Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Lactuca sativa
Species name
Garden lettuce (Lactuca sativa) is a species of eudicot in the family Asteraceae (daisy family).
Species info
Gene sequence info
Lactuca_sativa.CHS.fa
Download
>rna-XM_023878437.2
MVNVEEFRKAQRAEGPATIMAIGTATPPNCVLQSTYPDYYFRITKSEHKTDLKEKFRRMCDKSMITKRYMYLTEEILKEKPNICAYMAPSLDERQDIVVVEVPKLGKEAAIRAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRSSVKRFMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPNETHLDSLVGQALFGDGAAAIIVGSDPLPDVEKPLFELISAAQTILPDSEGAIDGHLREVGLTFHLLKDVPGLISKHIEKSLVEAFKPLGIADWNSLFWIAHPGGPAILDQVEEKLRLTPDKLRATRQVLSEYGNMSSACVLFILNEMRHSSATAGFDTTGEGLEWGVLFGFGPGLTVETVVLRSVSI
>rna-XM_023878441.2
MVSMVDFREAQRAKGPAAIMAIGTATPPNCVPQSTYADFYFRVTNCEHKTELKEKFKRMCDNSKIKKRYIHLTEEILKEKPNLCAHMAPSLDERQDIAIAEIPKLGAKAATQAINEWGQPKSMITHVVFSSVYGVDMPGADYQLTKLLGLSPSVKRVMLYQQGCFAGASVLRLAKDLAENNKGARVLVVCSEITTPNFRGPDEAHVDNLVSQVLFGDGAAAVIVGSDPIPDVEKKLFEIVSASQTIVPDSDGAIKGHIRQAGFITRLRRDVPELIGKHVEKSLLEAFQPLGISDWNSLFWIAHPGGRAILDHVEENLRLRPEKLRVSRHVLAEYGNLSSPCVLFILNKMRHSSVTQGAVTTGEGLEWGVLMGFGPGVTVDTVVLHSVSI
>rna-XM_023878452.2
MVNIEEFHKAQRAEGPATILAIATATPPNCVLQSTYPDSYFSVTKSEHMTELKEKFRRMCDKSMVKTRYMYFTDEMLQEKPNICAHMAPSLDERQDISIVEIPKLGAEAATHAIKEWGQPKSKITHVVFCSINGVDMPGADYQLIKLLRLNPSVKRVMLYHQGCFAGGTVLRLAKDLAENNKGARVLVVCSEIVAGTYRGPGEAHLDGLVAMALFGDGAAAVIVGADPIPDVEKPLYEIVSGFQTILPQSEAAIEGHLREVGIIIQLLKDVPGLIAKHIEKSLVEAFQPLGIEDWNSLFWIAHPGGPAILNQLEDKLSLKPEKLRASRQVLSKYGNMSSACVLFILDEMRRSSATDGAKTTGEGLEWGVLFGFGPGLTVDTVVLHSVSI
>rna-XM_023878454.2
MVSVDEFVKTQRAEGPATIIAIGTATPPNCVLQSTYPDYYFRITKSEHKTELKEKFRRMCEKSMVKKRYTCFTEELLKQKPEFCAHMAPSLDERQEIAIVEIPKLGAEAAAQAIEEWGQPKSKITHVVFCTTTGVDMPGADYKLIKLLGLPPSVKRVMMYTQGCFAGGTVLRLAKDMAENNKGARVLVVCSEITALTFRGPDEKHVDSLVGQALFGDGAAAIIVGSDPLHVVEKPLFQIVSASQTILPDSEGAIEGHLREAGLTLHLLKNVPSLISKHIEKSLVEAFQPFGIFDWNSLFWVPHPGGRAILDQVEESLSLTPDKLRATRHVLSEYGNLSCASVLFILNEMRHSSVNDGSKTTGEGLDWGVLFGFGPGLTVDTVVLHSVSI
>rna-XM_023878440.2
MVSMVDFREAQRAKGPAAIMAIGTATPPNCVPQSTYADFYFRVTNCEHKTELKEKFKRMCDNSKIKKRYIHLTEEILKEKPNLCAHMAPSLDERQDIAIAEIPKLGAKAATQAINEWGQPKSMITHVVFSSVYGVDMPGADYQLTKLLGLSPSVKRVMLYQQGCFAGASVLRLAKDLAENNKGARVLVVCSEITTPNFRGPDEAHVDNLVSQVLFGDGAAAVIVGSDPIPDVEMKLFEIVSASQTIVPDSDGAIKGHIRQAGFITRLHRDVPELIGKHVEKSLLEAFQPLGISDWNSLFWIAHPGGRAILDQVEENLCLRPEKLRASRHVLAEYGNLSSPCVLFILNEMRHSSVTQGAITTGEGLEWGVLMGFGPGVTVDTVVLHSVSI
>rna-XM_042899148.1
MSRTMEEIRKAQRAQGPATIMAIGTATPPTCVLQSTYPDFYFRVTKSEHMKELKEKFRRMCDKSTIKTRYMYLTEEILKDKPNLCAHMAPSLDERQDIAIVEVPKLGAEAATHAIKEWGQPKSKITHLVVSSINGVDMPGADYHITKLLGLSPSVKRVMMYLQEAGGTALRLAKDLAENNKGARVLVVCSEIATGTFRGPGEMHPDSLIAQALFGDGAAAVIVGSDPLFDVEKPLFEIISSSQTILPNSEGAIEAHLREAGLIVRLRKDVPELIAKHIEESLVEAFKPLGIVDWNSLFWIAHPGGPAFLDQIEEKLSLTPDKLRATRHVLSKYGNLSSACVLFILNEMRHASANITGDDLEWGVLFGFGPGLTIDTVVLHNVSN
>rna-XM_023878447.2
MVSVLELRMAQRAEGPATILAIGIATPINCVLQSTYPDYYFRVTNSENKKELKAKFKRMCDKSMIRKRYMHLTEDILKEKPSLCAYMAPSLDERQDIVVLEVPKLGAEAATHAIKEWGQPKSMITHLVFSTSCGVDMPGADNQITELLALRPSIKRVMIYENGCYAGGTAIRLAKDLAENNKGARVLVVCSEITAIGFRGPDETHLDGLVGQALFGDGAGAIIVGSDPLPDIEKPLFQIVSASQTIIPDTKSMLRGHVREVGLKYHLHKSIPELIANNIENSLVEAFQPLGIVDWNSLFWIVHPGGAGILDGVEEKLSLTPNKLRATRHILSEYGNMFSSCVLFILNEMRHSSTIDGFETTGEGLEWGVLFGFGPGLTIETVVLHSVRI
>rna-XM_023879789.2
MASSIDIAQIRNAQRAQGPATILAIGTATPSNCVYQADYPDYYFRITKSEHMVDLKEKFQRMCDKSMIRKRYMHLTEEFLKENPNLCEYMAPSLDARQDVVVVEVPKLGKEAATKAIKEWGQPKSKITHLIFCTTSGVDMPGADYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPNDTHLDSLVGQALFGDGAAAVIVGSDPDLTIERPLFEMVSAAQTILPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIEKALTQAFSPLGITDWNSIFWIAHPGGPAILDQVELKLGLKEEKMRATRHVLSEYGNMSSACVLFIIDEMRKKSAEDGAATTGEGLDWGVLFGFGPGLTVETVVLHSLPTTMPIPT
>rna-XM_023880615.2
MTTKSSVGKANILALGKAFPHQLVMQDLLVEGYFKDTHCDDPELKQKLTRLCKTTCVKTRYVVMSQEILEKYPELALEGLPTVRQRLEIANKAVTQMAIEASQACIKKWARPISDITHLVYVSSSEARLPGGDIYLAKGLGLSPNTNRVLLYFSGCSGGVAGLRVAKDIAENNPGSRVLLATAETTIVGYKPPNVNRPYDLVGVALFGDGAGAMMIGSDPTGPESPLFELHTAIQNFLPDTEKVIDGRLSEEGISFRLDRDLPEIIEDNVKGFCDKLMGYYGPNEMAYNDLFWAVHPGGPAILNKLEKKLDLLPDKLNASRKALADYGNASSNTIVYVLEYLIEEGLKRKKEGKDGGPDLGLILAFGPGVTFEGILTKNLTV
>rna-XM_023903627.2
MSKINGNGASGHRYSSATRRLPTPGKATVLAIGKAFPSQLIPQDCLVEGYFRDTNCIDHAMKEKLERLCKTTTVRTRYTVMSKEILDEYPELATEGTATISQRLSIANKAVTEMAKDASLACIKQWGRPAEDITHVVYVSSSEIRLPGGDLYLANELGLRNDVNRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPSKSRPYDLVGAALFGDGAAAAIIGADPIAKTESPFLELSYAVQQFLPGTHSVIDGRLSEEGINFKLGRDLPQKIDDNIEGFCNKLMEKANNVKDFNDMFWAVHPGGPAILNRLETTLKLRGEKLDCSRRALMDFGNVSSNTIIYVLEYMREELMNKEIGEEWGLALAFGPGITFEGILLRSLN
>rna-XM_023897706.2
MSLVPTLVDCEKIQEIQRAEGLANILAIGTATPSNFFYQSDYPDYYFRLTNSEHMVNLKQKFIRICDKTLIKKRHFFFTEEILKENPNICEYMAPSLNARHDLVVTELPKLGMEAATIAIEEWGLPKSKITHLIFCTTSCVDMPGADYYLTKLLELSPSVKRFMMYHQACCGGGMAIPLAKDLCENNKGSRVLVVCAEITAILFHGPNENDLDSLVGQALFSNGASAIIMGSDPDLSMEHSIFEIVTTSQTILPNTEKLLTIHLREAGLTFKLHKDIPKVISENIEDVLLHAFSPLGISDWNSLFWIVHPGGRAILDLVEQKLKLTEEKFRASRHVLSEYGNLASASVLFVIEEMRKKSIKEGKSTNGEGLDWGVLLGFGPGLTVETIVLLRSLPVSTPLSLAS
MVNVEEFRKAQRAEGPATIMAIGTATPPNCVLQSTYPDYYFRITKSEHKTDLKEKFRRMCDKSMITKRYMYLTEEILKEKPNICAYMAPSLDERQDIVVVEVPKLGKEAAIRAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRSSVKRFMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPNETHLDSLVGQALFGDGAAAIIVGSDPLPDVEKPLFELISAAQTILPDSEGAIDGHLREVGLTFHLLKDVPGLISKHIEKSLVEAFKPLGIADWNSLFWIAHPGGPAILDQVEEKLRLTPDKLRATRQVLSEYGNMSSACVLFILNEMRHSSATAGFDTTGEGLEWGVLFGFGPGLTVETVVLRSVSI
>rna-XM_023878441.2
MVSMVDFREAQRAKGPAAIMAIGTATPPNCVPQSTYADFYFRVTNCEHKTELKEKFKRMCDNSKIKKRYIHLTEEILKEKPNLCAHMAPSLDERQDIAIAEIPKLGAKAATQAINEWGQPKSMITHVVFSSVYGVDMPGADYQLTKLLGLSPSVKRVMLYQQGCFAGASVLRLAKDLAENNKGARVLVVCSEITTPNFRGPDEAHVDNLVSQVLFGDGAAAVIVGSDPIPDVEKKLFEIVSASQTIVPDSDGAIKGHIRQAGFITRLRRDVPELIGKHVEKSLLEAFQPLGISDWNSLFWIAHPGGRAILDHVEENLRLRPEKLRVSRHVLAEYGNLSSPCVLFILNKMRHSSVTQGAVTTGEGLEWGVLMGFGPGVTVDTVVLHSVSI
>rna-XM_023878452.2
MVNIEEFHKAQRAEGPATILAIATATPPNCVLQSTYPDSYFSVTKSEHMTELKEKFRRMCDKSMVKTRYMYFTDEMLQEKPNICAHMAPSLDERQDISIVEIPKLGAEAATHAIKEWGQPKSKITHVVFCSINGVDMPGADYQLIKLLRLNPSVKRVMLYHQGCFAGGTVLRLAKDLAENNKGARVLVVCSEIVAGTYRGPGEAHLDGLVAMALFGDGAAAVIVGADPIPDVEKPLYEIVSGFQTILPQSEAAIEGHLREVGIIIQLLKDVPGLIAKHIEKSLVEAFQPLGIEDWNSLFWIAHPGGPAILNQLEDKLSLKPEKLRASRQVLSKYGNMSSACVLFILDEMRRSSATDGAKTTGEGLEWGVLFGFGPGLTVDTVVLHSVSI
>rna-XM_023878454.2
MVSVDEFVKTQRAEGPATIIAIGTATPPNCVLQSTYPDYYFRITKSEHKTELKEKFRRMCEKSMVKKRYTCFTEELLKQKPEFCAHMAPSLDERQEIAIVEIPKLGAEAAAQAIEEWGQPKSKITHVVFCTTTGVDMPGADYKLIKLLGLPPSVKRVMMYTQGCFAGGTVLRLAKDMAENNKGARVLVVCSEITALTFRGPDEKHVDSLVGQALFGDGAAAIIVGSDPLHVVEKPLFQIVSASQTILPDSEGAIEGHLREAGLTLHLLKNVPSLISKHIEKSLVEAFQPFGIFDWNSLFWVPHPGGRAILDQVEESLSLTPDKLRATRHVLSEYGNLSCASVLFILNEMRHSSVNDGSKTTGEGLDWGVLFGFGPGLTVDTVVLHSVSI
>rna-XM_023878440.2
MVSMVDFREAQRAKGPAAIMAIGTATPPNCVPQSTYADFYFRVTNCEHKTELKEKFKRMCDNSKIKKRYIHLTEEILKEKPNLCAHMAPSLDERQDIAIAEIPKLGAKAATQAINEWGQPKSMITHVVFSSVYGVDMPGADYQLTKLLGLSPSVKRVMLYQQGCFAGASVLRLAKDLAENNKGARVLVVCSEITTPNFRGPDEAHVDNLVSQVLFGDGAAAVIVGSDPIPDVEMKLFEIVSASQTIVPDSDGAIKGHIRQAGFITRLHRDVPELIGKHVEKSLLEAFQPLGISDWNSLFWIAHPGGRAILDQVEENLCLRPEKLRASRHVLAEYGNLSSPCVLFILNEMRHSSVTQGAITTGEGLEWGVLMGFGPGVTVDTVVLHSVSI
>rna-XM_042899148.1
MSRTMEEIRKAQRAQGPATIMAIGTATPPTCVLQSTYPDFYFRVTKSEHMKELKEKFRRMCDKSTIKTRYMYLTEEILKDKPNLCAHMAPSLDERQDIAIVEVPKLGAEAATHAIKEWGQPKSKITHLVVSSINGVDMPGADYHITKLLGLSPSVKRVMMYLQEAGGTALRLAKDLAENNKGARVLVVCSEIATGTFRGPGEMHPDSLIAQALFGDGAAAVIVGSDPLFDVEKPLFEIISSSQTILPNSEGAIEAHLREAGLIVRLRKDVPELIAKHIEESLVEAFKPLGIVDWNSLFWIAHPGGPAFLDQIEEKLSLTPDKLRATRHVLSKYGNLSSACVLFILNEMRHASANITGDDLEWGVLFGFGPGLTIDTVVLHNVSN
>rna-XM_023878447.2
MVSVLELRMAQRAEGPATILAIGIATPINCVLQSTYPDYYFRVTNSENKKELKAKFKRMCDKSMIRKRYMHLTEDILKEKPSLCAYMAPSLDERQDIVVLEVPKLGAEAATHAIKEWGQPKSMITHLVFSTSCGVDMPGADNQITELLALRPSIKRVMIYENGCYAGGTAIRLAKDLAENNKGARVLVVCSEITAIGFRGPDETHLDGLVGQALFGDGAGAIIVGSDPLPDIEKPLFQIVSASQTIIPDTKSMLRGHVREVGLKYHLHKSIPELIANNIENSLVEAFQPLGIVDWNSLFWIVHPGGAGILDGVEEKLSLTPNKLRATRHILSEYGNMFSSCVLFILNEMRHSSTIDGFETTGEGLEWGVLFGFGPGLTIETVVLHSVRI
>rna-XM_023879789.2
MASSIDIAQIRNAQRAQGPATILAIGTATPSNCVYQADYPDYYFRITKSEHMVDLKEKFQRMCDKSMIRKRYMHLTEEFLKENPNLCEYMAPSLDARQDVVVVEVPKLGKEAATKAIKEWGQPKSKITHLIFCTTSGVDMPGADYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPNDTHLDSLVGQALFGDGAAAVIVGSDPDLTIERPLFEMVSAAQTILPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIEKALTQAFSPLGITDWNSIFWIAHPGGPAILDQVELKLGLKEEKMRATRHVLSEYGNMSSACVLFIIDEMRKKSAEDGAATTGEGLDWGVLFGFGPGLTVETVVLHSLPTTMPIPT
>rna-XM_023880615.2
MTTKSSVGKANILALGKAFPHQLVMQDLLVEGYFKDTHCDDPELKQKLTRLCKTTCVKTRYVVMSQEILEKYPELALEGLPTVRQRLEIANKAVTQMAIEASQACIKKWARPISDITHLVYVSSSEARLPGGDIYLAKGLGLSPNTNRVLLYFSGCSGGVAGLRVAKDIAENNPGSRVLLATAETTIVGYKPPNVNRPYDLVGVALFGDGAGAMMIGSDPTGPESPLFELHTAIQNFLPDTEKVIDGRLSEEGISFRLDRDLPEIIEDNVKGFCDKLMGYYGPNEMAYNDLFWAVHPGGPAILNKLEKKLDLLPDKLNASRKALADYGNASSNTIVYVLEYLIEEGLKRKKEGKDGGPDLGLILAFGPGVTFEGILTKNLTV
>rna-XM_023903627.2
MSKINGNGASGHRYSSATRRLPTPGKATVLAIGKAFPSQLIPQDCLVEGYFRDTNCIDHAMKEKLERLCKTTTVRTRYTVMSKEILDEYPELATEGTATISQRLSIANKAVTEMAKDASLACIKQWGRPAEDITHVVYVSSSEIRLPGGDLYLANELGLRNDVNRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPSKSRPYDLVGAALFGDGAAAAIIGADPIAKTESPFLELSYAVQQFLPGTHSVIDGRLSEEGINFKLGRDLPQKIDDNIEGFCNKLMEKANNVKDFNDMFWAVHPGGPAILNRLETTLKLRGEKLDCSRRALMDFGNVSSNTIIYVLEYMREELMNKEIGEEWGLALAFGPGITFEGILLRSLN
>rna-XM_023897706.2
MSLVPTLVDCEKIQEIQRAEGLANILAIGTATPSNFFYQSDYPDYYFRLTNSEHMVNLKQKFIRICDKTLIKKRHFFFTEEILKENPNICEYMAPSLNARHDLVVTELPKLGMEAATIAIEEWGLPKSKITHLIFCTTSCVDMPGADYYLTKLLELSPSVKRFMMYHQACCGGGMAIPLAKDLCENNKGSRVLVVCAEITAILFHGPNENDLDSLVGQALFSNGASAIIMGSDPDLSMEHSIFEIVTTSQTILPNTEKLLTIHLREAGLTFKLHKDIPKVISENIEDVLLHAFSPLGISDWNSLFWIVHPGGRAILDLVEQKLKLTEEKFRASRHVLSEYGNLASASVLFVIEEMRKKSIKEGKSTNGEGLDWGVLLGFGPGLTVETIVLLRSLPVSTPLSLAS
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University