Enzyme

Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.

COMT

Enzyme

Flavone 3'-O-methyltransferase

Enzyme name

EC:2.1.1.76

Entry

Transferases;Transferring one-carbon groups;Methyltransferases

Class

S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase

Sysname

S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]

Reaction

S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]

Product

Species information

Gelsemium sempervirens

Species name

Gelsemium sempervirens is a species of eudicot in the family Gelsemiaceae.

Species info

Gene sequence info

Gelsemium_sempervirens.COMT.fa

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>CRO_T101315
MGSANPDNKNSMTKEEEEACLSAMRLASASVLPMVLKSAIELDLLELIKKSGPGAYVSPSELAAQLPTQNPDAPVMLDRILRLLASYSVLNCTLKDLPDGGIERLYSLAPVCKFLTKNEDGVSMAALLLMNQDKVLMESWYHLKDAVLEGGIPFNKAYGMTAFEYHGKDPRFNKVFNQGMSNHSTIIMKKILEIYQGFQGLKTVVDVGGGTGATLNMIVSKYPSIKGINFDLPHVIEDAPSYPGVDHVGGDMFVSVPKGDAIFMKWICHDWSDAHCLKFLKNCHEALPENGKVILAECLLPEAPDSTLSTQNTVHVDVIMLAHNPGGKERTEKEFEALAKGAGFRGFIKVCCAYNSWIMELLK
>CRO_T117181
MGSQQKDQIIHISNKEEEDFLRVMQLPSGVVLSMVLKAAIELDLFQIMAKSGPKAQLSAAEIASNLPTKNPEAPVMLDRMMRFLANSSFLGCSVVTDEDGSSKRLYNLAPICKNFLPNEDGVSLAPLSIIPLDKVQFEYHLKDAILEGGIPFNRAHGMHAFEYPAKDSRFNELFNKGMYNHTCIAMKRLVQVYNGFEGVKQVVDVGGGFGATLGCIISKYPNIHAINFDLPHVIQNAPPRPGVEFVGGDMFESVPKGEVILMKWILHDWSDEHCVKLLKNCYKALPETSKVIVVETVLPETPEDGNIISKIGFQTDLCMMSINPGGKERTLKEFELVAKQAGFTSIQPICRAYSDWREQIIHISNKEEEDFLRVMQLPSGIVLPMVLKAAIELDLFQIMAKSGPNAQLSAAEIASNLPTKNPEAPVMLDRMMRFLANSSFLGCSVVTDEDGSSKRLYNLASICKNFLPNEDGVSLAPLYHLKDAILEGGIPFNRAHGMHAFEYPAKDSRFNEVFNKGMYNHTCIAMERLVQVYNGFEGVKQIVDVGGGFGATLGCIISKYPNIHAINFDLPHVIENAPPRPGVEFIGGDMFESVPKGEVILMKWILHDWSDEHCVKLLKNCYKALPETSKVIVVESILPETPEDGHILAKIGFQSDMSMMSINPGGKERTHKEFELVAKQAGFTSIQPICRAYSDWVIEFYKN
>CRO_T125117
MSSLVQDETTNIISNEKEDFLRVMQLSSGLILPMILKTVIELDLFELMAKAGPNAQLSAIEISSLLPTKNPEAPVMLDRILKFLASFSFLNCNVIADEQGGAKTLYSLAPICKKFLPDEDGISLASLLMLPVDKAHFDSWYHLKDAILEGGIPFIRAHGADAFEQPIKDTRFFDVFNKALHNHACMVMKRLLEVYKGFEEVKELVDVGGGHGGTLSCIVAKYPNIRAINYDIPQVVECAAPRSGVEFVRGNMFESIPKGEVMMMKWVLHDWDDDHCVTILKNCYEALPENGKLIVIELVLPETPNGDTISKIGYQFDINMLSVNTGGKERTEKEFEHLATQAGFASIKLICRADCDWVIEFYKN
>CRO_T125119
MGSYRPLEDTSDAILEEGIPFIRAHGADAFEQPIKDTRFFDVFNKALHNHACMVMKRLLEAYKGFEEVKELVDVGGGHVGTLALLPNIQIFVLLSMIFLRSWNVPLLARWVLHDWGDDHCVTILKNYYEALPENGKLIVIELVVPETPNGDTISKSGYQFNINMLSVNTGGKERTEKEFEHLATQSGFASIKLICRADCDWIIEFYKN
>CRO_T133320
MNIMYVRRFDQSVVRISSYRQDQKFNKTFNVSILQHTKVILAKIVENYKGFENLKPFVDVSCGACITLSVITSEFPTLNGGHYDLLWVEYAPTYPNMFLIYNLFHNICRSYKKEKLH
>CRO_T133966
MIHHTKLVVQRILKRYQEFETLKTLVDVDSGLHIVLRVITCKHSNLKSMHYLIHVGLYTFIYSRIATRLPSPANGKVIAVDAILPLNPDNSSSTKHTTQVDLFTLASYHPGGKERTEHEYLALAIEAVLKR
>CRO_T133962
MVFNSVVKLNVLKIIARAGTDAKLSPSQTVSQMPMLASYSVVTSYVVDPCRGFGQSQRVYGLGPVAKYFVNNENGASRGPLLDLLQDKVLNDIWNKLELILKGVQHSIGPTTCIYSNTEINIKFNYKFNATMIHHTKLVVQRILKSYEGFENLKTLVDVDGGLDIVLRVITCKHSNLKGINYDLSSFRNKSYSRIATRLPLPVNGKVIAVDAILPLNPHNSLSNKHTTQVDLFILASYHPGGKERTEQEFLALAIEAGFKEIRKVCVCYDSWVMEFYKRN
>CRO_T133974
MVLNYVIKLNVLKIIARANTGALSPSQTVSQMPMLASYSVVTSYVVDPSRGSGQSQKMYGLGPVAKYFVNNENGASLGPLLDLHQDKVLNDICYSRIATRLSSPVNGKVIAVDAFLPLNPDNSPSTEHTTQVDLFTLASYHSGGKERTEHEFLALAIEAGFKEIRKACVCYDSWLMEFYKRN
>CRO_T133976
MVLNSVIKLNVLKITARAGTGAQLSPSHTVSQMPMLASYSVVTSYVVDPSRGSGQSQRMYGLGPMEKYFVNNKNGASLGPLLDLLQDKNLQILKGVQHSIGLTTCIYSNIEINNKFNNKFNITMIHHTKLVVQRILKSYQEFETLKTLVDVDSGIDIVLRVIACKHSNLKVINYDLSHVIEHAPSYSRRTIHFHVSFFFFGESYSRIATRLPSPLNGKVIAGDAILPLNPDNIPSTKHTTQVDLFTLASYHPGGKERTEQEFLAIAIEAGFKKIRKACVCYDSWVMEFYKRN
>CRO_T133971
MEYRKGSKIWNLPDEFLLERFFKKDIDLQGLNFAPFVNEPDIRTFGTRKFLYPPGLVAGERLPIIGSYTSSPFERWHWCSTIPSQTVSQMPMLASYSVVTSYVVDPSRGSGQSQRMYGLGPLAKYFVNNENGASLGHLLDLLQDKVLDDICYQEFETLKTLVDVDSGLDIVLRVIACKHSNLKVINYDLSHVIEHTPSYSRRTIHFHWILHDWDDSHYLKLLKDCYKASFTSKVIAVDAILPLNPDNSPSTKHTTQVDLFTLASYHPGGKEQTEQEFLALAIEAGFKEIRKACICYDSWFMEFYKRN
>CRO_T134200
MDFQSVEFLKLGIADAIDNHNKKAFTLSKFTKELSIKPSKSSFLPRLMRQLVNNEQWNFRGIVLTMLDPAELKAWSVLNDWFQNDDPIAFQTAHEKNHWDYTVENTQHCPIFEDAMANDSVLVSKLLFLFEGLTSLIDLGGSTGTIAKAIAKSFPKSKCTVFDLPHVVANLKSTENLEFVGGDMFEKLPPTNAILLKKTSHGTPITCKPEKTSIT
>CRO_T138179
MCGPTVHFRQTSTHISGSSWTLDLLRSSYSNKFKESNLPLDTMGSHEVKTSSLSREEEENDNSSYALQLLFSGALPMVLNTVIKLNVFEIIAREGPNAQLSPSQIVSQIPNNKNPQAPEMLDRMLRMLASYSIFTCSVVDSNKRVYGLGTVSKMKMDHHLILFLTCFNINSPTKHGNKISLLLLSILYELGAAVLEGGIPFERAHGMPIYKYAGLDQKFNEIFNTSMLHHTKVVVAKIVENYKGFENIKTLVDVGGGTGMALSVITSKFPNLKGINYDLPHVIEHALIYPGVEHIGGDMFESVPEGDAIFMKTVLHNWDDDHCLVLLKNCYKSLPENGNLIVVDAVLPMNPDSSSSTKHTTQVDMFMLLNQQPGAKERTEQEFLTLATKVGFKGIRKKYVSFDLWVMEFYK
>CRO_T139166
MGLIFASFLVVQYFELPCGNAVSCLFPYYSARIYEGKKTTEPINNNNNNNNNNNNNNNNNNNNNNNNNSVSGDINPAINFHNRDEEQEDPIDQSWLLDLSENSTVNETKSTNCSLENGRNVSDHSKWPGKFVLGANDELNTTEGNDKSRLRHCDSGILGRNSPANKGISKGKVVSISAMNNMLIQSHDLSLSNSMEEQCYSARDQELLHARSSIQEAPIYKTNPALYAPIYWNVSRFQRSYELMEQTLKVYIYREGKRPVFHQPNLKGIYASEGWFMKLMESSKQYITTNPKEAHLFYLPFSSQMLEQTVYVPNSHSFDKLKQYLGNYLDLIKTKYSFWNRTNGADHFLVACHDWAPEETRRLMANCIRALCNADMIEGFQLGKDVSLPETFVQTARFSPKEFRGKPPSGRQFLAFFAGNMHGYVRPILLKYWENKDPDMKIFGRMNKGSYINHMKSSKYCICARGYEVNSPRLVEAIMYGCVPVIISDNFVPPFLEVLNWEKFAVFVLEKDIPNLKNILVSISERRYLVMQRRVKMIRQHFVWHPVPEKYDIFHMILHSIWYNREFPKMKESSLGPPGVAVSISEMNDKLLHSLALRHPVRPQWTSGADQELLHVKSLIENAPNSQDDLDLHAPLFRNISMFKRSYELMEQTLKVYIYKEGERPIYHTPVLKGIYASEGWFMKLIKRSKQFVTKNPKNAHLFYLPFSSRMLEETLYVPNYDSRDNLIQNLSDYLNVIIRRYQFWNRTGGSDHFLVACHDWAPEETRGIMANCIRALCNADVKEGFVFGKDVSLPETNVRSPQNPLKLLGGKPPSQRKILAFFAGRMHGYLRPILLKYWENDRDMKILGKMPRVKGQMNYVQHMQSSKYCICAKGYEVNSPRVVEAIFFECVPVIISDNLVPPYFETLNWESFAVFIMEKDIPNLKNILLSIPAKKYLQMQRRVKLVQRHFLWNPKPVKYDIFHMILHSIWFTRGVAVSISEMNDKLLHSLALPHSVRPRWTSRADQELLHVKSLIENAPNAQDDPNLHAPLFRNISMFKRSYELMAQTLKVYIYKEGARPIYHTPVLKGIYASEGWFMKLMKTSKQFVTKNPKSAHLFYLPFSSRLLEETLYVPNSHSRDNLIQNLSDYLNVIMRRYQFWNRTGGSDHFLVACHDWAPSETRRIMANCIRALCNADVKEGFVFGKDASLPETNVRSPQNPLKQVGGKPASKRKILAFFAGRMHGYLRPILLKYWENKDPDIKIFSKMPKVKGQMSYIQHMQSSKYCICAKGYEVNSPRVVEAIFYECIPVIISDNFVPPFFETLNWESFAVFIMEKDIPNLKNILLSIPKKKYIQMQRRVKLVQKHFLWNPKPVKYDIFHMILHSIWLNRPPKWYSNADQELLYAKSRILNAMTVNNAAGLQAPIYRNVSMFQRSYELMEKMLKVYIYKDGERPIFHDSILEGIYASEGWFIKLMESNKQYVTDDPAKAHLFFLPFSSRLLQLTLYKRHSHSRDNLIKYMKDYVEMLAQKYPFWNRTEGEDHFLAACHDWAPTETRGLLKNSLRALCNADIRVGFDIGKDVSLPTTYVRSSQKPLKDIGGEPPSQRHILAFFAGYMHGYVRPVLLDHWGKDPDMRIFDRMPHVKGDKNYIEHMKSSKYCICARGYAVNSPRVMESILYECVPVIISDNYVPPLFEVLNWESFAVFISEKDIPKLKSILLSISMEKYIEMQKRVKQVKEHFVWHADPVEYDLFHMILHSVWYNRVFRIKPP
>CRO_T107102
MGLFINFRFAVFGYKGSHEAKTTSFSTEEEENDNSSHAMQLLFSRALPMVLNTVIKLNVFEIIAREGPNAQLSPFQIVSQMPNNKNSQAPEMLDRMLRMLASYSIFTCSVVDSNKRVYGLGTVSKYFVKNESGSSLGPFLDLLQHKLTNEAWYELGAAVLDGGILFERAHRMPIYKYAGLDQKFNETFNVSMLHQIKMVVANIIENYKGFENLKTLVDVGDGAGIALSVITSKFPNIKGINYDLPHVILHAPKYPALPENGNLIVVDAIIPMNPDNRSSTKHTAQVDMFILLNQQLGVKERTKQEFFTLATKAGFKGIQKKCVFFDLWVMEFNK
>CRO_T109095
MTNEEEEEACLSAMRLASASVLPRVLKLAIELDLLELIKKSGTGAYVSPSELAAQLPTQNLEAPVMLDRILRLLACYSVLNCTLKDLPDGGVESLYGLAPVCKFFTKNEDGVSMAALLLMNQDKVLMESCYHLKDAAYGMSAFEYHGKDPRFNKVFNQGMSNHSTIIMKKILEIYQGFQGLKTVVDVGGGTGATLNMIVSKYLIIKGINFDLPHVIEDAPSYSGVDHIGGPKGDAIFFKVHYYYYFTSLSLLFVPISDSVNGFFLLALDCHDWSDEDRLKLLKNCHEALPENGKKPQTTLSTQNTVQVDVIMLAYNPGGKEGTENEFEALAKAADFRGFTKVCCPYNTWIMEFLK
>CRO_T112287
MSSHEEKPSSNKEDDDYSSYALQLVFSGALPMVLNAVIKLNVFEIIAKAGPGAKLSPSQIVSQMPTKNPEAPVVLDRMLRMLASYSVLTCSVVDFSHGSGQRVYGLSPVSKYFVKNENGGCFGPLLDLLQDKVLTDIWYELAPAVLEGGTAFNRAYNMHIFKYTGINQKFNETFNTATINHAKVIVQEILKNYKGFENLKTLVDVGGGLGVTLDLITSKYPNLKGINYDLPHVTQNAPTYPGVVHVGGDMFESVPKGDAIFMKWILHDWDDEHCLKLLKNCYKALPENGKVIAVDAILPMNPDNSSSTKHISQVDLFTLVLYHPGGKERTENEFLALVAEAGFGGIRKVCVCCDLWVMEFYK
>CRO_T114638
MVSYNKPQSLRSAVQLGIPDAIHQHGKPMKLSDLVSSIQIILLKHHPLMRLEIRLLMNYLIGLWLNIHKFFLSLWNNIFEGLTSLVDVGDGSGALAKTIAGKFPDLVCIIVYPPHVVAGLEMEENLEF
>CRO_T123024
MGSHEAKTTSFSTQEEENDNSSYAMQLLFSGALPMVLNTVIKLNVFEIIAREGPNAQLSPFQIVSQMPNNKNSQAPEMLDRMLRMLASYSIFXCSVVDSNKRVYGLGTVSKYFVKNESGSSLGPFLDLLQHKLTNEAWYELGAAVLDGGIPFERAHRMPIYKYAGLDQKFNETFNVSMLHQTKMVVANIIENYKGFENLKTLVDVGGGAGVALSVITSKFPNIKGINYDLPHVIEHAPKYPGVEHIGGDMFVSVPEGDAIFMKTVLHNWDDDHCLRLLKNCYKALPESGNLIVVDAIIPMNPDNSSSTKHIAQVDMFMLLNQQPGAKERTEQEFFTLATKAGFKRIQRKCVFFDLWVMEFNK
>CRO_T123019
MGSHEAKTSSFSTEEENDNSSYAMQLLFSGALPMVYGLGTVSKYFVKNENGSSLGPFLDLLQHKLTNEAWYELGAAVLYGGIPFERAHQMPIYKYAGRDQKFNETFNVSMLHQTKMVLAKIIENYQGFENLKTLVDVGVGASVALSVITCKFPNIKGINYDLPHVTEHAPKYSGVKHIGGDMFVSVPEGDVIFMKNTSLQFLPNEKVQRKLLKNCYKALPESGNLIVVDAIIPMNPDNSSSTKHTT
>CRO_T125237
MSSANPDNKKSMTNEEEEEEACLSAMRLASASVLPMVLKSAIELDLLELIKKSGPGAYVSPSELAAQLPTQNPDAPVMLDRILRLLASYSVLNCTLKDLPDGGVQRLYGLAPVCKFLTKNEDGVSMAALLLMNQDKVLMESWYHLKDAVLEGGIPFNKAYGMSAFEYHGKDPRFNKVFNQGMSNHSTIIMKKILEIYQGFQGLKTVVDVGGGTGATLNMIVSKYPSIKGINFDLPHVIEDAPSYPGVDHVGGDMFVSVPKGDAIFMKWICHDWSDEHCLKLLKNCHEALPENGKVILAECVLPEAPDSTLSTQNTVHVDVIMLAHNPGGKERTEKQFDALAKAAGFRGFNKVCCAYNSWIMELLK
>CRO_T125267
MDSSHTNQTKREVNINEEEEQHFSYAMQLVTTGSLPMVLLAAIRLDVFEIIAEAGPSAQLSPSEIATRLSLKNPDASLMLDRMLRLLATHSVLTCAGAAGEGEGAIPRVYGLSPVSKYFVRNPEGASLGALLALLQDKVFTDSWYELEDSVREGGIPFNRVHGTHAFEYPGRDPRFNEVFNKAMIDHTTIVINRILEIYKGFDEHLIRSLVDVGGGLGITLNMITMKYPNIKGINFDLPHVIQHAPAYPGVEHVGGDMFQRVPKGDAIFMKWILHDWDDNHCLKLLKNCHDALSDGGKVIVVDALLPAKPGEDDADTINSSAYGKATCQVDLIMMTQNPGGKERSKEEFVALAAAAGFRSINIEFFVCNLWIMEFYK

Gene tree

Gene tree

Sheng jun & Dong yang Teams, Yunnan agriculture University