Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Hamamelis virginiana
Species name
American witch-hazel (Hamamelis virginiana) is a species of eudicot in the family Hamamelidaceae (witch-hazel family).
Species info
Gene sequence info
Hamamelis_virginiana.CHS.fa
Download
>g47429.t2
MMSKIHKNGTLNHHVKPMRRIPTPGKATVLAIGKAFPSQLIPQECLVEGYIRNTKCEDLAIKEKLERLCKTTTVKTRYTVMSKEILDKYPELVIEGSPTIKQRLEIANPAVVEMAMEASLACLKEWGRPVEDITHIVYVSSSEIRLPGGDLYLATKLGLRNDIGRIMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNKARPYDLVGAALFGDGAAAVIVGSDPLMGKESPFFELNYAVQQFLPGTHDVIDGRLSEEGINFKLGRDLPQKIEENIEEFCRKLMAKSDLKEFNDLFWAVHPGGPAILNRLESTLKLRSEKLDCSRRALMDYGNVSSNTIFYVMEYMREELKRDGGEEWGLALAFGPGITFEGILIRSL
>g47429.t1
MLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNKARPYDLVGAALFGDGAAAVIVGSDPLMGKESPFFELNYAVQQFLPGTHDVIDGRLSEEGINFKLGRDLPQKIEENIEEFCRKLMAKSDLKEFNDLFWAVHPGGPAILNRLESTLKLRSEKLDCSRRALMDYGNVSSNTIFYVMEYMREELKRDGGEEWGLALAFGPGITFEGILIRSL
>g127754.t1
MVTVDEVRRSQRAEGPATILAIGTATPPHCVEQSTYPDYYFRITNSEHKTELKEKFQRMCDKSMIKKRYMYLTEDILKENPNVCAYMAPSLDARQDMVVVEVPKLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDAHLDSLVGQALFGDGAAALIVGSDPVPGVEKPLFEMVSAAQTILPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLAEAFQPLGITDWNSLYWIAHPGGPAILDQVEAKLALKPEKLRATRHVLSEYGNMSSACVLFILDEMRRKSAEEGLQTTGEGLEWGVLFGFGPGLTVETVVLHSVPA
>g127753.t1
MSSACVLFILDEMRKNSAKEGAKTTGDGLEWGVLFGFGPGLTVETANGVEDMHHLSPVVNDCRFFMTTFQKCQCNHVYWEMNSCADWLAKHSAAAIEGLIVFVVPPPLSLLLYYDCSGSLHPRCFPLI
>g43912.t1
MAPSLDARQDMVIVEVPKLSKEAATKAIKEWGQPKSKITHLVFCTNSGVDMPSADYQLTKLLCLRPSVKRIIIYHQGCFAGGTALRLAKDLAGNNAGAHVLVVCSEMTALTFRGPSDSHLDSLTGQALFGDGAVAVIVRSNPDTKIERPLFQLVSAAQTILPDSDRAIEGHLREVGLTFHLPKDVPGMISKNIEKSLVEAFKPIGISYWNSLFWIVHPSGPAILDQVEAKLGLKEEKLRANRYVLNDVEANLELKEKKLRATRHLLSEYGNMSSACVLFILDEVRKKSLEEGKVTTGEGLDWGVLFGFGPGITVETVVLQSVPSATTH
>g43910.t1
MASVEEIRKAQRAEGPATILAIGTATPANCVQQSEYPDYYFRITKSEHMTELKEKFKRMCDKSMINKRYMHLNEEILKENPNICEYMAPSLDARQDMVVVEVPKLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNAGARVLVVCSEITAVTFRGPSDSHLDSLVGQALFGDGAAAVIIGADPDTKIERPLFQLVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLVEAFKPIGITDWNSLFWIAHPGGPAILDQVEAKLGLKEEKLRATRHVLSEYGNMSSACVLFILDEVRKKSLEEGKDTTGEGLDWGVLFGFGPGLTVETVVLHSVPAVTTH
>g43915.t1
MASVEEIRKTQRAEGPATILAIGIATPPNCVYQSDYPDYYFRITNSEHMTELKDKFKRICDKSMIKKRYMYLTEEILKENPKICEFMAPSLDARQDMVVVEVPKLGKEAATNAIKEWGQPKSKITHLVFCTNSGVDMPGADYQLTKLLGLRPSVKRLIIYHQGCFAGGTALRLAKDLAENNAGARVLIVCSEITALTFRGPSESHLDSLTGQALFGDGAAAVIVGSDPDTKIERPLFQLVSAAQTILPDSDGAIEGHLREVGLTFHLPKDVPGMISKNIEKSLVEAFKPIGISDWNSLFWIVHPGGPAILDQVEAKLGLKEEKLRANRHVLNDVEANLGLKEEKLRATRHVLSEYGNMSSACVLFILDEVRKKSLKEGKVTTGEGLDWGVLFGFGPGITVETVVLHSVPVATIHG
>g55730.t1
MASSVKEMRGAQRARGAATILAIGTATPVNCLYQADYPDFYFRVTKSGHMTELKDKFKRICEKSMIKKRHMHLTEEILQENPNIGAYKAPSFNSRQDIVVVEVPKLGQEAALKAIKEWDQPKSKITHLVFCSSSGIDFPGADFQLTKLLGLQPSVKRVLINNQGCFAGGTSLRLAKDLAENNACARVLVVCSENMSISFQGPSEAHLDILVGQALFADGAAALIIGANPDTSIEHPLFQIVSAAQTIIPESECALVGHLSEMGLTYNLSANIPEFTSKNIEKSVVEAFGPIGITDWNSLFWIVHPGGPKILDGIESQLPSKRVETQSNSPHTQ
>g93952.t1
MGLTYNLSPNIPKFASKKIEKSLVAAFGPIGITDRNSLFWIVHPGGPAILDGIEAQLGLKESKLRASRHILSEYGNIWSVSVIFILDEIGKKSLEERRTTTGEGLEWGVLIGFGPGMTAETVMLHSMPIVATQ
>g91584.t1
MVTVDEVRMSQRAEGPATILAIGTVTPLHCVEQSTYPDYYLCITNSEHKTELKEKFSACGVETAVPVLLVDGYNITKTKPLSLLGHGAVGGWLVLAKDYKRRASSIKIMKRDQQEGRGKVESCSSMVAAGKGKIKMQEDEQETQDASGMDELLAVLGYKVRNSDMADVAQKLEQLEMVHLFWCMSRGGKSAAHASLCDDSASVAGRVKGGWGAAGAVEVDENISFNYFCEANQVVATTREVVEAAHGQELVGKDVQLVSMQLSKHVQPVPLTLLHLSCVCGAPQDAWPAVESGANLVNALMHWTYYFEVFIFEPSLLFEWKSTWFDAHV
>g71394.t1
MASSVEEMREAQRARGAATILAIGTATPVNCLYQADYPDFYFRVTKSEHMTELKDKFKRICEKSTIKKRHMHLTEEILQENTNIGAYKAPSLDARQDIAVVEVPKLGEEAALKAIKEWDQPKSKITHLVFCSSSGVDFPGADFQLTKLLGLQPSVKRVMINNQGCFAGGTGLRLAKDLAENNAGARVLVVCSEN
>g18117.t1
MCSFRAPSLDARQDILVAEIPRLGKGAAEKAIKEWGQPKSKITHLIVCTTSGVDMPGADYQLIKLLGLRSSVKRAMMYHQGCFAGGTVLRLAKDLTENNEGARVLAVCSEITVDTFRGPLENYLDSLVGQALFGDCAAAFIVGSDPLPGVEKPVFQLVSTAQTILPNSEGGIEGHLREVGLTFHLLDNVPELISKNIEKS
>g39781.t1
MLSVEEVCKAQRADGPATIMGFGTVNPPNCFDQSTYPDFYFDITNSQHMSDLKAKFQRICDKSMIKKRYMYLTEEILKENPNMCSFRAPSLDARQDMLVAEIPRLGKDAAEKAIKEWGQPKSKITHLIFCTTSGVDMPGADYQLIKLLGLRSSVKRAMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITVVTFRGPHENYLDSLVGQALFGDGAAAIIVGSDPLPEVEKPVFQLVSTAQTILPNSEGAIEGHLREVGLTFHLLDNVPELISKNIEKSLVEAFHPLGITDWNSIFWIAHPGGPAILNQVEAKVGLKPEKLRATRHVLSEYGNMSSACVLFILDEMRKNSAKEGAKTTGEGLEWGVLFGFGPGLTVETVVLHSVPI
>g138719.t1
MSLVVCSEITVVTFRGPHENYLVSLVGQALFGDGAAAIIVGSDPLPGVEKPVFQLVSTAQTILPNSEGAIEGHLREVGLTFHLLDNVPELISKNIEKSLVEAFHPLGITDWNSIFWIAHPGGPAILNQVEAKVGLKPEKLRATRHVLSEYGNMSSACVLFILDEMRKNSAKEGAKTTGEGLEWGVLFGFGPGLTVETVVLHSVPI
>g138720.t1
MCSFRAPSLGARQDILVAEIPRLGKGAAEKAIKEWGQPKSKITHLIVCTTSDVDMPGADCQLIKLLGLRSSVKRAMMYHQGCFACGTVLRLAKDLAENNKGARVLVVCSEITVDTFRGPHENYLNSLVGQALFGDGAAAIIVRSNPLPGVEKPVFQLVSTAQTILPNSEDWNSIFWIAHPGGPAILDQVEATVGLKPEKLRAVRHVLSEYGNMSSACVLFILDEMRKKSAKEGAKTTGEGLEWAPARVLRFSSPGKEGNVPLLLVNQFDGQQDYLLGQIIPIAMRAFPEIGINASGLLALFPTAYPRQSAQQISIGRKLYLSKGSLAFLVLPVDSPFNIRRDFHSTTGATCSDTVTGIILTTNCLSSSLSDPDPL
>g103924.t1
MMYQQGCFADGTVLRLAKDLAENNKGARVLVVCSEITVVPFRGPHENYLDSLVGHALFGDGAAAIIVGSDQLPGVEKPVFQLVSTAQTILPARIAKVPLKDTFGRCD
>g75280.t1
MNPEEHPQMKTENTYTERNIDGRLTEEGISFKLSRELPQIIEDNIQGFCDKLMGIGGLCGKDYNKMFWAVHPGGPAILNRLEKRLDLLPEKLNASRKALMDYGNASSNALVYVLEYMIKESLKMKKEEQGDDEWGLILAFGPGITLERILARNLTI
>g14780.t1
MVTVDEVRMSQRAEGPATILAIGTVTPLHCVEQSTYPDYYLCITNSEHKTELKEKFSACGVETAVPVLLVDGYNSTKTKPLSLLGHGAVGGWLVLAKDYKRRASSIKIMKRDQQEGRGKVESCSSMVAAGKGKIKMQEDEQETQDASGMDELLAVLGYKVRNSDMADVAQKLEQLEMVHLFWCMSRGGKSAAHASLCDDSASVAGRVKGGWGAAGAVEVDENISFYYFCEANQVVATTREVVEAAHGQELVGKDGKDGNTVAGFPAHATSILPTLSFHVAKGEYEARADGDNMPFNIDSGMQAGCSPNRVPIMHVVRDSHATRSCDTVEAIGKHAALEARAACSSDVIASLMRMWGSSRCLACCGKWCKFG
MMSKIHKNGTLNHHVKPMRRIPTPGKATVLAIGKAFPSQLIPQECLVEGYIRNTKCEDLAIKEKLERLCKTTTVKTRYTVMSKEILDKYPELVIEGSPTIKQRLEIANPAVVEMAMEASLACLKEWGRPVEDITHIVYVSSSEIRLPGGDLYLATKLGLRNDIGRIMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNKARPYDLVGAALFGDGAAAVIVGSDPLMGKESPFFELNYAVQQFLPGTHDVIDGRLSEEGINFKLGRDLPQKIEENIEEFCRKLMAKSDLKEFNDLFWAVHPGGPAILNRLESTLKLRSEKLDCSRRALMDYGNVSSNTIFYVMEYMREELKRDGGEEWGLALAFGPGITFEGILIRSL
>g47429.t1
MLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNKARPYDLVGAALFGDGAAAVIVGSDPLMGKESPFFELNYAVQQFLPGTHDVIDGRLSEEGINFKLGRDLPQKIEENIEEFCRKLMAKSDLKEFNDLFWAVHPGGPAILNRLESTLKLRSEKLDCSRRALMDYGNVSSNTIFYVMEYMREELKRDGGEEWGLALAFGPGITFEGILIRSL
>g127754.t1
MVTVDEVRRSQRAEGPATILAIGTATPPHCVEQSTYPDYYFRITNSEHKTELKEKFQRMCDKSMIKKRYMYLTEDILKENPNVCAYMAPSLDARQDMVVVEVPKLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDAHLDSLVGQALFGDGAAALIVGSDPVPGVEKPLFEMVSAAQTILPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLAEAFQPLGITDWNSLYWIAHPGGPAILDQVEAKLALKPEKLRATRHVLSEYGNMSSACVLFILDEMRRKSAEEGLQTTGEGLEWGVLFGFGPGLTVETVVLHSVPA
>g127753.t1
MSSACVLFILDEMRKNSAKEGAKTTGDGLEWGVLFGFGPGLTVETANGVEDMHHLSPVVNDCRFFMTTFQKCQCNHVYWEMNSCADWLAKHSAAAIEGLIVFVVPPPLSLLLYYDCSGSLHPRCFPLI
>g43912.t1
MAPSLDARQDMVIVEVPKLSKEAATKAIKEWGQPKSKITHLVFCTNSGVDMPSADYQLTKLLCLRPSVKRIIIYHQGCFAGGTALRLAKDLAGNNAGAHVLVVCSEMTALTFRGPSDSHLDSLTGQALFGDGAVAVIVRSNPDTKIERPLFQLVSAAQTILPDSDRAIEGHLREVGLTFHLPKDVPGMISKNIEKSLVEAFKPIGISYWNSLFWIVHPSGPAILDQVEAKLGLKEEKLRANRYVLNDVEANLELKEKKLRATRHLLSEYGNMSSACVLFILDEVRKKSLEEGKVTTGEGLDWGVLFGFGPGITVETVVLQSVPSATTH
>g43910.t1
MASVEEIRKAQRAEGPATILAIGTATPANCVQQSEYPDYYFRITKSEHMTELKEKFKRMCDKSMINKRYMHLNEEILKENPNICEYMAPSLDARQDMVVVEVPKLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNAGARVLVVCSEITAVTFRGPSDSHLDSLVGQALFGDGAAAVIIGADPDTKIERPLFQLVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLVEAFKPIGITDWNSLFWIAHPGGPAILDQVEAKLGLKEEKLRATRHVLSEYGNMSSACVLFILDEVRKKSLEEGKDTTGEGLDWGVLFGFGPGLTVETVVLHSVPAVTTH
>g43915.t1
MASVEEIRKTQRAEGPATILAIGIATPPNCVYQSDYPDYYFRITNSEHMTELKDKFKRICDKSMIKKRYMYLTEEILKENPKICEFMAPSLDARQDMVVVEVPKLGKEAATNAIKEWGQPKSKITHLVFCTNSGVDMPGADYQLTKLLGLRPSVKRLIIYHQGCFAGGTALRLAKDLAENNAGARVLIVCSEITALTFRGPSESHLDSLTGQALFGDGAAAVIVGSDPDTKIERPLFQLVSAAQTILPDSDGAIEGHLREVGLTFHLPKDVPGMISKNIEKSLVEAFKPIGISDWNSLFWIVHPGGPAILDQVEAKLGLKEEKLRANRHVLNDVEANLGLKEEKLRATRHVLSEYGNMSSACVLFILDEVRKKSLKEGKVTTGEGLDWGVLFGFGPGITVETVVLHSVPVATIHG
>g55730.t1
MASSVKEMRGAQRARGAATILAIGTATPVNCLYQADYPDFYFRVTKSGHMTELKDKFKRICEKSMIKKRHMHLTEEILQENPNIGAYKAPSFNSRQDIVVVEVPKLGQEAALKAIKEWDQPKSKITHLVFCSSSGIDFPGADFQLTKLLGLQPSVKRVLINNQGCFAGGTSLRLAKDLAENNACARVLVVCSENMSISFQGPSEAHLDILVGQALFADGAAALIIGANPDTSIEHPLFQIVSAAQTIIPESECALVGHLSEMGLTYNLSANIPEFTSKNIEKSVVEAFGPIGITDWNSLFWIVHPGGPKILDGIESQLPSKRVETQSNSPHTQ
>g93952.t1
MGLTYNLSPNIPKFASKKIEKSLVAAFGPIGITDRNSLFWIVHPGGPAILDGIEAQLGLKESKLRASRHILSEYGNIWSVSVIFILDEIGKKSLEERRTTTGEGLEWGVLIGFGPGMTAETVMLHSMPIVATQ
>g91584.t1
MVTVDEVRMSQRAEGPATILAIGTVTPLHCVEQSTYPDYYLCITNSEHKTELKEKFSACGVETAVPVLLVDGYNITKTKPLSLLGHGAVGGWLVLAKDYKRRASSIKIMKRDQQEGRGKVESCSSMVAAGKGKIKMQEDEQETQDASGMDELLAVLGYKVRNSDMADVAQKLEQLEMVHLFWCMSRGGKSAAHASLCDDSASVAGRVKGGWGAAGAVEVDENISFNYFCEANQVVATTREVVEAAHGQELVGKDVQLVSMQLSKHVQPVPLTLLHLSCVCGAPQDAWPAVESGANLVNALMHWTYYFEVFIFEPSLLFEWKSTWFDAHV
>g71394.t1
MASSVEEMREAQRARGAATILAIGTATPVNCLYQADYPDFYFRVTKSEHMTELKDKFKRICEKSTIKKRHMHLTEEILQENTNIGAYKAPSLDARQDIAVVEVPKLGEEAALKAIKEWDQPKSKITHLVFCSSSGVDFPGADFQLTKLLGLQPSVKRVMINNQGCFAGGTGLRLAKDLAENNAGARVLVVCSEN
>g18117.t1
MCSFRAPSLDARQDILVAEIPRLGKGAAEKAIKEWGQPKSKITHLIVCTTSGVDMPGADYQLIKLLGLRSSVKRAMMYHQGCFAGGTVLRLAKDLTENNEGARVLAVCSEITVDTFRGPLENYLDSLVGQALFGDCAAAFIVGSDPLPGVEKPVFQLVSTAQTILPNSEGGIEGHLREVGLTFHLLDNVPELISKNIEKS
>g39781.t1
MLSVEEVCKAQRADGPATIMGFGTVNPPNCFDQSTYPDFYFDITNSQHMSDLKAKFQRICDKSMIKKRYMYLTEEILKENPNMCSFRAPSLDARQDMLVAEIPRLGKDAAEKAIKEWGQPKSKITHLIFCTTSGVDMPGADYQLIKLLGLRSSVKRAMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITVVTFRGPHENYLDSLVGQALFGDGAAAIIVGSDPLPEVEKPVFQLVSTAQTILPNSEGAIEGHLREVGLTFHLLDNVPELISKNIEKSLVEAFHPLGITDWNSIFWIAHPGGPAILNQVEAKVGLKPEKLRATRHVLSEYGNMSSACVLFILDEMRKNSAKEGAKTTGEGLEWGVLFGFGPGLTVETVVLHSVPI
>g138719.t1
MSLVVCSEITVVTFRGPHENYLVSLVGQALFGDGAAAIIVGSDPLPGVEKPVFQLVSTAQTILPNSEGAIEGHLREVGLTFHLLDNVPELISKNIEKSLVEAFHPLGITDWNSIFWIAHPGGPAILNQVEAKVGLKPEKLRATRHVLSEYGNMSSACVLFILDEMRKNSAKEGAKTTGEGLEWGVLFGFGPGLTVETVVLHSVPI
>g138720.t1
MCSFRAPSLGARQDILVAEIPRLGKGAAEKAIKEWGQPKSKITHLIVCTTSDVDMPGADCQLIKLLGLRSSVKRAMMYHQGCFACGTVLRLAKDLAENNKGARVLVVCSEITVDTFRGPHENYLNSLVGQALFGDGAAAIIVRSNPLPGVEKPVFQLVSTAQTILPNSEDWNSIFWIAHPGGPAILDQVEATVGLKPEKLRAVRHVLSEYGNMSSACVLFILDEMRKKSAKEGAKTTGEGLEWAPARVLRFSSPGKEGNVPLLLVNQFDGQQDYLLGQIIPIAMRAFPEIGINASGLLALFPTAYPRQSAQQISIGRKLYLSKGSLAFLVLPVDSPFNIRRDFHSTTGATCSDTVTGIILTTNCLSSSLSDPDPL
>g103924.t1
MMYQQGCFADGTVLRLAKDLAENNKGARVLVVCSEITVVPFRGPHENYLDSLVGHALFGDGAAAIIVGSDQLPGVEKPVFQLVSTAQTILPARIAKVPLKDTFGRCD
>g75280.t1
MNPEEHPQMKTENTYTERNIDGRLTEEGISFKLSRELPQIIEDNIQGFCDKLMGIGGLCGKDYNKMFWAVHPGGPAILNRLEKRLDLLPEKLNASRKALMDYGNASSNALVYVLEYMIKESLKMKKEEQGDDEWGLILAFGPGITLERILARNLTI
>g14780.t1
MVTVDEVRMSQRAEGPATILAIGTVTPLHCVEQSTYPDYYLCITNSEHKTELKEKFSACGVETAVPVLLVDGYNSTKTKPLSLLGHGAVGGWLVLAKDYKRRASSIKIMKRDQQEGRGKVESCSSMVAAGKGKIKMQEDEQETQDASGMDELLAVLGYKVRNSDMADVAQKLEQLEMVHLFWCMSRGGKSAAHASLCDDSASVAGRVKGGWGAAGAVEVDENISFYYFCEANQVVATTREVVEAAHGQELVGKDGKDGNTVAGFPAHATSILPTLSFHVAKGEYEARADGDNMPFNIDSGMQAGCSPNRVPIMHVVRDSHATRSCDTVEAIGKHAALEARAACSSDVIASLMRMWGSSRCLACCGKWCKFG
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University