEMKIVDPETGASLPANSAGEICIRGDQIMKGYLNDLESTKRTIDKEGWLHTGDIGLIDDDGELFIVDRLKELIKFKAFQVAPAELEALLITHPKLSDAAVIGMPDVEAGEVPVAFVVKANGGAITEEEVKQFIAKQVVFYKRLKRVFFVNAIPKAPSGKILRKELRAKLAYGAYH
>Lsi02G026350.1
MAVESNQTNEFIFRSKLPDIHIPNHLPLHDYVFQNLSKFASRPCLINGATGDVYSYHDVQLTARRVAAGLHSLGIKKGDVVMNLLPNSPEFVFTFLGASYRGAIMTAANPFCTAVEIAKQAKAANAKLIVTMACFYDRVKDLAENGVKIVCVDFAVEGCFHFSVLSGADESHAPSVEFSADDVVALPYSSGTTGLPKGVMLTHKGLITSVAQQIDGQNPNLYYRGDDVILCVLPFFHIYSLNSILLCGLRAGAAIMIMQKFDIVSLLQLIEKYRISIMPIVPPIFLAIAKSSEFEKYDVSSVRVLKSGGAPLGKELEDAVRAKFPTAILGQGYGMTEAGPVLTMSLAFAKEPFQVKAGACGTVVRNAEMKIVDPETGASLPANSAGEICIRGDQIMKGYLNDLESTKRTIDKEGWLHTGDIGLIDDNDELFIIDRLKELIKFKAFQVAPAELEALLITHPKLSDAAVIGMPDVEAGEVPVAFVIKENDDAITEEDVKQFITKQVVFYKRLKRVFFVNTIPKAPSGKILRKELRTKLASSAYN
>Lsi02G026360.1
MPDVEAGEVPVAFVVKANDSIITEEEVKQFITKQVVFYKRLKRVFFVNTIPKAPSGKILRKELRAKLASGAYN
>Lsi03G020060.1
MAITMRKSFNTQSQIYTSRRPPIHFPTDPTISIASFLFRNSSSFPNALALADADSGESLTFRQLQIQVSKLAHVFIQLGIRKGDVVLIFAPNSIHFPVCFFAIVAIGAIATTCNPAYTFAELSKQVANCNPKLVITIPELWDVIGKLNLPSIILGSKISSKFSRPNIWGYSDLIEKAGDVSNLPVSEVGQNDIAALLYSSGTTGISKGVILTHSNFITTSLMVTQDQDLLGDPRNVFLCFLPMFHVFGLSIVVYSQLQRGNTVVSMAKFELEKALGVAMKYKITHLYVVPPVIIALTKQSVVKNYDLSSLKQILSGAAPLGKDVMEECSKIIPQARIIQGYGMTETCGVISVENMGVESTLSGATGSLVSGVEAQILSTETQKRLPPGETGEICVRGPNMMKDVSMNISGYFNNQKATSQTIDDQGWVHTGDIGYFNEEGELFVVDRIKELIKCYGFQVAPAELEALLLSHPQITDAIVIPYPDDKAGEVPIAFVVRSPDSTIKEEDVKIFIAGQVAPFKRLKRVTFTSSVPKSASGKLLRREVIAQVRAKM
>Lsi03G012450.1
MGIETVQNDVIFRSKLPDIYIPKHLPLHSYCLHENAAKIGDRTCLINGVTGESFTYNDVDLSARKVAAGLNKIGITKGDVIMLLLPNSPEFVFAFLGASYLGAIMTAANPFFTAAEIAKQAKGSKSKLIVTQSSYYEKVKEITEELPDVKIMTVDSPPEGCLWFGDLMKADEKDIPTVEINPDDVVALPYSSGTTGLPKGVMLTHKSLVTSVAQQVDGENPNLYYGNEDVILCVLPLFHIYSLNSVLLCGLRAGTAILIMPKFEIGLLLKLVEKYRVSIAPIVPPIVLAIAKSPDLEKYDLSSIRVIKCGGAPLGKELEDTVRAKFPKAVLGQVKSRMRYKIKRDVMKILFNWIKLKINVQAKIFFDGYGMTEAGPVLTMGLAFAKEPFPMKPGACGTVVRNAEMKIVDTETGCSLPRNTPGEICIRGDQIMKGYLNNPEATAATIDKDGWLHTGDIGFIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPVISDAAVVPMKDEQAGEVPVAFVVKLKNSEVVFYKRINRVFFIDAIPKSPSGKILRKDLRAKLAAAFPNSN
>Lsi03G000100.1
MEKSGYGRDGIFRSLRPPLVFPKDPNLSMISFLFRNSLSYPNRLAIVDAESSDSVSYSQLKASAIKVSNGLIQLGIEKNDVVLIFAPNSVQFSICFFGIIAIGAIVTTCNPVYTVSELTKQVKDAKPKLVISVAELWDKVKDLNIPTVLLDQQIPSAIHSSKILCFNDLMNMAGDKSGSEFPIVGVKQSDTAALLYSSGTTGASKGVILTHRNFITSSLMITMDQTFKGEEHGVYLNFLPMFHVFGLACITYAQLQKGNIIVSMPKFNLEKALWAVEKYKVTDLWVVPPVVLALAKQSVVKKYNLSSVKRVGSGAAPLGKELMEECANNIPSAVVLQGYGMTETCGVVALENPEVGKRNSGSAGTLASGVEAKIVSVDTLKPLPPNQYGEIHVRGPNMMLGYFNNPEATKQTIDKYGWVHTGDLGYFDENGQLYVVDRIKELIKYKGFQVAPAELEALLVSHPEILDAVVIPYPDAEAGEVPIAYVVRSTNSSLTEEDILKFIADQVSPYKRLRKVTFISSVPKSVSGKILRRELIEKVRAKI
>Lsi04G006900.1
MATCIQNLVEDEEHIFRSQLPEVQVPGDITLPEFVLQNAESYAENVAFVEAVSGKAYTYREVVRDTNRFAKALCSLRLKKGQVVIVVLPNVAEYAIVALGIMAAGGVFSGVNPAAHISEIKKQVEVADAKLVVTNSANFEKVKELKLPVILLGDELIEGSMNWHKLLEAADRAGNNFVKEDIKQTDLCALPFSSGTTGVSKGVMLTHRNLVANLCSTLSGVPQEMVGKVTTLGLIPFFHIYGITGICCATLRNKGKVVVMGRFDLRTFINALITQEVTFAPIVPPIILALVKNPIVEEFDLSGLKLQAIMTAAAPLAPELQTAFERKFPGVDVQEAYGLTEHSCITLNYGSIGKENLTAKKKTVGRILPNLEVKFIDPDSGRSLPKNTPGEICVRSQCVMQGYYKNEEETSRTIDNKGWMHTGDIGYIDDDGDVFIVDRIKELIKYKGFQVAPAELEAILLTHPSIEDAAVVPLPDEEAGEIPAASVVMAPNSKETEEEIIKHVASNVAHYKKVRLVHFVDTIPKSPSGKVMRRLIKEKMIEKIRAESALRSV
>Lsi06G011330.1
MSLLSAFFCSHLTSLTKTKSTSLTLFHSFLYTSTSATPPMAAADDPSLEFIFRSKLPQIPIPTHLPLHTYCFEKISEFKHRPCLINAATGESYTYGEVQETSRRVAAGLHKLGIGKGDVIMLLLQNTPQFVLAFLGTSYLGAAATTVNPFFMPAEIAKQAASSGAKLIITQAAFAEKVKKLSQENKATIKVIFIDDDPPLEGGYHFSSLIDDVAKVEMEDVKISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPHLYIRSDDVVLCVLPLFHIYSLNTIMMCSLRVGAAILIVRKFDVNSLVELIPKYRVTFAPFVPPIVLAIVKSPAVDHSDMSSLRMALSGAAPLGKNLEDAFRTKFSHVILGQGYGMTELGSVMTMSLAFAKERFEMKSGGCGTIMRNTEMKIINPQTGASLPRNQAGEICIRSPQMMKGYLNDEEATKGIIDKDGWLHTGDIGFVDDDDEVFIVDRLKELIKYKGFQVAPAELEALLISHGHIADAAVIPMKDEVAGEVPVAFIVLSDGSNITEDEIKQYISKQFSGLISHYLLPIDGDFCIDFTVVFYKRINRVFFVDSIPKSPSGKILRRQLRALLATSIPN
>Lsi10G002320.1
MISITPLSDARRSNVSSEFSPSPPPATATTHIFRSKLPDITIPDHLPLHTYCFQKLSEVSDRPCLIVGSTGKSYSYSETYLFSRKAAATFSKLGVKKGDVIMILLQNSPEFVFSFMGSSMLAAVSTTANPYYTAAEIAKQLKVSGAKFVVTYSQCVDKLKESGVDLTIVTVDDPPENCLSFSMVYDADENDVPFVEIDTNDAVSLPFSSGTTGLPKGVILTHKNMVSSVAQQVDGENPNLYLRRNDVVLCVLPMFHIFSLSSIVLISIRSGATLLLMEKFEIKALLQLIERHKVTVATVVPPLVVALVKNPIVADFDLSSIRLVLSGAAPLRKELEEALMQRLPQAIFGPVLSMCSAFAKEPPMPTKSGSCGRVVRNSELKVIDSQTGVSLGYLNDPVSTSLTVDEEGWLHTGDIGYIDDDDEIFIVDRVAPAELEALLVTHPSIVDAAVVPQNDDVAGEVPVAFVVPSTHNELTEDVVKEFIAKQVVFYKRLQKVYFVQTIPKSPSGKILRKELKEKLRV
>Lsi11G007230.1
MEHELMNGQDFIFRSKLPDIYIPNHLPLHTYCFEHLSQFQHRPCLINGTTGEVHTYAAVDLAARCVAAGLSKIGVGQGDVIMLMLQNSPEFVFAFLGASFAGAISTTANPLYKPGEIAKQAAAARPKVIITQAEFVEKVWGFAVEHGVKILCTDSPPVGCLRFSEVMEADENEIPAVKINSNDVVALPFSSGTTGVPKGVMLTHKSLVTSVAQQVDGENPNVNLNSNDVIICVLPLFHIYSLNSVLLCGLRVGASILILQKYDMSSLLRLIQTHKATIAPFVPPIVLDFAKNPDIHRYDLSSIRIVMSGAAPMGKDLEDTVKARLPNATLGQGYGMTEAGPVLSMCLAFAKEPFEVKSGACGTVVRNAEMKIIHPQTSVSLPRNHPGYLNNKEATEKTIDKDGWLHTGDLGFIDDDDEIFIVDRLKELIKYKGYQVAPAELEALLTSNPYISAAAVIPMEDEAAGEIPVAFVVRSKGSKISENDIKKYISDQVIYYKKIRKVFFVDSIPIAPSGKILRKVLKAQLEAGAF
MAVESNQTNEFIFRSKLPDIHIPNHLPLHDYVFQNLSKFASRPCLINGATGDVYSYNDVQITARRVAAGLHKLGIKKGDVIMNLLPNSPEFVFTFLGASYRGAIMTAANPFYTAVEIAKQAKAANAKLIVTMACFYDRVKDLAENGVKIVCVDFAVEGCSHFSVLSGADESSLPPVEFSPDDVVALPYSSGTTGLPKGVMLTHKGLITSVAQQMDGQNPNLHYHSDDVILCVLPFFHIYSLNSILLCGLRVGAAIMIMQKFDIVSLLQLIEKHRISIMPIVPPIFVAIAKSPDFEKYDVSSVRVLKSGGAPLGKELEDAVREKFPAAVLGQGYGMTEAGPVLSMSLAFAKEPFQVKAGACGTVVRNAEMKIVDPETGASLPANSAGEICIRGDQIMKGYLNDLESTKRTIDKEGWLHTGDIGLIDDDGELFIVDRLKELIKFKAFQVAPAELEALLITHPKLSDAAVIGMPDVEAGEVPVAFVVKANGGAITEEEVKQFIAKQVVFYKRLKRVFFVNAIPKAPSGKILRKELRAKLAYGAYH
>Lsi02G026350.1
MAVESNQTNEFIFRSKLPDIHIPNHLPLHDYVFQNLSKFASRPCLINGATGDVYSYHDVQLTARRVAAGLHSLGIKKGDVVMNLLPNSPEFVFTFLGASYRGAIMTAANPFCTAVEIAKQAKAANAKLIVTMACFYDRVKDLAENGVKIVCVDFAVEGCFHFSVLSGADESHAPSVEFSADDVVALPYSSGTTGLPKGVMLTHKGLITSVAQQIDGQNPNLYYRGDDVILCVLPFFHIYSLNSILLCGLRAGAAIMIMQKFDIVSLLQLIEKYRISIMPIVPPIFLAIAKSSEFEKYDVSSVRVLKSGGAPLGKELEDAVRAKFPTAILGQGYGMTEAGPVLTMSLAFAKEPFQVKAGACGTVVRNAEMKIVDPETGASLPANSAGEICIRGDQIMKGYLNDLESTKRTIDKEGWLHTGDIGLIDDNDELFIIDRLKELIKFKAFQVAPAELEALLITHPKLSDAAVIGMPDVEAGEVPVAFVIKENDDAITEEDVKQFITKQVVFYKRLKRVFFVNTIPKAPSGKILRKELRTKLASSAYN
>Lsi02G026360.1
MPDVEAGEVPVAFVVKANDSIITEEEVKQFITKQVVFYKRLKRVFFVNTIPKAPSGKILRKELRAKLASGAYN
>Lsi03G020060.1
MAITMRKSFNTQSQIYTSRRPPIHFPTDPTISIASFLFRNSSSFPNALALADADSGESLTFRQLQIQVSKLAHVFIQLGIRKGDVVLIFAPNSIHFPVCFFAIVAIGAIATTCNPAYTFAELSKQVANCNPKLVITIPELWDVIGKLNLPSIILGSKISSKFSRPNIWGYSDLIEKAGDVSNLPVSEVGQNDIAALLYSSGTTGISKGVILTHSNFITTSLMVTQDQDLLGDPRNVFLCFLPMFHVFGLSIVVYSQLQRGNTVVSMAKFELEKALGVAMKYKITHLYVVPPVIIALTKQSVVKNYDLSSLKQILSGAAPLGKDVMEECSKIIPQARIIQGYGMTETCGVISVENMGVESTLSGATGSLVSGVEAQILSTETQKRLPPGETGEICVRGPNMMKDVSMNISGYFNNQKATSQTIDDQGWVHTGDIGYFNEEGELFVVDRIKELIKCYGFQVAPAELEALLLSHPQITDAIVIPYPDDKAGEVPIAFVVRSPDSTIKEEDVKIFIAGQVAPFKRLKRVTFTSSVPKSASGKLLRREVIAQVRAKM
>Lsi03G012450.1
MGIETVQNDVIFRSKLPDIYIPKHLPLHSYCLHENAAKIGDRTCLINGVTGESFTYNDVDLSARKVAAGLNKIGITKGDVIMLLLPNSPEFVFAFLGASYLGAIMTAANPFFTAAEIAKQAKGSKSKLIVTQSSYYEKVKEITEELPDVKIMTVDSPPEGCLWFGDLMKADEKDIPTVEINPDDVVALPYSSGTTGLPKGVMLTHKSLVTSVAQQVDGENPNLYYGNEDVILCVLPLFHIYSLNSVLLCGLRAGTAILIMPKFEIGLLLKLVEKYRVSIAPIVPPIVLAIAKSPDLEKYDLSSIRVIKCGGAPLGKELEDTVRAKFPKAVLGQVKSRMRYKIKRDVMKILFNWIKLKINVQAKIFFDGYGMTEAGPVLTMGLAFAKEPFPMKPGACGTVVRNAEMKIVDTETGCSLPRNTPGEICIRGDQIMKGYLNNPEATAATIDKDGWLHTGDIGFIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPVISDAAVVPMKDEQAGEVPVAFVVKLKNSEVVFYKRINRVFFIDAIPKSPSGKILRKDLRAKLAAAFPNSN
>Lsi03G000100.1
MEKSGYGRDGIFRSLRPPLVFPKDPNLSMISFLFRNSLSYPNRLAIVDAESSDSVSYSQLKASAIKVSNGLIQLGIEKNDVVLIFAPNSVQFSICFFGIIAIGAIVTTCNPVYTVSELTKQVKDAKPKLVISVAELWDKVKDLNIPTVLLDQQIPSAIHSSKILCFNDLMNMAGDKSGSEFPIVGVKQSDTAALLYSSGTTGASKGVILTHRNFITSSLMITMDQTFKGEEHGVYLNFLPMFHVFGLACITYAQLQKGNIIVSMPKFNLEKALWAVEKYKVTDLWVVPPVVLALAKQSVVKKYNLSSVKRVGSGAAPLGKELMEECANNIPSAVVLQGYGMTETCGVVALENPEVGKRNSGSAGTLASGVEAKIVSVDTLKPLPPNQYGEIHVRGPNMMLGYFNNPEATKQTIDKYGWVHTGDLGYFDENGQLYVVDRIKELIKYKGFQVAPAELEALLVSHPEILDAVVIPYPDAEAGEVPIAYVVRSTNSSLTEEDILKFIADQVSPYKRLRKVTFISSVPKSVSGKILRRELIEKVRAKI
>Lsi04G006900.1
MATCIQNLVEDEEHIFRSQLPEVQVPGDITLPEFVLQNAESYAENVAFVEAVSGKAYTYREVVRDTNRFAKALCSLRLKKGQVVIVVLPNVAEYAIVALGIMAAGGVFSGVNPAAHISEIKKQVEVADAKLVVTNSANFEKVKELKLPVILLGDELIEGSMNWHKLLEAADRAGNNFVKEDIKQTDLCALPFSSGTTGVSKGVMLTHRNLVANLCSTLSGVPQEMVGKVTTLGLIPFFHIYGITGICCATLRNKGKVVVMGRFDLRTFINALITQEVTFAPIVPPIILALVKNPIVEEFDLSGLKLQAIMTAAAPLAPELQTAFERKFPGVDVQEAYGLTEHSCITLNYGSIGKENLTAKKKTVGRILPNLEVKFIDPDSGRSLPKNTPGEICVRSQCVMQGYYKNEEETSRTIDNKGWMHTGDIGYIDDDGDVFIVDRIKELIKYKGFQVAPAELEAILLTHPSIEDAAVVPLPDEEAGEIPAASVVMAPNSKETEEEIIKHVASNVAHYKKVRLVHFVDTIPKSPSGKVMRRLIKEKMIEKIRAESALRSV
>Lsi06G011330.1
MSLLSAFFCSHLTSLTKTKSTSLTLFHSFLYTSTSATPPMAAADDPSLEFIFRSKLPQIPIPTHLPLHTYCFEKISEFKHRPCLINAATGESYTYGEVQETSRRVAAGLHKLGIGKGDVIMLLLQNTPQFVLAFLGTSYLGAAATTVNPFFMPAEIAKQAASSGAKLIITQAAFAEKVKKLSQENKATIKVIFIDDDPPLEGGYHFSSLIDDVAKVEMEDVKISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPHLYIRSDDVVLCVLPLFHIYSLNTIMMCSLRVGAAILIVRKFDVNSLVELIPKYRVTFAPFVPPIVLAIVKSPAVDHSDMSSLRMALSGAAPLGKNLEDAFRTKFSHVILGQGYGMTELGSVMTMSLAFAKERFEMKSGGCGTIMRNTEMKIINPQTGASLPRNQAGEICIRSPQMMKGYLNDEEATKGIIDKDGWLHTGDIGFVDDDDEVFIVDRLKELIKYKGFQVAPAELEALLISHGHIADAAVIPMKDEVAGEVPVAFIVLSDGSNITEDEIKQYISKQFSGLISHYLLPIDGDFCIDFTVVFYKRINRVFFVDSIPKSPSGKILRRQLRALLATSIPN
>Lsi10G002320.1
MISITPLSDARRSNVSSEFSPSPPPATATTHIFRSKLPDITIPDHLPLHTYCFQKLSEVSDRPCLIVGSTGKSYSYSETYLFSRKAAATFSKLGVKKGDVIMILLQNSPEFVFSFMGSSMLAAVSTTANPYYTAAEIAKQLKVSGAKFVVTYSQCVDKLKESGVDLTIVTVDDPPENCLSFSMVYDADENDVPFVEIDTNDAVSLPFSSGTTGLPKGVILTHKNMVSSVAQQVDGENPNLYLRRNDVVLCVLPMFHIFSLSSIVLISIRSGATLLLMEKFEIKALLQLIERHKVTVATVVPPLVVALVKNPIVADFDLSSIRLVLSGAAPLRKELEEALMQRLPQAIFGPVLSMCSAFAKEPPMPTKSGSCGRVVRNSELKVIDSQTGVSLGYLNDPVSTSLTVDEEGWLHTGDIGYIDDDDEIFIVDRVAPAELEALLVTHPSIVDAAVVPQNDDVAGEVPVAFVVPSTHNELTEDVVKEFIAKQVVFYKRLQKVYFVQTIPKSPSGKILRKELKEKLRV
>Lsi11G007230.1
MEHELMNGQDFIFRSKLPDIYIPNHLPLHTYCFEHLSQFQHRPCLINGTTGEVHTYAAVDLAARCVAAGLSKIGVGQGDVIMLMLQNSPEFVFAFLGASFAGAISTTANPLYKPGEIAKQAAAARPKVIITQAEFVEKVWGFAVEHGVKILCTDSPPVGCLRFSEVMEADENEIPAVKINSNDVVALPFSSGTTGVPKGVMLTHKSLVTSVAQQVDGENPNVNLNSNDVIICVLPLFHIYSLNSVLLCGLRVGASILILQKYDMSSLLRLIQTHKATIAPFVPPIVLDFAKNPDIHRYDLSSIRIVMSGAAPMGKDLEDTVKARLPNATLGQGYGMTEAGPVLSMCLAFAKEPFEVKSGACGTVVRNAEMKIIHPQTSVSLPRNHPGYLNNKEATEKTIDKDGWLHTGDLGFIDDDDEIFIVDRLKELIKYKGYQVAPAELEALLTSNPYISAAAVIPMEDEAAGEIPVAFVVRSKGSKISENDIKKYISDQVIYYKKIRKVFFVDSIPIAPSGKILRKVLKAQLEAGAF
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University