Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Amborella trichopoda
Species name
Amborella trichopoda is a species of flowering plant in the family Amborellaceae.
Species info
Gene sequence info
Amborella_trichopoda.4CL.fa
Download
>XP_006843037.1
MEKSGYGKDGIYRSLRPPVVFPKDPYLNMMSFMFRNSSLYGEKLAVADAETDEGLNFRELEVVVDRVRNGLNKIGIRRGDVVLIFAPNSMHFATCFFGVVSLGAIATTVNPMYTSMEVAKQVKDSGSKLVITVPQLWEKVNCLGLPAVILDYAKTSSINSQRGITYYSDLLEMGASTKNSLPVARVRQSDTAALLYSSGTTGTSKGVILTHGNFIAASLMAASDQDWKGELHNRFLCVIPMFHIFGLSILNYAQLQRGNAVVIMSRFDLHQMLRSVEKFRVTHLFVVPPIMIALAKQTVVSKYDLSSLRQLGVGAAPVGKDILEDCARNIPLAEVVQGYGMTESCGIISLEMRMKGKHHFGSTGFLVPGVEAKIVNVDTLKPLPPNQLGEIWIRGPHIMQGYFNNPQATKSTIVKEGWLLTGDLGYFDDEGRLFVVDRIKELIKYKAFQIAPAELEGLLLSHPEILDAVVIPFPDAEAGEVPIAYVVRSQGSSITEKDVQEFVAKQVASFKRLRRVTFVNSVPKSASGKILRRELIEKVRSKM
>XP_006845618.1
MAVGTITKEHIYRSKLPDIEIPNHLPLHTYCFQHLDTFRSRPCLIDGSTGRQYSYDEVHSISRRVASGLVKLGIQQHDIIMLLLPNSPEFVFAFLGASFCGATATTANPFYTPAEVQKQARACRARLVVTLARYVERLSGLEGVKIVCVDEPPEGCLHMSELTESTEPFTEPSIEPDDVVALPYSSGTTGLPKGVMLTHKSLITSVAQQVDGENPNLYFHSEDVILCVLPLFHIYSLNSVLLCGLRVGASILLMQKFENVGLMELVERYKVTIMPIVPPIVLAITKSKEVGRYDMSSIRTVMSGAAPMGKELEDALRAMLPDAKLGQGYGMTEAGPVLSMCLAFAKEPFEIKSGSCGTVVRNAELKIVDPETGVSLPHNQAGEICIRGAQIMKGYLNDSEATKGTIDKDGWLHTGDIGYVDDDEEIFIVDRLKELIKFKGFQVAPAELEALLVSHPAIADAAVVPMKDEAAGEVPVAFVVRLNGSQITEDEIKQYIAKQVIFYKRIAKVFFENSIPKASSGKILRKELRARLAAGSPQ
>XP_006851001.2
MANNITLLHREKQHLEPLERDNGGEHIFTSKFPAVPVPYLTLPEFVLENWEKYEEKVAIVEAIGGKEFTYRQVVDGVRDFGNGLKGMGMVKGSVVIVLLPNIAEYPIIALGVMSAGGVFSGSNPLAHPSEVRKQVEDSGAKLIVTNGPCYEKVRDLGIPVLIVGGDPIENTIPWEELLKRGRNNDHFALKGDLLSENDQFAPTSKGSDENIHFTPDHATGWKNDHFTPKQGEVVCQDDLCALPYSSGTTGTSKGVMLTHRNLVANMCSTLFGVTPEMIGEFTTLGLMPFFHIYGITGICCATLRNKGKVVVMSRFELRLFLDALITHGVNFAPIVPPIMLSLVKNPIVDEFDLSRLKLRSVMTAAAPLAPDLLQVFEQKFPGVQVQEAYGLTEHSCITMSHCTSEEAGGVAKRTSVGLILPNLEIKFIDPDTRISLPKTTIGELCVRSQCVMKGYYKNEEETARTLDSEGWLHTGDVGYIDDDGHVFIVDRIKELIKYKGFQVAPAELEAILLSHPSVEDAAVVAVADQEAGEIPAACVVMAPTSKESEEEIMKYVASNVASYKRVRVVHFVNSIPKSPSGKILRRLLRDSVMRRLNSSSNTSKDHGSAQSA
>XP_006854065.1
MIKVAARDSPAPPMPHENRHEPAQTGHIFRSKLPDIPIPASLPLTKYIFQNLADHSDRPCLITVTGQRLSYLEFHTCCKETASGLFKLGIRRGDIIMLLLHNSPEFVISFIGAAMIGAVSTTCNPFFTPGEVSKQIKACNPKIVITLSQYVVKLKDHCPGNGVAGKLTERSFSGESKTQESELGSAEKHINQSQLSRKPLSSELENQRPDSQLADKPPVLEISWDELPVKPQIQATHIRVITVDDPPEGCLHFSVLSDSGESDPPEITIDPEDPIALPFSSGTTGLPKGVVLTHKTIVSSIAQQVDGENPNLYIHSQDVVLCVLPLFHIYSLNSVLLCSLRVGAEVVLMPKFEIGTMLEVVEKYRVSVAPVVPPLVLALAKNGAVEKFDLRSIRIVLSGAAPLGKDLQEALRTRVPQAVFGQGYGMTEAGPVLSMCLAFAKKPFPSKPGSCGTVVRNSELKVIDTESGASLSYNQPGEICIRGPQVMKGYLNDSEATAATIDSEGWLHTGDIGYVDEEEEVFIVDRVKELIKYKGFQVPPAEIEALLLSHPSIADAAVVPQKDEAAGEVPVAFIVRSNGFELTEEVVKDFIAKQVVFYKRLQKVYFIHVIPKSPSGKILRKELKAKLA
>XP_011622865.1
MEKSGYGKDGIYRSLRPPVVFPKDPYLNMMSFMFRNSSLYGEKLAVADAETDEGLNFRELEVVVDRVRNGLNKIGIRRGDVVLIFAPNSMHFATCFFGVVSLGAIATTVNPMYTSMEVAKQVKDSGSKLVITVPQLWEKVNCLGLPAVILDYAKTSSINSQRGITYYSDLLEMGASTKNSLPVARVRQSDTAALLYSSGTTGTSKGVILTHGNFIAASLMAASDQDWKGELHNRFLCVIPMFHIFGLSILNYAQLQRGNAVVIMSRFDLHQMLRSVEKFRVTHLFVVPPIMIALAKQTVVSKYDLSSLRQLGVGAAPVGKDILEDCARNIPLAEVVQGYGMTESCGIISLEMRMKGKHHFGSTGFLVPGVEAKIVNVDTLKPLPPNQLGEIWIRGPHIMQGYFNNPQATKSTIVKEGWLLTGDLGYFDDEGRLFVVDRIKELIKYKAFQIAPAELEGLLLSHPEILDAVVIPFPDAEAGEVPIAYVVRSQGSSITEKDVQEFVAKQVASFKRLRRVTFVNSVPKSASGKILRRELIEKVRSKM
>XP_011622866.1
MEKSGYGKDGIYRSLRPPVVFPKDPYLNMMSFMFRNSSLYGEKLAVADAETDEGLNFRELEVVVDRVRNGLNKIGIRRGDVVLIFAPNSMHFATCFFGVVSLGAIATTVNPMYTSMEVAKQVKDSGSKLVITVPQLWEKVNCLGLPAVILDYAKTSSINSQRGITYYSDLLEMGASTKNSLPVARVRQSDTAALLYSSGTTGTSKGVILTHGNFIAASLMAASDQDWKGELHNRFLCVIPMFHIFGLSILNYAQLQRGNAVVIMSRFDLHQMLRSVEKFRVTHLFVVPPIMIALAKQTVVSKYDLSSLRQLGVGAAPVGKDILEDCARNIPLAEVVQGYGMTESCGIISLEMRMKGKHHFGSTGFLVPGVEAKIVNVDTLKPLPPNQLGEIWIRGPHIMQGYFNNPQATKSTIVKEGWLLTGDLGYFDDEGRLFVVDRIKELIKYKAFQIAPAELEGLLLSHPEILDAVVIPFPDAEAGEVPIAYVVRSQGSSITEKDVQEFVAKQVASFKRLRRVTFVNSVPKSASGKILRRELIEKVRSKM
>XP_011626913.1
MIKVAARDSPAPPMPHENRHEPAQTGHIFRSKLPDIPIPASLPLTKYIFQNLADHSDRPCLITVTGQRLSYLEFHTCCKETASGLFKLGIRRGDIIMLLLHNSPEFVISFIGAAMIGAVSTTCNPFFTPGEVSKQIKACNPKIVITLSQYVVKLKDHCPGNGVAGKLTERSFSGESKTQESELGSAEKHINQSQLSRKPLSSELENQRPDSQLADKPPVLEISWDELPVKPQIQATHIRVITVDDPPEGCLHFSVLSDSGESDPPEITIDPEDPIALPFSSGTTGLPKGVVLTHKTIVSSIAQQVDGENPNLYIHSQDVVLCVLPLFHIYSLNSVLLCSLRVGAEVVLMPKFEIGTMLEVVEKYRVSVAPVVPPLVLALAKNGAVEKFDLRSIRIVLSGAAPLGKDLQEALRTRVPQAVFGQGYGMTEAGPVLSMCLAFAKKPFPSKPGSCGTVVRNSELKVIDTESGASLSYNQPGEICIRGPQVMKGYLNDSEATAATIDSEGWLHTGDIGYVDEEEEVFIVDRVKELIKYKGFQVPPAEIEALLLSHPSIADAAVVPQKDEAAGEVPVAFIVRSNGFELTEEVVKDFIAKQVVFYKRLQKVYFIHVIPKSPSGKILRKELKAKLA
>XP_020522039.1
MEKSGYGKDGIYRSLRPPVVFPKDPYLNMMSFMFRNSSLYGEKLAVADAETDEGLNFRELEVVVDRVRNGLNKIGIRRGDVVLIFAPNSMHFATCFFGVVSLGAIATTVNPMYTSMEVAKQVKDSGSKLVITVPQLWEKVNCLGLPAVILDYAKTSSINSQRGITYYSDLLEMGASTKNSLPVARVRQSDTAALLYSSGTTGTSKGVILTHGNFIAASLMAASDQDWKGELHNRFLCVIPMFHIFGLSILNYAQLQRGNAVVIMSRFDLHQMLRSVEKFRVTHLFVVPPIMIALAKQTVVSKYDLSSLRQLGVGAAPVGKDILEDCARNIPLAEVVQGYGMTESCGIISLEMRMKGKHHFGSTGFLVPGVEAKIVNVDTLKPLPPNQLGEIWIRGPHIMQGYFNNPQATKSTIVKEGWLLTGDLGYFDDEGRLFVVDRIKELIKYKAFQDISC
MEKSGYGKDGIYRSLRPPVVFPKDPYLNMMSFMFRNSSLYGEKLAVADAETDEGLNFRELEVVVDRVRNGLNKIGIRRGDVVLIFAPNSMHFATCFFGVVSLGAIATTVNPMYTSMEVAKQVKDSGSKLVITVPQLWEKVNCLGLPAVILDYAKTSSINSQRGITYYSDLLEMGASTKNSLPVARVRQSDTAALLYSSGTTGTSKGVILTHGNFIAASLMAASDQDWKGELHNRFLCVIPMFHIFGLSILNYAQLQRGNAVVIMSRFDLHQMLRSVEKFRVTHLFVVPPIMIALAKQTVVSKYDLSSLRQLGVGAAPVGKDILEDCARNIPLAEVVQGYGMTESCGIISLEMRMKGKHHFGSTGFLVPGVEAKIVNVDTLKPLPPNQLGEIWIRGPHIMQGYFNNPQATKSTIVKEGWLLTGDLGYFDDEGRLFVVDRIKELIKYKAFQIAPAELEGLLLSHPEILDAVVIPFPDAEAGEVPIAYVVRSQGSSITEKDVQEFVAKQVASFKRLRRVTFVNSVPKSASGKILRRELIEKVRSKM
>XP_006845618.1
MAVGTITKEHIYRSKLPDIEIPNHLPLHTYCFQHLDTFRSRPCLIDGSTGRQYSYDEVHSISRRVASGLVKLGIQQHDIIMLLLPNSPEFVFAFLGASFCGATATTANPFYTPAEVQKQARACRARLVVTLARYVERLSGLEGVKIVCVDEPPEGCLHMSELTESTEPFTEPSIEPDDVVALPYSSGTTGLPKGVMLTHKSLITSVAQQVDGENPNLYFHSEDVILCVLPLFHIYSLNSVLLCGLRVGASILLMQKFENVGLMELVERYKVTIMPIVPPIVLAITKSKEVGRYDMSSIRTVMSGAAPMGKELEDALRAMLPDAKLGQGYGMTEAGPVLSMCLAFAKEPFEIKSGSCGTVVRNAELKIVDPETGVSLPHNQAGEICIRGAQIMKGYLNDSEATKGTIDKDGWLHTGDIGYVDDDEEIFIVDRLKELIKFKGFQVAPAELEALLVSHPAIADAAVVPMKDEAAGEVPVAFVVRLNGSQITEDEIKQYIAKQVIFYKRIAKVFFENSIPKASSGKILRKELRARLAAGSPQ
>XP_006851001.2
MANNITLLHREKQHLEPLERDNGGEHIFTSKFPAVPVPYLTLPEFVLENWEKYEEKVAIVEAIGGKEFTYRQVVDGVRDFGNGLKGMGMVKGSVVIVLLPNIAEYPIIALGVMSAGGVFSGSNPLAHPSEVRKQVEDSGAKLIVTNGPCYEKVRDLGIPVLIVGGDPIENTIPWEELLKRGRNNDHFALKGDLLSENDQFAPTSKGSDENIHFTPDHATGWKNDHFTPKQGEVVCQDDLCALPYSSGTTGTSKGVMLTHRNLVANMCSTLFGVTPEMIGEFTTLGLMPFFHIYGITGICCATLRNKGKVVVMSRFELRLFLDALITHGVNFAPIVPPIMLSLVKNPIVDEFDLSRLKLRSVMTAAAPLAPDLLQVFEQKFPGVQVQEAYGLTEHSCITMSHCTSEEAGGVAKRTSVGLILPNLEIKFIDPDTRISLPKTTIGELCVRSQCVMKGYYKNEEETARTLDSEGWLHTGDVGYIDDDGHVFIVDRIKELIKYKGFQVAPAELEAILLSHPSVEDAAVVAVADQEAGEIPAACVVMAPTSKESEEEIMKYVASNVASYKRVRVVHFVNSIPKSPSGKILRRLLRDSVMRRLNSSSNTSKDHGSAQSA
>XP_006854065.1
MIKVAARDSPAPPMPHENRHEPAQTGHIFRSKLPDIPIPASLPLTKYIFQNLADHSDRPCLITVTGQRLSYLEFHTCCKETASGLFKLGIRRGDIIMLLLHNSPEFVISFIGAAMIGAVSTTCNPFFTPGEVSKQIKACNPKIVITLSQYVVKLKDHCPGNGVAGKLTERSFSGESKTQESELGSAEKHINQSQLSRKPLSSELENQRPDSQLADKPPVLEISWDELPVKPQIQATHIRVITVDDPPEGCLHFSVLSDSGESDPPEITIDPEDPIALPFSSGTTGLPKGVVLTHKTIVSSIAQQVDGENPNLYIHSQDVVLCVLPLFHIYSLNSVLLCSLRVGAEVVLMPKFEIGTMLEVVEKYRVSVAPVVPPLVLALAKNGAVEKFDLRSIRIVLSGAAPLGKDLQEALRTRVPQAVFGQGYGMTEAGPVLSMCLAFAKKPFPSKPGSCGTVVRNSELKVIDTESGASLSYNQPGEICIRGPQVMKGYLNDSEATAATIDSEGWLHTGDIGYVDEEEEVFIVDRVKELIKYKGFQVPPAEIEALLLSHPSIADAAVVPQKDEAAGEVPVAFIVRSNGFELTEEVVKDFIAKQVVFYKRLQKVYFIHVIPKSPSGKILRKELKAKLA
>XP_011622865.1
MEKSGYGKDGIYRSLRPPVVFPKDPYLNMMSFMFRNSSLYGEKLAVADAETDEGLNFRELEVVVDRVRNGLNKIGIRRGDVVLIFAPNSMHFATCFFGVVSLGAIATTVNPMYTSMEVAKQVKDSGSKLVITVPQLWEKVNCLGLPAVILDYAKTSSINSQRGITYYSDLLEMGASTKNSLPVARVRQSDTAALLYSSGTTGTSKGVILTHGNFIAASLMAASDQDWKGELHNRFLCVIPMFHIFGLSILNYAQLQRGNAVVIMSRFDLHQMLRSVEKFRVTHLFVVPPIMIALAKQTVVSKYDLSSLRQLGVGAAPVGKDILEDCARNIPLAEVVQGYGMTESCGIISLEMRMKGKHHFGSTGFLVPGVEAKIVNVDTLKPLPPNQLGEIWIRGPHIMQGYFNNPQATKSTIVKEGWLLTGDLGYFDDEGRLFVVDRIKELIKYKAFQIAPAELEGLLLSHPEILDAVVIPFPDAEAGEVPIAYVVRSQGSSITEKDVQEFVAKQVASFKRLRRVTFVNSVPKSASGKILRRELIEKVRSKM
>XP_011622866.1
MEKSGYGKDGIYRSLRPPVVFPKDPYLNMMSFMFRNSSLYGEKLAVADAETDEGLNFRELEVVVDRVRNGLNKIGIRRGDVVLIFAPNSMHFATCFFGVVSLGAIATTVNPMYTSMEVAKQVKDSGSKLVITVPQLWEKVNCLGLPAVILDYAKTSSINSQRGITYYSDLLEMGASTKNSLPVARVRQSDTAALLYSSGTTGTSKGVILTHGNFIAASLMAASDQDWKGELHNRFLCVIPMFHIFGLSILNYAQLQRGNAVVIMSRFDLHQMLRSVEKFRVTHLFVVPPIMIALAKQTVVSKYDLSSLRQLGVGAAPVGKDILEDCARNIPLAEVVQGYGMTESCGIISLEMRMKGKHHFGSTGFLVPGVEAKIVNVDTLKPLPPNQLGEIWIRGPHIMQGYFNNPQATKSTIVKEGWLLTGDLGYFDDEGRLFVVDRIKELIKYKAFQIAPAELEGLLLSHPEILDAVVIPFPDAEAGEVPIAYVVRSQGSSITEKDVQEFVAKQVASFKRLRRVTFVNSVPKSASGKILRRELIEKVRSKM
>XP_011626913.1
MIKVAARDSPAPPMPHENRHEPAQTGHIFRSKLPDIPIPASLPLTKYIFQNLADHSDRPCLITVTGQRLSYLEFHTCCKETASGLFKLGIRRGDIIMLLLHNSPEFVISFIGAAMIGAVSTTCNPFFTPGEVSKQIKACNPKIVITLSQYVVKLKDHCPGNGVAGKLTERSFSGESKTQESELGSAEKHINQSQLSRKPLSSELENQRPDSQLADKPPVLEISWDELPVKPQIQATHIRVITVDDPPEGCLHFSVLSDSGESDPPEITIDPEDPIALPFSSGTTGLPKGVVLTHKTIVSSIAQQVDGENPNLYIHSQDVVLCVLPLFHIYSLNSVLLCSLRVGAEVVLMPKFEIGTMLEVVEKYRVSVAPVVPPLVLALAKNGAVEKFDLRSIRIVLSGAAPLGKDLQEALRTRVPQAVFGQGYGMTEAGPVLSMCLAFAKKPFPSKPGSCGTVVRNSELKVIDTESGASLSYNQPGEICIRGPQVMKGYLNDSEATAATIDSEGWLHTGDIGYVDEEEEVFIVDRVKELIKYKGFQVPPAEIEALLLSHPSIADAAVVPQKDEAAGEVPVAFIVRSNGFELTEEVVKDFIAKQVVFYKRLQKVYFIHVIPKSPSGKILRKELKAKLA
>XP_020522039.1
MEKSGYGKDGIYRSLRPPVVFPKDPYLNMMSFMFRNSSLYGEKLAVADAETDEGLNFRELEVVVDRVRNGLNKIGIRRGDVVLIFAPNSMHFATCFFGVVSLGAIATTVNPMYTSMEVAKQVKDSGSKLVITVPQLWEKVNCLGLPAVILDYAKTSSINSQRGITYYSDLLEMGASTKNSLPVARVRQSDTAALLYSSGTTGTSKGVILTHGNFIAASLMAASDQDWKGELHNRFLCVIPMFHIFGLSILNYAQLQRGNAVVIMSRFDLHQMLRSVEKFRVTHLFVVPPIMIALAKQTVVSKYDLSSLRQLGVGAAPVGKDILEDCARNIPLAEVVQGYGMTESCGIISLEMRMKGKHHFGSTGFLVPGVEAKIVNVDTLKPLPPNQLGEIWIRGPHIMQGYFNNPQATKSTIVKEGWLLTGDLGYFDDEGRLFVVDRIKELIKYKAFQDISC
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University