Enzyme
The enzyme participates in the flavonoid biosynthesis pathway found in plants. It catalyses the double reduction of anthocyanidins, producing (2R,3R)-flavan-3-ol monomers required for the formation of proanthocyanidins. While the enzyme from the legume Medicago truncatula (MtANR) can use both NADPH and NADH as reductant, that from the crucifer Arabidopsis thaliana (AtANR) uses only NADPH. Also, while the substrate preference of MtANR is cyanidin>pelargonidin>delphinidin, the reverse preference is found with AtANR. cf. EC 1.3.1.112, anthocyanidin reductase [(2S)-flavan-3-ol-forming].
ANR
Enzyme
Anthocyanidin reductase
Enzyme name
EC:1.3.1.77
Entry
Oxidoreductases;Acting on the CH-CH group of donors;With NAD+ or NADP+ as acceptor
Class
(2R,3R)-flavan-3-ol:NAD(P)+ 3,4-oxidoreductase
Sysname
a (2R,3R)-flavan-3-ol + 2 NAD(P)+ = an anthocyanidin with a 3-hydroxy group + 2 NAD(P)H + H+ [RN:R07351 R07352]
Reaction
anthocyanidin with a 3-hydroxy group [CPD:C21381];NADH [CPD:C00004];NADPH [CPD:C00005];H+ [CPD:C00080]
Product
Species information
Lablab purpureus
Species name
Antaque (Lablab purpureus) is a species of eudicot in the family Fabaceae (pea family).
Species info
Gene sequence info
Lablab_purpureus.ANR.fa
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>Labpu437S15293_LABPU
MGSVSETVCVTGASGFIGSWLVMRLIERGYTVRATVRDPGSLLRHNEVIKPTVNGVLDIMKACMKAKTVRRLVFTSSAGSLNVIEHQKPVFDESCWSDVEFCRRVKMTGWMYFVSKTLAEKEAWKFAKEHGMDFITIIPPLVVGPFLMPAMPPSLITALSPITGNEGHYSIIKQGQFVHLDDLCLAHIFLFEQPKVEGRYICSACDTTIHHIAKLINEKYPEYRVPTKFKNIPDELELVRFSSKKITDLGFQFKYSLEDMYSGAIETCRDKGLLPKPAETPLSSIIQKAETSMRSWLVMRLMERGYTVRATVRDPGLNEVIKPTIKGLLDIMKACVKAKSVRRIVFTSSAGTVDVAEQPKPVYDEKCWSDVEFCRRVKMTGWMYFVSKTLAEKEAWKFAKEHNIDFVSVIPPLVVGPFLMPTMPPSLITALSLITGNEGHYHIIKQGQFVHLDDLCLAHIFVFENPKAEGRYICCSHEATIHDIAKLLNKKYPLYNFPTKFKDIPDELEIIRFSSKKITDMGFKFEYSLEDMFTGAVETCREKGLLPEPAQTPVNGLLPKLAETAVNGTMHK
>Labpu710S17668_LABPU
MLSYEKDENGGGGLEVVTLPCGLVGGDTLLSSSTTGIVCIAQIVQHERAYKSLKFLERLLGKIPLVHIDDVCEAHIFCMESTFISGRFLCASSYISLQEMANYYALHHPEFTIKQEHEDEPKKDIKWTSTKLCDRGFEYKYDAKMILDDCIKCARRMGGSGYIGSWLIKKLLAKGYTVHATLRDLKNESKVRLLKSLPHAEGKLVLFEADIYDPTQFDPAIQGCEFVFHVATPLTHEPGSSQYKDTTEAAVAGAKSIAMSCVRSGTVKRLIYTASVVSASPLKEDGSGFKDVMDETCWTPLNDSFECVYLDDPLYKDYTYSKTLSEKYLLSYANDENCGGGLEVVTLPCGLVGGDTLLSSIKVVCIAQIIQNERAYKSLKFLEGLLGKIPLVHIDDVCEAHIFCMESTFISGRFLCASSYISLQEMANHYALHHPEFTVKQDCLQFSSELHFKHEDGLKKDIKWTSTKLCDRGFVYKYDAKMILDDCIKCARRMGEL
>Labpu710S17670_LABPU
MRNCKKVCVTGGSGYIGSWLIKKLLAKDYTVHATLRDLRNESKVGFLKSLPHAEGKLVLFEADIYNPTHFDPAIQGCEFVFHVATPLSHEPGSSQYKDTTEAAVAGAKSIAMSCVRSGTVKRLIYTASVVSASPLKEDGSGFKDDYIFSKTISEKHLLGYGNDENGDTLCGGGLEVVTLLCGLVGGDTLLSSTLGSIGVCIAQILQDEKAYKSLKSLVGLLGKIPLVHIDDVCEAHIFCMESTSINGRFLCASSYISLQEMANHYSLHHPEFTLKQEHEDWPKKDIKWTSTKLCDRGFVYKYDAKMILDDCIKCARRMGGSGYIGSWLIKKLLAKGYTVHATLRDLKNESKVRLLKSLPHAEGKLVLFEADIYDPTHFDPAIQGCEFVFHVATPLIHEPGSSQYKDTTEAAVAGAKSIAMSCVKSGTVKRLIYTASVVSASPLKADGSDFKDVMDETCWTPLNDSLEYVYLDDPLYKDYTYSKTLSEKHLLSYEDDENGGEGLEVVTLPCGLVGGDSLLSSTLGSRVVCIAQIVQNEMAYKSLKFLEKLLGKIPLVHIDDVCEAHIFCMESTSIRGRFLCASSYISLQDMANHYVLYHPEFTVKLEHEDGPKKEIKWTSTKLCDRGFVYKYDAKMILDDCIKCAIRMGEL
>Labpu754S18080_LABPU
MGSMKSMGKKACVIGGSGFMASLLIKQLLQKGYSVNTTVRDPGNPNKISHLVELQSLGKLEIFGADLRVEEDFDAPVSGCELVFQFATPVNFASEDPENDMIKPAISGVLNVLKACAKAKVKRVILTSSTAAVTINQPNGTDLVMDESNWTDVEYLRTAKPHGWGYAASKALAEKAAWKFAEENHIDLITVLPTLTTGPSITLDIPSSVVLATSLITGNDFFFKAFRGIQMLSGSISITHVEDICRAHMFVAEKESASGRYIVCAHNTTIPELAKFLSKRYPQYQIPTEFDDIPSKAKFVISSEKLVKEGFSFKHGIEEIFEHSVEYLNNNTKKISHLLALQSLGELNIFGADLKGEKDFDAPIAGCELVFQLATPVNFASEDPENDMIKPAISGVLNVLKACARAKGVKRVILTSSAAAVTINPLKETGLVMNESSWTDVEFLKTAKPPTWGYPVSKALAEKAAWKFAEENHIDLITVIPTLTTGPSLTPDIPSSVGLATSLITGNDFLINALKGMQFLSGSVSITHVEDICRAHIFVAEKESASGRYIVSAHSTSVPELAKFLNKRYPQYKVPTEFDDCPSKAKLTISSEKLVKEGFSFKYGIEEIYDQTVEYLKSKGALKN
>Labpu1502S09944_LABPU
MIFNDVSSLMGAIHNMYKTKSLSSWMIISSTKHNLKARCLIKEEKMSSNTGKVVCVTGASGFIASWIIKFLLQRGYTVRATVPNREKVDHLLKLDGAKERLHLFKADLLEEGSFDYAFEGCYGVFHTASPVHFVVNDPQKQLIDPAVKGTLNVVKSCAKSTSVKRVVLTSSVAAVLYNGRPRTPEVVVDETWFSDPNVLRENERWYALSKTLAEDAARNFLKEQDIKLIVINPAMTIGPLLQPEVNGSSSSILNLINGSQTFPNLSFGWVNVKDVANAHIQAYESDSASGRYGLVERVAHFSEVTKILHHVYPNLQVADKCEDDEPFVPTFQVSKEKAKSLGIEFISLEESLRETVESFKEKKFWVEGSMSSEGKLVCVTGASGYIASWIVKFLLQRGYTVRATVRNPNDHRKVEHLLKLEGAEERLHLLKADLLSENSFDSIVEGCDGVFHTASPFFHNVKDPQAELIDPAVNGTLNVLKSCVKSSSVKRVVLTSSVAAVAYNERPKSPEVVVDETWFSNPDYCRGLKMWYLLSKTLAEDAAWKFSKENNLDLVSVNPAMVVGPLLQSELNTSASAILNLINGSETFPNDTYGWINVKDVANAHIQAYEIASASGRYCLVERVAHYSELAKILHDLYPTYPIPEKSADDKPYVPTFQVSKEKAKSLGIEFIPLEVSLKETVESLKEKNFANF
MGSVSETVCVTGASGFIGSWLVMRLIERGYTVRATVRDPGSLLRHNEVIKPTVNGVLDIMKACMKAKTVRRLVFTSSAGSLNVIEHQKPVFDESCWSDVEFCRRVKMTGWMYFVSKTLAEKEAWKFAKEHGMDFITIIPPLVVGPFLMPAMPPSLITALSPITGNEGHYSIIKQGQFVHLDDLCLAHIFLFEQPKVEGRYICSACDTTIHHIAKLINEKYPEYRVPTKFKNIPDELELVRFSSKKITDLGFQFKYSLEDMYSGAIETCRDKGLLPKPAETPLSSIIQKAETSMRSWLVMRLMERGYTVRATVRDPGLNEVIKPTIKGLLDIMKACVKAKSVRRIVFTSSAGTVDVAEQPKPVYDEKCWSDVEFCRRVKMTGWMYFVSKTLAEKEAWKFAKEHNIDFVSVIPPLVVGPFLMPTMPPSLITALSLITGNEGHYHIIKQGQFVHLDDLCLAHIFVFENPKAEGRYICCSHEATIHDIAKLLNKKYPLYNFPTKFKDIPDELEIIRFSSKKITDMGFKFEYSLEDMFTGAVETCREKGLLPEPAQTPVNGLLPKLAETAVNGTMHK
>Labpu710S17668_LABPU
MLSYEKDENGGGGLEVVTLPCGLVGGDTLLSSSTTGIVCIAQIVQHERAYKSLKFLERLLGKIPLVHIDDVCEAHIFCMESTFISGRFLCASSYISLQEMANYYALHHPEFTIKQEHEDEPKKDIKWTSTKLCDRGFEYKYDAKMILDDCIKCARRMGGSGYIGSWLIKKLLAKGYTVHATLRDLKNESKVRLLKSLPHAEGKLVLFEADIYDPTQFDPAIQGCEFVFHVATPLTHEPGSSQYKDTTEAAVAGAKSIAMSCVRSGTVKRLIYTASVVSASPLKEDGSGFKDVMDETCWTPLNDSFECVYLDDPLYKDYTYSKTLSEKYLLSYANDENCGGGLEVVTLPCGLVGGDTLLSSIKVVCIAQIIQNERAYKSLKFLEGLLGKIPLVHIDDVCEAHIFCMESTFISGRFLCASSYISLQEMANHYALHHPEFTVKQDCLQFSSELHFKHEDGLKKDIKWTSTKLCDRGFVYKYDAKMILDDCIKCARRMGEL
>Labpu710S17670_LABPU
MRNCKKVCVTGGSGYIGSWLIKKLLAKDYTVHATLRDLRNESKVGFLKSLPHAEGKLVLFEADIYNPTHFDPAIQGCEFVFHVATPLSHEPGSSQYKDTTEAAVAGAKSIAMSCVRSGTVKRLIYTASVVSASPLKEDGSGFKDDYIFSKTISEKHLLGYGNDENGDTLCGGGLEVVTLLCGLVGGDTLLSSTLGSIGVCIAQILQDEKAYKSLKSLVGLLGKIPLVHIDDVCEAHIFCMESTSINGRFLCASSYISLQEMANHYSLHHPEFTLKQEHEDWPKKDIKWTSTKLCDRGFVYKYDAKMILDDCIKCARRMGGSGYIGSWLIKKLLAKGYTVHATLRDLKNESKVRLLKSLPHAEGKLVLFEADIYDPTHFDPAIQGCEFVFHVATPLIHEPGSSQYKDTTEAAVAGAKSIAMSCVKSGTVKRLIYTASVVSASPLKADGSDFKDVMDETCWTPLNDSLEYVYLDDPLYKDYTYSKTLSEKHLLSYEDDENGGEGLEVVTLPCGLVGGDSLLSSTLGSRVVCIAQIVQNEMAYKSLKFLEKLLGKIPLVHIDDVCEAHIFCMESTSIRGRFLCASSYISLQDMANHYVLYHPEFTVKLEHEDGPKKEIKWTSTKLCDRGFVYKYDAKMILDDCIKCAIRMGEL
>Labpu754S18080_LABPU
MGSMKSMGKKACVIGGSGFMASLLIKQLLQKGYSVNTTVRDPGNPNKISHLVELQSLGKLEIFGADLRVEEDFDAPVSGCELVFQFATPVNFASEDPENDMIKPAISGVLNVLKACAKAKVKRVILTSSTAAVTINQPNGTDLVMDESNWTDVEYLRTAKPHGWGYAASKALAEKAAWKFAEENHIDLITVLPTLTTGPSITLDIPSSVVLATSLITGNDFFFKAFRGIQMLSGSISITHVEDICRAHMFVAEKESASGRYIVCAHNTTIPELAKFLSKRYPQYQIPTEFDDIPSKAKFVISSEKLVKEGFSFKHGIEEIFEHSVEYLNNNTKKISHLLALQSLGELNIFGADLKGEKDFDAPIAGCELVFQLATPVNFASEDPENDMIKPAISGVLNVLKACARAKGVKRVILTSSAAAVTINPLKETGLVMNESSWTDVEFLKTAKPPTWGYPVSKALAEKAAWKFAEENHIDLITVIPTLTTGPSLTPDIPSSVGLATSLITGNDFLINALKGMQFLSGSVSITHVEDICRAHIFVAEKESASGRYIVSAHSTSVPELAKFLNKRYPQYKVPTEFDDCPSKAKLTISSEKLVKEGFSFKYGIEEIYDQTVEYLKSKGALKN
>Labpu1502S09944_LABPU
MIFNDVSSLMGAIHNMYKTKSLSSWMIISSTKHNLKARCLIKEEKMSSNTGKVVCVTGASGFIASWIIKFLLQRGYTVRATVPNREKVDHLLKLDGAKERLHLFKADLLEEGSFDYAFEGCYGVFHTASPVHFVVNDPQKQLIDPAVKGTLNVVKSCAKSTSVKRVVLTSSVAAVLYNGRPRTPEVVVDETWFSDPNVLRENERWYALSKTLAEDAARNFLKEQDIKLIVINPAMTIGPLLQPEVNGSSSSILNLINGSQTFPNLSFGWVNVKDVANAHIQAYESDSASGRYGLVERVAHFSEVTKILHHVYPNLQVADKCEDDEPFVPTFQVSKEKAKSLGIEFISLEESLRETVESFKEKKFWVEGSMSSEGKLVCVTGASGYIASWIVKFLLQRGYTVRATVRNPNDHRKVEHLLKLEGAEERLHLLKADLLSENSFDSIVEGCDGVFHTASPFFHNVKDPQAELIDPAVNGTLNVLKSCVKSSSVKRVVLTSSVAAVAYNERPKSPEVVVDETWFSNPDYCRGLKMWYLLSKTLAEDAAWKFSKENNLDLVSVNPAMVVGPLLQSELNTSASAILNLINGSETFPNDTYGWINVKDVANAHIQAYEIASASGRYCLVERVAHYSELAKILHDLYPTYPIPEKSADDKPYVPTFQVSKEKAKSLGIEFIPLEVSLKETVESLKEKNFANF
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University