Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Hordeum vulgare
Species name
Barley (Hordeum vulgare) is a species of monocot in the family Poaceae (grass family).
Species info
Gene sequence info
Hordeum_vulgare.4CL.fa
Download
>HORVU1Hr1G051190.2.r1
PHEAKREGWGHWTGQPTAGIDPWINGRKNPRVMRICRFSGYVNFSVDHDLSSKYSPNYSRRSAAAAMQDAADDPSAAAAFYSAAAGLYASTHPPVPLPVDPGLSLVPHIFSRLPLGPPPHSRPCLLDAATAASLSRADLRRLVASLARGLRRAHGVRAGAVVLLVLPNSVAFPVAFLAVLAAGGVATTMNPSSSGAEIAGRLRDTAPSLVLASPDNAAKVPPSAAAPVVLVPETFHPSPSTGNEFAPFRALLDSDADDGLPSAEVGQDDAAAVLYSSGTSGRSKGVVLTHRNLITMVELFVCFEASQYARPACDNVYLAVLPMFHVYGLSLFAAGLLSLGSTVVVMRRFDVGDAVRAIHKYKVTHLPLVPPIMAALLRARATGASSLESLVQVSSGAAPLSGKLVQDFLKAFPHVDFIQGYGMTESTAVGTRGFNTSKHKKYASVGLLAPNMHAKIVDLETGLCLPPGSCGELWLHGPAIMKGYLNDEDTCMRNDGWFQTGDLAYFDSDGYLYIVGRLKDTIKYKGFQVAPADLEAVLVQHPEIVDVAVTSVEDEEAGEIPVAFVVRRSGSHLTCVQVMEYVAKQVSPYKKVRKVIFVEAIPKSAAGKVLRRLLKDSLRLDAAASRSDHTKPSSRL
>HORVU2Hr1G066630.1.r1
MAAGAVFSGVNPRSLAAEIRKQVEDSEARLVVANEVAYDKVKDVGVPVIGIGEQGLMAGAISWDELLAAADRTGPPVVPLEPVQQSDLCALPYSSGTTGVSKGVMLSHRNLVSNLCSSMFAVGTELLGQVVTLGLMPFFHIYGITGICCATLRHKGTVVVMDRFDLRTFLGALVAHRVMFAPVVPPVMLAMVKNPIADEFDLSGLALKSVMTAAAPLAPDLLAAFQRKFPGVQVEEAYGLTEHSCITLTHAGDDPEKGHIAKKNSVGFILPNLEVKFVDPDTGRSLAKNTPGELCVRSQCVMQGYYRKKEETERTIDANGWLHTGDIGYIDDDGDVFIVDRIKELIKYKGFQVAPAELEAILLSHPSVEDAAVFGLPDEEAGEIPVSCVVRRSGAAESEADIMAYVAARVASYKKLRMLHLVDAIPKSVSGKILRRQLRDEFINMIKPAAA
>HORVU4Hr1G072130.2.r1
XFGSSVHIKLPKRHIFRNVGSGYGMTETCGIISLEYPEKGQARQFGSTGTLVVGVEAKVIDVETQKHLPPSQLGEICIRGPHIMQGYFNNVEATEFTIRQGWLHTGDLGYFDEEGQLFVVDRLKELIKYKGFQIAPAELEGLLLSHPEILDAVVIPFPDDEAGEVPIAYVVRSPASSLTEVDVQKFIAKQVTYYKRLRRVTFVESVPKSAAGKILRRELIAQVRSSKL
>HORVU4Hr1G072150.1.r1
PSGAIYPVDLAESPTVDSHNQWWGGGGRGGGXRPVRRRPPPPPRRRVPVRARADRRRHGPRALLRRPPLRGAHHGRRARLPRGRPPRRRRAPPRAQLRPLPGLLLRGHRRRRRRQHRQPALHPAGDRQAGVRRPRQARRHRGGAAPQGRRPRPARHPPRRRRVRHPIGDGQRDALLGPRVRRGRVPVPPPADKAGRHGRVALLLRHDGGEQGRGPDAPQLHRGGDDGDVGPGRAGGAAQRVPLLPAHVPHLRPLRHHLRAAAARQRRGRHVGLRHGLGDEGRAAAPGDARLLRAAGDDRARQARAGRQVRPQLAQVHRLRRRAARQGRHGGGGQELPRRRDRSGNQPVNQGYGMTETCGIISLEYPEKGQARQFGSTGTLVVGVEAKVIDVETQKHLPPSQLGEICIRGPHIMQGYFNNVEATEFTIRQGWLHTGDLGYFDEEGQLFVVDRLKELIKYKGFQIAPAELEGLLLSHPEILDAVVIPFPDDEAGEVPIAYVVRSPASSLTEVDVQKFIAKQVTYYKRLRRVTFVESVPKSAAGKILRRELIAQVRSSKL
>HORVU6Hr1G030390.2.r1
MGSVPEETVVAAAPAAAEEVVFRSRLPDIEIPNEQTLQSYCFAKMAEVGSRPCIIDGQTGASYTYAEVESLSRRAAAGLRRMGVGKGDVVMNLLRNCPEFAFSFLGAARLGAATTTANPFYTPHEIHRQADAAGAMLIVTEACAVDKVLEYAAAKGLPVVTVDGKRDGCVEFAELIAGEELPQAEEAGIHPDDVVALPYSSGTTGLPKGVMLTHRSLITSVAQQVDGENPNLYFRKEDVLLCLLPLFHIYSLNSVLLAGLRAGSAMVIMRKFDIGALVELVRAHGITVAPFVPPIVVEIAKSPQVTAGDLASIRMVMSGAAPMGKELQDAFMAKIPNAVLGQGYGMTEAGPVLAMCLAFAKEPFKVKSGSCGTVVRNAGLKIVDPDTGASLGRNQPGEICIRGEQIMKGYLNDPESTKNTIDKDGWLHTGDIGIVDDDDEIFIVDRLKEIIKYKGFQVAPAELEALLITHPEIKDAAVVSLKDDLAGEVPIAFVMRIEGSEITEDDIKKFVAKEVVFYKRIHKVFFTDSIPKNPSGKILRKDLRARLAAGIPS
>HORVU7Hr1G111130.3.r1
PSSRSRAEHAHGIPSPIFSPPRHQFLPPGPAPAARSMGSVAAEAPETVFRSRLPDIEIPAHLTLQDYCFERLPEVAARPCLIDGQTGAVHTYADVSQLSRRCAAGLRKLGIGKGDVVMNLLRNCPEFAFVFLGAARLGAATTTANPFCTPHEIHRQASAAGARLIVTEACAVDKVRAFAAERGIPVVTVDGPASESDGCLAFNETLLPEEPLAADEAVDPDDVVALPYSSGTTGLPKGVMLTHRSLVTSVAQQVDGENPNLYFGEEDVVLCVLPLFHIYSLNSVLLAGLRAGCAIVIMRKFDHGALVRLVRAHGVTVAPFVPPIVVEIAKSDRVTAADLASIRMVMSGAAPMGKDLQDAFMAKIPNAVLGQGYGMTEAGPVLSMCLAFAKEPFAVKSGSCGTVVRNAELKIVDPDTGASLARNLPGEICIRGKQIMKGYLNDPEATKNTIDKDGWLHTGDIGYVDDDDEIFIVDRLKEIIKYKGFQVPPAELEALLITHAEIKDAAVVSMQDELTGEVPVAFIVRIEGSEISESEIKQFVAKEVVFYKRIHKVFFADSVPKSPAGKILRKDLRAKLAAGIPGSGSTASKS
>HORVU0Hr1G018190.2.r1
MIKVAAPEVQQPQAVAADAVSAVVPEETIFRSKLPDIDIPNHLPLHEYCFAKAAEVPDAPCLIAAATGRTYTFAETHALCRKAAAALHRLGVGHGDRVMILLQNCVEFAVAFFGASFLGAISTAANPFCTPQEIHKQFVASGAKVIVTQSAYVDKLRHESFPRIATGGGEDTLAVITVDDEAGTPDGCLPFWGILASADEGSVPEVRIAAEDAVALPYSSGTTGLPKGVVLTHGGLVSSVAQQVDGENPNLYMREGDVALCVLPLFHIFSLNSVLLCAVRACAAVMLMPRFEMGAMLAGIERWRVTVAAVVPPLVLALAKNPVVEEHDLSSIRIVLSGAAPLGKELEDALRGRLPQAIFGQGYGMTEAGPVLSMCPAFAREPTPAKSGSCGTVVRNAELKVVDPDTGLSLARNLPGEICIRGPQIMKGYLDDPVATAATIDVEGWLHTGDIGYVDDDDEVFIVDRVKELIKFKGFQVPPAELEALLIAHPSIADAAVVPQKDDAAGEVPVAFVVRAADSDIAEEAIKEFVSKQVVFYKRLHKVYFTHAIPKSASGKILRKELRAKLVTV
>HORVU0Hr1G002720.3.r1
TRSSCELPTKHHRLPPLSIYNYKYHSASSFHSTPQDNSILQPAVRASTDPTAPPTNPFSSKRSKPDAKKWARCRSSSSSRSSSAPRCRTSPSRTTSRSTTTSSSAWPSAATAPASSTAPRARRSLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVKMMELVERHGITIAPLVPPIVVEMAKGDAMDRHDLSSVRMVISGAAPMGKELQDIIHAKLPNAPPPPGYGMTEAGPVLSMCMAFAKEPSPVKSGACGTVVRNAELKIVDPETGLCLGRNQPGEICIRGRQIMKGYLDNPEATAETVDKDGWLHTGDVGFVDDDDEIFIVDRLKELIKYKGFQVAPAELEAMLIAHPGIADAAVVPMKDDASGEVPVAFVVPSSSEGADMTEDEIKQYVAKQVVFYKRLQKVFFVSSIPKAPSGKILRKDLRAKLAAGAC
PHEAKREGWGHWTGQPTAGIDPWINGRKNPRVMRICRFSGYVNFSVDHDLSSKYSPNYSRRSAAAAMQDAADDPSAAAAFYSAAAGLYASTHPPVPLPVDPGLSLVPHIFSRLPLGPPPHSRPCLLDAATAASLSRADLRRLVASLARGLRRAHGVRAGAVVLLVLPNSVAFPVAFLAVLAAGGVATTMNPSSSGAEIAGRLRDTAPSLVLASPDNAAKVPPSAAAPVVLVPETFHPSPSTGNEFAPFRALLDSDADDGLPSAEVGQDDAAAVLYSSGTSGRSKGVVLTHRNLITMVELFVCFEASQYARPACDNVYLAVLPMFHVYGLSLFAAGLLSLGSTVVVMRRFDVGDAVRAIHKYKVTHLPLVPPIMAALLRARATGASSLESLVQVSSGAAPLSGKLVQDFLKAFPHVDFIQGYGMTESTAVGTRGFNTSKHKKYASVGLLAPNMHAKIVDLETGLCLPPGSCGELWLHGPAIMKGYLNDEDTCMRNDGWFQTGDLAYFDSDGYLYIVGRLKDTIKYKGFQVAPADLEAVLVQHPEIVDVAVTSVEDEEAGEIPVAFVVRRSGSHLTCVQVMEYVAKQVSPYKKVRKVIFVEAIPKSAAGKVLRRLLKDSLRLDAAASRSDHTKPSSRL
>HORVU2Hr1G066630.1.r1
MAAGAVFSGVNPRSLAAEIRKQVEDSEARLVVANEVAYDKVKDVGVPVIGIGEQGLMAGAISWDELLAAADRTGPPVVPLEPVQQSDLCALPYSSGTTGVSKGVMLSHRNLVSNLCSSMFAVGTELLGQVVTLGLMPFFHIYGITGICCATLRHKGTVVVMDRFDLRTFLGALVAHRVMFAPVVPPVMLAMVKNPIADEFDLSGLALKSVMTAAAPLAPDLLAAFQRKFPGVQVEEAYGLTEHSCITLTHAGDDPEKGHIAKKNSVGFILPNLEVKFVDPDTGRSLAKNTPGELCVRSQCVMQGYYRKKEETERTIDANGWLHTGDIGYIDDDGDVFIVDRIKELIKYKGFQVAPAELEAILLSHPSVEDAAVFGLPDEEAGEIPVSCVVRRSGAAESEADIMAYVAARVASYKKLRMLHLVDAIPKSVSGKILRRQLRDEFINMIKPAAA
>HORVU4Hr1G072130.2.r1
XFGSSVHIKLPKRHIFRNVGSGYGMTETCGIISLEYPEKGQARQFGSTGTLVVGVEAKVIDVETQKHLPPSQLGEICIRGPHIMQGYFNNVEATEFTIRQGWLHTGDLGYFDEEGQLFVVDRLKELIKYKGFQIAPAELEGLLLSHPEILDAVVIPFPDDEAGEVPIAYVVRSPASSLTEVDVQKFIAKQVTYYKRLRRVTFVESVPKSAAGKILRRELIAQVRSSKL
>HORVU4Hr1G072150.1.r1
PSGAIYPVDLAESPTVDSHNQWWGGGGRGGGXRPVRRRPPPPPRRRVPVRARADRRRHGPRALLRRPPLRGAHHGRRARLPRGRPPRRRRAPPRAQLRPLPGLLLRGHRRRRRRQHRQPALHPAGDRQAGVRRPRQARRHRGGAAPQGRRPRPARHPPRRRRVRHPIGDGQRDALLGPRVRRGRVPVPPPADKAGRHGRVALLLRHDGGEQGRGPDAPQLHRGGDDGDVGPGRAGGAAQRVPLLPAHVPHLRPLRHHLRAAAARQRRGRHVGLRHGLGDEGRAAAPGDARLLRAAGDDRARQARAGRQVRPQLAQVHRLRRRAARQGRHGGGGQELPRRRDRSGNQPVNQGYGMTETCGIISLEYPEKGQARQFGSTGTLVVGVEAKVIDVETQKHLPPSQLGEICIRGPHIMQGYFNNVEATEFTIRQGWLHTGDLGYFDEEGQLFVVDRLKELIKYKGFQIAPAELEGLLLSHPEILDAVVIPFPDDEAGEVPIAYVVRSPASSLTEVDVQKFIAKQVTYYKRLRRVTFVESVPKSAAGKILRRELIAQVRSSKL
>HORVU6Hr1G030390.2.r1
MGSVPEETVVAAAPAAAEEVVFRSRLPDIEIPNEQTLQSYCFAKMAEVGSRPCIIDGQTGASYTYAEVESLSRRAAAGLRRMGVGKGDVVMNLLRNCPEFAFSFLGAARLGAATTTANPFYTPHEIHRQADAAGAMLIVTEACAVDKVLEYAAAKGLPVVTVDGKRDGCVEFAELIAGEELPQAEEAGIHPDDVVALPYSSGTTGLPKGVMLTHRSLITSVAQQVDGENPNLYFRKEDVLLCLLPLFHIYSLNSVLLAGLRAGSAMVIMRKFDIGALVELVRAHGITVAPFVPPIVVEIAKSPQVTAGDLASIRMVMSGAAPMGKELQDAFMAKIPNAVLGQGYGMTEAGPVLAMCLAFAKEPFKVKSGSCGTVVRNAGLKIVDPDTGASLGRNQPGEICIRGEQIMKGYLNDPESTKNTIDKDGWLHTGDIGIVDDDDEIFIVDRLKEIIKYKGFQVAPAELEALLITHPEIKDAAVVSLKDDLAGEVPIAFVMRIEGSEITEDDIKKFVAKEVVFYKRIHKVFFTDSIPKNPSGKILRKDLRARLAAGIPS
>HORVU7Hr1G111130.3.r1
PSSRSRAEHAHGIPSPIFSPPRHQFLPPGPAPAARSMGSVAAEAPETVFRSRLPDIEIPAHLTLQDYCFERLPEVAARPCLIDGQTGAVHTYADVSQLSRRCAAGLRKLGIGKGDVVMNLLRNCPEFAFVFLGAARLGAATTTANPFCTPHEIHRQASAAGARLIVTEACAVDKVRAFAAERGIPVVTVDGPASESDGCLAFNETLLPEEPLAADEAVDPDDVVALPYSSGTTGLPKGVMLTHRSLVTSVAQQVDGENPNLYFGEEDVVLCVLPLFHIYSLNSVLLAGLRAGCAIVIMRKFDHGALVRLVRAHGVTVAPFVPPIVVEIAKSDRVTAADLASIRMVMSGAAPMGKDLQDAFMAKIPNAVLGQGYGMTEAGPVLSMCLAFAKEPFAVKSGSCGTVVRNAELKIVDPDTGASLARNLPGEICIRGKQIMKGYLNDPEATKNTIDKDGWLHTGDIGYVDDDDEIFIVDRLKEIIKYKGFQVPPAELEALLITHAEIKDAAVVSMQDELTGEVPVAFIVRIEGSEISESEIKQFVAKEVVFYKRIHKVFFADSVPKSPAGKILRKDLRAKLAAGIPGSGSTASKS
>HORVU0Hr1G018190.2.r1
MIKVAAPEVQQPQAVAADAVSAVVPEETIFRSKLPDIDIPNHLPLHEYCFAKAAEVPDAPCLIAAATGRTYTFAETHALCRKAAAALHRLGVGHGDRVMILLQNCVEFAVAFFGASFLGAISTAANPFCTPQEIHKQFVASGAKVIVTQSAYVDKLRHESFPRIATGGGEDTLAVITVDDEAGTPDGCLPFWGILASADEGSVPEVRIAAEDAVALPYSSGTTGLPKGVVLTHGGLVSSVAQQVDGENPNLYMREGDVALCVLPLFHIFSLNSVLLCAVRACAAVMLMPRFEMGAMLAGIERWRVTVAAVVPPLVLALAKNPVVEEHDLSSIRIVLSGAAPLGKELEDALRGRLPQAIFGQGYGMTEAGPVLSMCPAFAREPTPAKSGSCGTVVRNAELKVVDPDTGLSLARNLPGEICIRGPQIMKGYLDDPVATAATIDVEGWLHTGDIGYVDDDDEVFIVDRVKELIKFKGFQVPPAELEALLIAHPSIADAAVVPQKDDAAGEVPVAFVVRAADSDIAEEAIKEFVSKQVVFYKRLHKVYFTHAIPKSASGKILRKELRAKLVTV
>HORVU0Hr1G002720.3.r1
TRSSCELPTKHHRLPPLSIYNYKYHSASSFHSTPQDNSILQPAVRASTDPTAPPTNPFSSKRSKPDAKKWARCRSSSSSRSSSAPRCRTSPSRTTSRSTTTSSSAWPSAATAPASSTAPRARRSLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVKMMELVERHGITIAPLVPPIVVEMAKGDAMDRHDLSSVRMVISGAAPMGKELQDIIHAKLPNAPPPPGYGMTEAGPVLSMCMAFAKEPSPVKSGACGTVVRNAELKIVDPETGLCLGRNQPGEICIRGRQIMKGYLDNPEATAETVDKDGWLHTGDVGFVDDDDEIFIVDRLKELIKYKGFQVAPAELEAMLIAHPGIADAAVVPMKDDASGEVPVAFVVPSSSEGADMTEDEIKQYVAKQVVFYKRLQKVFFVSSIPKAPSGKILRKDLRAKLAAGAC
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University