Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Amaranthus hypochondriacus
Species name
Grain amaranth (Amaranthus hypochondriacus) is a species of eudicot in the family Amaranthaceae (amaranth family).
Species info
Gene sequence info
Amaranthus_hypochondriacus.4CL.fa
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>AH017444-RA.v2.1
MERSGYGKDGIFRSLRPTLTIPKNPNLNMVSFLFRNIDSYSEQPALIDSTSGETLNFSQFKSMVANLSNRLTQLGIQKGHVVLMFAPNSVQYPVTFLGIIATGAIATTVNPIYTVSEIKKQAEDCNPKLIVTIPELWDKVKGLNLPVLILGSKENGKIDSNSNTPTFYFRDLVNGDYVDFPKVSIKQNDTAALLYSSGTTGVSKGVILTHKNFITASLMVVSDQEFEGIVHEVFMCVIPMFHVFGLSVILYAQLQKGNTVVCMPKFDFEMMLKAIEKYRVTRLWVVPPIMLGFAKQIAVKKYDLSSLKQIGSGAAPLGQEIMQECSKNVPQALIIQGYGMTETCGIISLEHPRLGGRHSGSTGLLVPGVEAQIVKVDTLEPLPPKQQGEIWVRGPNMMKGWVHTGDLGYFDEEGQLYVVDRLKELIKYKGFQVAPAELEAVLLSHPEILEAAVIPFPDDEAGEVPIGYVVRSPKSTLTEQDVMKYVADQVAPYKRLRNVTFLNTIPKLASGKLLRRELIEKSRSKL
>AH020984-RA.v2.1
MGSLQETTHDEILPIVEQKEYIFKSKLPDIYIPNHIPLHTYCFKNVHDHGCRPCIIDGPTGREWTYDEVEQTSKRVGAGFYHKLGLQKGQVIMLLLQNCPEFVFSFLGASFIGAISTTANPFCTPAEIEKQARASKARAILTQSAFAEKVKPFCEQNNIHLIVIDPSTSSDHTSYWDLLDDKNDLPKIEIVPNDVVALPYSSGTTGLPKGVMLTHKSLVTSVAQQVDGENPNLYFNNEDVILCVLPLFHIYSLNSVLLCGLRVGAAILIMPKFEINMLMELVQKYKVTIAPFVPPIVLAIAKNPDVDKYDLSSVRVVLSGAAPMGKDLEDAGYGMTEAGPVLAMCLAFAKEPMEVKSGSCGTVVRNAELKIVDPETGFSLPRNKPGEICIRGCQIMKGYLNDPEATSNTIDKEGWLHTGDIGFVDDDDEIFIVDRLKELIKYKGFQVAPAELEGMLINHPSIHDAAVVAMQDETAGEVPVAFVVRSNGSQITEDDVKQYVSKQVVFYKRINRVFFVDSIPKLPSGKILRKELRARLANGITNK
>AH002921-RA.v2.1
MERSGYGRDGIYKSLRPPLILPSDPNLDMVSFLFRNIHCYPEQPALIDSNSGDTLNFSQLKSMVAKLSHGLTQLGIQKGDVVLMFAPNSVQYPVTFLGIIAIGAIATTVNPLYTLTEIKKQVQDCNPKLIVTVPELWDKVKGLNLPALILGFTENGYFDPNSKIVYYSDLINGSCVDFPKVLIKQNDTAALLYSSGTTGVSKGVILTHKNFISASLMISNDQEFEGDLHEVFLVVIPMFHVFGLGVILYAQLQKGNCVVCMPKFDFEMMLKAIEKFRVTRLWVVPPIMLGLAKQSVVKKYDLSSLKLIGSGAAPLGKEMMQECSKNIPQALIVQGYGMTETCGVISIEHPRLGSRHSGSAGMLVSGIEAQIMKVDTLKPLPPNQMGEIWVRGPNIMKGYYNNPQATKSTIDDQGWLHTGDLGYFDEEGQLYVVDRLKELIKYKGFQVAPAELEAVLLSHPEILEAAVIPFPDDEAGEVPIAFVVRSPKSALTEENVMKFVADQVAPYKRLRKVTFLSSIPKAASGKLLRRDLIEKTRSKL
>AH005186-RA.v2.1
MGTDISNQVPIEEEIIFRSRFSPVPIPDNLSLPDFVLQDAELYSDNVAFVDATTGKKYTYGQVAKDTKRFARALRSLGLRKGHVKDISLPKIILGEEKIQENAGAIYWEELLTAADKTNINLISDPIQQTDLCALPFSSGTTGLSKGVMLTHRNIVANLCSTLFSVSPEMIGKVTILGLMPFFHIYGIAGICCSTLRNKGKVVVMGRYELRTFLHALISHEINFAPIVPPIILALVKNPIVDEFDLSKLKLKAIMTAAAPLAPEILNSFEKKFPGVQVQEAYGLTEHSCITLTHAAPSEDHGGTAKRNSVGFILPNIEVKFIDPDTSKSLPNNTPGEICVRSQCVMQGYYKNDEATHQTVDKYGWLHTGDIGYIDDDGDIFIVDRIKELIKFKGFQVAPAELEAILLSHPSIEDAAVIPLPDEDAGEVPAACVVINKNAKENEEDIMNYVASNVSSYKRLRSVYFMESIPKSPSGKIMRRILKDKITHMIKADVKQI
>AH007272-RA.v2.1
MQGYGMTEAGPVLSMCPAFAKEPIQTKPGSCGVVVRNAEMKIVDPDTNVSLGYNQPGEICIRGYLNDPVSTAATIDIEGWLHTGDIGLSGKFTLL
>AH007273-RA.v2.1
MKLPGKFLSHSSLDPVNALDLTEQTVKDYVAKQVVFYKKLQKVYFVDAIPKSASGKILRKELRARLASPNNTTSV
>AH007271-RA.v2.1
MSMAAVEAQPLDSEIQSLKSSPTKSKPDHIFKSTLPDIPITDHLPLHSYLFEKLEQFSDKPCLISGPTGKIYSYAETHLLCQKTAVGLSKLGIKKGDTIMILLQNCPEFVFTFFGASMIGAISTPANPYYTPSEIFKQLKTSSAKLIITQSQFVDKLRDHDEYKLGEDFNVITVDNPPENCLNFSVLFDSNETELTQPEIDPNDPVVLPFSSGTTGLPKGVILTHKSLSTSVGQQVDGENPNMYLTKEDVMLCVLPLFHIFSLNSVLMIALRAGSGILLMPKFEINLLLELIEKYKVSVAMVVPPLVLALAKHPNVEKYDLSSVRIVMSGAAPLGKELEDALRERIPQAILGQTTSSNQHFLISPSHIISLHSYLFEKLEQFSDKPCLISGPTGKIYAYAETHLLCQKTAVGLSKLGIKKGDTIMILLQNCPEFVFTFFGASMIGAISTPANPYYTPSEIFKQLKTSSAKLIITQSQFVDKLRDHDEYKLGEDFNVITVDNPPENCLNFSVLSESKNHL
>AH014390-RA.v2.1
MLLLQNCPEFVFSFLGASFIGATSTTANPFCTPTEIQKQARASNARAIITQSAFADKVKPYCQENNIHLITVDAPPFISCPDSKYFWDLLDVQEKLPKVKILPNDMVALPYSSGTTGLPKGVMLTHKSLVTSVAQQVDGENPNLYFNSEDVILCVLPLFHIYSLNSVLLCALRVGAAILIMPKFEIKMLMELVQKYKVTIAPFVPPIVLAIAKNEDVDKYDVSSIRVVLSGAAPMGKELEDALRTKLPNAKLGQGYGMTEAGPVLAMCLAFAKEPMEVKSGSCGTVVRNAELKIVDPETGFSLPRNMPGEICIRGSQIMKGYLNDAEATANTIDKEGWLHTGDVGFVDNDDEIFIVDRLKELIKYKGFQVAPAELEGMLINHPNIHDAAVVAMQDEAAGEVPVAFVVTSNGSQITEDDVKQYISKQVVFYKRINRVFFVDTIPKLPSGKILRKELRSRLANGITK
MERSGYGKDGIFRSLRPTLTIPKNPNLNMVSFLFRNIDSYSEQPALIDSTSGETLNFSQFKSMVANLSNRLTQLGIQKGHVVLMFAPNSVQYPVTFLGIIATGAIATTVNPIYTVSEIKKQAEDCNPKLIVTIPELWDKVKGLNLPVLILGSKENGKIDSNSNTPTFYFRDLVNGDYVDFPKVSIKQNDTAALLYSSGTTGVSKGVILTHKNFITASLMVVSDQEFEGIVHEVFMCVIPMFHVFGLSVILYAQLQKGNTVVCMPKFDFEMMLKAIEKYRVTRLWVVPPIMLGFAKQIAVKKYDLSSLKQIGSGAAPLGQEIMQECSKNVPQALIIQGYGMTETCGIISLEHPRLGGRHSGSTGLLVPGVEAQIVKVDTLEPLPPKQQGEIWVRGPNMMKGWVHTGDLGYFDEEGQLYVVDRLKELIKYKGFQVAPAELEAVLLSHPEILEAAVIPFPDDEAGEVPIGYVVRSPKSTLTEQDVMKYVADQVAPYKRLRNVTFLNTIPKLASGKLLRRELIEKSRSKL
>AH020984-RA.v2.1
MGSLQETTHDEILPIVEQKEYIFKSKLPDIYIPNHIPLHTYCFKNVHDHGCRPCIIDGPTGREWTYDEVEQTSKRVGAGFYHKLGLQKGQVIMLLLQNCPEFVFSFLGASFIGAISTTANPFCTPAEIEKQARASKARAILTQSAFAEKVKPFCEQNNIHLIVIDPSTSSDHTSYWDLLDDKNDLPKIEIVPNDVVALPYSSGTTGLPKGVMLTHKSLVTSVAQQVDGENPNLYFNNEDVILCVLPLFHIYSLNSVLLCGLRVGAAILIMPKFEINMLMELVQKYKVTIAPFVPPIVLAIAKNPDVDKYDLSSVRVVLSGAAPMGKDLEDAGYGMTEAGPVLAMCLAFAKEPMEVKSGSCGTVVRNAELKIVDPETGFSLPRNKPGEICIRGCQIMKGYLNDPEATSNTIDKEGWLHTGDIGFVDDDDEIFIVDRLKELIKYKGFQVAPAELEGMLINHPSIHDAAVVAMQDETAGEVPVAFVVRSNGSQITEDDVKQYVSKQVVFYKRINRVFFVDSIPKLPSGKILRKELRARLANGITNK
>AH002921-RA.v2.1
MERSGYGRDGIYKSLRPPLILPSDPNLDMVSFLFRNIHCYPEQPALIDSNSGDTLNFSQLKSMVAKLSHGLTQLGIQKGDVVLMFAPNSVQYPVTFLGIIAIGAIATTVNPLYTLTEIKKQVQDCNPKLIVTVPELWDKVKGLNLPALILGFTENGYFDPNSKIVYYSDLINGSCVDFPKVLIKQNDTAALLYSSGTTGVSKGVILTHKNFISASLMISNDQEFEGDLHEVFLVVIPMFHVFGLGVILYAQLQKGNCVVCMPKFDFEMMLKAIEKFRVTRLWVVPPIMLGLAKQSVVKKYDLSSLKLIGSGAAPLGKEMMQECSKNIPQALIVQGYGMTETCGVISIEHPRLGSRHSGSAGMLVSGIEAQIMKVDTLKPLPPNQMGEIWVRGPNIMKGYYNNPQATKSTIDDQGWLHTGDLGYFDEEGQLYVVDRLKELIKYKGFQVAPAELEAVLLSHPEILEAAVIPFPDDEAGEVPIAFVVRSPKSALTEENVMKFVADQVAPYKRLRKVTFLSSIPKAASGKLLRRDLIEKTRSKL
>AH005186-RA.v2.1
MGTDISNQVPIEEEIIFRSRFSPVPIPDNLSLPDFVLQDAELYSDNVAFVDATTGKKYTYGQVAKDTKRFARALRSLGLRKGHVKDISLPKIILGEEKIQENAGAIYWEELLTAADKTNINLISDPIQQTDLCALPFSSGTTGLSKGVMLTHRNIVANLCSTLFSVSPEMIGKVTILGLMPFFHIYGIAGICCSTLRNKGKVVVMGRYELRTFLHALISHEINFAPIVPPIILALVKNPIVDEFDLSKLKLKAIMTAAAPLAPEILNSFEKKFPGVQVQEAYGLTEHSCITLTHAAPSEDHGGTAKRNSVGFILPNIEVKFIDPDTSKSLPNNTPGEICVRSQCVMQGYYKNDEATHQTVDKYGWLHTGDIGYIDDDGDIFIVDRIKELIKFKGFQVAPAELEAILLSHPSIEDAAVIPLPDEDAGEVPAACVVINKNAKENEEDIMNYVASNVSSYKRLRSVYFMESIPKSPSGKIMRRILKDKITHMIKADVKQI
>AH007272-RA.v2.1
MQGYGMTEAGPVLSMCPAFAKEPIQTKPGSCGVVVRNAEMKIVDPDTNVSLGYNQPGEICIRGYLNDPVSTAATIDIEGWLHTGDIGLSGKFTLL
>AH007273-RA.v2.1
MKLPGKFLSHSSLDPVNALDLTEQTVKDYVAKQVVFYKKLQKVYFVDAIPKSASGKILRKELRARLASPNNTTSV
>AH007271-RA.v2.1
MSMAAVEAQPLDSEIQSLKSSPTKSKPDHIFKSTLPDIPITDHLPLHSYLFEKLEQFSDKPCLISGPTGKIYSYAETHLLCQKTAVGLSKLGIKKGDTIMILLQNCPEFVFTFFGASMIGAISTPANPYYTPSEIFKQLKTSSAKLIITQSQFVDKLRDHDEYKLGEDFNVITVDNPPENCLNFSVLFDSNETELTQPEIDPNDPVVLPFSSGTTGLPKGVILTHKSLSTSVGQQVDGENPNMYLTKEDVMLCVLPLFHIFSLNSVLMIALRAGSGILLMPKFEINLLLELIEKYKVSVAMVVPPLVLALAKHPNVEKYDLSSVRIVMSGAAPLGKELEDALRERIPQAILGQTTSSNQHFLISPSHIISLHSYLFEKLEQFSDKPCLISGPTGKIYAYAETHLLCQKTAVGLSKLGIKKGDTIMILLQNCPEFVFTFFGASMIGAISTPANPYYTPSEIFKQLKTSSAKLIITQSQFVDKLRDHDEYKLGEDFNVITVDNPPENCLNFSVLSESKNHL
>AH014390-RA.v2.1
MLLLQNCPEFVFSFLGASFIGATSTTANPFCTPTEIQKQARASNARAIITQSAFADKVKPYCQENNIHLITVDAPPFISCPDSKYFWDLLDVQEKLPKVKILPNDMVALPYSSGTTGLPKGVMLTHKSLVTSVAQQVDGENPNLYFNSEDVILCVLPLFHIYSLNSVLLCALRVGAAILIMPKFEIKMLMELVQKYKVTIAPFVPPIVLAIAKNEDVDKYDVSSIRVVLSGAAPMGKELEDALRTKLPNAKLGQGYGMTEAGPVLAMCLAFAKEPMEVKSGSCGTVVRNAELKIVDPETGFSLPRNMPGEICIRGSQIMKGYLNDAEATANTIDKEGWLHTGDVGFVDNDDEIFIVDRLKELIKYKGFQVAPAELEGMLINHPNIHDAAVVAMQDEAAGEVPVAFVVTSNGSQITEDDVKQYISKQVVFYKRINRVFFVDTIPKLPSGKILRKELRSRLANGITK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University