Enzyme
This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)-dihydromyricetin, although some enzymes may act only on a subset of these compounds. Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4-diol. NAD+ can act instead of NADP+, but more slowly.
DFR
Enzyme
Dihydroflavonol 4-reductase
Enzyme name
EC:1.1.1.219
Entry
Oxidoreductases;Acting on the CH-OH group of donors;With NAD+ or NADP+ as acceptor
Class
(2R,3S,4S)-leucoanthocyanidin:NADP+ 4-oxidoreductase
Sysname
a (2R,3S,4S)-leucoanthocyanidin + NADP+ = a (2R,3R)-dihydroflavonol + NADPH + H+ [RN:R11500]
Reaction
(2R,3R)-dihydroflavonol [CPD:C21417];NADPH [CPD:C00005];H+ [CPD:C00080]
Product
Species information
Hydrangea quercifolia
Species name
Hydrangea quercifolia is a species of eudicot in the family Hydrangeaceae (hydrangea family).
Species info
Gene sequence info
Hydrangea_quercifolia.DFR.fa
Download
>Hyque.05G095300.1.v1.1
MTGTMAPAATTTTTVCVTGAAGFIGSWLIMRLLERGYVVRATVRDPGNLKKVKHLIELPKAETNLTIWKADLNEEGSFDEAIEGCSGVFHVATPMDFESKDPENEVIKPTIEGVLSIIRSCVKAKTVKRLVFTSSAGTVNVQEHQKPVFDETNWSDLDFIYAKKMTGWMYFVSKTLAEKAAWEASKENKIDFISIIPTLVVGPFIMPSFPPSLITALSPITGNEAHYSIIKQGQFVHLDDLCEAHIFLYEHPNAEGRYICSSHDATIYDLVKMIKEKWPEYTVPTEFKGIDKNLESICFSSKKLIEMGFEFKYSLEDMFRGAIETCREKNLLPYSTEKQANGKIEEEQAKKTINEVFV
>Hyque.05G020600.1.v1.1
MIKFNGGGGGVGNLKKVKHLIELPKAETNLAIWKADLNEEGSFDEAIEGCSCVFHVATPMDFDSKDPED
>Hyque.05G095500.1.v1.1
MAPATTTTTTVCVTGASGFIGSWLIMRLLERGYVVRATVRDPGNLKKVKHLIELPKAETNLTIWKADLNEEGSFDEAIEGCSGVFHVATPMDFESKDPENEVIKPTIEGVLSIIRSYVKAKTVKRLVFTSSTGTVDVQEHQKPVFDETNWSDLDFIYAKKMTSWMYFVSKTLAEKAASEASTKNKIDFISIIPPLVVGPFIVPSFPPSLITALSPITGSRALIRTWKVSVSHQRS
>Hyque.05G095400.1.v1.1
MFRGAIETCREKNLLPYSTEKQANGKIEEEQAKKTINEVFVFKSIDKNLESISFSSKKLIEMGFEFKYSLEDMFRGAIETCREKNLLPYSTEKQANGKI
>Hyque.09G119700.1.v1.1
MFEPATVRDPGNTRKVKHLLDLPNASTHLSLWRGDLTEEGSYDDAIQGCSGVFHVAATMDFVSVQDPENEFIKPTINGVLNILRSSSKAKTVKRVIYTSTTGTIVIQRQPPIEYDESFWTDIDFCEAQKMRGWMYFVAKTRSEKAAWEFAKESGLDLITVQPSIVIGPFITSSIPPSIDISLALITRNEIFYPMLTRARGVHLDDVCNAHIYLFEHPQAEGRYICSSHCFTIFDLAKSLSQKYPEYNIPTKFEGIDESLKAIPCSSQKLIDLGFKFKYTSDEYGVADLFVEAIESTKEKGLIPLQGDIRAP
>Hyque.13G052000.1.v1.1
MNGDAAPATTVCVTGATGFIGSWLVMRLLERGYTVRVTVRDPDGGAANIEKVKHLLELPKADKNLTIWKADLNQEGSIDEAIEGCYGVFHLAAPMNLNSKDPENEVIKPTIKGVSSIIRSCVKAKTVKRLVFTSSAAAVIAQKQPKSVYDETSWSDLDFIYATKMPGWVYFVIKTIAEKAALEACKENNIEFISIIPPQVVGPFITPTLPPSLFTALPLITGNEAFYSCIKEGQYVHLDDLCNAQIFLYEHPDADGRYICSSHEATIYDLANMIRVKWPEYNIPTEFKGIDKNLQVASLSSKKLTGMGFKFKYSLEDMYRGAIDTCREKKLIPYSSEKHANGNI
MTGTMAPAATTTTTVCVTGAAGFIGSWLIMRLLERGYVVRATVRDPGNLKKVKHLIELPKAETNLTIWKADLNEEGSFDEAIEGCSGVFHVATPMDFESKDPENEVIKPTIEGVLSIIRSCVKAKTVKRLVFTSSAGTVNVQEHQKPVFDETNWSDLDFIYAKKMTGWMYFVSKTLAEKAAWEASKENKIDFISIIPTLVVGPFIMPSFPPSLITALSPITGNEAHYSIIKQGQFVHLDDLCEAHIFLYEHPNAEGRYICSSHDATIYDLVKMIKEKWPEYTVPTEFKGIDKNLESICFSSKKLIEMGFEFKYSLEDMFRGAIETCREKNLLPYSTEKQANGKIEEEQAKKTINEVFV
>Hyque.05G020600.1.v1.1
MIKFNGGGGGVGNLKKVKHLIELPKAETNLAIWKADLNEEGSFDEAIEGCSCVFHVATPMDFDSKDPED
>Hyque.05G095500.1.v1.1
MAPATTTTTTVCVTGASGFIGSWLIMRLLERGYVVRATVRDPGNLKKVKHLIELPKAETNLTIWKADLNEEGSFDEAIEGCSGVFHVATPMDFESKDPENEVIKPTIEGVLSIIRSYVKAKTVKRLVFTSSTGTVDVQEHQKPVFDETNWSDLDFIYAKKMTSWMYFVSKTLAEKAASEASTKNKIDFISIIPPLVVGPFIVPSFPPSLITALSPITGSRALIRTWKVSVSHQRS
>Hyque.05G095400.1.v1.1
MFRGAIETCREKNLLPYSTEKQANGKIEEEQAKKTINEVFVFKSIDKNLESISFSSKKLIEMGFEFKYSLEDMFRGAIETCREKNLLPYSTEKQANGKI
>Hyque.09G119700.1.v1.1
MFEPATVRDPGNTRKVKHLLDLPNASTHLSLWRGDLTEEGSYDDAIQGCSGVFHVAATMDFVSVQDPENEFIKPTINGVLNILRSSSKAKTVKRVIYTSTTGTIVIQRQPPIEYDESFWTDIDFCEAQKMRGWMYFVAKTRSEKAAWEFAKESGLDLITVQPSIVIGPFITSSIPPSIDISLALITRNEIFYPMLTRARGVHLDDVCNAHIYLFEHPQAEGRYICSSHCFTIFDLAKSLSQKYPEYNIPTKFEGIDESLKAIPCSSQKLIDLGFKFKYTSDEYGVADLFVEAIESTKEKGLIPLQGDIRAP
>Hyque.13G052000.1.v1.1
MNGDAAPATTVCVTGATGFIGSWLVMRLLERGYTVRVTVRDPDGGAANIEKVKHLLELPKADKNLTIWKADLNQEGSIDEAIEGCYGVFHLAAPMNLNSKDPENEVIKPTIKGVSSIIRSCVKAKTVKRLVFTSSAAAVIAQKQPKSVYDETSWSDLDFIYATKMPGWVYFVIKTIAEKAALEACKENNIEFISIIPPQVVGPFITPTLPPSLFTALPLITGNEAFYSCIKEGQYVHLDDLCNAQIFLYEHPDADGRYICSSHEATIYDLANMIRVKWPEYNIPTEFKGIDKNLQVASLSSKKLTGMGFKFKYSLEDMYRGAIDTCREKKLIPYSSEKHANGNI
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University