Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Helianthus annuus
Species name
Common sunflower (Helianthus annuus) is a species of eudicot in the family Asteraceae (daisy family).
Species info
Gene sequence info
Helianthus_annuus.4CL.fa
Download
>rna-XM_022129909.2
MAESQNSLRVYNPTTGIYTSPRPPLPLPQSPTTSITDFLFRNLHTHSNSPALIDPYTHKTITFFQLKQHMTQLAHVLHHSFNISKYDVVLIFSPNSILFPVAFLAVTSIGAIVTTANPLYTVAELSHQISDSKPKLIITVDQLKPKVNGFNLPVLDLNTISDLIEKADKTTSLAKYPVGKSSHKTTSAEQQSESVSQNDVVNRISYPVFNSSHKTTSLAQQSESESVSRNDVVSSISNAEHKTTSFAPTVSQNDVAAILYSSGTTGLSKGVVLTHRSIIATSLMVTSDQEEYGEGRSVFLIVVPLFHVMGLITFTYSQMQRGNAMVVMVRFEVEKALEAIERFKVTHLYTAPPVVLALVKQVAVVKRFDTTSLVEIGSGAAPLGKDVMEECCRVFPKTKVLQGYGMTETGGIIAIENTRVGSRHSGSSGTLCPGMESQIIHIQTLKPLPPNQLGEIWVRGPNLMTEYFHNKEATEETIDKQGWLHTGDLGYFDEEGRIYVVDRLKELIKYKGYQVAPAELEGLLMSHPEIMDAAVIPYIDEEEGEIPMAYVVRKTGSSLTSEQVQDFIAKQVAPFKRIRKVAFIDIIPKSAAGKILRRELRQKVQSKL
>rna-XM_022170627.2
MHKSGYGRDGIFRSLRPPLTIPTTTNTSMTTFLFRNISSYPNKPALHDSDSGETLTFSQFKTTVAKLSHAFNTQLGITKNDVVLILAPNSIQYPVTVYSIIALGAIVTTVNPQYTVGEISKQIKDSNPKVIVTVQDLYEKVANFGLPVVFLGSGGVKKGCSYVKDLILSSGSVSELPKVEISGDHTAALLYSSGTTGVCKGVVLSHMNFIAVSQMLASDQRLMGGKDYVFLCLLPMFHIFGFGGLLYAQLQEGNAVVSMGKFDFIGMLKNVEKYRVTHLWVVPPVFLALAKQEVVNKFDLSSLKQIGSGAAPLGKELMEECVKKLPHVMALQGYGATETTGIISVESPILGPRNSGSAGRLIPGVEAQIVSVDTDKPLGPNQTGEIWVRGANMMQGYLNNPQATKLTIDKQGFVHTGDLGYFDDEGQLYVVDRIKELIKYKGFQVAPAELEGLLLSHSEILNAAVIPFPDTEAGEVPVAFVVRSPDSLLTEEDVKKFISEQVAPYKRLKKVTFVSSVPKSASGKLLRRELIERVRSKM
>rna-XM_022170626.2
MEKSGYGRDGIFRSLRPPLTIPKTTNKSMISFLFRNVSSYPNKPALCDSDSGESLTFSQFKTTVAKLSHAFNTQLGITKNDVVLIFAPNSIQYPVTVYSIIALGAIVTTVNPQYTVGEISKQIKDSNPKVIITVQDLYEKVANFGLPVVFLGSGGVKKGCFYVKDLILTSGSVSELPNVEISGDHTAALLYSSGTTGVSKGVVLSHMNFIAVSQMLTSDQRLMGGKDYVFLCLLPMFHIFGFGVVLYAQLQEGNAVVSMGKFDFIGMLKNVEKYRVTHLWVVPPVFLALAKQEVVNKFDLSSLKQLGSGAAPLGKELMEECAKKLPHVVALQGYGMTETTGVISVESPIMGPRHSGSAGRLIPGVEAQIVSVDTGKPLGPNQTGEIWVRGANMMQGYFNNPQATKLTIDKQRFVHTGDLGYFDDEGQLYVVDRIKELIKYKGFQVAPAELEGLLLSHSEILDAAVIPFPDAEAGEVPIAFVVRSPNSSLTEEDVKKFISEQVAPYKRLKRVTFVNSVPKSASGKLLRRELIERVRSKM
>rna-XM_022183620.2
MEGKTEIIFRSKLPDIYIPKHLPLHSYCFENISTFKNRPCLIDGATGHEYTYADVELTSRKVGSALYKLGINKGDVIMILLPNSSEFVFSFLGASFIGAVSTMANPFFTPAEIIKQAKASGAKIIVTQSVHVAKVKDFSTENSIKIVCIDETIEGCLHFSELTSGDENELPAVEISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLWIHEEDVLICVLPLFHIYSLNSILLCGLRAGAAILIMQKFDIVPFLELIQKYKVTIGPFVPPIVLAIAKNEEIVDKYDLSSIRTVMSGAAPLGKELEDTVRAKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPDTGATLPRNQRGEICIRGDQIMKGYINDPEATKRTIVDGWLHTGDIGLIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLLTHPDISDAAVVPMVDENAGEVPVAFVVKSNGSTITETDVKQFISKQVVFYKRINRVFFVDAIPKSPSGKILRKDLRAKLAAGVPN
>rna-XM_022120333.2
MEKTTKELTKVEDEDIVFRSRFPSVSIPDNVTLPEFVLKDAELYADHVAFVDATTKKSCTHGEVVRDVRRFSKGLRSLGLRTGHVVVVILPNVIEYAIVALGVMTAGGVFSGANPSSHSSEIKKQVDLAEAKLIVTDERTYNKVKELGLPVIILGEERVQGTIYWDELLATSERSITNETETVVNQNDLCALPFSSGTTGLSKGVMLTHRNIVANLCSTLFSVNPDYIGKVTILGLIPYFHIYGLTGILCANIRNKGKVVVMGRYDLSSVLKALIEHEVHFAPLVPPILLGLVKHPLDEDLAKLQLRSVMTAAAPLAPEIYEEFRRKFPQIEVQEAYGMTEHSCITLTHGHGDPNKGHHTAKKRSVGCILPNLEVKFVDPDTGRSLPANTPGEVCVRSQCVMKGYYKNEAETAQTIDEYGWLHTGDIGYIDDEGDLFIVDRLKELIKYKGFQVAPAELEGILLGHPSVEDAAVVGLPDKEAGEIPGAHVVMSKDAKESEEDMMKYIANNVAHYKKVRVLHFVDEIPKSPSGKIMRRLIKQKMLENITKSTSP
>rna-XM_022128564.2
MAPEKEIIFRSKLPDIYIPKHLPLHSYCFENISTFNNRPCLIDGATGVVHTYADVELTSRKVASAFHQHGINKGDVIMILLPNSPEFVYSFFGASYLGAVSTMANPFFTSAEIIKQAKASNAKIIVTQASHVPKIKEYAAENSIKIVCIDSAPEGCLHFTELVSGDETKLPEVEISSDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLWIHSEDVLMCVLPLFHIYSLNSILLCGLRAGAAILIMQKFDIVPFLELIEKYKVTIGPFVPPIVLAIANNEEVVDKYDLSSMRTVMSGAAPLGKELEDMVRRKFTNAKLGQGYGMTEAGPVLAMCLAFAKEPYEIKSGACGTVVRNAEMKIVDPETGLSLPRNQRGEICIRGDQIMKGYLNDPESTKTTIDSDGWLHTGDIGLIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPQISDVAVVPMVNEAAGEVPVAFVVKTKDSSVTEDDIKQFVHKQVVFYKRINRVFFIDTIPKSPAGKILRKELRAKLAAGVPN
>rna-XM_022130814.2
MNFIAVSQMLTSDQRLMGGKDYVFLCLLPMFHIFEKYRVTYLWVVPPVFLALAKQEVVNKFDLSSLKQLGSGAAPLGKELMEECAKKLPHVVALQVNFMILFTVLLVENFVLVVSYL
>rna-XM_022136671.2
MSFYPQSPTTSITDFLFRNLHTHSNSPALIDPYTHKTITFFQLKQHITQLAHVLHHSFNISKYDVVLIFSPNSILFPVAFLAVTSIGAIVTTANPLYTVTELSHQISDSKPKLIITVDQLKPKVNGFNLPVLDLNTISDLIEKADKTTSLAKYPVGKSSHKTTSSEQQSESVSQNDVVNRISYPVFNSSHKTTLLAQQSESESVSRNDVVSSISNAEHKTTSFAPTVSQNDVAAILYSSGTTGLSKGVVLTHRSIIATSLMVTSDQEEYGEGRSVFLIVVPLFHVMGLITFIFLSALSLYIYIYRRRKRTYV
>rna-XM_022141462.2
MGKTTQTMTKEDDEEIVFRSRYPSVPIPDNLTLPEFVLKDAELYADHVAFVDAATKRSYTYGEVVRDVQRFSKSLRSLGLRTGHVVVVVLPNVIEYAIVALGIMAAGSVFSGANPSSHSSEIKKQVDLAEAKLIVTDDHTYNKVKEVGLPVIIIGEERVNGTIFWSELLEAAERASSTGIQNTVTQNDLCALPFSSGTTGLSKGVMLTHRNIIANLCSTLFSVGPDLIGKVTILGLIPYFHIYGLTGILCATVRNKGKVVVMGRYDLSTVLKALIEHEVTFAPIVPPILLGLVKYPIDEDLEKLKVSAVMTAAAPLAPEIYEEFHRKFPQIEIQEAYGMTEHSCITLTHGDLRKGHHTSKKRSVGHILPNLEVKFVDPDTGRSLPSNTPGEICVRSQCVMKGYYKNEVETAQTIDEHGWLHTGDIGYIDDEGDMFIVDRMKELIKYKGFQVAPAELEGILLGHPSVEDAAVVGLPDKEAGEIPGAHVVISKDAKETEEDIMKYVANSVAQYKKVRVLHFVDKIPKSPSGKIMRRLIKEKMLEDISKSQ
>rna-XM_022151064.2
MLSVKAQKPETHPPPPPPPLISSSCINNNNNNHDDSSTRVFRSKLPDLPCIPNHMPLHSYCFQNLSRFSDRPCLVVGSTGTTYSYSQTHLLSRRIAAGLSSLGVSKGDVIMLLLQNCAEFALAFIAASMIGAVTTAANPFCTAGEISKQLTSSKAKIIITQAQYVEKLRPHCVPVITVDDPPEKCMHFSVLLLCQNSIPSVTIDPDDAVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLYLKQDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVVLMPKFEIRSLLEHIQRYRVTVAAVVPPLVLALAKNPMVGSYDLSSIRVVLSGAAPLGKELEDGLRSRVPQAIFGQGYGMTEAGPVLSMSAAFAKQPLPTKSGSCGSVVRNAELKVIDPDTHHSLGYNQPGEICIRGPQIMKGYLNDAMSTAATIDELGWLHTGDIGYVDHDDEVFIVDRVKELIKFKGFQVPPAELEALLVSHPCIADAAVVPQKDIAAGEVPVAFVVLVTGMEITEEDVKDYIAKQMQVVFYKKLHKVYFVSSIPKSPSGKILRKDLRAKLPST
>rna-XM_022168869.1
MLIQACIVLLVVAEGDGKILEFWCSSDARDKIQIHQEYLNNAEATSSTIDKDGWLQTGNIVYFDQDGYLYIVDRIKKMIKYKGFQIALGDLEDVLASHPAILDAAITGIRDEEAGDIPVAFVMMKARS
MAESQNSLRVYNPTTGIYTSPRPPLPLPQSPTTSITDFLFRNLHTHSNSPALIDPYTHKTITFFQLKQHMTQLAHVLHHSFNISKYDVVLIFSPNSILFPVAFLAVTSIGAIVTTANPLYTVAELSHQISDSKPKLIITVDQLKPKVNGFNLPVLDLNTISDLIEKADKTTSLAKYPVGKSSHKTTSAEQQSESVSQNDVVNRISYPVFNSSHKTTSLAQQSESESVSRNDVVSSISNAEHKTTSFAPTVSQNDVAAILYSSGTTGLSKGVVLTHRSIIATSLMVTSDQEEYGEGRSVFLIVVPLFHVMGLITFTYSQMQRGNAMVVMVRFEVEKALEAIERFKVTHLYTAPPVVLALVKQVAVVKRFDTTSLVEIGSGAAPLGKDVMEECCRVFPKTKVLQGYGMTETGGIIAIENTRVGSRHSGSSGTLCPGMESQIIHIQTLKPLPPNQLGEIWVRGPNLMTEYFHNKEATEETIDKQGWLHTGDLGYFDEEGRIYVVDRLKELIKYKGYQVAPAELEGLLMSHPEIMDAAVIPYIDEEEGEIPMAYVVRKTGSSLTSEQVQDFIAKQVAPFKRIRKVAFIDIIPKSAAGKILRRELRQKVQSKL
>rna-XM_022170627.2
MHKSGYGRDGIFRSLRPPLTIPTTTNTSMTTFLFRNISSYPNKPALHDSDSGETLTFSQFKTTVAKLSHAFNTQLGITKNDVVLILAPNSIQYPVTVYSIIALGAIVTTVNPQYTVGEISKQIKDSNPKVIVTVQDLYEKVANFGLPVVFLGSGGVKKGCSYVKDLILSSGSVSELPKVEISGDHTAALLYSSGTTGVCKGVVLSHMNFIAVSQMLASDQRLMGGKDYVFLCLLPMFHIFGFGGLLYAQLQEGNAVVSMGKFDFIGMLKNVEKYRVTHLWVVPPVFLALAKQEVVNKFDLSSLKQIGSGAAPLGKELMEECVKKLPHVMALQGYGATETTGIISVESPILGPRNSGSAGRLIPGVEAQIVSVDTDKPLGPNQTGEIWVRGANMMQGYLNNPQATKLTIDKQGFVHTGDLGYFDDEGQLYVVDRIKELIKYKGFQVAPAELEGLLLSHSEILNAAVIPFPDTEAGEVPVAFVVRSPDSLLTEEDVKKFISEQVAPYKRLKKVTFVSSVPKSASGKLLRRELIERVRSKM
>rna-XM_022170626.2
MEKSGYGRDGIFRSLRPPLTIPKTTNKSMISFLFRNVSSYPNKPALCDSDSGESLTFSQFKTTVAKLSHAFNTQLGITKNDVVLIFAPNSIQYPVTVYSIIALGAIVTTVNPQYTVGEISKQIKDSNPKVIITVQDLYEKVANFGLPVVFLGSGGVKKGCFYVKDLILTSGSVSELPNVEISGDHTAALLYSSGTTGVSKGVVLSHMNFIAVSQMLTSDQRLMGGKDYVFLCLLPMFHIFGFGVVLYAQLQEGNAVVSMGKFDFIGMLKNVEKYRVTHLWVVPPVFLALAKQEVVNKFDLSSLKQLGSGAAPLGKELMEECAKKLPHVVALQGYGMTETTGVISVESPIMGPRHSGSAGRLIPGVEAQIVSVDTGKPLGPNQTGEIWVRGANMMQGYFNNPQATKLTIDKQRFVHTGDLGYFDDEGQLYVVDRIKELIKYKGFQVAPAELEGLLLSHSEILDAAVIPFPDAEAGEVPIAFVVRSPNSSLTEEDVKKFISEQVAPYKRLKRVTFVNSVPKSASGKLLRRELIERVRSKM
>rna-XM_022183620.2
MEGKTEIIFRSKLPDIYIPKHLPLHSYCFENISTFKNRPCLIDGATGHEYTYADVELTSRKVGSALYKLGINKGDVIMILLPNSSEFVFSFLGASFIGAVSTMANPFFTPAEIIKQAKASGAKIIVTQSVHVAKVKDFSTENSIKIVCIDETIEGCLHFSELTSGDENELPAVEISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLWIHEEDVLICVLPLFHIYSLNSILLCGLRAGAAILIMQKFDIVPFLELIQKYKVTIGPFVPPIVLAIAKNEEIVDKYDLSSIRTVMSGAAPLGKELEDTVRAKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPDTGATLPRNQRGEICIRGDQIMKGYINDPEATKRTIVDGWLHTGDIGLIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLLTHPDISDAAVVPMVDENAGEVPVAFVVKSNGSTITETDVKQFISKQVVFYKRINRVFFVDAIPKSPSGKILRKDLRAKLAAGVPN
>rna-XM_022120333.2
MEKTTKELTKVEDEDIVFRSRFPSVSIPDNVTLPEFVLKDAELYADHVAFVDATTKKSCTHGEVVRDVRRFSKGLRSLGLRTGHVVVVILPNVIEYAIVALGVMTAGGVFSGANPSSHSSEIKKQVDLAEAKLIVTDERTYNKVKELGLPVIILGEERVQGTIYWDELLATSERSITNETETVVNQNDLCALPFSSGTTGLSKGVMLTHRNIVANLCSTLFSVNPDYIGKVTILGLIPYFHIYGLTGILCANIRNKGKVVVMGRYDLSSVLKALIEHEVHFAPLVPPILLGLVKHPLDEDLAKLQLRSVMTAAAPLAPEIYEEFRRKFPQIEVQEAYGMTEHSCITLTHGHGDPNKGHHTAKKRSVGCILPNLEVKFVDPDTGRSLPANTPGEVCVRSQCVMKGYYKNEAETAQTIDEYGWLHTGDIGYIDDEGDLFIVDRLKELIKYKGFQVAPAELEGILLGHPSVEDAAVVGLPDKEAGEIPGAHVVMSKDAKESEEDMMKYIANNVAHYKKVRVLHFVDEIPKSPSGKIMRRLIKQKMLENITKSTSP
>rna-XM_022128564.2
MAPEKEIIFRSKLPDIYIPKHLPLHSYCFENISTFNNRPCLIDGATGVVHTYADVELTSRKVASAFHQHGINKGDVIMILLPNSPEFVYSFFGASYLGAVSTMANPFFTSAEIIKQAKASNAKIIVTQASHVPKIKEYAAENSIKIVCIDSAPEGCLHFTELVSGDETKLPEVEISSDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLWIHSEDVLMCVLPLFHIYSLNSILLCGLRAGAAILIMQKFDIVPFLELIEKYKVTIGPFVPPIVLAIANNEEVVDKYDLSSMRTVMSGAAPLGKELEDMVRRKFTNAKLGQGYGMTEAGPVLAMCLAFAKEPYEIKSGACGTVVRNAEMKIVDPETGLSLPRNQRGEICIRGDQIMKGYLNDPESTKTTIDSDGWLHTGDIGLIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPQISDVAVVPMVNEAAGEVPVAFVVKTKDSSVTEDDIKQFVHKQVVFYKRINRVFFIDTIPKSPAGKILRKELRAKLAAGVPN
>rna-XM_022130814.2
MNFIAVSQMLTSDQRLMGGKDYVFLCLLPMFHIFEKYRVTYLWVVPPVFLALAKQEVVNKFDLSSLKQLGSGAAPLGKELMEECAKKLPHVVALQVNFMILFTVLLVENFVLVVSYL
>rna-XM_022136671.2
MSFYPQSPTTSITDFLFRNLHTHSNSPALIDPYTHKTITFFQLKQHITQLAHVLHHSFNISKYDVVLIFSPNSILFPVAFLAVTSIGAIVTTANPLYTVTELSHQISDSKPKLIITVDQLKPKVNGFNLPVLDLNTISDLIEKADKTTSLAKYPVGKSSHKTTSSEQQSESVSQNDVVNRISYPVFNSSHKTTLLAQQSESESVSRNDVVSSISNAEHKTTSFAPTVSQNDVAAILYSSGTTGLSKGVVLTHRSIIATSLMVTSDQEEYGEGRSVFLIVVPLFHVMGLITFIFLSALSLYIYIYRRRKRTYV
>rna-XM_022141462.2
MGKTTQTMTKEDDEEIVFRSRYPSVPIPDNLTLPEFVLKDAELYADHVAFVDAATKRSYTYGEVVRDVQRFSKSLRSLGLRTGHVVVVVLPNVIEYAIVALGIMAAGSVFSGANPSSHSSEIKKQVDLAEAKLIVTDDHTYNKVKEVGLPVIIIGEERVNGTIFWSELLEAAERASSTGIQNTVTQNDLCALPFSSGTTGLSKGVMLTHRNIIANLCSTLFSVGPDLIGKVTILGLIPYFHIYGLTGILCATVRNKGKVVVMGRYDLSTVLKALIEHEVTFAPIVPPILLGLVKYPIDEDLEKLKVSAVMTAAAPLAPEIYEEFHRKFPQIEIQEAYGMTEHSCITLTHGDLRKGHHTSKKRSVGHILPNLEVKFVDPDTGRSLPSNTPGEICVRSQCVMKGYYKNEVETAQTIDEHGWLHTGDIGYIDDEGDMFIVDRMKELIKYKGFQVAPAELEGILLGHPSVEDAAVVGLPDKEAGEIPGAHVVISKDAKETEEDIMKYVANSVAQYKKVRVLHFVDKIPKSPSGKIMRRLIKEKMLEDISKSQ
>rna-XM_022151064.2
MLSVKAQKPETHPPPPPPPLISSSCINNNNNNHDDSSTRVFRSKLPDLPCIPNHMPLHSYCFQNLSRFSDRPCLVVGSTGTTYSYSQTHLLSRRIAAGLSSLGVSKGDVIMLLLQNCAEFALAFIAASMIGAVTTAANPFCTAGEISKQLTSSKAKIIITQAQYVEKLRPHCVPVITVDDPPEKCMHFSVLLLCQNSIPSVTIDPDDAVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLYLKQDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVVLMPKFEIRSLLEHIQRYRVTVAAVVPPLVLALAKNPMVGSYDLSSIRVVLSGAAPLGKELEDGLRSRVPQAIFGQGYGMTEAGPVLSMSAAFAKQPLPTKSGSCGSVVRNAELKVIDPDTHHSLGYNQPGEICIRGPQIMKGYLNDAMSTAATIDELGWLHTGDIGYVDHDDEVFIVDRVKELIKFKGFQVPPAELEALLVSHPCIADAAVVPQKDIAAGEVPVAFVVLVTGMEITEEDVKDYIAKQMQVVFYKKLHKVYFVSSIPKSPSGKILRKDLRAKLPST
>rna-XM_022168869.1
MLIQACIVLLVVAEGDGKILEFWCSSDARDKIQIHQEYLNNAEATSSTIDKDGWLQTGNIVYFDQDGYLYIVDRIKKMIKYKGFQIALGDLEDVLASHPAILDAAITGIRDEEAGDIPVAFVMMKARS
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University