Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Amaranthus hypochondriacus
Species name
Grain amaranth (Amaranthus hypochondriacus) is a species of eudicot in the family Amaranthaceae (amaranth family).
Species info
Gene sequence info
Amaranthus_hypochondriacus.COMT.fa
Download
>AH019732-RA.v2.1
MGSLATQMGENEAFSFAMAMVTGSVQPMVLRAIYELDVLEIIKRAGPGNSILSYSTRNRADGQVETLYGLTPVCQFLAKNEDGIGLRNLTLVNTDQVLMESWYHLKDAVLNGGIAFTKAHNMEAFEYHGIDLRFNKVFNNGMFNHSTIIMKKITETYKGFKGVSTLVDVGGGIGASLNMIISKYPTIKAINFDLPHVVQHAPSRNGLTHIGGDMFESVPKGDAIFMKWICHDWSDEHCIKLLKNCYASLPDHGKVIVCEYILPIEPEPSQAVRAVYQVDCIMMNNYTGGKERTEQEFKTLAKAAGFSDFRIACSVYNAKIMEFLKNNTESNSNTTNHVENDEICAFAMAITSSSVPPMVLKVVIELNVFEIIKKAGPGAYLSAAEIVAKLPTNNNPDAATMLDRLLRLLASFSILSYSIQIRPDGRVERLYGLAPVCQFLTKNEDGWVCHCWSDEECVKLLKNCYDSLPENHGKVIMCEYILPIAPETTHAARTVIQSNAIMLAQNDGGKERTELEYKNLAKRAGFNGFRVASSAYDIKVMELYKKA
>AH019727-RA.v2.1
MKNTGPYAHLSAAEIIAKMPTQNPEAAAGMLGRLLDFLVSHSIFTVSPITLSDGSIERHYGLAPICKFLTPNCDVVSLAPFFNTSF
>AH019561-RA.v2.1
MSSIIGNDETQVKPTTEEEASCMAMCLATWSVPSMVFKTVLELHVIDIIYAAGPNAQLSAVDIVAKLPTNNPNAASMLDRMLRLLASFTILTCTQNVGPDGRPLRLYGLGPVCQFLAKNDDEVSYAAFATLMHDRVIMDTWVHLKEAVLEGGVPFRKNYGRDSRFYKVFYDGMDHHSTIVMKKIMDIYEGFEGINTLVDVGGATGVEHVGGNMYDSVPKEDGKVIICEYVMPETPETSYQAHTAFIWDAIMLTFPDGKSRTKQEYEELGKHAGFHTFRVVGFACDTWVMEYLKN
>AH019731-RA.v2.1
MATHMKEHEACSFAMAMANWYAQPMVLRALYELDVFEIIKRAGPGVHLSPAQIAAQLPTKNPSAASMLDRMLRIQASYSILSYSIETRPDGGVQTLYGLTPVCELLTKDENGVGLSNLDAILDGGIAFEKAHNMPLNELLRRDHRFNKVFDNGMLSHSKIIMKKIIENYKGFEGLSTLVHVGGGIGASLNMILSKYSKIKGINFDLPHAVEDAPTHNAMEHIEGDMFVSIPKGDAIFMKGICHEWSDEQCINLLKNCYTSLPDDGKVILCEFILPAIPETSHAVRAAYQIDALMLVSCGAGKVVRTEKEFEHLAKAAGFDGFRVACSAYGTKIIELLKTKNKMGLITNQEEQDDVCSFAMEITSGSVAPMVLKAVVELNVLEIIKKAGPNAHLSPAEIAAQLPTNNPNAATMLDRMLRLLASYSILSCSLQTRPDGHVERLYGLTPNEDGVSMSAFFLTIHDQDAVLNGGVPFNKAHGNVVYEQIGTDVRFNKVFNKGMSDHSAIIIKRMLEIYKGFEGVSTLIDVGGGTGVEHVSGNMFVSVPKADAMFTKWVCHSWTDEECSKFLKNCYDSLPENGKMIVCEYIRPVTPETNHSAKTVFQCDCIMLASFPGGIVRTELEFKNLAKKAGFQGFKVACSAYDIKVMEFIKNNA
>AH020974-RA.v2.1
MQNTRPKNNPKPSKDGEEGVQRQAMQLTTAIALPMTLKAAIDLGLLEIMQKGGPDVRLSPSEIASRLVPNTNNQLSRISDMTDRILRLLSSYSIVCCHEAENGEFERLYSLGPVSRYFLPSRDDQGSLAPMFNMIHDKFMVDGVEMGQYLKQLYQSTQLLKAFSLILPSIIHKQPAYPGIQHVAGDMLTSIPKGDAIFMKCLQVLKNCFEALEDGGKLMIVELVIPEILDNNTNTRNQSVYQFDLYLTNMNVDGKERTAKEFQNLVK
>AH009480-RA.v2.1
MEGGIPFNKVYGMHAFEYPSVDPRFNEIFNNAMLAHSKHTIKKVLQNYKGFENIKQLVDVGGGVEHVGGDMFESVPKGDAIFMKWILHDWSDDKCLVLLKNCYKALPENGKVIVVETNITDEPETTSLSRAISQLDVSMMTQNPGGKERTRREFEALAKSAGFAGVKFHCYVCNFWVMEFHK
>AH009479-RA.v2.1
MSTNHNDQTITNTNGVINGSLNHSNHDQNEDETHAYAAQILNSCVLPMILNATIDLGVLQIINKEVGSDGLSTTELATRIQSKNPEAPVMLDRMLRVLATYSVVSCKAITNEDGSVLRLYGPAPVTKFFVPDEDGVSLAPMLNLVIDKVFLSTW
>AH009478-RA.v2.1
MSNSSASEKPTTISNTNLQLPDHEEQEDADFLAAAQILQSGTLPLALKTAVELNIFGIMAKAGLPLSPNEIAAELPACQNPDAPSLLDRVLRLLACHSVVSCSVVEAADGNVERRVKFNEAILEGGIPFNKMYGVHAFDYPGLDPRFNQVFNAAMFSYTTIITKKLLDKYKGFEGINTLVDVGGGLGHTLHAITSMYPSIKAINFDLPHVISNAQSYLGVEHVGGDMFECVPQGEAIFMKWILHDWSDDRCLTILKNCHKAIPENGKVIVLESIFTEEPETSDIAKTISQMDVYMMNKNPGGKERTQKEFIALANATGFTQVKFVCRVCQFWVMEFYK
>AH012397-RA.v2.1
MSLNLDATQINGTPNEEEAACMAMCLATWAVPYMTFKTVEEMNVINIIKSAGPSGQLSAAEIVAHLPTTNPNATFDLDRMLRLLASSTILTCTQKVGPDGQPLRLYGLGPVCQFFTKSSEYHKLAPYTAYANLIHDQTFMDMKYAKDRVLNGGIPFEKAHGMELYEYLEKDSRLLKVFHDAQEHHSTINQKFILEKYKGFEGISSLVDVGGIEHVAGDMYVSIPKAEAIYMKATFLQGSDEQCIKLLKNCHEALPEEGKVIVCDYVVPDSAETNYRARTAFNFDLLVMLLLGSGGRTTQEFEILGKKAGFDVFQFICFASDIGVMEFLKTKNVN
>AH011881-RA.v2.1
MCLKSSKEQDQVRIYPPYEIAARLPTKNPDAASMLDRMLKVLASYSVFSCEIKTQLDGRVDRVYGLAPDAVLDGGIPFNKAHGKAVFEYIGTDPRFNKVFNNAMSNHSTIIMKKILETYKGFEGLSTLVDVGGGTGAILNMIISKYPTIKGINFDLPHVIADAPQYDGVEHVGGDMFVSVPKGDAIFMKTCHAALPDHGKVIVCEFILPVAPETTDSARTQFILDAIMLAHCAGGKERTQPEYERLAKEAGFKGFRIACSAYDIKIIEFLKMDEVSSVTTQLPEDEMCSYAMTIAAGLIPPMVLRAVVELDVLEIIKKAGVAAYLSPQQIAAQLPTNNPEAASMLDRMLRLLASYCVLSYSLQTLPDGRVQRLYGLSPVCEFLTKNDDGVSLGALSLTIQDKISLKSCYYLKDAVLDGVIPFKKAHGNAAYEYIGTDPRFYNIFNNGKANHSTIIMKRMLKTYKGFEGVSTLVDVGGGTGATLNMIISKNPTIKGINFDVPHVIDVAPKYTENGKVIVCEYILPSAVETSYGARTMFQYDALMLAHSTGGKERTKPEYEALAKGAGFKDFTVAY
>AH011882-RA.v2.1
MGSSSGPTTQMGEDEACSFAMTITSGSVPPMVLKAVIELDVLEIIKRAGPGAHLSPAEIAAQLPTKNPDAATMLDRMLRLLASYSILSYSLQTRPDGRVERLYGLAPVCQFLTKNDDGVTLSALALMNQDKILMESWYYLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKIFNNGMSNHSTITMKRILDTYKGFDGLSTLVDVGGVEHVGGDMFVSIPKGDAMFMKWICHDWSDEHCLKFLKNCYASLPDHGKVIVCEYILHEETMRDSVHVDDNVGYNQRKKEQEFFGFF
>AH012712-RA.v2.1
MSSPPEKPSDLDETSESRNKARLAIMELANMISIPMALNAIVRLKVPTAMWSSSPKTPLTPSQIIPLILPNNPHADADNLGRLLRLLSTYGVFSEHPPLPEESSRRYSLTEIGRTLVGDDEIGISHGEYVLQHHQEALLKAWLLVDRAVIGPTSKTPFEVGNGEPAYDYYGKSEEMNVLMQRAMAGVSVPFMKAVLYGGYDGFDGVVRLVDVGGSAGDCLKMIMGKYGGIKEGINFDLPEVVAQAPQIPGVIHVGGDMFKSIPSGDAIFMKWVLTTWTNDEIKQIMKNCYDALPAGGKLIACEPVLPDTTDESHRTRALLSGDIFVMTIYGAKGRHRMEEEYQQLGSSAGFPHFRAVHIDYFFTVLEFQK
MGSLATQMGENEAFSFAMAMVTGSVQPMVLRAIYELDVLEIIKRAGPGNSILSYSTRNRADGQVETLYGLTPVCQFLAKNEDGIGLRNLTLVNTDQVLMESWYHLKDAVLNGGIAFTKAHNMEAFEYHGIDLRFNKVFNNGMFNHSTIIMKKITETYKGFKGVSTLVDVGGGIGASLNMIISKYPTIKAINFDLPHVVQHAPSRNGLTHIGGDMFESVPKGDAIFMKWICHDWSDEHCIKLLKNCYASLPDHGKVIVCEYILPIEPEPSQAVRAVYQVDCIMMNNYTGGKERTEQEFKTLAKAAGFSDFRIACSVYNAKIMEFLKNNTESNSNTTNHVENDEICAFAMAITSSSVPPMVLKVVIELNVFEIIKKAGPGAYLSAAEIVAKLPTNNNPDAATMLDRLLRLLASFSILSYSIQIRPDGRVERLYGLAPVCQFLTKNEDGWVCHCWSDEECVKLLKNCYDSLPENHGKVIMCEYILPIAPETTHAARTVIQSNAIMLAQNDGGKERTELEYKNLAKRAGFNGFRVASSAYDIKVMELYKKA
>AH019727-RA.v2.1
MKNTGPYAHLSAAEIIAKMPTQNPEAAAGMLGRLLDFLVSHSIFTVSPITLSDGSIERHYGLAPICKFLTPNCDVVSLAPFFNTSF
>AH019561-RA.v2.1
MSSIIGNDETQVKPTTEEEASCMAMCLATWSVPSMVFKTVLELHVIDIIYAAGPNAQLSAVDIVAKLPTNNPNAASMLDRMLRLLASFTILTCTQNVGPDGRPLRLYGLGPVCQFLAKNDDEVSYAAFATLMHDRVIMDTWVHLKEAVLEGGVPFRKNYGRDSRFYKVFYDGMDHHSTIVMKKIMDIYEGFEGINTLVDVGGATGVEHVGGNMYDSVPKEDGKVIICEYVMPETPETSYQAHTAFIWDAIMLTFPDGKSRTKQEYEELGKHAGFHTFRVVGFACDTWVMEYLKN
>AH019731-RA.v2.1
MATHMKEHEACSFAMAMANWYAQPMVLRALYELDVFEIIKRAGPGVHLSPAQIAAQLPTKNPSAASMLDRMLRIQASYSILSYSIETRPDGGVQTLYGLTPVCELLTKDENGVGLSNLDAILDGGIAFEKAHNMPLNELLRRDHRFNKVFDNGMLSHSKIIMKKIIENYKGFEGLSTLVHVGGGIGASLNMILSKYSKIKGINFDLPHAVEDAPTHNAMEHIEGDMFVSIPKGDAIFMKGICHEWSDEQCINLLKNCYTSLPDDGKVILCEFILPAIPETSHAVRAAYQIDALMLVSCGAGKVVRTEKEFEHLAKAAGFDGFRVACSAYGTKIIELLKTKNKMGLITNQEEQDDVCSFAMEITSGSVAPMVLKAVVELNVLEIIKKAGPNAHLSPAEIAAQLPTNNPNAATMLDRMLRLLASYSILSCSLQTRPDGHVERLYGLTPNEDGVSMSAFFLTIHDQDAVLNGGVPFNKAHGNVVYEQIGTDVRFNKVFNKGMSDHSAIIIKRMLEIYKGFEGVSTLIDVGGGTGVEHVSGNMFVSVPKADAMFTKWVCHSWTDEECSKFLKNCYDSLPENGKMIVCEYIRPVTPETNHSAKTVFQCDCIMLASFPGGIVRTELEFKNLAKKAGFQGFKVACSAYDIKVMEFIKNNA
>AH020974-RA.v2.1
MQNTRPKNNPKPSKDGEEGVQRQAMQLTTAIALPMTLKAAIDLGLLEIMQKGGPDVRLSPSEIASRLVPNTNNQLSRISDMTDRILRLLSSYSIVCCHEAENGEFERLYSLGPVSRYFLPSRDDQGSLAPMFNMIHDKFMVDGVEMGQYLKQLYQSTQLLKAFSLILPSIIHKQPAYPGIQHVAGDMLTSIPKGDAIFMKCLQVLKNCFEALEDGGKLMIVELVIPEILDNNTNTRNQSVYQFDLYLTNMNVDGKERTAKEFQNLVK
>AH009480-RA.v2.1
MEGGIPFNKVYGMHAFEYPSVDPRFNEIFNNAMLAHSKHTIKKVLQNYKGFENIKQLVDVGGGVEHVGGDMFESVPKGDAIFMKWILHDWSDDKCLVLLKNCYKALPENGKVIVVETNITDEPETTSLSRAISQLDVSMMTQNPGGKERTRREFEALAKSAGFAGVKFHCYVCNFWVMEFHK
>AH009479-RA.v2.1
MSTNHNDQTITNTNGVINGSLNHSNHDQNEDETHAYAAQILNSCVLPMILNATIDLGVLQIINKEVGSDGLSTTELATRIQSKNPEAPVMLDRMLRVLATYSVVSCKAITNEDGSVLRLYGPAPVTKFFVPDEDGVSLAPMLNLVIDKVFLSTW
>AH009478-RA.v2.1
MSNSSASEKPTTISNTNLQLPDHEEQEDADFLAAAQILQSGTLPLALKTAVELNIFGIMAKAGLPLSPNEIAAELPACQNPDAPSLLDRVLRLLACHSVVSCSVVEAADGNVERRVKFNEAILEGGIPFNKMYGVHAFDYPGLDPRFNQVFNAAMFSYTTIITKKLLDKYKGFEGINTLVDVGGGLGHTLHAITSMYPSIKAINFDLPHVISNAQSYLGVEHVGGDMFECVPQGEAIFMKWILHDWSDDRCLTILKNCHKAIPENGKVIVLESIFTEEPETSDIAKTISQMDVYMMNKNPGGKERTQKEFIALANATGFTQVKFVCRVCQFWVMEFYK
>AH012397-RA.v2.1
MSLNLDATQINGTPNEEEAACMAMCLATWAVPYMTFKTVEEMNVINIIKSAGPSGQLSAAEIVAHLPTTNPNATFDLDRMLRLLASSTILTCTQKVGPDGQPLRLYGLGPVCQFFTKSSEYHKLAPYTAYANLIHDQTFMDMKYAKDRVLNGGIPFEKAHGMELYEYLEKDSRLLKVFHDAQEHHSTINQKFILEKYKGFEGISSLVDVGGIEHVAGDMYVSIPKAEAIYMKATFLQGSDEQCIKLLKNCHEALPEEGKVIVCDYVVPDSAETNYRARTAFNFDLLVMLLLGSGGRTTQEFEILGKKAGFDVFQFICFASDIGVMEFLKTKNVN
>AH011881-RA.v2.1
MCLKSSKEQDQVRIYPPYEIAARLPTKNPDAASMLDRMLKVLASYSVFSCEIKTQLDGRVDRVYGLAPDAVLDGGIPFNKAHGKAVFEYIGTDPRFNKVFNNAMSNHSTIIMKKILETYKGFEGLSTLVDVGGGTGAILNMIISKYPTIKGINFDLPHVIADAPQYDGVEHVGGDMFVSVPKGDAIFMKTCHAALPDHGKVIVCEFILPVAPETTDSARTQFILDAIMLAHCAGGKERTQPEYERLAKEAGFKGFRIACSAYDIKIIEFLKMDEVSSVTTQLPEDEMCSYAMTIAAGLIPPMVLRAVVELDVLEIIKKAGVAAYLSPQQIAAQLPTNNPEAASMLDRMLRLLASYCVLSYSLQTLPDGRVQRLYGLSPVCEFLTKNDDGVSLGALSLTIQDKISLKSCYYLKDAVLDGVIPFKKAHGNAAYEYIGTDPRFYNIFNNGKANHSTIIMKRMLKTYKGFEGVSTLVDVGGGTGATLNMIISKNPTIKGINFDVPHVIDVAPKYTENGKVIVCEYILPSAVETSYGARTMFQYDALMLAHSTGGKERTKPEYEALAKGAGFKDFTVAY
>AH011882-RA.v2.1
MGSSSGPTTQMGEDEACSFAMTITSGSVPPMVLKAVIELDVLEIIKRAGPGAHLSPAEIAAQLPTKNPDAATMLDRMLRLLASYSILSYSLQTRPDGRVERLYGLAPVCQFLTKNDDGVTLSALALMNQDKILMESWYYLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKIFNNGMSNHSTITMKRILDTYKGFDGLSTLVDVGGVEHVGGDMFVSIPKGDAMFMKWICHDWSDEHCLKFLKNCYASLPDHGKVIVCEYILHEETMRDSVHVDDNVGYNQRKKEQEFFGFF
>AH012712-RA.v2.1
MSSPPEKPSDLDETSESRNKARLAIMELANMISIPMALNAIVRLKVPTAMWSSSPKTPLTPSQIIPLILPNNPHADADNLGRLLRLLSTYGVFSEHPPLPEESSRRYSLTEIGRTLVGDDEIGISHGEYVLQHHQEALLKAWLLVDRAVIGPTSKTPFEVGNGEPAYDYYGKSEEMNVLMQRAMAGVSVPFMKAVLYGGYDGFDGVVRLVDVGGSAGDCLKMIMGKYGGIKEGINFDLPEVVAQAPQIPGVIHVGGDMFKSIPSGDAIFMKWVLTTWTNDEIKQIMKNCYDALPAGGKLIACEPVLPDTTDESHRTRALLSGDIFVMTIYGAKGRHRMEEEYQQLGSSAGFPHFRAVHIDYFFTVLEFQK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University