Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Gelsemium sempervirens
Species name
Gelsemium sempervirens is a species of eudicot in the family Gelsemiaceae.
Species info
Gene sequence info
Gelsemium_sempervirens.4CL.fa
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>CRO_T101191
MLSVEAPHNKELSSSTTTNPKQSSSHHELHIFRSKLPEIPISNHLPLHTYCFEKFSEFPDRTCLIVGSNGKTFTFAETHLICRKVAAGLTTLGIKQGDVIMILLQNSAEFVFSFMGASIIGAVTTTANPFYTSTEIFKQFKASKAKLIITQSHYVQKLRDAPDDCPRLGEEFRVITVDEPPKDCLHFSVLSEGNENEVPSVTINPDDPVALPFSSGTTGLPKGVILTHKSLVTSVAQQVDGENPNLYLKSDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLLMQKFEIGTLLELIQKHRVSMAAVVPPLVLALAKNPTVDSYDLSSIRMVLSGAAPLGKELEEALRSRVPQATFGQGYGMTEAGPVLSMSASFAKQPLSSKSGSCGTVVRNAELKVVDPETGCSLGRNQPGEICIRGPQIMKGYLNDAEATARTIDVDGWLHTGDIGYVDDDDEVFIVDRVKELIKFKGFQVPPAELEALLVSHPLVADAAVVPQKDQVAGEVPVAFVVRSNGVELTEETVKDFIAKQVVFYKRLHKVYFVHAIPKSPSGKILRKDLRAKLALALAAQAS
>CRO_T134633
MEKSGYGRDGIYRSLRPPLVLPKASNNISMVSFLFRNFSAFPDKPALIDGRTSQTLSFMDLKSMVYKVSHGLHHQFGIKKNDVVLIFAPNSIQFPLCFFGIIAIGGIASTANPIYTTSELSKQVKDCAPKLIITVPELIPKVSGFNLPLLLLGSGRNTNISSNFSGKTMSFSDLIKNEGSLDLDYFTSAIKQSDTAALLYSSGTTGTSKGVVLTHRNFIASSLMVTADQEAAGEMHNLFLCVLPMFHVFGLAVIMYAQLQRGNGIVSMGKFDLEMILKAVEKYRVTHFWLVPPIMLALAKNAIVKKYDLTSLKQIGSGAAPLGRELMQECANNFPHAVVMQGYGMTETCGIVSVENPNLGPRHSGSTGMLVPGVEAQIVSVEKLKPLPPGQLGEIWVRGPNMMQGYFHNPEATKLTLDKQGWVHTGDLGYFNEAGQLFVVDRIKELIKYKGFQVAPAELEGLLISHPEILDAVVIPFPDAEAGEVPIAYVVRSPNSSLTEEDVQKFIADQVAPFKRLRRVTFINSVPKSASGKILRRELIEKVGSKL
>CRO_T137739
MNTIQQLKLTFPYKMPLDINQLHHSKTTKTNMGTNIPIFPEEEHIFRSRYPPVEVPHGITLPDFVLQNAEMFSDKVAFVDATTGRTYTYGEVNRDVRRFAKALRSLDSRKGLVAVVVLPNIVEYAVIALGIMAAGGVFSGANPASHASEIRKQVELAEAKLIVTDASTHDKTKLILKGANFKKNIESFGSILNIIDACTFLVNLDMFAVQKQVKDFGLPVIVVGEEPVEGSISWKRLLEAGDRISSDIINQVIEQTDLCALPFSSGTTGLSKGVMLTHRNIVANLCSSLFSVGPELIGKVTILGLIPFFHIYGLTGICCASIRNKGKVVVMPKYELRAFLDALIKHEVNFAPVVPPIILGLVKNPIVDEFDLSKLKLKSVMTAAAPLAPEILKEFEKKFPGIQVQEAYGMTEHSCITLSHGDPSKGHGISKRNSVGFILPNLEVKFVDPDSGRSLPKKTPGEICVRSQCVMKGYYKNEYETNLTIDKDGWLHTGDIGYIDDDGDVFLVDRIKELIKYKGFQVAPAEIEGVLLTHPSVEDAAVVGVADEEAGEIPAACVVMNTEAKETEEEIMEFVASNVAHYKKVRKLRFVDSIPKSHSGKIMRRLIKEKMTQNVNNINNPTSVSL
>CRO_T103111
MESTAADHHHQQYIFRSKLPDIYIPHHLPLHTYCFENLSEFSSRPCLINGTNGDVFSYADVELTARKFASGLHKIKIQQGDVIMLLLHNSPEFVFAFLGASYIGATVTTANPFCTSAEIKKQAKLSNTKLIITQSCYIEKIKDFAVENCIKIIFSDESLPENDFFGLKLKLNFSELIEAADENEIPAVKINQNDVVCLPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHKEDVILCVLPLFHIYSLNSIMLCGIRVGAAILIMQKFEINALMELVEKYKVTIAPFVPPIILGIAKSGATEKYDLKSIRMVMSGAAPMGKELEETFRPKLPNAKLGQGYGMTEAGPVISMCLAFAKEPFEVKPGACGTVVRNAEMKITDPETGLSLPPNQPGEICIRGNQIMKGYLNDPEATERTIDKDGWLHTGDIGYIDDDDEIFIVDRLKELIKYKGFQVAPAELEAMLISHPSISDAAVVPMKDEGAGEVPIAFVVRGNGSNISEDDVKQFISKQVVFYKRIHRVIFTDTIPKAPSGKILRRDLRAKLAAEAFC
>CRO_T107735
MATFLRSYQNSEELETNIYRNSKSHFSETSYPSWYSPETGIYRSKHSSVTLPSDPFLDIVSFIFSQKHNGFTALIDSVSGFSISYSQLLPLIKSMASGLHQMGLSQGDVVLISLPNSIYFPIIFLSVLSLGAVATVINPLSSLSEIKKQAMDFKVTLGFCLPEKVDELSELGFPVIGVPSLMSHSRGSDYSSLINKLMTSDPNLAPRPNINQQDTAAILYSSGTTGACKGTVLTHGNFIAMMVLFVRFEASQYQELPSENVYLASVPMFHVYGLSLFVMGLLTLAPVPKELIQDFIQAFPNVDFIQGYGMTESAAIGTRGYNTEKFQRHSSVGLLAPNVEAKVVDWINGSFSPPGCTGELWLRSPGTMKGYLNNDEATKSTIDKEGWLRTGDIVYFDQDGYLYVIDRLKEVIKYKGFQIAPADLESVLMSHPHILDAAVTAARDEEAGEIPVAFVVRTTEGSRLCEADVIDFVAKQSFHVHTKFPASQFKNVSTWPPTSPFYSNIFVMAATAPGIPQNVFILNHHHPRLYSHKNLKPRKIPTKIYPTLSALASNGVQVTLNESGNFRATSKRGVLGPHFNFLESRRGRIMVQALSSSDGATSTNLQSKVFGVLHLLVSLGIILAMDNFLKKAFVAAAIKFPSALFGMFCIFTILLALDSIIPAAATGLMNFFEPALLFIQRWLPLFYVPSLVVLPLAVKDIPAASGLKICAIIGAGWLASLAVAGYTAITVRKMVKTELIPAEPMSKPSPFSSLELWTWSGIFLISFVGAIFYPTVLGTSARTCLPFLLSATVLGYMVGSGLPYNIKKVFHPIVCCALSADLAAFAYGYLSHVGLNPVLGHYLTKASSDPGAGDILMGFLGSVILSFAFSMFKQRKLVKRHAAEIFSSVIIATLFSLYSTALLGRLLGLEQNLTVSVLPRCITVALALSIVSFFEGANSSLTAAVVVLTGLIGANFVQAMLDKFGFNDPIARGIATASSAHGLGTAALSAKEPEALPFCAIAYALTGIFGSLICSVPTVRQSLLAVIG
>CRO_T110289
MAAAVAIEEQKKDIIFRSKLPDIYIPKNLPLHSYCFENISKFSSRPCLINGATDEIFTYADVELISRRVGSGLSKLGIKQGDTIMILLPNSPEFVFAFLGASFIGSISTMANPFFTSTEVIKQAKASNAKLIITQGCYVDKVKDYACENGVKIISIDTTTTADDAANILHFSELTGADENEMPKVEISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYMHSDDVLLCVLPLFHIYSLNSVLLCGLRAGSGILIMQKFEIVPFLELIQKYKVTIGPFVPPIVLAIAKSTVVDNYDLSSVRTVMSGAAPLGKELEDAVRAKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFDIKSGACGTVVRNAEMKIVDPETGSSLPRNHPGEICIRGDQIMKGYLNDPEATARTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPCISDAAVVPMKDEAAGEVPVAFVVKSNGHNITEDEIKQFISKQVIFYKRINRVFFVEAIPKAPSGKILRKDLRARLAAAALPTN
MLSVEAPHNKELSSSTTTNPKQSSSHHELHIFRSKLPEIPISNHLPLHTYCFEKFSEFPDRTCLIVGSNGKTFTFAETHLICRKVAAGLTTLGIKQGDVIMILLQNSAEFVFSFMGASIIGAVTTTANPFYTSTEIFKQFKASKAKLIITQSHYVQKLRDAPDDCPRLGEEFRVITVDEPPKDCLHFSVLSEGNENEVPSVTINPDDPVALPFSSGTTGLPKGVILTHKSLVTSVAQQVDGENPNLYLKSDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLLMQKFEIGTLLELIQKHRVSMAAVVPPLVLALAKNPTVDSYDLSSIRMVLSGAAPLGKELEEALRSRVPQATFGQGYGMTEAGPVLSMSASFAKQPLSSKSGSCGTVVRNAELKVVDPETGCSLGRNQPGEICIRGPQIMKGYLNDAEATARTIDVDGWLHTGDIGYVDDDDEVFIVDRVKELIKFKGFQVPPAELEALLVSHPLVADAAVVPQKDQVAGEVPVAFVVRSNGVELTEETVKDFIAKQVVFYKRLHKVYFVHAIPKSPSGKILRKDLRAKLALALAAQAS
>CRO_T134633
MEKSGYGRDGIYRSLRPPLVLPKASNNISMVSFLFRNFSAFPDKPALIDGRTSQTLSFMDLKSMVYKVSHGLHHQFGIKKNDVVLIFAPNSIQFPLCFFGIIAIGGIASTANPIYTTSELSKQVKDCAPKLIITVPELIPKVSGFNLPLLLLGSGRNTNISSNFSGKTMSFSDLIKNEGSLDLDYFTSAIKQSDTAALLYSSGTTGTSKGVVLTHRNFIASSLMVTADQEAAGEMHNLFLCVLPMFHVFGLAVIMYAQLQRGNGIVSMGKFDLEMILKAVEKYRVTHFWLVPPIMLALAKNAIVKKYDLTSLKQIGSGAAPLGRELMQECANNFPHAVVMQGYGMTETCGIVSVENPNLGPRHSGSTGMLVPGVEAQIVSVEKLKPLPPGQLGEIWVRGPNMMQGYFHNPEATKLTLDKQGWVHTGDLGYFNEAGQLFVVDRIKELIKYKGFQVAPAELEGLLISHPEILDAVVIPFPDAEAGEVPIAYVVRSPNSSLTEEDVQKFIADQVAPFKRLRRVTFINSVPKSASGKILRRELIEKVGSKL
>CRO_T137739
MNTIQQLKLTFPYKMPLDINQLHHSKTTKTNMGTNIPIFPEEEHIFRSRYPPVEVPHGITLPDFVLQNAEMFSDKVAFVDATTGRTYTYGEVNRDVRRFAKALRSLDSRKGLVAVVVLPNIVEYAVIALGIMAAGGVFSGANPASHASEIRKQVELAEAKLIVTDASTHDKTKLILKGANFKKNIESFGSILNIIDACTFLVNLDMFAVQKQVKDFGLPVIVVGEEPVEGSISWKRLLEAGDRISSDIINQVIEQTDLCALPFSSGTTGLSKGVMLTHRNIVANLCSSLFSVGPELIGKVTILGLIPFFHIYGLTGICCASIRNKGKVVVMPKYELRAFLDALIKHEVNFAPVVPPIILGLVKNPIVDEFDLSKLKLKSVMTAAAPLAPEILKEFEKKFPGIQVQEAYGMTEHSCITLSHGDPSKGHGISKRNSVGFILPNLEVKFVDPDSGRSLPKKTPGEICVRSQCVMKGYYKNEYETNLTIDKDGWLHTGDIGYIDDDGDVFLVDRIKELIKYKGFQVAPAEIEGVLLTHPSVEDAAVVGVADEEAGEIPAACVVMNTEAKETEEEIMEFVASNVAHYKKVRKLRFVDSIPKSHSGKIMRRLIKEKMTQNVNNINNPTSVSL
>CRO_T103111
MESTAADHHHQQYIFRSKLPDIYIPHHLPLHTYCFENLSEFSSRPCLINGTNGDVFSYADVELTARKFASGLHKIKIQQGDVIMLLLHNSPEFVFAFLGASYIGATVTTANPFCTSAEIKKQAKLSNTKLIITQSCYIEKIKDFAVENCIKIIFSDESLPENDFFGLKLKLNFSELIEAADENEIPAVKINQNDVVCLPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHKEDVILCVLPLFHIYSLNSIMLCGIRVGAAILIMQKFEINALMELVEKYKVTIAPFVPPIILGIAKSGATEKYDLKSIRMVMSGAAPMGKELEETFRPKLPNAKLGQGYGMTEAGPVISMCLAFAKEPFEVKPGACGTVVRNAEMKITDPETGLSLPPNQPGEICIRGNQIMKGYLNDPEATERTIDKDGWLHTGDIGYIDDDDEIFIVDRLKELIKYKGFQVAPAELEAMLISHPSISDAAVVPMKDEGAGEVPIAFVVRGNGSNISEDDVKQFISKQVVFYKRIHRVIFTDTIPKAPSGKILRRDLRAKLAAEAFC
>CRO_T107735
MATFLRSYQNSEELETNIYRNSKSHFSETSYPSWYSPETGIYRSKHSSVTLPSDPFLDIVSFIFSQKHNGFTALIDSVSGFSISYSQLLPLIKSMASGLHQMGLSQGDVVLISLPNSIYFPIIFLSVLSLGAVATVINPLSSLSEIKKQAMDFKVTLGFCLPEKVDELSELGFPVIGVPSLMSHSRGSDYSSLINKLMTSDPNLAPRPNINQQDTAAILYSSGTTGACKGTVLTHGNFIAMMVLFVRFEASQYQELPSENVYLASVPMFHVYGLSLFVMGLLTLAPVPKELIQDFIQAFPNVDFIQGYGMTESAAIGTRGYNTEKFQRHSSVGLLAPNVEAKVVDWINGSFSPPGCTGELWLRSPGTMKGYLNNDEATKSTIDKEGWLRTGDIVYFDQDGYLYVIDRLKEVIKYKGFQIAPADLESVLMSHPHILDAAVTAARDEEAGEIPVAFVVRTTEGSRLCEADVIDFVAKQSFHVHTKFPASQFKNVSTWPPTSPFYSNIFVMAATAPGIPQNVFILNHHHPRLYSHKNLKPRKIPTKIYPTLSALASNGVQVTLNESGNFRATSKRGVLGPHFNFLESRRGRIMVQALSSSDGATSTNLQSKVFGVLHLLVSLGIILAMDNFLKKAFVAAAIKFPSALFGMFCIFTILLALDSIIPAAATGLMNFFEPALLFIQRWLPLFYVPSLVVLPLAVKDIPAASGLKICAIIGAGWLASLAVAGYTAITVRKMVKTELIPAEPMSKPSPFSSLELWTWSGIFLISFVGAIFYPTVLGTSARTCLPFLLSATVLGYMVGSGLPYNIKKVFHPIVCCALSADLAAFAYGYLSHVGLNPVLGHYLTKASSDPGAGDILMGFLGSVILSFAFSMFKQRKLVKRHAAEIFSSVIIATLFSLYSTALLGRLLGLEQNLTVSVLPRCITVALALSIVSFFEGANSSLTAAVVVLTGLIGANFVQAMLDKFGFNDPIARGIATASSAHGLGTAALSAKEPEALPFCAIAYALTGIFGSLICSVPTVRQSLLAVIG
>CRO_T110289
MAAAVAIEEQKKDIIFRSKLPDIYIPKNLPLHSYCFENISKFSSRPCLINGATDEIFTYADVELISRRVGSGLSKLGIKQGDTIMILLPNSPEFVFAFLGASFIGSISTMANPFFTSTEVIKQAKASNAKLIITQGCYVDKVKDYACENGVKIISIDTTTTADDAANILHFSELTGADENEMPKVEISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYMHSDDVLLCVLPLFHIYSLNSVLLCGLRAGSGILIMQKFEIVPFLELIQKYKVTIGPFVPPIVLAIAKSTVVDNYDLSSVRTVMSGAAPLGKELEDAVRAKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFDIKSGACGTVVRNAEMKIVDPETGSSLPRNHPGEICIRGDQIMKGYLNDPEATARTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPCISDAAVVPMKDEAAGEVPVAFVVKSNGHNITEDEIKQFISKQVIFYKRINRVFFVEAIPKAPSGKILRKDLRARLAAAALPTN
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University