Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Gelsemium sempervirens
Species name
Gelsemium sempervirens is a species of eudicot in the family Gelsemiaceae.
Species info
Gene sequence info
Gelsemium_sempervirens.CHS.fa
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>CRO_T104104
MACIQKIWRAQRAEGPASIMAIGTSVPVNCVPQSTFPDYYFRVTNAEHLTELKEKFRRICKGSTIKKRYMYLNEEILKQHPNLCSFMAHSLDARQDMAMKEVPKLGKDAAEKAIEEWGQPKSTITHLIFCTSTGSELPGADYRLTRLLDLNPSIKRIMLYQLGCYGGGEALRVAKDMAENNKGARVLVVCSEISSVGMLCHPNNTNSNPIVANALFGDGAGACIVGSDPINGCEKPLFELISASQTIIPNSECAIESFISEVGISLRILRDIPELISSRAENILREVFQPLGIYDWNSIFWVVHPGGRAIFDQIEKKLALDPERLNVSRHVLSEYGNPLGASIFFVLDEMRNYSAKNGFCTTGEGLEWGVLFAFGPGLTCETIVLHSIPN
>CRO_T104096
MAATVVSIRRAQRAEGPASIMAIGTAVPVNCVTQNTFPDYFFRVTNAEHLTELKEKFRRMCKGSLIKKRYMHMSEQILKENPNLSTYMAPSLGVRQKILLAELPKLGKEAAEKAIKEWGQSKSKITHLIFCTTFGGELPGADHCLTGLLDLNPSIKRIMLYQLGCYGGNAALRAAKDLAENNKGARILVVCSEIPSIAMFGHPDNSNIDTVLGHALYGDGAGACIVGSDPIIGFERPIFELAFADQTIIPDTDGAIESSIIEVGTRLHLEKGIPELISNNIENLLKDAFKPLGIFNWNSIFWVAHLGGSAIFDQVEKKLGLQPEKLYVSKYVLSEYGNPLGASTFFILDEMRRYSAKNGFNYSGEGLEWGVLFGFGPGLTCETMVLRSVSI
>CRO_T113006
MAGPKNEKPRKATILALGKAFPHQLVMQEFLVDGYFKNTNCDDPLLKQKLTRLCKTTTVKTRYVVMSEEILSKYPELATEGLPTVKQRLDICNSAVTQMAIEASQSCIKNWGRSISDITHLVYVSSSEVRLPGGDLYLAKGLGLSPETQRVMLYFSGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGYKPPSAERPYDLVGAALFGDGAGAMIIGINPIPGSENPLFELHTSIQHFLPETEKIIDGRLTEEGISFKLARELPQIIEDNIEGFCSKLMKNSGFCEKDYNKLFWAVHPGGPAILNRIEKKFELSPEKLIASRRALADYGNVSSNTIVYVLEYMLEESKKKASKEENDDEWGLVLAFGPGITFEGILARNLTI
>CRO_T122241
MDITEFRRAQRAEGPATIMAIGTATPPNCMDQSTYPDYYFRITNSEKSMIKKRYMYLTEEILKGNPNLCGYMEPSLNARQDMMVVEVPRLGKEAAQKAIREWGQPKSKITHLIFCTTSGIDIPGADYQLTKLLGLRPSVNRFMIYQQGCFAGGTALRLAKDLAENTKGARILIVCSEITAFTFRGPSLTHVDTLVGQALFADGAAAAIVGSDPIQDIEKPLFQIISASQTLIREGHGAIDGHVREAGLLIHLLKDIPGIISNNIETALDEAFQPFGISDWNSIFWIVHPGGPAILDQVEEKLALKPEKLRSTRHILSEYGNMSSACVLFILDEMRMSSLKDGLSTTGEGFEWGILFGLGPGLTVEKVVLRSTSI
>CRO_T125803
MVNVEEIRNAQRAQGPATVLAIGTSTPLNCVDQSTYPDYYFRITNSEHKTELKEKFKRMCEKSMIKKRYMHLTEEILQENPNICAYMAPSLDARQDIVVVEVPKLGKEAAQKAIKEWGQSKSKITHLVFCTTSGVDMPGADYQLTKLLGLRSSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSESHLDSLVGQALFGDGAAAIIVGSDPIPEIERPLFELVSTAQTLLPDSHGAIDGHLREVGLTFHLLKDVPGLISKNIGKALDEAFQPLGISDWNSIFWIAHPGGPAILDQVEEKLGLKPEKLRATRHVLSEYGNMSSACVLFILDEMRKASARDGLSTTGEGLEWGVLFGFGPGLTVETVVLHSLNV
>CRO_T110117
MAQISTITTVSSRRAPTPGKATLLSIGKAFPSQLVPQEHLVEGYIRDTKCDDIIIKEKLERLCKTTTVKTRYTVMSKEILEKYPELATEGSPTIKQRLEIANPAVVKMAKEASLACIKEWGRPVEEITHIVYVSSSEIRLPGGDLYLASELGLRSDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNKSRPYDLVGAALFGDGAAAIIIGADPIVGKEFPFMELNFAVQQFLPGTNDVIDGRLSEEGINFRLGRDLPQKIEENIEEFCKKLMSKADNLKEYNDLFWAVHPGGPAILNRLESILKLKHEKLDCSRRALMDFGNVSSNTIFYVMEYMREELKKNKEEDSEEWGLALAFGPGITFEGILMRRKRKTGYTGGLAEKFGRLTPLIKTSAILHPSLHSGPLFLTANFFHRLPSSISASSSTISYQGYRLLSSLLTKIIAEHAVRDSDGREMETFVSAETRPLLGNDASSSGSTFSISETSSAALDAPPVHDGTSRASAGNSFQNSHSHTNSSNSNQSGISLFQGLIDRVRKTVRGSADDIGWMQRDPHMPPVEDGTEKFVEILDDIRHGLHRLPSSMVYLLVPGAHHDMSRGEMLQPSLFSNHGPLYFTATKTSFSKMGLTCHIAKIHSEASVEKNAREIKDYIEEIYWGSRKRVLLLGHSKGGIDAAAALSMYWMDLKDKVAGLALAQSPYGGSPIASDILREGQLGDYVNIRKLMEILICKVIKGDMQALEDLTYDKRKDFLRKYHLPQELPVVSFHTEASISPAVLATLSRVAHAELPMFSTGQATTLPVVMPLGAVMAACAQLLQIRYGEKSDGLVTCRDAEVPGSVVVRPKRKLDHAWMVYSSLNDDPSEADASQVCEALLALVVEVGHKKRHQLANKDE
MACIQKIWRAQRAEGPASIMAIGTSVPVNCVPQSTFPDYYFRVTNAEHLTELKEKFRRICKGSTIKKRYMYLNEEILKQHPNLCSFMAHSLDARQDMAMKEVPKLGKDAAEKAIEEWGQPKSTITHLIFCTSTGSELPGADYRLTRLLDLNPSIKRIMLYQLGCYGGGEALRVAKDMAENNKGARVLVVCSEISSVGMLCHPNNTNSNPIVANALFGDGAGACIVGSDPINGCEKPLFELISASQTIIPNSECAIESFISEVGISLRILRDIPELISSRAENILREVFQPLGIYDWNSIFWVVHPGGRAIFDQIEKKLALDPERLNVSRHVLSEYGNPLGASIFFVLDEMRNYSAKNGFCTTGEGLEWGVLFAFGPGLTCETIVLHSIPN
>CRO_T104096
MAATVVSIRRAQRAEGPASIMAIGTAVPVNCVTQNTFPDYFFRVTNAEHLTELKEKFRRMCKGSLIKKRYMHMSEQILKENPNLSTYMAPSLGVRQKILLAELPKLGKEAAEKAIKEWGQSKSKITHLIFCTTFGGELPGADHCLTGLLDLNPSIKRIMLYQLGCYGGNAALRAAKDLAENNKGARILVVCSEIPSIAMFGHPDNSNIDTVLGHALYGDGAGACIVGSDPIIGFERPIFELAFADQTIIPDTDGAIESSIIEVGTRLHLEKGIPELISNNIENLLKDAFKPLGIFNWNSIFWVAHLGGSAIFDQVEKKLGLQPEKLYVSKYVLSEYGNPLGASTFFILDEMRRYSAKNGFNYSGEGLEWGVLFGFGPGLTCETMVLRSVSI
>CRO_T113006
MAGPKNEKPRKATILALGKAFPHQLVMQEFLVDGYFKNTNCDDPLLKQKLTRLCKTTTVKTRYVVMSEEILSKYPELATEGLPTVKQRLDICNSAVTQMAIEASQSCIKNWGRSISDITHLVYVSSSEVRLPGGDLYLAKGLGLSPETQRVMLYFSGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGYKPPSAERPYDLVGAALFGDGAGAMIIGINPIPGSENPLFELHTSIQHFLPETEKIIDGRLTEEGISFKLARELPQIIEDNIEGFCSKLMKNSGFCEKDYNKLFWAVHPGGPAILNRIEKKFELSPEKLIASRRALADYGNVSSNTIVYVLEYMLEESKKKASKEENDDEWGLVLAFGPGITFEGILARNLTI
>CRO_T122241
MDITEFRRAQRAEGPATIMAIGTATPPNCMDQSTYPDYYFRITNSEKSMIKKRYMYLTEEILKGNPNLCGYMEPSLNARQDMMVVEVPRLGKEAAQKAIREWGQPKSKITHLIFCTTSGIDIPGADYQLTKLLGLRPSVNRFMIYQQGCFAGGTALRLAKDLAENTKGARILIVCSEITAFTFRGPSLTHVDTLVGQALFADGAAAAIVGSDPIQDIEKPLFQIISASQTLIREGHGAIDGHVREAGLLIHLLKDIPGIISNNIETALDEAFQPFGISDWNSIFWIVHPGGPAILDQVEEKLALKPEKLRSTRHILSEYGNMSSACVLFILDEMRMSSLKDGLSTTGEGFEWGILFGLGPGLTVEKVVLRSTSI
>CRO_T125803
MVNVEEIRNAQRAQGPATVLAIGTSTPLNCVDQSTYPDYYFRITNSEHKTELKEKFKRMCEKSMIKKRYMHLTEEILQENPNICAYMAPSLDARQDIVVVEVPKLGKEAAQKAIKEWGQSKSKITHLVFCTTSGVDMPGADYQLTKLLGLRSSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSESHLDSLVGQALFGDGAAAIIVGSDPIPEIERPLFELVSTAQTLLPDSHGAIDGHLREVGLTFHLLKDVPGLISKNIGKALDEAFQPLGISDWNSIFWIAHPGGPAILDQVEEKLGLKPEKLRATRHVLSEYGNMSSACVLFILDEMRKASARDGLSTTGEGLEWGVLFGFGPGLTVETVVLHSLNV
>CRO_T110117
MAQISTITTVSSRRAPTPGKATLLSIGKAFPSQLVPQEHLVEGYIRDTKCDDIIIKEKLERLCKTTTVKTRYTVMSKEILEKYPELATEGSPTIKQRLEIANPAVVKMAKEASLACIKEWGRPVEEITHIVYVSSSEIRLPGGDLYLASELGLRSDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNKSRPYDLVGAALFGDGAAAIIIGADPIVGKEFPFMELNFAVQQFLPGTNDVIDGRLSEEGINFRLGRDLPQKIEENIEEFCKKLMSKADNLKEYNDLFWAVHPGGPAILNRLESILKLKHEKLDCSRRALMDFGNVSSNTIFYVMEYMREELKKNKEEDSEEWGLALAFGPGITFEGILMRRKRKTGYTGGLAEKFGRLTPLIKTSAILHPSLHSGPLFLTANFFHRLPSSISASSSTISYQGYRLLSSLLTKIIAEHAVRDSDGREMETFVSAETRPLLGNDASSSGSTFSISETSSAALDAPPVHDGTSRASAGNSFQNSHSHTNSSNSNQSGISLFQGLIDRVRKTVRGSADDIGWMQRDPHMPPVEDGTEKFVEILDDIRHGLHRLPSSMVYLLVPGAHHDMSRGEMLQPSLFSNHGPLYFTATKTSFSKMGLTCHIAKIHSEASVEKNAREIKDYIEEIYWGSRKRVLLLGHSKGGIDAAAALSMYWMDLKDKVAGLALAQSPYGGSPIASDILREGQLGDYVNIRKLMEILICKVIKGDMQALEDLTYDKRKDFLRKYHLPQELPVVSFHTEASISPAVLATLSRVAHAELPMFSTGQATTLPVVMPLGAVMAACAQLLQIRYGEKSDGLVTCRDAEVPGSVVVRPKRKLDHAWMVYSSLNDDPSEADASQVCEALLALVVEVGHKKRHQLANKDE
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University