Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Kingdonia uniflora
Species name
Kingdonia uniflora is a species of flowering plant in the family Circaeasteraceae.
Species info
Gene sequence info
Kingdonia_uniflora.4CL.fa
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>rna-gnl|WGS:JACGCM|KingUnif39594.1
MISVASPESSPQITPHISTSDISKPIPETLIFRSKLPDIPISNHLPLHTYCFEKVSEFADRPCLITGSNGGAYTFAETHLMCRKTATGLSNLGVKKGDVIMLLLPNCPEFVFSFMGASIIGAITTTANPFYTSSEIFKQLSSSGAKLIITQSSYVEKLRKTEENVPKLGEDFKVVTIDDSPENCIHFSVISEADERETESDSIDPNDPVALPFSSGTTGLPKGVILTHKSLISSIAQQVDGENPNLHLKEDDIVLCVLPLFHIYSLNSVLLCSLRAGAGVLLMQKFEIGVLLELIQRYKVSVAPVVPPLVLALAKNSMVENYDLSSIRIVLSGAAPLGKELEEALSTRVPQAIFGQGYGMTEAGPVLSMCLGFAKNPVPTKSGSCGTVVRNAELKVVDPETGLSLSHNQPGEICIRGPQIMKGYLNDSDSTSNTIDIEGWLHTGDIGYVDDDEEIFIVDRVKELIKFKGFQVPPAELEALLTSHPSISDAAVVPQKDAGAGEVPVAFVVRSNNDLELTEEAVKEFIAKQVVFYKKLHKVYFIHAIPKSPTGKILRKDLRAKLASPS
>rna-gnl|WGS:JACGCM|KingUnif26138.1
MERSGYGTDGIYRSLRSPITIPKDPNISMVQFLFRNSTSYSNHLALIDSDSTETLTFSQLKTTIAKVAHGFIQLGIKKGDVVLILAPNSLQFPVSFLGVTAIGAIATTVNPLYTVTEITKQVKDSKPKLVVTVSQLWEKVKGFGLPAVILGSGSGVFAPIESSTRITNFFELIEMAGVMTDFPKVSVKQTDTAALLYSSGTTGTSKGVILTHRNFISAALMVAADQDFRGEMHNVYLCFLPMFHIFGLSVLTYSQLQRGNSVVTMARFDIGMVLRTVEKYRVTHLFVVPPVVLALVKMDSLKKFNLSSLKQLGSGAAPLGKELMEECSKKLPGADVVQGYGLTETCGIVSLENPNEGVRHSGCAGTLVPGVESQIVSVDTVKPLPPNQLGEIWVRGQNMMQGYFNNPQATKLTIDKQGWVHTGDLGYFDEQGQLFVVDRIKELIKCKGFQVAPAELEGLLLSHPEILDAVVIPYPDAEAGEVPVAYVVRSPSSSLNEEDVQNFIAKQVASFKRLRRVTFITTVPKSVSGKILRKELIAKVRSKM
>rna-gnl|WGS:JACGCM|KingUnif27934.1
MTGTPAKEIMEEEEEEDKYVFRSQFPGVPVPDNMTLPEFVLHEAELFADKVAFVEAITGKEYTYAQVVRDTRRFAKALRSLGLRKGRVVVVVLPNVAEYAIVALGIMAAGGVFSGANPLAHVSELRKQVESADAKLIVTSGPIYEKVKGLDIPVIIMGEERIDSTISWDELLEAADRAGGDVIEEKINQNDLCALPFSSGTTGTSKGVMLTHRNLVANLCSTLFSVGPEMIGQVITLGLMPFFHIYGTVGICCATLRNKGKVVVMGRFELRMFLNTLITYEVGFAPIVPPIMLALVKNPVVEEFDLSRLKLRAVMTAAAPLAPDLLLAFERKFPGVQVQEAYGLTEHSCITLSHGDPTKEHGIAKKSSVGFILPNLEVKFIDPDTGRSLPRNTPGEVCVRSQCVMQGYYNNKEETDRTIDSEGWLHTGDIGYIDDDGDVFIVDRIKELIKYKGFQVAPAELEATLLSHPSVEDAAVVPLADEEAGEIPAACVVMNRNAKESEEEMMRFVASNVASYKKVRVLHFVDTIPKSPSGKIMRRFLKEKMEKRMMVPNNSNPTGSHCWNA
>rna-gnl|WGS:JACGCM|KingUnif13910.1
MPASSRIRTELMESSVMDKYMVSISPSIGILGIGGRPKVISPVVDSFEPLKPVIIVVEAFTESARPKTSIALQNKTSVALSVWMRSVWFFCVHLFLFVALERGHADLPFSDFFSMAICFGSSRNAPLQIKSFWNVLISYGTRMTSQVNVCHLDGFEIGNGIKWCGFPIKGYGMTEAGSVLSMGVAFAKEPLEIKSGSCGTVIRNAEIKIIDPDTSAFLPRNKPGENLQIMKGYLNDPEAWERTIDKEGWLHTGDIGYIDDDDEIFIVDRLKKLIKYEGFQVAPVELEAMLLTHPKISDLAIVSMKDDNAGEVPVAFVVWANRYKITEEEIKQFISKQVTLFPHPIPNLLEGSLMDWFNTMSLK
>rna-gnl|WGS:JACGCM|KingUnif06589.1
MDSTYVEEDEVEEEFSGDGVVAGLDGVSSSTYLGNQKDDNEKTIMYNAAPMGKELEDTVIARIPSAKLGQGYGMTEAGPVLSMCLAFTKDPLEIKSRSCGIVVSNAEIKITDPDTSVFLPGTNPVKFALEGNRLGKKKKKDKLTKSQVGYLNKYFGKIQQPETSNEGLVTKNVSEDHRDVNMGITEDLGNEDAIEETKNVIEEIGNETNIEEVKNESVNKENENANNIEEVDEENVDEEDENDNIQVLLSIMIPGLGRGLISL
>rna-gnl|WGS:JACGCM|KingUnif24761.1
MSNRSCKRLTNYLCLLLTGYLNDPEASERTINKEGWLHTGDIGYVDDDDEIFNVDRLKELIKYKGFQVAPAGLEAMLLTHPEISDAAVV
>rna-gnl|WGS:JACGCM|KingUnif27361.1
MGVAFAKEPLEIKTGSCGTVVKNAEIKIIDPDTSAFLPRNKPGEILQIMKGYLNDPEASERTIDKEGWLHTGDIGYIDDDDEIFIVDRLKELIKYKGFQVAPVEMETMLLTHPKISDLAIVS
>rna-gnl|WGS:JACGCM|KingUnif20158.1
MSNRSCKRLTNYLCLLLTGYLNDPEASERTINKEGWLHTGDIGYVDDDDEIFNVDRLKELIKYKGFQVAPAGLEAMLLTHPEISDAAVV
>rna-gnl|WGS:JACGCM|KingUnif33672.1
MDTKTEQKDIIFRSKLPDIHIPNHLPLHSYCFENISAFSSRPCLINGGTGDVHTYADVELASRKVASGLNKFGIKQGEVIMLLLPNCPEFVYVFLGASYIGATTTTANPFYTPTDISKQVKASNAKLIITQACYVPKMKDLDVTIMCIDAPLENCLHFSELTQCGDDKPELPDVDISPDDAVALPYSSGTTGLPKGVMLTHKSLVTSVAQQVDGENPNLYIHSEDVVLCVLPLFHIYSLNSVLLCGLRVGAAILIMQKFEIITLMDLVQKYKVTVAPIVPPIVLAIAKCPVVDNYDLSSIRTIMSGAAPMGKELEDTVRAKIPSAKLGQGYGMTEAGPVLSMCLAFAKQPFEIKSGSCGTVVRNAEIKIIDPDTSAFLPRNQPGEICIRGAQIMKGYLNDPEASERTIDKEGWLHTGDIGYIDDDDEIFIVDRLKELIKYKGFQVAPAELEAILLTHPEISDAAVVSMKDDDAGEVPIAFVVRANGYKITEDEIKQFITKQVVFYKRLNRVFFIEAIPKAPSGKILRKELRAKLAAGYPN
MISVASPESSPQITPHISTSDISKPIPETLIFRSKLPDIPISNHLPLHTYCFEKVSEFADRPCLITGSNGGAYTFAETHLMCRKTATGLSNLGVKKGDVIMLLLPNCPEFVFSFMGASIIGAITTTANPFYTSSEIFKQLSSSGAKLIITQSSYVEKLRKTEENVPKLGEDFKVVTIDDSPENCIHFSVISEADERETESDSIDPNDPVALPFSSGTTGLPKGVILTHKSLISSIAQQVDGENPNLHLKEDDIVLCVLPLFHIYSLNSVLLCSLRAGAGVLLMQKFEIGVLLELIQRYKVSVAPVVPPLVLALAKNSMVENYDLSSIRIVLSGAAPLGKELEEALSTRVPQAIFGQGYGMTEAGPVLSMCLGFAKNPVPTKSGSCGTVVRNAELKVVDPETGLSLSHNQPGEICIRGPQIMKGYLNDSDSTSNTIDIEGWLHTGDIGYVDDDEEIFIVDRVKELIKFKGFQVPPAELEALLTSHPSISDAAVVPQKDAGAGEVPVAFVVRSNNDLELTEEAVKEFIAKQVVFYKKLHKVYFIHAIPKSPTGKILRKDLRAKLASPS
>rna-gnl|WGS:JACGCM|KingUnif26138.1
MERSGYGTDGIYRSLRSPITIPKDPNISMVQFLFRNSTSYSNHLALIDSDSTETLTFSQLKTTIAKVAHGFIQLGIKKGDVVLILAPNSLQFPVSFLGVTAIGAIATTVNPLYTVTEITKQVKDSKPKLVVTVSQLWEKVKGFGLPAVILGSGSGVFAPIESSTRITNFFELIEMAGVMTDFPKVSVKQTDTAALLYSSGTTGTSKGVILTHRNFISAALMVAADQDFRGEMHNVYLCFLPMFHIFGLSVLTYSQLQRGNSVVTMARFDIGMVLRTVEKYRVTHLFVVPPVVLALVKMDSLKKFNLSSLKQLGSGAAPLGKELMEECSKKLPGADVVQGYGLTETCGIVSLENPNEGVRHSGCAGTLVPGVESQIVSVDTVKPLPPNQLGEIWVRGQNMMQGYFNNPQATKLTIDKQGWVHTGDLGYFDEQGQLFVVDRIKELIKCKGFQVAPAELEGLLLSHPEILDAVVIPYPDAEAGEVPVAYVVRSPSSSLNEEDVQNFIAKQVASFKRLRRVTFITTVPKSVSGKILRKELIAKVRSKM
>rna-gnl|WGS:JACGCM|KingUnif27934.1
MTGTPAKEIMEEEEEEDKYVFRSQFPGVPVPDNMTLPEFVLHEAELFADKVAFVEAITGKEYTYAQVVRDTRRFAKALRSLGLRKGRVVVVVLPNVAEYAIVALGIMAAGGVFSGANPLAHVSELRKQVESADAKLIVTSGPIYEKVKGLDIPVIIMGEERIDSTISWDELLEAADRAGGDVIEEKINQNDLCALPFSSGTTGTSKGVMLTHRNLVANLCSTLFSVGPEMIGQVITLGLMPFFHIYGTVGICCATLRNKGKVVVMGRFELRMFLNTLITYEVGFAPIVPPIMLALVKNPVVEEFDLSRLKLRAVMTAAAPLAPDLLLAFERKFPGVQVQEAYGLTEHSCITLSHGDPTKEHGIAKKSSVGFILPNLEVKFIDPDTGRSLPRNTPGEVCVRSQCVMQGYYNNKEETDRTIDSEGWLHTGDIGYIDDDGDVFIVDRIKELIKYKGFQVAPAELEATLLSHPSVEDAAVVPLADEEAGEIPAACVVMNRNAKESEEEMMRFVASNVASYKKVRVLHFVDTIPKSPSGKIMRRFLKEKMEKRMMVPNNSNPTGSHCWNA
>rna-gnl|WGS:JACGCM|KingUnif13910.1
MPASSRIRTELMESSVMDKYMVSISPSIGILGIGGRPKVISPVVDSFEPLKPVIIVVEAFTESARPKTSIALQNKTSVALSVWMRSVWFFCVHLFLFVALERGHADLPFSDFFSMAICFGSSRNAPLQIKSFWNVLISYGTRMTSQVNVCHLDGFEIGNGIKWCGFPIKGYGMTEAGSVLSMGVAFAKEPLEIKSGSCGTVIRNAEIKIIDPDTSAFLPRNKPGENLQIMKGYLNDPEAWERTIDKEGWLHTGDIGYIDDDDEIFIVDRLKKLIKYEGFQVAPVELEAMLLTHPKISDLAIVSMKDDNAGEVPVAFVVWANRYKITEEEIKQFISKQVTLFPHPIPNLLEGSLMDWFNTMSLK
>rna-gnl|WGS:JACGCM|KingUnif06589.1
MDSTYVEEDEVEEEFSGDGVVAGLDGVSSSTYLGNQKDDNEKTIMYNAAPMGKELEDTVIARIPSAKLGQGYGMTEAGPVLSMCLAFTKDPLEIKSRSCGIVVSNAEIKITDPDTSVFLPGTNPVKFALEGNRLGKKKKKDKLTKSQVGYLNKYFGKIQQPETSNEGLVTKNVSEDHRDVNMGITEDLGNEDAIEETKNVIEEIGNETNIEEVKNESVNKENENANNIEEVDEENVDEEDENDNIQVLLSIMIPGLGRGLISL
>rna-gnl|WGS:JACGCM|KingUnif24761.1
MSNRSCKRLTNYLCLLLTGYLNDPEASERTINKEGWLHTGDIGYVDDDDEIFNVDRLKELIKYKGFQVAPAGLEAMLLTHPEISDAAVV
>rna-gnl|WGS:JACGCM|KingUnif27361.1
MGVAFAKEPLEIKTGSCGTVVKNAEIKIIDPDTSAFLPRNKPGEILQIMKGYLNDPEASERTIDKEGWLHTGDIGYIDDDDEIFIVDRLKELIKYKGFQVAPVEMETMLLTHPKISDLAIVS
>rna-gnl|WGS:JACGCM|KingUnif20158.1
MSNRSCKRLTNYLCLLLTGYLNDPEASERTINKEGWLHTGDIGYVDDDDEIFNVDRLKELIKYKGFQVAPAGLEAMLLTHPEISDAAVV
>rna-gnl|WGS:JACGCM|KingUnif33672.1
MDTKTEQKDIIFRSKLPDIHIPNHLPLHSYCFENISAFSSRPCLINGGTGDVHTYADVELASRKVASGLNKFGIKQGEVIMLLLPNCPEFVYVFLGASYIGATTTTANPFYTPTDISKQVKASNAKLIITQACYVPKMKDLDVTIMCIDAPLENCLHFSELTQCGDDKPELPDVDISPDDAVALPYSSGTTGLPKGVMLTHKSLVTSVAQQVDGENPNLYIHSEDVVLCVLPLFHIYSLNSVLLCGLRVGAAILIMQKFEIITLMDLVQKYKVTVAPIVPPIVLAIAKCPVVDNYDLSSIRTIMSGAAPMGKELEDTVRAKIPSAKLGQGYGMTEAGPVLSMCLAFAKQPFEIKSGSCGTVVRNAEIKIIDPDTSAFLPRNQPGEICIRGAQIMKGYLNDPEASERTIDKEGWLHTGDIGYIDDDDEIFIVDRLKELIKYKGFQVAPAELEAILLTHPEISDAAVVSMKDDDAGEVPIAFVVRANGYKITEDEIKQFITKQVVFYKRLNRVFFIEAIPKAPSGKILRKELRAKLAAGYPN
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University