Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Lactuca sativa
Species name
Garden lettuce (Lactuca sativa) is a species of eudicot in the family Asteraceae (daisy family).
Species info
Gene sequence info
Lactuca_sativa.COMT.fa
Download
>rna-XM_023916005.2
MGSIVEAKQEEEAFLFAMQLASASVLPMVLKSAVELDLLETIAKAGPGAYVSPAELAAQLPKVENPEAAVMLDRICRLLASYSVLTCTLKDVAGDGVVQRLYGLAPVCKFLVKNEDGVSMAPLLLMNQDKILMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGKDARFNKVFNSGMFNHSTMTMKKILDMYDGFNGLTTLVDVGGGTGASLSMIVSKHPSVKGINFDLPHVIQDATSIPGIEHVGGDMFESVPEGDAIFMKWICHDWSDAHCLKFLNNCYKALPEKGKVIVAECILPEAPDTSLATQNVVHIDVIMLAHNPGGKERTEKDFEALAKGAGFSGFRKACCALNTWVMEFTK
>rna-XM_023901178.2
MYHVTNIHTPKRLNCPLHSLMVISTDTSNQAENTKMETPDAETPPPTSNAARLAIMELANMISVPMSLNAVVRLNVADAIWQNGSNKPLSAAEIIPLILPSGAGDPENLQRILRMLTSYGVFNEHIISGDILQRRYSLTEIGKTLVTDENGLSYGAYVLQHHQEELMKAWGVVHEAVVDSSTEPFVKANGGETAYGLYGKKPEMNDLMLKAMSGVTVPFMKVVLEGYDGFNGVERLVDVGGSAGDCLRMILQKHSHIKEGVNFDLPEVVAKAPKIDGVSHVGGDMFDSIPNGDAIFMKWILTTWTDDEVKAIMTNCFKAIPIGGKLIACEPVLPDETNDSHRTRALLEGDIFVMTIYRAKGKHRTEEEYCQLGKSAGFKSFRAVYIDHFYTLLEFGK
>rna-XM_023899175.2
MGSTSDASVNVPHDDESFLFAMQLASASVLPMVVKTAIELDLLETIAKAGPGASLSSSDLASQLPNVNNPEAPAMLDRICSLLASHSVLTCTLKDSGDGGVERFYGLAPVCKFLIKNEGGVSLAPLLLMNQDKILMESWYHLKDAVLDGGIPFNKAYGMSAFEYHGKDQRFNKVFNSGMFNHSTMTMEKIVDLYDGFSGLKTLVDVGGGIGASLNKIISKHTSLKGINFDLPHVIEDATTYPGIEHVGGDMFQSVPKGDAIFMKWILHDWSDAHCLKILKNCYEALPDNGKVIVAECMLPEAPDSTAATQNVVHIDVIMLAHNPGGKERTEKDFEALAKGAGFKGFRKAACALNTWVMEFSK
>rna-XM_023881820.2
MESLEEDYSMSTEEEGLLKVMQINGTIALPMVIKTVIELDLFEIMAKTPNGQFSSLDLASSLPTQAPETPGLIERLLRFLASQSILTSTLVTDESGNSKNLYGMTPLSNNYVRNQDGTSLASSILMIYDKIFVDCWYYLKDAVANGGIPFNKAHGVHAFEYPAKDNRFNQVFNKCMYDNTTIVMKMFLGKYKGFEGVKQLVDVGGGLGANLNIIVSKYPTIKGINFDLPHVIKDTHSSPGVDHVGGDMFESVPIGDVIFMKWILHDWGDNECITVLKNCWAALPEFGKVVAVETIIPDLENQPRDHATNIDVSKTVISSDMIMMIANPGGKERTLKEYNSLAKKAGFTSLKIVCRVSTFWIMEFYKNA
>rna-XM_023881833.2
MNEEEELLRVMRMVAGTVLPMVMKTAIELDLFEIMVKLTNHGHCGQFTSSDIVSCLPTQNPQTPIIIERILRYLATKSILTSKFFTDENGVTKKLYAMTPICKYFVSNEEGASFANFFLFQNDKVVIDSWHHLKDAVLEGGTPFNKAHGENIFEYQAKDKRFGKLFDKAMFGNTSILMKMVLEKYKGFSGVEKLVDVGGGLGATLGIILSKYPNIKGINFDMPHVIKDAPLICPGVEHVGGDMFQSVPKGDVIFMKWILHDWGDDYCMKLLKNCWMALPEDGKVVVLETVVPDEQPTNNNGETDVVMSNLDGDMVMLAINPGGKERTAKEYEALATDSGFVSSKIVCRVSFYSIMEFYKKI
>rna-XM_023898795.2
MGSREEDFAYAMQLVTSTSLPMVLVTTIKLKVFDKIAEAGPGAQLSAHEIVSRLSMTNPSAHQMLDRMLRLLASYSVVTCNQRDHDQLGLVRVYGLTSVAKYFIPNKDGVSLCPVMELLQDKVFIESWFKLKDAVLEGGVPFDKVHGTHAFEYPALDARFNRVFNNGMLNFTTIMMNEILKCYHGFDNLKCVIDVGGGLGVALNIITSKYPTIKGINFDLPHVIRHAPVYPGIEHMGGDMFEEVPQGDAIFMKWILHDWSDDHCAKLLMNCYKALPNDGKVIVVEYILPFLSNTSSFDKVTTHMDASMMTQNQGGKERMEDEFLVLAKGAGFKGIRKECCVCNMYVIEFYK
>rna-XM_023898797.2
MGSDEEQFAYAMQLVTSMSLTMVLVNAMKLKIFETIAEAGPDARLSAHEIVSRLSMTNPSAHQMLDRMLRLLATHSVVTCNQQEREFGLVRVYGLTPVAKYFVPNEDGVSLCALMELLQDKAFVDSWFKLKDSLLEGGVPFDMVHGTHAFEYPALDARFNKVFNNAMTNHTTMVMNKILECYHGFENLKQVVDVGGGLGVNLNIIISKYPTIKGINFDLPHVIQHAPVSPGIEHIGGDMFEEVPPSDAIFMKWILHDWSDDHCEKLLKNCYKALSNEGKVIVVESILPFLSNTSSSDKVTTQIDAIMMTQNPGGKERTKHEFLVLAKNAGFTGIKMECFVCNLWVMEFYK
MGSIVEAKQEEEAFLFAMQLASASVLPMVLKSAVELDLLETIAKAGPGAYVSPAELAAQLPKVENPEAAVMLDRICRLLASYSVLTCTLKDVAGDGVVQRLYGLAPVCKFLVKNEDGVSMAPLLLMNQDKILMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGKDARFNKVFNSGMFNHSTMTMKKILDMYDGFNGLTTLVDVGGGTGASLSMIVSKHPSVKGINFDLPHVIQDATSIPGIEHVGGDMFESVPEGDAIFMKWICHDWSDAHCLKFLNNCYKALPEKGKVIVAECILPEAPDTSLATQNVVHIDVIMLAHNPGGKERTEKDFEALAKGAGFSGFRKACCALNTWVMEFTK
>rna-XM_023901178.2
MYHVTNIHTPKRLNCPLHSLMVISTDTSNQAENTKMETPDAETPPPTSNAARLAIMELANMISVPMSLNAVVRLNVADAIWQNGSNKPLSAAEIIPLILPSGAGDPENLQRILRMLTSYGVFNEHIISGDILQRRYSLTEIGKTLVTDENGLSYGAYVLQHHQEELMKAWGVVHEAVVDSSTEPFVKANGGETAYGLYGKKPEMNDLMLKAMSGVTVPFMKVVLEGYDGFNGVERLVDVGGSAGDCLRMILQKHSHIKEGVNFDLPEVVAKAPKIDGVSHVGGDMFDSIPNGDAIFMKWILTTWTDDEVKAIMTNCFKAIPIGGKLIACEPVLPDETNDSHRTRALLEGDIFVMTIYRAKGKHRTEEEYCQLGKSAGFKSFRAVYIDHFYTLLEFGK
>rna-XM_023899175.2
MGSTSDASVNVPHDDESFLFAMQLASASVLPMVVKTAIELDLLETIAKAGPGASLSSSDLASQLPNVNNPEAPAMLDRICSLLASHSVLTCTLKDSGDGGVERFYGLAPVCKFLIKNEGGVSLAPLLLMNQDKILMESWYHLKDAVLDGGIPFNKAYGMSAFEYHGKDQRFNKVFNSGMFNHSTMTMEKIVDLYDGFSGLKTLVDVGGGIGASLNKIISKHTSLKGINFDLPHVIEDATTYPGIEHVGGDMFQSVPKGDAIFMKWILHDWSDAHCLKILKNCYEALPDNGKVIVAECMLPEAPDSTAATQNVVHIDVIMLAHNPGGKERTEKDFEALAKGAGFKGFRKAACALNTWVMEFSK
>rna-XM_023881820.2
MESLEEDYSMSTEEEGLLKVMQINGTIALPMVIKTVIELDLFEIMAKTPNGQFSSLDLASSLPTQAPETPGLIERLLRFLASQSILTSTLVTDESGNSKNLYGMTPLSNNYVRNQDGTSLASSILMIYDKIFVDCWYYLKDAVANGGIPFNKAHGVHAFEYPAKDNRFNQVFNKCMYDNTTIVMKMFLGKYKGFEGVKQLVDVGGGLGANLNIIVSKYPTIKGINFDLPHVIKDTHSSPGVDHVGGDMFESVPIGDVIFMKWILHDWGDNECITVLKNCWAALPEFGKVVAVETIIPDLENQPRDHATNIDVSKTVISSDMIMMIANPGGKERTLKEYNSLAKKAGFTSLKIVCRVSTFWIMEFYKNA
>rna-XM_023881833.2
MNEEEELLRVMRMVAGTVLPMVMKTAIELDLFEIMVKLTNHGHCGQFTSSDIVSCLPTQNPQTPIIIERILRYLATKSILTSKFFTDENGVTKKLYAMTPICKYFVSNEEGASFANFFLFQNDKVVIDSWHHLKDAVLEGGTPFNKAHGENIFEYQAKDKRFGKLFDKAMFGNTSILMKMVLEKYKGFSGVEKLVDVGGGLGATLGIILSKYPNIKGINFDMPHVIKDAPLICPGVEHVGGDMFQSVPKGDVIFMKWILHDWGDDYCMKLLKNCWMALPEDGKVVVLETVVPDEQPTNNNGETDVVMSNLDGDMVMLAINPGGKERTAKEYEALATDSGFVSSKIVCRVSFYSIMEFYKKI
>rna-XM_023898795.2
MGSREEDFAYAMQLVTSTSLPMVLVTTIKLKVFDKIAEAGPGAQLSAHEIVSRLSMTNPSAHQMLDRMLRLLASYSVVTCNQRDHDQLGLVRVYGLTSVAKYFIPNKDGVSLCPVMELLQDKVFIESWFKLKDAVLEGGVPFDKVHGTHAFEYPALDARFNRVFNNGMLNFTTIMMNEILKCYHGFDNLKCVIDVGGGLGVALNIITSKYPTIKGINFDLPHVIRHAPVYPGIEHMGGDMFEEVPQGDAIFMKWILHDWSDDHCAKLLMNCYKALPNDGKVIVVEYILPFLSNTSSFDKVTTHMDASMMTQNQGGKERMEDEFLVLAKGAGFKGIRKECCVCNMYVIEFYK
>rna-XM_023898797.2
MGSDEEQFAYAMQLVTSMSLTMVLVNAMKLKIFETIAEAGPDARLSAHEIVSRLSMTNPSAHQMLDRMLRLLATHSVVTCNQQEREFGLVRVYGLTPVAKYFVPNEDGVSLCALMELLQDKAFVDSWFKLKDSLLEGGVPFDMVHGTHAFEYPALDARFNKVFNNAMTNHTTMVMNKILECYHGFENLKQVVDVGGGLGVNLNIIISKYPTIKGINFDLPHVIQHAPVSPGIEHIGGDMFEEVPPSDAIFMKWILHDWSDDHCEKLLKNCYKALSNEGKVIVVESILPFLSNTSSSDKVTTQIDAIMMTQNPGGKERTKHEFLVLAKNAGFTGIKMECFVCNLWVMEFYK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University