Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Lablab purpureus
Species name
Antaque (Lablab purpureus) is a species of eudicot in the family Fabaceae (pea family).
Species info
Gene sequence info
Lablab_purpureus.COMT.fa
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>Labpu130S09329_LABPU
MAPSQETNSGEAMQLKHVEEDQDGILFALNMVSSVMYPLAVKAAIELGIFDIMAKAGEGAKLSAEEITEKVGAKNPDAPTMVERILRLLASHSMLSCSLGEDGPNSGKRLYSLTYASKYFVADTDGVSFGASLNLVLGKVFLETWTELKGSIVEGGIAFNRVYGMNAFEYPAVDPGYNDVFNKAMFNITTIITNRVLELYDGFKNINRLVDVGGGLGINLKLITSKYPNVQGVNFDLPHVIEHAPTYPGVEHVAGDMFESVPSGDAIFMKWILHDWSDEHCLKLLKNCYKAIPSDGKVIVVDLIIPALPESTTTARTGFQADLLMMAQNPGGKERTQNEFMELALSSGFSGIRFVSSVSGFWVMEFFK
>Labpu164S10257_LABPU
MTINHMGSNCEEINGEENDPCLSAMLLSFSPMVYTAVLNAAIELNLFEIIAKATTTETLGVSASEIASHLPIQHKRLPQRLDRMLSLLASHSLLTCSTLANEEGKVQRLFQLSPSGKYFLNAETTASLALFSTFMSHPKLVQALLNFKEILLDCDNGLYMKVHGMPIFEGIQSDPAWNHTFNEAMANICTTEMTKILQIYSGFEGISLLIDVGGGVGQSLNMIISKYPSIKGVNFDLPQVIQQAPPYPGIEHVEGDMFESVPKGDAILLKGILHNWSDENCLKVLSNCYNALPENGKVVVVDFIMPEAIGSTEADKMVTSFDNLMFLDGGSERTEKEFTNLCQCSQFSSFKVVSRAFTALGVMEFHK
>Labpu315S14019_LABPU
MASCSSEKENHVVVERDDTETTLRAMVLGSNVVFPAALNAAIELNLFDIIAKEGSAESGGLMSPSEIASKLLIPTQQQQHCDLANRLERLLRLLASYSLLTVSSRSDGDGGSVRVYGVSASGKYFVREQNGEGCLASFTSFLCHPSLSGVWLNFKEAVIDPEIDLFKKVHGMSKFEYFGKYPEINHVFNKAMDDICTTHMKRILEVYTGYEGISTLVDVGGGTGQCLKMIISKYPSIKGINFDLPHVIENSPPVPGVEHVGGNMFECVPQGDAIMLKAICHNWSDEKAVELLSNCHKALPPKGKVIVGDFILPEDPEPTNEHKVISILDNIMFITPGGRERTEKQFQSLGRRAGFSRFQVVCRAFSTMSLMEFYK
>Labpu245S12925_LABPU
MSSNSKENEVPLEQEKVDDAYLSAVLLCFSRVLPAVLNAAIDINLFDVIAKAKSSCDDSSFSASEIASLLPNQHPQLANRLERMLPLLTSYSLLHCSIRTNEDGKIERVYALSPVGKYFAYDDEGISVAPLSTLLHRGFHDLWKDAKGAYLDPDCNNHFENVYGMLSYQYMEKNAELNEMFYKAMAHAGPIEVKRVLKVYKGFEGLSTLVDVGGGVGETLKLIVSAYPSIKGVNFDLPQMIEDAPAHPGVEHVGGDMFESVPSGDAILVKSICHNWADEDCIKFLRNCHKALPAHGKVIVLDYIIPEVPNSSDASKHSSIVDNHMFLAHGGRERTEIEFENLCKSSGFSKFQVACSGISATVGVMEFYK
>Labpu432S15038_LABPU
MGSTGETQITPSHVSDEEANLFAMQLASASVLPMVLKSAIELDLLEIIAKAGPGVHLSPTQIASQLPTRNPDAPVMLDRILRLLASYNILSFTLRNLPDGKVERLYGLAPVAKYLVKNEDGVSIAALNLMNQDKVLMESWYYLKDAVLEGGIPFNKAYGMTAFEYHGTDPRFNKVFNKGMADHSTITMKKILEIYTGFEGLKSLVDVGGGTGAIINMIVSKYSTIKGINFDLPHVIDDAPSYPGVEHVGGDMFVSVPTADAIFMKWICHDWSDEHCLKFLKNCYDALPENGKVIVAECILPVAPDSSLATKGVVHIDVIMLAHNPGGKERTEKEFEALAKGSGFQGFRVFCCAFNTYIMEFLKKV
>Labpu27S13581_LABPU
MGTELKDAIREGGVPFDRAHGTHAFEYPSLDSRFNEVFNTAMINHTTLVMKKILESYKGFENIKKLVDVGGGLGININLITSKYPHVQGINFDLSHVIQHAHSYPGVEHVGGDMFENVPKGDAIFMKWILHDWSDEQCVKLLKNCYDAIPDDGKVIVVEALLPKIAETNAAYKAVSQMDVLMMTQNPGGKERCEQEFLALATAAGFRGIRYECHVHLFWVMEFFKEEEEEDELTFCMEKMVSFVVPMALRTLFELGVFDILAKGDKLCAKEIAIKIGSNNPEAPAMLDRLLSLLVSHSLLSCSIPQQEPHPQRFYALSPASRYFVTDPQGVSLGSAIRLLLDPERTERSNPRRGCSIRQGPWHECFRISTFNEVFNNGMIGLSTVIMKRILELYNGFEHVTRLIDVGGGYGVNINLIKSKHPHIQAINFDLPHVVENAPLHSGVEYVGGDMFESVPSGDAIFMKWVLHDWSDEQCVKLLKNCYGGIPDDGKVIVVDSILSMVPETSGTAKSASGSDLIMMTQNPGGKERTRQKFIELAEASGFSGVKFICCVCGNWVMEFYKGHVGTSI
>Labpu784S18605_LABPU
MEEEGTDSRKQARLAIMELANMISVPMALNAVVRLNVADTIWNAGANVPLSAAQILPRILPAGDAENLQRLLRILTSYGVFREHLAAGERKYSLTDIGKTLVTDEEGLSYGAYVLQHHQDALMRAWPLVHEAVVDPTREPFERANGEGAYGYYLKQPEMNELMVKAMSGVSVPFMRAMLEGYDGFQGVEKLVDVGGSGGDCLRMILQKHPTIREGINFDLPEVVAKAPPTPRVTHVGGDMFNSIPQGDAIFMKWVLTTWTDEEIKQIMQNCHKAVPEGGKLIACEPVLPEHSDESHRTRALLEGDIFVMTIYRAKGKHRTEEQFRQLGIDAGFPRFRAINVDHFYTVLEFQK
>Labpu1814S10967_LABPU
MVKFWLQIRIGRTIIMQLADTEKETRMDSSYAEEENAFISAMLHCFGPIYSAVLNAALELNLFEIIAKASPSSLGVSASDVASQLPTQHPELPRRVDRMLSLLASHSLLTCSTRTSQDGHPQRFYHLSLAGQYFIKDHNKGSLSFLSTFFTHPSIVHVLLNYKEVPLEFDKDLYEKVHGVPLYEGMYSDPKLSNIFKETMTHLGKIEMKKILNLYRGFEEISLLVDVGGGIGQDLNMIISKYPSTNGINFDLPHVIQNAPIYSGIKQVEGNMFESVPKGDAIILKAVLHNWSDEKCLQILSNCYKALPEKGKVIVVDIIVPEAIESTDADKMVTGFHNLMFLDGGTERTEKEFQNLCKLAGFSHFEVVCRVFSALGVIEFHK
MAPSQETNSGEAMQLKHVEEDQDGILFALNMVSSVMYPLAVKAAIELGIFDIMAKAGEGAKLSAEEITEKVGAKNPDAPTMVERILRLLASHSMLSCSLGEDGPNSGKRLYSLTYASKYFVADTDGVSFGASLNLVLGKVFLETWTELKGSIVEGGIAFNRVYGMNAFEYPAVDPGYNDVFNKAMFNITTIITNRVLELYDGFKNINRLVDVGGGLGINLKLITSKYPNVQGVNFDLPHVIEHAPTYPGVEHVAGDMFESVPSGDAIFMKWILHDWSDEHCLKLLKNCYKAIPSDGKVIVVDLIIPALPESTTTARTGFQADLLMMAQNPGGKERTQNEFMELALSSGFSGIRFVSSVSGFWVMEFFK
>Labpu164S10257_LABPU
MTINHMGSNCEEINGEENDPCLSAMLLSFSPMVYTAVLNAAIELNLFEIIAKATTTETLGVSASEIASHLPIQHKRLPQRLDRMLSLLASHSLLTCSTLANEEGKVQRLFQLSPSGKYFLNAETTASLALFSTFMSHPKLVQALLNFKEILLDCDNGLYMKVHGMPIFEGIQSDPAWNHTFNEAMANICTTEMTKILQIYSGFEGISLLIDVGGGVGQSLNMIISKYPSIKGVNFDLPQVIQQAPPYPGIEHVEGDMFESVPKGDAILLKGILHNWSDENCLKVLSNCYNALPENGKVVVVDFIMPEAIGSTEADKMVTSFDNLMFLDGGSERTEKEFTNLCQCSQFSSFKVVSRAFTALGVMEFHK
>Labpu315S14019_LABPU
MASCSSEKENHVVVERDDTETTLRAMVLGSNVVFPAALNAAIELNLFDIIAKEGSAESGGLMSPSEIASKLLIPTQQQQHCDLANRLERLLRLLASYSLLTVSSRSDGDGGSVRVYGVSASGKYFVREQNGEGCLASFTSFLCHPSLSGVWLNFKEAVIDPEIDLFKKVHGMSKFEYFGKYPEINHVFNKAMDDICTTHMKRILEVYTGYEGISTLVDVGGGTGQCLKMIISKYPSIKGINFDLPHVIENSPPVPGVEHVGGNMFECVPQGDAIMLKAICHNWSDEKAVELLSNCHKALPPKGKVIVGDFILPEDPEPTNEHKVISILDNIMFITPGGRERTEKQFQSLGRRAGFSRFQVVCRAFSTMSLMEFYK
>Labpu245S12925_LABPU
MSSNSKENEVPLEQEKVDDAYLSAVLLCFSRVLPAVLNAAIDINLFDVIAKAKSSCDDSSFSASEIASLLPNQHPQLANRLERMLPLLTSYSLLHCSIRTNEDGKIERVYALSPVGKYFAYDDEGISVAPLSTLLHRGFHDLWKDAKGAYLDPDCNNHFENVYGMLSYQYMEKNAELNEMFYKAMAHAGPIEVKRVLKVYKGFEGLSTLVDVGGGVGETLKLIVSAYPSIKGVNFDLPQMIEDAPAHPGVEHVGGDMFESVPSGDAILVKSICHNWADEDCIKFLRNCHKALPAHGKVIVLDYIIPEVPNSSDASKHSSIVDNHMFLAHGGRERTEIEFENLCKSSGFSKFQVACSGISATVGVMEFYK
>Labpu432S15038_LABPU
MGSTGETQITPSHVSDEEANLFAMQLASASVLPMVLKSAIELDLLEIIAKAGPGVHLSPTQIASQLPTRNPDAPVMLDRILRLLASYNILSFTLRNLPDGKVERLYGLAPVAKYLVKNEDGVSIAALNLMNQDKVLMESWYYLKDAVLEGGIPFNKAYGMTAFEYHGTDPRFNKVFNKGMADHSTITMKKILEIYTGFEGLKSLVDVGGGTGAIINMIVSKYSTIKGINFDLPHVIDDAPSYPGVEHVGGDMFVSVPTADAIFMKWICHDWSDEHCLKFLKNCYDALPENGKVIVAECILPVAPDSSLATKGVVHIDVIMLAHNPGGKERTEKEFEALAKGSGFQGFRVFCCAFNTYIMEFLKKV
>Labpu27S13581_LABPU
MGTELKDAIREGGVPFDRAHGTHAFEYPSLDSRFNEVFNTAMINHTTLVMKKILESYKGFENIKKLVDVGGGLGININLITSKYPHVQGINFDLSHVIQHAHSYPGVEHVGGDMFENVPKGDAIFMKWILHDWSDEQCVKLLKNCYDAIPDDGKVIVVEALLPKIAETNAAYKAVSQMDVLMMTQNPGGKERCEQEFLALATAAGFRGIRYECHVHLFWVMEFFKEEEEEDELTFCMEKMVSFVVPMALRTLFELGVFDILAKGDKLCAKEIAIKIGSNNPEAPAMLDRLLSLLVSHSLLSCSIPQQEPHPQRFYALSPASRYFVTDPQGVSLGSAIRLLLDPERTERSNPRRGCSIRQGPWHECFRISTFNEVFNNGMIGLSTVIMKRILELYNGFEHVTRLIDVGGGYGVNINLIKSKHPHIQAINFDLPHVVENAPLHSGVEYVGGDMFESVPSGDAIFMKWVLHDWSDEQCVKLLKNCYGGIPDDGKVIVVDSILSMVPETSGTAKSASGSDLIMMTQNPGGKERTRQKFIELAEASGFSGVKFICCVCGNWVMEFYKGHVGTSI
>Labpu784S18605_LABPU
MEEEGTDSRKQARLAIMELANMISVPMALNAVVRLNVADTIWNAGANVPLSAAQILPRILPAGDAENLQRLLRILTSYGVFREHLAAGERKYSLTDIGKTLVTDEEGLSYGAYVLQHHQDALMRAWPLVHEAVVDPTREPFERANGEGAYGYYLKQPEMNELMVKAMSGVSVPFMRAMLEGYDGFQGVEKLVDVGGSGGDCLRMILQKHPTIREGINFDLPEVVAKAPPTPRVTHVGGDMFNSIPQGDAIFMKWVLTTWTDEEIKQIMQNCHKAVPEGGKLIACEPVLPEHSDESHRTRALLEGDIFVMTIYRAKGKHRTEEQFRQLGIDAGFPRFRAINVDHFYTVLEFQK
>Labpu1814S10967_LABPU
MVKFWLQIRIGRTIIMQLADTEKETRMDSSYAEEENAFISAMLHCFGPIYSAVLNAALELNLFEIIAKASPSSLGVSASDVASQLPTQHPELPRRVDRMLSLLASHSLLTCSTRTSQDGHPQRFYHLSLAGQYFIKDHNKGSLSFLSTFFTHPSIVHVLLNYKEVPLEFDKDLYEKVHGVPLYEGMYSDPKLSNIFKETMTHLGKIEMKKILNLYRGFEEISLLVDVGGGIGQDLNMIISKYPSTNGINFDLPHVIQNAPIYSGIKQVEGNMFESVPKGDAIILKAVLHNWSDEKCLQILSNCYKALPEKGKVIVVDIIVPEAIESTDADKMVTGFHNLMFLDGGTERTEKEFQNLCKLAGFSHFEVVCRVFSALGVIEFHK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University