Enzyme

4CL

Enzyme

4-coumarate:CoA ligase

Enzyme name

EC:6.2.1.12

Entry

Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases

Class

4-coumarate:CoA ligase (AMP-forming)

Sysname

ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]

Reaction

AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]

Product

Species information

Hevea brasiliensis

Species name

Rubber tree (Hevea brasiliensis) is a species of eudicot in the family Euphorbiaceae (spurge family).

Species info

Gene sequence info

Hevea_brasiliensis.4CL.fa

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>rna-XM_021799686.1
MEAKIDQQEFIFRSKLPDIYIPNHLPLHTYCFEKVSQFKDNPCLINGATGDIYTYADVELISRKVAAGLDKLGIQQGDVIMLLLQNSQEFVFAFLGASYRGAISTTANPFYTPAEIAKQATASKAKLIVTQAAYAEKVKQFAKENDIKIMTTDSPPDGCLHFSELTEADENNIPAVNINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNPNLYFHEKDVILCVLPLFHIYSLNSVLLCGLRVGAAILIMQKFDIIALMELVQKYKVTIAPFVPPIVLAIAKSPVVDEYDLSSIRTVMSGAAPMGKELEDTVRAKLPNAKLGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGSVVRNAEMKIVDPETGNSLPRNQTGEICIRGSQIMKGYLNDPEATVNTIDKEGWLHTGDVGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLIAHPSISDAAVVPMKDEAAGEVPVAFVVRSNGCKVTEDEIKQYISKQVIFYKRINRVFFTEAIPKAPSGKILRKDLRAKLIAGVPN
>rna-XM_021816436.1
MISIASLELEPAKPEISPPQNSDTHIFRSKLPDIPISSLLSLHAYCFENLFSFADRPCLISGSTGKIYSFAETHLIAQKTAAGLSNLGIKKGDVIMILLQNCPEFVFSFMGASMLGAVTTTANPFYTPNEIFKQFTSSRAKLIITQSQYVDKLRDSHENHPKLGQDFTVITIDDPPENCLHFSVLSSASESEIPDVTIHPDDPVALPFSSGTTGLPKGVVLTHKSLITSVAQQVDGENPNLYLKEEDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLLMQKFEIGALLELIQRHKVSVAAVVPPLVLALAKNPMVAGFDLSSIRVVLSGAAPLGKDLEDALRSRVPQAILGQGYGMTEAGPVLSMCLGFAKQPFPTKSGSCGTVVRNAELKVIDPETGCSLGYNQPGEICIRGQQIMKGYLNDPEATANTIDVEGWLHTGDIGYVDDDEEVFIVDRVKEIIKFKGFQVPPAELEALLINHPSIADAAVVPQKDEVAGEVPVAFVVPSNGFELTEEAVKEYIAKQVVFYKKLHRVYFVHAIPKSPSGKILRKDLKAKLATTSSSS
>rna-XM_021826662.1
MTKSYDPRTQTYSSPRPRVHLPTNPDLSLTSFLFHSTFSSSCTAALIDADSGDTLTFEQLRIQVSKLAHVLLELNIVKNDVVLILAPNSIHFPVCFLAIVSTGAIASTCNPGYTTAEISKQVKDCNPKLIITIPQLLHKVKPFNLSLILLNSPNSDGLVSNSKIWNYSDLIKLSGEVSDLPVNDVKQNDVAALFYSSGTTGMSKGVILTHRNFIATSVMVTADQDRYMEPENVFLCFLPMFHIFGFAVTTYSQLRRGNAVVSMEKFELDKMLRSIERYRVTHLYVVPPVMIALAKQNAVKKFDLSSLKLIGSGAAPMGKDVMEECAKNLPHVDIIQGYGMTETCGIISIENPREGTRLSGSTGVLVPGVESQIVSVETSKPLPPNELGEICLRGANMMQGYFNNLQATKLTIDGQGWVHTGDLGYFNEEGQLFVVDRIKELIKCNGFQVAPAELEGLLLSHPEIIDAVVIPFPDSKAGEVPIAYVVCSPNSSLTEEDIQKYIADQVAPFKQLRRVTFINSVPKSASGKILRREMIDKVRSKI
>rna-XM_021786655.1
METQVIKQQEETIFRSKLPDICIPKHLPLHSYVFENISSHSSRPCLINGVTGDVYTYAEVELTARRVASGLNKLGVKQGEVIMLLLHNSPQFVLSFIGASYRGAIATAANPFFTPAEIAKQAKASNSKLIITQAAYAEKVKDLASDHGIKVLCIDSAPDGCLHFSELSEADERDMPDVDISPEDVVALPYSSGTTGLPKGVMLTHKGQVTSVAQQVDGDNPNLYFHSEDVILCVLPMFHVYALNSIMLCGLRVGAAILIMPKFEIGALLQLIQKYKITIAPIVPPIVLSIAKSPDTEKYDLSSIRMLKSGAAPLGKELEDTVRAKFPQATLGQGYGMTEAGPVLAMCLAFAKKPFQIKPGACGTVVRNAEMKIVDPETGESLPRNQPGEICIRGDQIMKGYLNDPEATARTIDKQGWLHTGDIGYIDYDDELFIVDRLKEIIKYKGFQVAPAEIEAMLLAHPDISDAAVVGMKDEDAGEVPIAFVVRSDKSQITEDEIKQYIHKQVVFYKRISRVFFIESIPKAPSGKILRKILREKLATDFKK
>rna-XM_021792722.1
MERSGYGRDGIYRSLRPTLIVPKDPNLSMVSFLFRNSNSYPHKPALIDADLSITLSFAQLKSIVVKVSHGLRHLVISKNDVVLIFAPNSYQYLICFLAITAIGAIATTANPLYTTTELSKQIKDSKPKLVITVPELWNKVKDFNLPAVFLGSKESLSIEPNSRIKSFHHLVELGGSNSEFPENKVKQTDTAALLYSSGTTGTSKGVILTHGNFIAASLMVTMDQEMAGEMHHVFLCVLPMFHVFGLSVITYSQLQKGNAIVSMAKFDFEMVLKNVEKYRVTHLWIVPPVILALAKQSSVKKYDLSSLQHVGSGAAPLGKELMEECAKRIPHAAVAQGYGMTETTGIVSVENPRIGIRHSGSAGILAPGVEAQIISVDTLKPLPPNQLGEIWVRGPNMMQGYLNNPQATKQTIDKKGWVHTGDLGYFNEDGQLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYIVRSPNSSLTEEDVLKFIADQVAPFKRLRRVNFINSVPKSAAGKILRRELIEKAKSKI
>rna-XM_021793140.1
MISIASLELEPAKPEISPPQNSDTHIFRSKLPDIPISSLLSLHAYCFENLFSFADRPCLISGSTGKIYSFAETHLIAQKTAAGLSNLGIKKGDVIMILLQNCPEFVFSFMGASMLGAVTTTANPFYTPNEIFKQFTSSRAKLIITQSQYVDKLRDSHENHPKLGQDFTVITIDDPPENCLHFSVLSSASESEIPDVTIHPDDPVALPFSSGTTGLPKGVVLTHKSLITSVAQQVDGENPNLYLKEEDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLLMQKFEIGALLELIQRHKVSVAAVVPPLVLALAKNPMVAGFDLSSIRVVLSGAAPLGKDLEDALRSRVPQAILGQGYGMTEAGPVLSMCLGFAKQPFPTKSGSCGTVVRNAELKVIDPETGCSLGYNQPGEICIRGQQIMKGYLNDPEATANTIDVEGWLHTGDIGYVDDDEEVFIVDRVKEIIKFKGFQVPPAELEALLINHPSIADAAVVPQKDEVAGEVPVAFVVPSNGFELTEEAVKEYIAKQVVFYKKLHRVYFVHAIPKSPSGKILRKDLKAKLATTSSSS
>rna-XM_021797631.1
METKVTKQQEETIFRSKLPDIYIPKHLPLHSYIFENISNHSSRPCLINGVTGDVYTYAEVELTARRVASGLNKLGVKQGEVIMLLLHNSPQFVLSFLGASYRGAIATAANPFFTPAEIAKQAKASNSKLIITQAAYADKVKDLASDHGIKILCIDSAPDGCLHFSGLSEANEIDMPDVDISPEDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNPNLYFRSEDVILCVLPMFHIYALNSIMLCGLRVGAAILIMPKFDIGALLQLIQKYKITIAPIVPPIVLSIAKSPDTDKYDLSSIRMLKSGAAPLGKELEDSVRAKFPQATLGQGYGMTEAGPVLAMCLAFAKEPFDIKPGACGTVVRNAEMKIVDPETGESLPRNQPGEICIRGDQIMKGYLNDPEATARTIDKQGWLHTGDIGFIDDDDELFIVDRLKEIIKYKGFQVAPAEIEALLLAHPEISDAAVVGTKDEGAGEVPVAFVVRSDKSQITEDDIKQYIYKQVVFYKRISRVFFVEAIPKAPSGKILRKILREKLATDFPK
>rna-XM_021807321.1
MILKFLSFQFPLKHCSVLPFSPRPLYKSIMATPPPVPLSAHEEHIFRSRYPAVLVPENVTLPDFVFQDSELYADKVAFVEAVTGKAYTYGELVRETRRFAKALRSIGLRKGHVVIVVLPNVPEYGIVALGIMAAGGVYSGVNPAAHESEIKKQVQAANAKIIVTNDLSYGKVVGLELPVILLGEARIGSAMNWYELLDAADRATDKYAYEDVHQNDLCALPFSSGTTGMSKGVMLTHRNLVANLCSSLFSVGPEMVGQVTTLGLIPFFHIYGITGICFATLRNKGKVVVMSRFELRTFLNALITQEVTFAPIVPPIILALVKNPIVEEFDLSKLKLRAIMTAAAPLAPELLTAFENKFPGVQVQEAYGLTEHSCITLTHGDPNLEHGIAKKNSVGFILPNLEVKFIDPDTGRSLPKNTPGEICVRSQCVMQGYYNNKEETDRAIDKDGWLHTGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAEIEAILLTHPSVEDVAVVPLPDEEAGEIPAACVVMKKEARESEEDIINYVESNVAHYKKVRVVHFVDGIPKSPSGKIMRRLLKEKMIEKIKVNDPKPMTKAAAAAAPALI

Gene tree

Gene tree

Sheng jun & Dong yang Teams, Yunnan agriculture University