Enzyme
This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)-dihydromyricetin, although some enzymes may act only on a subset of these compounds. Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4-diol. NAD+ can act instead of NADP+, but more slowly.
DFR
Enzyme
Dihydroflavonol 4-reductase
Enzyme name
EC:1.1.1.219
Entry
Oxidoreductases;Acting on the CH-OH group of donors;With NAD+ or NADP+ as acceptor
Class
(2R,3S,4S)-leucoanthocyanidin:NADP+ 4-oxidoreductase
Sysname
a (2R,3S,4S)-leucoanthocyanidin + NADP+ = a (2R,3R)-dihydroflavonol + NADPH + H+ [RN:R11500]
Reaction
(2R,3R)-dihydroflavonol [CPD:C21417];NADPH [CPD:C00005];H+ [CPD:C00080]
Product
Species information
Herrania umbratica
Species name
Herrania umbratica is a species of eudicot in the family Malvaceae (mallow family).
Species info
Gene sequence info
Herrania_umbratica.DFR.fa
Download
>rna-XM_021445185.1
MRLLQRGYTVKATVRDPANLNKVKHLLELPKADENLTLRKADLMEDGSFDEAVRGCLGVFHVATPMDFESQDPENEVIKPTVDGALSIIKSCANAKTVERLVFVSFAGTVVMQERKLVQYDETCWIDIDFIRATKMTGWMYFASKTQAEKAAWEAAKENNIDFISVIPTPVVGPLIMPSMPPSLITALSLITRNEGHYSIIKQCQYVHLDDLCNALVFLYENPEAHGRIICSSHDTTIFDLEEMLRQKYPGYNIPIQFEGVEEDLEVISFSSKKLMGLGFQFKYGF
>rna-XM_021424665.1
MEKETKVCVTGAASFLGSWLVKKLLEQGYTVNATLRNLGDPNKVGLLSSLPNAGTKLRLYEADVYNPGSFKQAIEGCEYVVHMATPLLHQPLSSQFKNTSEAAVAGVKSIMELCIRSGTVKRLIYTASVTAASPIKENGKGFKDRMHESCWTPQEITLPYSNELLAEYTRSKTLSEKELLRHNGELEVVSLVCGLVGGKTLLSSMPESMAVLISQPAKNKRRYRTLRFLEELLGRVPILHIEDVCNAHIFCLEKPSIKGRFLCASAYLSSADIASHGRKLYPHIEIPEEFVENLGREIFWGSAKLEEVGFDYRCDVKMILEDSINCGLRLGECGLHFPATR
>rna-XM_021424797.1
MEKETKVCVTGAAGYLGSSLVKKLLEKGYIVHATTRNLGDPNKIGLLKSLPNAETRLRLYEADIYNPSQFEHAIEGCRFVVHMATPLQHEPQNSQFKDTSEAAVAGVKSIVESCIRSGSVTRLIYTASNVAASALREDGEGFKDQLDESCWTPKDVALPYTTEYLMGYVSSKTASEKELLRYDSEIEIVSLACGLVGGDTLHSSMPESTGVLISQATKNKRRYNILRFLEELLGKVPILHIEDVCDAHIYCMETPSIRGRLLCASAYLSSADIASHCQKIYPDIEIPDEFVENLGREIHWGSTKLKEIGFEYKCDVKTILEDSINCGLKLGEFSIF
>rna-XM_021426015.1
MSGTGKVVCVTGASGYIASWLVKFLLQRGYTVKATVRDPSDPKKTEHLLALDGAKERLHLFKAELLDKGAFDSVVDGCEGVFHTASPFYLNVKDPQQPYLACLLKHVANGRRNKLAEMIDPAVKGTLNVLRSCAKVPSIKRVVITSSIVAVIFNGRPLGPDVIVDETWFSDPSFCEKSKLWYMLSKTLAEEAAWKYAKENGIDMVTVNPGLVIGPLLQPTINTSVEPILKLINGAETFPNTSYRLIDVRDVANTHILAYENSSACGRYLLVERVMHCSKIVQTLRELYPALRLPERCADEKLGVPVFQVSNDRAKSLGVNFTPMEVSIKDTVQSLKEKNFFSG
>rna-XM_021428555.1
MPIPVNEVIKPIINGVLSIMKACAKTETVRRFLFTSSAGTMDVAEHQKPFYDETCWSDLEFIQAEKMTGWMYFVSKTMAEQAAWKLAKENNIDFVSIIPPLVVGPFIMQSMPPSLITALSPITGNEAHYSIIKQGQFVHLDDLCSAHIFLFKNPKAEGSYICASHHATILDIAKMLREKYPEYNVPSEFRLNYQNFDSGPDETIVVTFKDVDESPKSVEFSSKKLTDLGFEFKFSWEDMFTGAVETCREKGLLPLSNEKKIDIN
>rna-XM_021427935.1
MGSAAQSVCVTGASGFIGSWLVMRLLENGYAVRATVRDPDNVKKVKHLLELPKADSHLTLWKADLSEEGSFDAAIQGCTGVFHVATPMDFESKDPENEVIKPTINGVLDIMKACVKAKTVRKLVFTSSAGTVNVEEHQKPVYDESNWSDLEFVYAEKMTGWMYFVSKTLAEQAAWKFAKENNLDFITIIPTLVIGPFLMPSMPPSLITGLSPITGNEAHYTIIRQGQFVHLDDLCMAHIFLFENPKAEGRYICSSHEATIAELAKMLREKYPEYNIPTKFKDADENLANVVFSSKKLLDLGFQFKYSLEDMFTGAVETCREKGLIPAPIKKDAVDAKGCTTPVPVETAVNGTS
>rna-XM_021432696.1
MEDNLGAPAKGKSVVAAPTYCVTGATGYIGSWLVKLLLEKGCKVHATVRNPEKALRLLPLWSGSDRLRLFKADLQEEGSFDEAVKGCNGVFHVAASMEFGVNVNENIEGYVRSNIIDPAIKGTENLLKACSKSKSVKRVVFTSSISTITAKDSNGNWRPVVDESCHNTFDHVLNAKASGWVYVLSKLLTEEAAFKFANENGIDLVSLITTTVAGPFLTTTIPSSIQVLLSPLTGDPKYFSILSAVNARMGSAALVHIEDICSAHIFLMEQANAEGRYICCVCSSPMSELIDLLAQKYPCSNLQRLEAEGKGTKPPEISSKKLRDLGFTYKHNIEDIIHQTITACVDYGFLPPTRR
MRLLQRGYTVKATVRDPANLNKVKHLLELPKADENLTLRKADLMEDGSFDEAVRGCLGVFHVATPMDFESQDPENEVIKPTVDGALSIIKSCANAKTVERLVFVSFAGTVVMQERKLVQYDETCWIDIDFIRATKMTGWMYFASKTQAEKAAWEAAKENNIDFISVIPTPVVGPLIMPSMPPSLITALSLITRNEGHYSIIKQCQYVHLDDLCNALVFLYENPEAHGRIICSSHDTTIFDLEEMLRQKYPGYNIPIQFEGVEEDLEVISFSSKKLMGLGFQFKYGF
>rna-XM_021424665.1
MEKETKVCVTGAASFLGSWLVKKLLEQGYTVNATLRNLGDPNKVGLLSSLPNAGTKLRLYEADVYNPGSFKQAIEGCEYVVHMATPLLHQPLSSQFKNTSEAAVAGVKSIMELCIRSGTVKRLIYTASVTAASPIKENGKGFKDRMHESCWTPQEITLPYSNELLAEYTRSKTLSEKELLRHNGELEVVSLVCGLVGGKTLLSSMPESMAVLISQPAKNKRRYRTLRFLEELLGRVPILHIEDVCNAHIFCLEKPSIKGRFLCASAYLSSADIASHGRKLYPHIEIPEEFVENLGREIFWGSAKLEEVGFDYRCDVKMILEDSINCGLRLGECGLHFPATR
>rna-XM_021424797.1
MEKETKVCVTGAAGYLGSSLVKKLLEKGYIVHATTRNLGDPNKIGLLKSLPNAETRLRLYEADIYNPSQFEHAIEGCRFVVHMATPLQHEPQNSQFKDTSEAAVAGVKSIVESCIRSGSVTRLIYTASNVAASALREDGEGFKDQLDESCWTPKDVALPYTTEYLMGYVSSKTASEKELLRYDSEIEIVSLACGLVGGDTLHSSMPESTGVLISQATKNKRRYNILRFLEELLGKVPILHIEDVCDAHIYCMETPSIRGRLLCASAYLSSADIASHCQKIYPDIEIPDEFVENLGREIHWGSTKLKEIGFEYKCDVKTILEDSINCGLKLGEFSIF
>rna-XM_021426015.1
MSGTGKVVCVTGASGYIASWLVKFLLQRGYTVKATVRDPSDPKKTEHLLALDGAKERLHLFKAELLDKGAFDSVVDGCEGVFHTASPFYLNVKDPQQPYLACLLKHVANGRRNKLAEMIDPAVKGTLNVLRSCAKVPSIKRVVITSSIVAVIFNGRPLGPDVIVDETWFSDPSFCEKSKLWYMLSKTLAEEAAWKYAKENGIDMVTVNPGLVIGPLLQPTINTSVEPILKLINGAETFPNTSYRLIDVRDVANTHILAYENSSACGRYLLVERVMHCSKIVQTLRELYPALRLPERCADEKLGVPVFQVSNDRAKSLGVNFTPMEVSIKDTVQSLKEKNFFSG
>rna-XM_021428555.1
MPIPVNEVIKPIINGVLSIMKACAKTETVRRFLFTSSAGTMDVAEHQKPFYDETCWSDLEFIQAEKMTGWMYFVSKTMAEQAAWKLAKENNIDFVSIIPPLVVGPFIMQSMPPSLITALSPITGNEAHYSIIKQGQFVHLDDLCSAHIFLFKNPKAEGSYICASHHATILDIAKMLREKYPEYNVPSEFRLNYQNFDSGPDETIVVTFKDVDESPKSVEFSSKKLTDLGFEFKFSWEDMFTGAVETCREKGLLPLSNEKKIDIN
>rna-XM_021427935.1
MGSAAQSVCVTGASGFIGSWLVMRLLENGYAVRATVRDPDNVKKVKHLLELPKADSHLTLWKADLSEEGSFDAAIQGCTGVFHVATPMDFESKDPENEVIKPTINGVLDIMKACVKAKTVRKLVFTSSAGTVNVEEHQKPVYDESNWSDLEFVYAEKMTGWMYFVSKTLAEQAAWKFAKENNLDFITIIPTLVIGPFLMPSMPPSLITGLSPITGNEAHYTIIRQGQFVHLDDLCMAHIFLFENPKAEGRYICSSHEATIAELAKMLREKYPEYNIPTKFKDADENLANVVFSSKKLLDLGFQFKYSLEDMFTGAVETCREKGLIPAPIKKDAVDAKGCTTPVPVETAVNGTS
>rna-XM_021432696.1
MEDNLGAPAKGKSVVAAPTYCVTGATGYIGSWLVKLLLEKGCKVHATVRNPEKALRLLPLWSGSDRLRLFKADLQEEGSFDEAVKGCNGVFHVAASMEFGVNVNENIEGYVRSNIIDPAIKGTENLLKACSKSKSVKRVVFTSSISTITAKDSNGNWRPVVDESCHNTFDHVLNAKASGWVYVLSKLLTEEAAFKFANENGIDLVSLITTTVAGPFLTTTIPSSIQVLLSPLTGDPKYFSILSAVNARMGSAALVHIEDICSAHIFLMEQANAEGRYICCVCSSPMSELIDLLAQKYPCSNLQRLEAEGKGTKPPEISSKKLRDLGFTYKHNIEDIIHQTITACVDYGFLPPTRR
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University