Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Herrania umbratica
Species name
Herrania umbratica is a species of eudicot in the family Malvaceae (mallow family).
Species info
Gene sequence info
Herrania_umbratica.COMT.fa
Download
>rna-XM_021444921.1
MGSAGETQMTPTQVSDEEANLFAMQLTCASVLPMVLKSAIELDLLEIMAKAGPGAFLSPKELASQLPTKNPDAPVMLDRILRLLASYSVLNCSLRTLPDGKVERLYGLGPVCKFLTKNEDGVTLSTLSLMNQDKVLMESWYYLKDAVLEGGIPFNKAYGMTAFEYHGTDPRFNKVFNRGMSEHSTITMRKILETYDGFEGVKTLVDVGGGTGATLNMIISKYPSIKGINFDLPHVIDDAPAYPGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCSKFLKKCYEALPDNGKVIVAECNLPDYPDASLATKLVVHIDCIMLAHNPGGKERTEKEFEALAKGSGFQGFQVKCCAFGTYIMEFLKTV
>rna-XM_021418257.1
MNNKESQARVSIDEEDKQAQQYAMQLVSASVMPMVLKAAIQLGVFEIIQRNGPGALLSASQIASQLPTQINPDAPLILDRILRLLASYSILTFSLVTDHQDGQVVRLYGLAPVAKYFNRSQGGGSLSSLLDLFQDRVSLDLWYHLKDAVVEGWCPFKEHGISSLEYMGKDARFGEIFRGSMIDFNGMFVEEMLKTYKGFEGLNSLVDVGGGNGSILHSIVSKYPAIKAINFDLPQIIENSPSYPGIEHVAGDMFDGVPKGDAIFMKWIIHCLDDKKCLELLKNCYEALPANGKVIIVELVIPESPDSSHVVKSVYQFESFMMNLNGNQKERTETAFESLAKGAGFSRVQVACCVCSFSVVELYKST
>rna-XM_021422538.1
MGYSVETQFHGNNDHSEQDEESFSYAMQLVNSTALPMSLHAANQLEIFEIIAKAGPDAKLSPQEIAAQLPTQNPDAPMMLDSILRLLASHSVLACSLAVVEQGDSLQRLYSLTPVTKFFIRNEDGVSLAPLVTLVQDKIFLDSWCQLKDAILEGGIPFNRVHGTHAFEYPGKDPRFNKIFNTAMMNQATIVMKKILEAYKGFEHVSQLVDVGGGLGVALSIITSKYPSIKGINFDQPHVIRHAPAYPGVEHVGGDMFASVPKGDTVFMKWILHDWSDDDCLKLLKNCYKAIPDDGKVIVIDAVLPILPESNAASKANSELDVVMMTQNPGGKERTKPELEALATAAGFSGIRYECFVCNCWVMEFFK
>rna-XM_021422390.1
MESSTERDQESFSYAIQIVNSIALPMSMHAAIQLQLFEIIAKSGPDAKLSPKEIAAQLRTKNPQAPSMLDRLLSVLASHNIVGCSVANDEQGNSPQRLYSLTPVSKFFVPNDDGVSLGPLMSLLQDKVFLDSWSQLKDAILEGGIPFDRVHGTHAFEYPGKDPRFNQVFNTAMINHTTVVLKKILETYKGFEQLNRVVDVGGGLGVALSIITSKYPSIRGINFDLPHVIQHAPAYPGVEHVGGDMFKSVPKGDAIFMKWILHDWSDEHCLKLLKNCYDAIPDDGKVIVADTVLPIVPEANAFVRGVSMMDVLMMTQNPGGKERTKPEFEALATKAGFAGIRYECFVRNFCVMEFFK
>rna-XM_021424069.1
MDIRHKMHSEVILINFYNIVRKKKGVKSLDLWSTRIPRNLLGTPLGRNNISLALKIHTVKAEKGRKKLGKKSRSKAKSNPEIAFQDKKPNPELENFTQAMRLASASALPMAMQAAIDLGVFDMLAPLCSGLRSVDIAARLGCRHPDSLKMLDRLIAVLCCHNVLACSEGCYSLTPAAKYFAKNEDGVSLAPLLRLNHDRVFLESWSGVKDAILEGGNPFSRAHGMHCFEYLGKDGRFNQVYSTAMFNHTTVIVKKILKTFNGFKNVKTLVDVGGGIGVALSLIISMYPSIKGINFDLPHVIQHAPPFPGVKHVAGDMFESVPSGDAILMKGILWDWSDDQCLKLLKNCYNALPKDGKVIVIEQILPTVADLASVHKGKLLNDVLTMTLNPGGKERKQGEMFRLAEESGFDSIGISSFQCHYCVLELIKSPNKLVGSG
>rna-XM_021427152.1
MSSKVDNLNITANEEEEEFHQAIHLATSTVLPMVLQAAIDLDLLEIIAKAGPADCKLSPIEIASHLPTQNPDASSIIDRILRVLASHSILTCGLATNEDGHIQRLYGLASIAKYFLHNDDGISVLPALAISTDKFLLEPWYHLKEATLEGGAIPFVKAYGMDLFELAAKNDEISSKFNNAMANQTAIIMKKVLGIYKGFEGVNQLVDVGGGLGTNLKLIVSKYPQIKGINFDLPHVIKDAPHFLGIDHVGGDMFIEVPQGDVIFMKCILHDWDDDRCLKLLRNCYNALPKFGKVVAVESIVPESPMTDIVTKNTLTLDICLFNVVPGAKERTKEEYKALARKAGFSTFKFVCRAYGYWAMEFHKNAIA
>rna-XM_021427387.1
MENCYLSFQTYIAKPFCKHFYIQIEEINIMSTSLPGQQQFISKEEEDCLQAIQFATSTVLPFALKTAIDLDLLEIIARAGPGCMLSPAEIVSNLPAKNPDAPAIIDRILRVLTAHSILACHLVTDEDGHTKRTYGIASIGRCFLQNEDGISVTPFLNMALYKRFIDSWNFFKEATLEGGLSFVKGFGMNFFEMAAKDNNFFNPFNQAKSNHTAIVMKKILEIYKGFEVVSQVVGVGGGLGTNLKLVLSKYPQIKGINFDLPLLVKDAPNFPGLEHVRGDMFTQISHREVIFMKWLLHQCDDQCLKLPKNCYDATPESGKVIILESILPELPMTALLPTTTLNLDLGLAHLLPGAKERTKKELETLARDAGFSTLKLVCRAYNYWVIELSKL
>rna-XM_021427199.1
MASLPDQQKMSQNELDFLRALQAATAPTLPLVLKAAIDLDLLEIMAAATASNSMLSPTEIASRLPTQNPDAPTILDRILRLLASHSILTCKLVAGRDEHAQRLYGLGPVGKYFVRNQEGNSLVPTLRVSLEKFYMECWYHLKEATLEGVLPFMKVHGMHLFELAAKDDKVSSMFNASMSNLTGMVMKKVLETYKGFEALSQVVDVGGGVGANLSLLVSKYPQIKGTNFDLPHVVRDAPLIPGVEHVGGDMFSKVPKGEVIFMKWILHDWGDEQCSKLLKNCFEALPENGKVVIVESLLPEFPMTDIVTKITFELDVSVLHMIPGAKERTKQEFEALAREAGFKTLNVVCRIYSYWVMELCKNVNIAN
>rna-XM_021427216.1
MSSKLDKQHITANEEEEELHQAMQLATSTALPMLLKVAIDLDLLEIIAKASPAGSKLSPIEIASHLPTKNPDASSIIDRILRVLASHSILTCDLATNEDGHVQRLYGLAPIAKYFLHNDDGISLIPTLTISTDIYLLEPWHHLKEATLEGGAIPFVKAHGMDLFELAGKNDEISGKFNSTMGNQTAIIMEKVLEIYKGFEGINQLVDVGGGLGTNLKLIVSKYPQTKGINFDLPHVIKEAPHFLGVDHVGGDMFIEVPQGEVIFMKCVLHDWGDDRCLKLLKNCYNALPKFGKVVVVELIVPEFPMTDIVTKNTLTLDVCLFNVIPGAKERTKEEYEALARNAGFSTFKLVCCANGYWVMEFQKNVFF
>rna-XM_021428625.1
MSQEDQDQELGKLAVRLANAVILPMVLKSALELNIIDIISAAGDGMFLSPSQIASGLPTNNPEASVLLDRMLRLLASYSVLKCSVRTKESGEVERLYGAGPLCKFLVKNQDGGSVAPLFLLHHDKVFMESWCHLNDAILDGGIPFNRAYGMTAFEYPGTDLRFNRVFNQAMSNHTTLIMRKILDVYKGFDEVEVLVDVGGGIGVALGIITSKYPHIKAINFDLPHVLADAPTYSGVEHVGGDMFESVPKGDAIFMKWILHDWSDDHCLKLLKNCWEALPNGGKVIIVESILPEAPDSSVSSNIVCEQDLLMLAQNPGGKERTRKEYEALALRTGFSGCEVICCAYNSWVMEFHKRETL
>rna-XM_021434083.1
MEDETADSRNKARLAIVELANMISVPMSLNAVVRLNVPDAIWQGGANTPLSAAQILSRVLPSGGGDPENLQRILRMLTSYGVFAENLDSESRERRYSLTDIGKTLVTDADGLSYAPYVLQHHQDALLRAWPLVHEAVLDPTSEPFVKANGEAAYSYYGKKPEMNGLMQKAMSGVSVPFMRAILNNYDVFKGVKRLVDVGGSAGDCLRMILQKHPHVEEGINFDLPEVIAKAPVIPGVSHVGGDMFKSIPGGDAIFMKWILTTWTDDECKLIMENCYKALPVGGKLIACEPVLPKDSDDSHRTRALLEGDIFVMTIYRAKGKHRTDEEFKQLGLSAGFPHFRAFYVDYFYTVLEFQK
>rna-XM_021440618.1
MSTSMSEEEEAFGYAWCLRSSHMFCFVLDAAIQLGLFDIIAKAGPGAHLSSSEIASQLNANNPEAPSLLDRVLRLLACYDLVTCITQNLDGDGEVERLYGLALPGQAFVPDESKGCLAGFAITKAKIEACLYLKDMILDGGNVFERLYGVGMPVYQYMSLHPDMARKFDTTMTNLSKVVMNKVLDKYHGFQGITCLVDVGGDYGVSLNIIISKYPSIHGVNYDMPHVIQDAPSFPGIQHIGGDMFSSVPKADAIMIKDVLHNWNDERCLKLLTNCYEALPERGKVIVVSYVMIGEPEASDGAKFVCQMDLLMALQGGAKQRTENQFKDLSKAAGFSDFQLNCRIFNAIGVMEFFK
>rna-XM_021441948.1
MASSVENQFHGNNNAEQDQESFSYAMQIVSSSALSMSLYAAIQLELLEIIAKAGPKAKLSPKEIAAQLPCKNPEAPSMLDRILRVLASHGIVSCSVVDEQSNNPQRFYGLTPVSKFFVPNEDGVSFGPLMALNQDRVSLDSWYQLKDAVLEGGVPFDRAHETHVFEYLGKDPRLNQVFNTAMINHTTIIVKKILETYKGFEQLNRLVDVAGGLGVTLSLITSKCPFIKGINFDLPHVIQHAPTYPGVEHVGGDMFESIPKGDAIFMKGVLHNWSDEQCLKLLKNCYNAIPDDGKVIVVDTVLPILPETNAFGRSTSQMDILMMTQLPRGKERNKLELEALATNAGFRGIKYECFVYNVWVMEFFK
MGSAGETQMTPTQVSDEEANLFAMQLTCASVLPMVLKSAIELDLLEIMAKAGPGAFLSPKELASQLPTKNPDAPVMLDRILRLLASYSVLNCSLRTLPDGKVERLYGLGPVCKFLTKNEDGVTLSTLSLMNQDKVLMESWYYLKDAVLEGGIPFNKAYGMTAFEYHGTDPRFNKVFNRGMSEHSTITMRKILETYDGFEGVKTLVDVGGGTGATLNMIISKYPSIKGINFDLPHVIDDAPAYPGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCSKFLKKCYEALPDNGKVIVAECNLPDYPDASLATKLVVHIDCIMLAHNPGGKERTEKEFEALAKGSGFQGFQVKCCAFGTYIMEFLKTV
>rna-XM_021418257.1
MNNKESQARVSIDEEDKQAQQYAMQLVSASVMPMVLKAAIQLGVFEIIQRNGPGALLSASQIASQLPTQINPDAPLILDRILRLLASYSILTFSLVTDHQDGQVVRLYGLAPVAKYFNRSQGGGSLSSLLDLFQDRVSLDLWYHLKDAVVEGWCPFKEHGISSLEYMGKDARFGEIFRGSMIDFNGMFVEEMLKTYKGFEGLNSLVDVGGGNGSILHSIVSKYPAIKAINFDLPQIIENSPSYPGIEHVAGDMFDGVPKGDAIFMKWIIHCLDDKKCLELLKNCYEALPANGKVIIVELVIPESPDSSHVVKSVYQFESFMMNLNGNQKERTETAFESLAKGAGFSRVQVACCVCSFSVVELYKST
>rna-XM_021422538.1
MGYSVETQFHGNNDHSEQDEESFSYAMQLVNSTALPMSLHAANQLEIFEIIAKAGPDAKLSPQEIAAQLPTQNPDAPMMLDSILRLLASHSVLACSLAVVEQGDSLQRLYSLTPVTKFFIRNEDGVSLAPLVTLVQDKIFLDSWCQLKDAILEGGIPFNRVHGTHAFEYPGKDPRFNKIFNTAMMNQATIVMKKILEAYKGFEHVSQLVDVGGGLGVALSIITSKYPSIKGINFDQPHVIRHAPAYPGVEHVGGDMFASVPKGDTVFMKWILHDWSDDDCLKLLKNCYKAIPDDGKVIVIDAVLPILPESNAASKANSELDVVMMTQNPGGKERTKPELEALATAAGFSGIRYECFVCNCWVMEFFK
>rna-XM_021422390.1
MESSTERDQESFSYAIQIVNSIALPMSMHAAIQLQLFEIIAKSGPDAKLSPKEIAAQLRTKNPQAPSMLDRLLSVLASHNIVGCSVANDEQGNSPQRLYSLTPVSKFFVPNDDGVSLGPLMSLLQDKVFLDSWSQLKDAILEGGIPFDRVHGTHAFEYPGKDPRFNQVFNTAMINHTTVVLKKILETYKGFEQLNRVVDVGGGLGVALSIITSKYPSIRGINFDLPHVIQHAPAYPGVEHVGGDMFKSVPKGDAIFMKWILHDWSDEHCLKLLKNCYDAIPDDGKVIVADTVLPIVPEANAFVRGVSMMDVLMMTQNPGGKERTKPEFEALATKAGFAGIRYECFVRNFCVMEFFK
>rna-XM_021424069.1
MDIRHKMHSEVILINFYNIVRKKKGVKSLDLWSTRIPRNLLGTPLGRNNISLALKIHTVKAEKGRKKLGKKSRSKAKSNPEIAFQDKKPNPELENFTQAMRLASASALPMAMQAAIDLGVFDMLAPLCSGLRSVDIAARLGCRHPDSLKMLDRLIAVLCCHNVLACSEGCYSLTPAAKYFAKNEDGVSLAPLLRLNHDRVFLESWSGVKDAILEGGNPFSRAHGMHCFEYLGKDGRFNQVYSTAMFNHTTVIVKKILKTFNGFKNVKTLVDVGGGIGVALSLIISMYPSIKGINFDLPHVIQHAPPFPGVKHVAGDMFESVPSGDAILMKGILWDWSDDQCLKLLKNCYNALPKDGKVIVIEQILPTVADLASVHKGKLLNDVLTMTLNPGGKERKQGEMFRLAEESGFDSIGISSFQCHYCVLELIKSPNKLVGSG
>rna-XM_021427152.1
MSSKVDNLNITANEEEEEFHQAIHLATSTVLPMVLQAAIDLDLLEIIAKAGPADCKLSPIEIASHLPTQNPDASSIIDRILRVLASHSILTCGLATNEDGHIQRLYGLASIAKYFLHNDDGISVLPALAISTDKFLLEPWYHLKEATLEGGAIPFVKAYGMDLFELAAKNDEISSKFNNAMANQTAIIMKKVLGIYKGFEGVNQLVDVGGGLGTNLKLIVSKYPQIKGINFDLPHVIKDAPHFLGIDHVGGDMFIEVPQGDVIFMKCILHDWDDDRCLKLLRNCYNALPKFGKVVAVESIVPESPMTDIVTKNTLTLDICLFNVVPGAKERTKEEYKALARKAGFSTFKFVCRAYGYWAMEFHKNAIA
>rna-XM_021427387.1
MENCYLSFQTYIAKPFCKHFYIQIEEINIMSTSLPGQQQFISKEEEDCLQAIQFATSTVLPFALKTAIDLDLLEIIARAGPGCMLSPAEIVSNLPAKNPDAPAIIDRILRVLTAHSILACHLVTDEDGHTKRTYGIASIGRCFLQNEDGISVTPFLNMALYKRFIDSWNFFKEATLEGGLSFVKGFGMNFFEMAAKDNNFFNPFNQAKSNHTAIVMKKILEIYKGFEVVSQVVGVGGGLGTNLKLVLSKYPQIKGINFDLPLLVKDAPNFPGLEHVRGDMFTQISHREVIFMKWLLHQCDDQCLKLPKNCYDATPESGKVIILESILPELPMTALLPTTTLNLDLGLAHLLPGAKERTKKELETLARDAGFSTLKLVCRAYNYWVIELSKL
>rna-XM_021427199.1
MASLPDQQKMSQNELDFLRALQAATAPTLPLVLKAAIDLDLLEIMAAATASNSMLSPTEIASRLPTQNPDAPTILDRILRLLASHSILTCKLVAGRDEHAQRLYGLGPVGKYFVRNQEGNSLVPTLRVSLEKFYMECWYHLKEATLEGVLPFMKVHGMHLFELAAKDDKVSSMFNASMSNLTGMVMKKVLETYKGFEALSQVVDVGGGVGANLSLLVSKYPQIKGTNFDLPHVVRDAPLIPGVEHVGGDMFSKVPKGEVIFMKWILHDWGDEQCSKLLKNCFEALPENGKVVIVESLLPEFPMTDIVTKITFELDVSVLHMIPGAKERTKQEFEALAREAGFKTLNVVCRIYSYWVMELCKNVNIAN
>rna-XM_021427216.1
MSSKLDKQHITANEEEEELHQAMQLATSTALPMLLKVAIDLDLLEIIAKASPAGSKLSPIEIASHLPTKNPDASSIIDRILRVLASHSILTCDLATNEDGHVQRLYGLAPIAKYFLHNDDGISLIPTLTISTDIYLLEPWHHLKEATLEGGAIPFVKAHGMDLFELAGKNDEISGKFNSTMGNQTAIIMEKVLEIYKGFEGINQLVDVGGGLGTNLKLIVSKYPQTKGINFDLPHVIKEAPHFLGVDHVGGDMFIEVPQGEVIFMKCVLHDWGDDRCLKLLKNCYNALPKFGKVVVVELIVPEFPMTDIVTKNTLTLDVCLFNVIPGAKERTKEEYEALARNAGFSTFKLVCCANGYWVMEFQKNVFF
>rna-XM_021428625.1
MSQEDQDQELGKLAVRLANAVILPMVLKSALELNIIDIISAAGDGMFLSPSQIASGLPTNNPEASVLLDRMLRLLASYSVLKCSVRTKESGEVERLYGAGPLCKFLVKNQDGGSVAPLFLLHHDKVFMESWCHLNDAILDGGIPFNRAYGMTAFEYPGTDLRFNRVFNQAMSNHTTLIMRKILDVYKGFDEVEVLVDVGGGIGVALGIITSKYPHIKAINFDLPHVLADAPTYSGVEHVGGDMFESVPKGDAIFMKWILHDWSDDHCLKLLKNCWEALPNGGKVIIVESILPEAPDSSVSSNIVCEQDLLMLAQNPGGKERTRKEYEALALRTGFSGCEVICCAYNSWVMEFHKRETL
>rna-XM_021434083.1
MEDETADSRNKARLAIVELANMISVPMSLNAVVRLNVPDAIWQGGANTPLSAAQILSRVLPSGGGDPENLQRILRMLTSYGVFAENLDSESRERRYSLTDIGKTLVTDADGLSYAPYVLQHHQDALLRAWPLVHEAVLDPTSEPFVKANGEAAYSYYGKKPEMNGLMQKAMSGVSVPFMRAILNNYDVFKGVKRLVDVGGSAGDCLRMILQKHPHVEEGINFDLPEVIAKAPVIPGVSHVGGDMFKSIPGGDAIFMKWILTTWTDDECKLIMENCYKALPVGGKLIACEPVLPKDSDDSHRTRALLEGDIFVMTIYRAKGKHRTDEEFKQLGLSAGFPHFRAFYVDYFYTVLEFQK
>rna-XM_021440618.1
MSTSMSEEEEAFGYAWCLRSSHMFCFVLDAAIQLGLFDIIAKAGPGAHLSSSEIASQLNANNPEAPSLLDRVLRLLACYDLVTCITQNLDGDGEVERLYGLALPGQAFVPDESKGCLAGFAITKAKIEACLYLKDMILDGGNVFERLYGVGMPVYQYMSLHPDMARKFDTTMTNLSKVVMNKVLDKYHGFQGITCLVDVGGDYGVSLNIIISKYPSIHGVNYDMPHVIQDAPSFPGIQHIGGDMFSSVPKADAIMIKDVLHNWNDERCLKLLTNCYEALPERGKVIVVSYVMIGEPEASDGAKFVCQMDLLMALQGGAKQRTENQFKDLSKAAGFSDFQLNCRIFNAIGVMEFFK
>rna-XM_021441948.1
MASSVENQFHGNNNAEQDQESFSYAMQIVSSSALSMSLYAAIQLELLEIIAKAGPKAKLSPKEIAAQLPCKNPEAPSMLDRILRVLASHGIVSCSVVDEQSNNPQRFYGLTPVSKFFVPNEDGVSFGPLMALNQDRVSLDSWYQLKDAVLEGGVPFDRAHETHVFEYLGKDPRLNQVFNTAMINHTTIIVKKILETYKGFEQLNRLVDVAGGLGVTLSLITSKCPFIKGINFDLPHVIQHAPTYPGVEHVGGDMFESIPKGDAIFMKGVLHNWSDEQCLKLLKNCYNAIPDDGKVIVVDTVLPILPETNAFGRSTSQMDILMMTQLPRGKERNKLELEALATNAGFRGIKYECFVYNVWVMEFFK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University