Enzyme
Found in hops (Humulus lupulus). The enzyme can also methylate xanthogalenol.
OMT
Enzyme
Xanthohumol 4-O-methyltransferase
Enzyme name
EC:2.1.1.338
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:desmethylxanthohumol 6'-O-methyltransferase
Sysname
S-adenosyl-L-methionine + desmethylxanthohumol = S-adenosyl-L-homocysteine + xanthohumol [RN:R08004]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];xanthohumol [CPD:C16417]
Product
Species information
Lactuca sativa
Species name
Garden lettuce (Lactuca sativa) is a species of eudicot in the family Asteraceae (daisy family).
Species info
Gene sequence info
Lactuca_sativa.OMT.fa
Download
>rna-XM_023910372.2
MSLLNDEQSTNLLHSQAHIWNHIFSFINSMSLKCAIQLQIPDIINRHGAPMLLSELVEALSINKERAHFVYRLMRILVHSGFFIKQSICTTGDHKEEEREGYLLAPASRFLLKEEPLSISPFLLAMLDPILMDPWQHLSKWFQNDDVNPFHTAHGRNLWDFAGHDPNLNQFFNEAMGSDARLVTSLVLKHSTNVFERLNSIVDVGGGTGTVAKAIAEAFPDMTCISFDLPHVVDGLVGSKNLSFLGGDMFESIPKADAVLVKWILHDWSDEECIKILMQCKEAIPSKENGGKVIIIDMVLKNGEGDKELLETQLFFDMLMLTLTTGRERSEKNWAKLFVDAGFSDYKITPILGLRSLIEVYP
>rna-XM_023915732.2
MELQNDEQSLDLLRSEAHIWNHIYSFINSMSLKCAIQLQIPDIINRHGAPMLLSELVEALSINKEKTQYVFRLMRILVHSGFFVKQSISTTEDNDEEETKGYLLAPASRYLLTEEPLSSRSLVLAMLDPILMNPWQQMSKWFQNDDANPFLTTHGSHYWEFLGEEPKLKQFFNESMANDSRLVMSVVLKHCADSFRTLNSIVDVGGGTGTVAKAIAEAFPDISCISFDLPHVVIGLVGSKNLRYIGGDMFEVIPKADAVVLKWILHDWSDEECIKILKQCKEAIPSKENGGKLIIIDMVVKNHKEDNNLLMTQLYFDMLMMTVLTGKERSEKEWAKLFLDADFSDYKITPILGLRSLIEVYP
>rna-XM_023910369.2
MSLQNREQSKEMLHSQAHIWNHIFSFVNSMSLKCAIELQIPDIIDGHGAPMLLSELVEALPINKERTTFVYRLMRILVHSGCFMKQSLSTTTGNDEEEEREGYLLTPASRLLLKEEPFSIRPLLLFMLDPILMDPWQNMSEWFKNKDITPFHTTHGKSMWDLASREPKVNQFVNETMASDAKLIGSFITKHCADVFQGLNSVVDVGGGTGTIAKAIAKAFPSISCISFDLPHVVNGLEGSKNMSYVCGDMFEAIPKADAVFLKWILHDWNDEECIKILKRCKEAIPNKEYGGKVIIVDMVLKNEEAGEKSLETQLFFDMLMMVNATGRERSEKDWSKLFYDACFSHYKITPILGLRSIIEVYP
>rna-XM_023914837.2
MNIQSGMEDDAMLVGQAQIWRYLYGAFDGMALRCCVDLRIPDIISNNNRPTTLSEIASGIDSPSIDVDGLKRLMSFMVYRKVFDEEDGEGSETIYSLNHCSKLLLSSTNVTLAPLVMMFTNPVIGLAINALSQSVKEGGTAFKHTHGEEFFDFTLLNSGFNRIFNEGMACTAKITMDAIISVYKDGFLGSKGSVVDVGGGTGVAISKIAKTYPHLKGINFDLPHVISTAPTYDGVTHVAGDMFKVIPPTETIFMKWVLHNWSNDDCIKILKNCRRAIPKETGKVIIVEIVQHSTEDDPFNYTRITFDLVMFAFFPSGRQRSENEWKNLLGECGFSHYNIIKIPALVSIIEAFP
>rna-XM_023886177.2
MMNTQSGIEEDVVLTGQTQISQCLNGVFDAMALRCCVELRIADIISNHNRPTTLSEIATGIDSPSINIDGLERLMKFLVHKKVFNEIPQAEELEGERETLYAMNNCSKWLLSDAHLTLAPIVMSCTDPVMVSPLHVLSRAIKEGGTAFKMTHGEELYSFSLRNPKFNRIFNEDMACAAKINLDAIISSYRNGFLGMKGSVVDVGGGTGVAISEIVKAYPHLKGINFDLQHVISTAPTYDGVTHVAGDMFEAIPPVDTIFMKWILHNWSDDDCAKILTNCRKAIPKETGRVIIVEIVQQPKEDDAFSDTRFILDLSMLAYFSSGKERSEKEWKKLLGDCGFFRYNITKMPSLLSIIEAFP
>rna-XM_023900681.2
MNTQGGIEDNAALLGNAQIARYLFGSFDAMAIRCCVELGIADIISNYNRPTTLSEITTGINSPSVNVDGLGRLMRFLVHRKVFDELPQPEEDGDGETVYSLNHYSNWLLSHTNVTMAPMVMFFTDPFMLSPLRNLSRSIKEGDSAFKMTHGDDIFDFSLINSEFNKMFNNAMACTTKFTMDVIMSNYKNGFLGMKGTVVDVGGGTGGAISAIVKTYPHLKGINFDLPQVISNAPTYDDVTNVAGDMFQAIPPAETIFMKWILHNWSNDDCVKILKNCRKAIPMDTGKVIIVEIVQHPGQHDLLNDVRVPFDLTMFAYFSRGRERTEGEWKKLLEEGGFHRHKIIYIPEIVSIIEAFPI
>rna-XM_023900679.2
MNAQSGIDDNTMLIGQAQILRYLCGAIDAMAMRCCVELHIADIISNHSRPTLSDIATGINSPSINLDGLERLMRFLVHRKVFDEEDGDGETVYSLNHSSKWLLCNTNMTLAPFIMMFTNPFMALPANALSRSVKEGGTAFKLAHGEEFFDFLSHNSDINSLFNEAMASVTTITMDAIISNYRNGFLGLKGSVVDVGGGTGVAISVIVKAYPHLKGINIDLPHVISTATSYDGVTHVAGDMFEAIPPAETIFMKTILHSWSDDDCVKILKNCRKAVPKGTGKVIMVEIVQHPTGDDPLNDTRVTFDLVMLTCFSTGRERTEVEWEKLLISECGFCRYNIIKIPTLFSVIEAFP
>rna-XM_023880950.2
MDLEQSLGGASELFEAQAHIYRHILNYINSMVLGCALELGIPNIIHGHQKPITLQELVSKLNISVEKTLHLKRLMRLLIHSNFFSVAKFHDEEGEDEKEGYVLTVSSKMLLKNNSSPNIPNLLPFVSLMVDHVYVSTFQSLGRWFNRNELNAFETAHGTHIWEFADKNPRFNQLFNDAMASNSEMMKLVVKENKEIFEGVDSLVDVGGGNGANAKILLEAFPHLKCIVFELPHVIADMVDTKNLKYVGGDMFHSIPSADAIILKNILHDWSDEDVLKILERCKEAIAVAPKDGKKGKVIILDMVIGDSHDHERHEITEAKLFFDLKMMALATGKERTKEEWEKLFLQVNLDQYKITHISGLMSVIELFP
>rna-XM_023878746.2
MNTQDEVGCNADAMVAGQAQILRYIYGALDGMAIRCCVELRIADIIHNHGHPITLSEIANGIASPSINLDGLRRLMRFLVHRKIFQVGDGEGGNEDVYSLNHCSKWLLCDADVTLAPMVMMRTDPSMVLPLHVLSRSITEGGTAFKMIHGEEMFDFSSSNSGFNRVFNEGMACTAKITINAILASYKTGFLGTKGSVVDVGGGTGVAISEIVKAYPHLNGINFDLPHVISMAPRYDNGVTHIGGDMFEAIPPAETIFMKWILHDWSDDDCIKILKNCRKAIPKESGKIVIAEIVNHPTGDDPFVDTQLTYDLVMFSHFSGGRERNESEWKRILNEGGFRRYNIIKIPSLQSIIEAFPE
>rna-XM_023910679.1
FENKMSSEINSKEEEAAVKEIWKYVLGFTPMAVVKCAIELRIPDILQKHDTPMTLAELASELGCSSSLLYRIMRFLIQYKIFQEKPISDTSIGYALTPLSRLLTRHGKHSMADLVLLESTPVMLAPWHKLSSMVLGSQNTPFEAAHGVDLWKFAAANPSLSKLINDAMACDARNAVRAVIEGCPEVFEGLKTVVDVGGGDGTALGLIVEGCPWIKGINFDQPHVVSVAPAWKGVEHVGGNMFDHIPKADAAYLMKVLHDWGDDECIDMLRKCREAIPQDTGKVIIVESIVGLEENHDFEDVVLMLDMVMMTHTSTGKERTLKEWSYMFDEAGFTRYTIKQITSYHSVIEVYP
>rna-XM_023910677.2
MSAEINKEEIDSKEEEAAVKEIWKYVLGFTPMAVVKCAIELRIPDIIQKHETPMTLADLASELGCSSSFLYRIMRFLIQYKIFQEKPISDTSTGYALTPLSRLLTRHGKHSMADLVLLESTPVMLAPWHKLSSMVLGSENTPFGETHGDDLWKFTAANPSHSKLFDDGMACDARNAVRAVIDGCPEVFKGLKTVVDVGGGDGTALGLIVEGCPWIKGINFDLPHVVSVAPAWKGVEHVGGSMFDHIPKADAAYMMKVLHDWGDDECIDVLRKCREAIPQDTGKVILLEAIVGLEENHEYNDVVLMIDMVMMAHTSTGKERTLREWSYVFNEAGFTRYTIKQIRSYHSVIEVYP
>rna-XM_023910678.2
MSSEIKKEEIDSKEEEAAVKEIWKYVLGFTPMAVVKCAIELRIPDILQKHDTPMTLAELASELRCSSSFLYRIMRFLIQYKIFQEKPISDTSLGYALTPLSRLLTRHGKQSMADFVLLESSPVMLAPWHKLSAMVLGSQNTPFEAAHGVDLWKFAAANPSHSKLINDAMACDARNAVRAVIEGCPEVFEGLKTVVDVGGGDGTALGLIVEGCPWIKGINFDLPHVVSVAPAWKGVEHVGGSMFDHIPKADAAYLMKVLHDWGDEECIEILRKCREAIPQDTGKVIIVESIVGLEENHDFEDVVLMLDMVMMAHTSTGKERTLEEWSYMFDEAGFTRYTIKQITSYHSVIEVYP
>rna-XM_023910676.2
MSAEINMEKVDSKEEEAAAREIWKYVFGFTPMAVAKCAIELGIPDILEKQETPMPLAELASELGCSSSSLYRIMRFLIQYKIFQEKPISETSLGYAQTSLSRLLTRRGKHSMADFVLLESSPVMLAPWQKLSARVLSNKNLPFGAAHGDDVWKFAAANPGHSKLIDDAMACDARVAVGAVIEGCPEVFEGLKTVVDVGGGDGTALRLIVEACPWIKGINFDLPHVVSVAPVCRGVEHVGGNMFDHIPKTDATYLMKVLHDWGDHECIDILRKCREAIPQDTGKVIIVESIVGLEENHDFEDVVLMLDMVMMAHTSTGKERTLKEWSYVFTEAGFTRYTIKHIRTYQSVIEVYP
>rna-XM_023901346.2
MALQNEEQSTNLLHAQAHIWNNIFSYINSMSLKCAIELQIPDIINRHGAPMLLSELVEALPINKERTNYVYRLMRILIHSGFFMKQSISNGEEEREGYLLAPVSRFLLKQEPLSLRPFLLSMLDPVLMESWQPMSKWFQNDDVNSFYTAHGRTFWDFAGQDSRHNQLFNEAMASDARLVTNIMLRDFGDAFTNLNSIVDVGGGTGTVSKLIAEAFPHISCICFDLQHVVNGLEGSNNFSYVCGDMFEAIPKADAVLLKWILHDWNDEDCIKILKRCKEAIPSNEYGGKLIIIDMVLKNDEVGEKSLETQLFFDVLMMVDQTGRERTEKEWAKLFLDAGFSDYKIIPCLGLRSMIEVYP
MSLLNDEQSTNLLHSQAHIWNHIFSFINSMSLKCAIQLQIPDIINRHGAPMLLSELVEALSINKERAHFVYRLMRILVHSGFFIKQSICTTGDHKEEEREGYLLAPASRFLLKEEPLSISPFLLAMLDPILMDPWQHLSKWFQNDDVNPFHTAHGRNLWDFAGHDPNLNQFFNEAMGSDARLVTSLVLKHSTNVFERLNSIVDVGGGTGTVAKAIAEAFPDMTCISFDLPHVVDGLVGSKNLSFLGGDMFESIPKADAVLVKWILHDWSDEECIKILMQCKEAIPSKENGGKVIIIDMVLKNGEGDKELLETQLFFDMLMLTLTTGRERSEKNWAKLFVDAGFSDYKITPILGLRSLIEVYP
>rna-XM_023915732.2
MELQNDEQSLDLLRSEAHIWNHIYSFINSMSLKCAIQLQIPDIINRHGAPMLLSELVEALSINKEKTQYVFRLMRILVHSGFFVKQSISTTEDNDEEETKGYLLAPASRYLLTEEPLSSRSLVLAMLDPILMNPWQQMSKWFQNDDANPFLTTHGSHYWEFLGEEPKLKQFFNESMANDSRLVMSVVLKHCADSFRTLNSIVDVGGGTGTVAKAIAEAFPDISCISFDLPHVVIGLVGSKNLRYIGGDMFEVIPKADAVVLKWILHDWSDEECIKILKQCKEAIPSKENGGKLIIIDMVVKNHKEDNNLLMTQLYFDMLMMTVLTGKERSEKEWAKLFLDADFSDYKITPILGLRSLIEVYP
>rna-XM_023910369.2
MSLQNREQSKEMLHSQAHIWNHIFSFVNSMSLKCAIELQIPDIIDGHGAPMLLSELVEALPINKERTTFVYRLMRILVHSGCFMKQSLSTTTGNDEEEEREGYLLTPASRLLLKEEPFSIRPLLLFMLDPILMDPWQNMSEWFKNKDITPFHTTHGKSMWDLASREPKVNQFVNETMASDAKLIGSFITKHCADVFQGLNSVVDVGGGTGTIAKAIAKAFPSISCISFDLPHVVNGLEGSKNMSYVCGDMFEAIPKADAVFLKWILHDWNDEECIKILKRCKEAIPNKEYGGKVIIVDMVLKNEEAGEKSLETQLFFDMLMMVNATGRERSEKDWSKLFYDACFSHYKITPILGLRSIIEVYP
>rna-XM_023914837.2
MNIQSGMEDDAMLVGQAQIWRYLYGAFDGMALRCCVDLRIPDIISNNNRPTTLSEIASGIDSPSIDVDGLKRLMSFMVYRKVFDEEDGEGSETIYSLNHCSKLLLSSTNVTLAPLVMMFTNPVIGLAINALSQSVKEGGTAFKHTHGEEFFDFTLLNSGFNRIFNEGMACTAKITMDAIISVYKDGFLGSKGSVVDVGGGTGVAISKIAKTYPHLKGINFDLPHVISTAPTYDGVTHVAGDMFKVIPPTETIFMKWVLHNWSNDDCIKILKNCRRAIPKETGKVIIVEIVQHSTEDDPFNYTRITFDLVMFAFFPSGRQRSENEWKNLLGECGFSHYNIIKIPALVSIIEAFP
>rna-XM_023886177.2
MMNTQSGIEEDVVLTGQTQISQCLNGVFDAMALRCCVELRIADIISNHNRPTTLSEIATGIDSPSINIDGLERLMKFLVHKKVFNEIPQAEELEGERETLYAMNNCSKWLLSDAHLTLAPIVMSCTDPVMVSPLHVLSRAIKEGGTAFKMTHGEELYSFSLRNPKFNRIFNEDMACAAKINLDAIISSYRNGFLGMKGSVVDVGGGTGVAISEIVKAYPHLKGINFDLQHVISTAPTYDGVTHVAGDMFEAIPPVDTIFMKWILHNWSDDDCAKILTNCRKAIPKETGRVIIVEIVQQPKEDDAFSDTRFILDLSMLAYFSSGKERSEKEWKKLLGDCGFFRYNITKMPSLLSIIEAFP
>rna-XM_023900681.2
MNTQGGIEDNAALLGNAQIARYLFGSFDAMAIRCCVELGIADIISNYNRPTTLSEITTGINSPSVNVDGLGRLMRFLVHRKVFDELPQPEEDGDGETVYSLNHYSNWLLSHTNVTMAPMVMFFTDPFMLSPLRNLSRSIKEGDSAFKMTHGDDIFDFSLINSEFNKMFNNAMACTTKFTMDVIMSNYKNGFLGMKGTVVDVGGGTGGAISAIVKTYPHLKGINFDLPQVISNAPTYDDVTNVAGDMFQAIPPAETIFMKWILHNWSNDDCVKILKNCRKAIPMDTGKVIIVEIVQHPGQHDLLNDVRVPFDLTMFAYFSRGRERTEGEWKKLLEEGGFHRHKIIYIPEIVSIIEAFPI
>rna-XM_023900679.2
MNAQSGIDDNTMLIGQAQILRYLCGAIDAMAMRCCVELHIADIISNHSRPTLSDIATGINSPSINLDGLERLMRFLVHRKVFDEEDGDGETVYSLNHSSKWLLCNTNMTLAPFIMMFTNPFMALPANALSRSVKEGGTAFKLAHGEEFFDFLSHNSDINSLFNEAMASVTTITMDAIISNYRNGFLGLKGSVVDVGGGTGVAISVIVKAYPHLKGINIDLPHVISTATSYDGVTHVAGDMFEAIPPAETIFMKTILHSWSDDDCVKILKNCRKAVPKGTGKVIMVEIVQHPTGDDPLNDTRVTFDLVMLTCFSTGRERTEVEWEKLLISECGFCRYNIIKIPTLFSVIEAFP
>rna-XM_023880950.2
MDLEQSLGGASELFEAQAHIYRHILNYINSMVLGCALELGIPNIIHGHQKPITLQELVSKLNISVEKTLHLKRLMRLLIHSNFFSVAKFHDEEGEDEKEGYVLTVSSKMLLKNNSSPNIPNLLPFVSLMVDHVYVSTFQSLGRWFNRNELNAFETAHGTHIWEFADKNPRFNQLFNDAMASNSEMMKLVVKENKEIFEGVDSLVDVGGGNGANAKILLEAFPHLKCIVFELPHVIADMVDTKNLKYVGGDMFHSIPSADAIILKNILHDWSDEDVLKILERCKEAIAVAPKDGKKGKVIILDMVIGDSHDHERHEITEAKLFFDLKMMALATGKERTKEEWEKLFLQVNLDQYKITHISGLMSVIELFP
>rna-XM_023878746.2
MNTQDEVGCNADAMVAGQAQILRYIYGALDGMAIRCCVELRIADIIHNHGHPITLSEIANGIASPSINLDGLRRLMRFLVHRKIFQVGDGEGGNEDVYSLNHCSKWLLCDADVTLAPMVMMRTDPSMVLPLHVLSRSITEGGTAFKMIHGEEMFDFSSSNSGFNRVFNEGMACTAKITINAILASYKTGFLGTKGSVVDVGGGTGVAISEIVKAYPHLNGINFDLPHVISMAPRYDNGVTHIGGDMFEAIPPAETIFMKWILHDWSDDDCIKILKNCRKAIPKESGKIVIAEIVNHPTGDDPFVDTQLTYDLVMFSHFSGGRERNESEWKRILNEGGFRRYNIIKIPSLQSIIEAFPE
>rna-XM_023910679.1
FENKMSSEINSKEEEAAVKEIWKYVLGFTPMAVVKCAIELRIPDILQKHDTPMTLAELASELGCSSSLLYRIMRFLIQYKIFQEKPISDTSIGYALTPLSRLLTRHGKHSMADLVLLESTPVMLAPWHKLSSMVLGSQNTPFEAAHGVDLWKFAAANPSLSKLINDAMACDARNAVRAVIEGCPEVFEGLKTVVDVGGGDGTALGLIVEGCPWIKGINFDQPHVVSVAPAWKGVEHVGGNMFDHIPKADAAYLMKVLHDWGDDECIDMLRKCREAIPQDTGKVIIVESIVGLEENHDFEDVVLMLDMVMMTHTSTGKERTLKEWSYMFDEAGFTRYTIKQITSYHSVIEVYP
>rna-XM_023910677.2
MSAEINKEEIDSKEEEAAVKEIWKYVLGFTPMAVVKCAIELRIPDIIQKHETPMTLADLASELGCSSSFLYRIMRFLIQYKIFQEKPISDTSTGYALTPLSRLLTRHGKHSMADLVLLESTPVMLAPWHKLSSMVLGSENTPFGETHGDDLWKFTAANPSHSKLFDDGMACDARNAVRAVIDGCPEVFKGLKTVVDVGGGDGTALGLIVEGCPWIKGINFDLPHVVSVAPAWKGVEHVGGSMFDHIPKADAAYMMKVLHDWGDDECIDVLRKCREAIPQDTGKVILLEAIVGLEENHEYNDVVLMIDMVMMAHTSTGKERTLREWSYVFNEAGFTRYTIKQIRSYHSVIEVYP
>rna-XM_023910678.2
MSSEIKKEEIDSKEEEAAVKEIWKYVLGFTPMAVVKCAIELRIPDILQKHDTPMTLAELASELRCSSSFLYRIMRFLIQYKIFQEKPISDTSLGYALTPLSRLLTRHGKQSMADFVLLESSPVMLAPWHKLSAMVLGSQNTPFEAAHGVDLWKFAAANPSHSKLINDAMACDARNAVRAVIEGCPEVFEGLKTVVDVGGGDGTALGLIVEGCPWIKGINFDLPHVVSVAPAWKGVEHVGGSMFDHIPKADAAYLMKVLHDWGDEECIEILRKCREAIPQDTGKVIIVESIVGLEENHDFEDVVLMLDMVMMAHTSTGKERTLEEWSYMFDEAGFTRYTIKQITSYHSVIEVYP
>rna-XM_023910676.2
MSAEINMEKVDSKEEEAAAREIWKYVFGFTPMAVAKCAIELGIPDILEKQETPMPLAELASELGCSSSSLYRIMRFLIQYKIFQEKPISETSLGYAQTSLSRLLTRRGKHSMADFVLLESSPVMLAPWQKLSARVLSNKNLPFGAAHGDDVWKFAAANPGHSKLIDDAMACDARVAVGAVIEGCPEVFEGLKTVVDVGGGDGTALRLIVEACPWIKGINFDLPHVVSVAPVCRGVEHVGGNMFDHIPKTDATYLMKVLHDWGDHECIDILRKCREAIPQDTGKVIIVESIVGLEENHDFEDVVLMLDMVMMAHTSTGKERTLKEWSYVFTEAGFTRYTIKHIRTYQSVIEVYP
>rna-XM_023901346.2
MALQNEEQSTNLLHAQAHIWNNIFSYINSMSLKCAIELQIPDIINRHGAPMLLSELVEALPINKERTNYVYRLMRILIHSGFFMKQSISNGEEEREGYLLAPVSRFLLKQEPLSLRPFLLSMLDPVLMESWQPMSKWFQNDDVNSFYTAHGRTFWDFAGQDSRHNQLFNEAMASDARLVTNIMLRDFGDAFTNLNSIVDVGGGTGTVSKLIAEAFPHISCICFDLQHVVNGLEGSNNFSYVCGDMFEAIPKADAVLLKWILHDWNDEDCIKILKRCKEAIPSNEYGGKLIIIDMVLKNDEVGEKSLETQLFFDVLMMVDQTGRERTEKEWAKLFLDAGFSDYKIIPCLGLRSMIEVYP
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University