Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Fragaria vesca
Species name
Wild strawberry (Fragaria vesca) is a species of eudicot in the family Rosaceae (rose family).
Species info
Gene sequence info
Fragaria_vesca.COMT.fa
Download
>rna-XM_011462229.1
MESHGSLENHISAWGLSTSVTIQMTLRAAIELDVFNIIAKAGSGAHLTSKQIVSQIPTTNPKAAVENLERMLRYLSVHSLLSTSQTPNPNDPTIKDTSYGLTEDTLCLVPNEDGVSFAPFLIWKTEMHSLKSLSMLKYTVLEPESSPFLKAHGETPIYEYMSKKPGLPSLFDEVMKLHSYICYERKVFEEYKGFEEVKELMDVGGGDGSAIAKIVSVYPHIQGINFNLPSGVARAPEYPGVKHVNGDMFETIPYTQAIMLKLILHNWDDDHCKKILRNCSNALPNNGKVIVVEYCVLPEVIENTLETKTMLLPADIAMMTLCNGKERTISEYDALAKSVGFVQTKAFPICHGTYVIEFLK
>rna-XM_011463713.1
MHTFKSLQMLKYTVLEPESTPFQKAHGETMYEYMSKKPELCQLFDKAETTYYEQKVFEKYKGFEEVKKLMDVGGGDGSAIAKIVSLYPHIQAINFNLSSVVARAPSYRGVKHVNGDMLETIPDTQAIMLKWVLHNWDDDHCKKI
>rna-XM_004295476.1
MESHGSLENHISAWGVSTSLTIQMTLKAAIELDVFNIIAKAGSGAHLTSKQIVSHIPTTKPNSAIENLERILRFLSFHSLLSTSQTPNPNDLTIKETSYRLTKDALCLVPNENGVSFAPFLIWCSEMHTFKSLSMLKYTVLEPKSTPFLKAHGETMYEYMSKKPELCQLFDKVMRLHSHIYYEQKVFEEYKGFGEVKELMDVGGGDGSAIAKIVSVYPHIQGINFNLPSVVARAPEYQGQYTNIS
>rna-XM_011470049.1
MATPVSLENDISAYYLGSSICIQMAQRAAIELDVFNIIAKSGPEAHLTSKEIVSEIPTTDPNAAAENLERILNLLSAVKSLLSTYLKQRHNDKTPQRAYGLTKEVLLCLVPNEDGVSFTSEIISGSEMHIIQSLCMLKHPVLEPGSVPFCKAHGVSFYEFMSERPEMISWFNKHMRTASYLHFDLKVLKVYEGFEEVKELMDAGGGDGSSLAKIVSMYPHIHGINFDISSVIVQAPNYQAGVKHVSGDV
>rna-XM_011470169.1
MEGHGSLSNHSSAWGLANSITVQMTLRAAIELNVVNIIAKSVVLWGSEMLVMNSYSMLKYTVLEPGSSPFLKGHGESMYEYMSKKPELCQLFDKVMGVISYLYFDHKVFEVYKGFEEVKELMDVGGGDGTAIAKIVSMYGVEHLSGDMFELIPKTQSVMLMLILHNWNDDHFENTPDIKLVLYIDIVMMAMFQGAKERTTAEYDTLAKSVGFVETKIFPLPHGRSYILEFLKGGSVESIVG
>rna-XM_004304282.2
MEDANRIKEASNEARIAILELANMISVPMSLNAVVRLNVADAIWQKGSNTPLSASQILERVLPTGSGDAENLQRILRMLTSYGVFSEHFNADGSERKFSLTEVGQTLVTNQDGLSYGDYVLQHHQDVLMGAWPLVHEAVIDPSVEPFVKANGEPAYQYYGKRPEMNGLMQKAMSGVSVPFIKAVLDGYDGFQGVTRLVDVGGSAGDCLKMIMDRYPNVREGINFDLPEVVAKAPTIAGVTHVGGDMFKSIPSADVIFMKWILSTWTDCECKLILENCYKALPAGGKLIACEPVVPRKSDDSHRTRALLENDIFVMTIYRTKGKNRTEEELRQLGHSAGFSHFRPIYIDYFYTVLEFQK
>rna-XM_011470584.1
MASTKEEEESFCYAMQLVTSTVLSMSMQSAVELGVFDIIAKAGVGPGLSSPEIAAQIGTKNPEAPVMLDRILRLLASHSVLNCTVVNANDDDHGDGPNFLRVYSLAPVSRYFVKSAGDGVSLGTLMALIQDKVFLDS*FQLKGAVLEGGIPFNRVYGTHAFEYPGLDPRFNQVFNTAMFNHTTIVIKKILDLYKGFEHLEKLVDVGGGLGVTLSLITSRYPHIKGINFDLPHVIKDAPSYIGVEHVGGDMFASVPSGDAIFMKWILHDWSDEHCLKLLKNCYNAIPDNGKVIVVEALLPVVPETSTAVKSTSQIDVLMMTQNPGGKERTEQEFIALATGAGFRGIRYECFVCNFWVMEFFK
>rna-XM_004307851.2
MGSTGETQMTPTQVSDEEANLFAMQLASASVLPMVLKAAIELDLLEIMAKAGPGSFLSPNDLASQLPTENPEAPVMLDRMLRLLASYSILTYSLRTLPDGKVERLYGLGPVCKFLTKNEDGVSIAALCLMNQDKVLVESWYHLKDAVLDGGIPFNKAYGMTAFDYHGTDPRFNKVFNKGMADHSTITMKKILETYKGFEGLKSIVDVGGGTGAVVNMIVAKYPSIKGINFDLPHVIEDAPQYPGVQHVGGDMFVSVPKGDAIFMKWICHDWSDEHCIKFLKNCYAALPDDGKVILGECILPVAPDTSLATKGVVHIDVIMLAHNPGGKERTEQEFEALAKGSGFQGIRVCCDAFNTYVIEFLKKI
>rna-XM_011472572.1
MESHSQYAMQLVSASLAPMVLKAAIELGVLEIIHRAGPGAQLSPSEIASQLHSNNNPDAPAVLDRMLRLLSAHSILTCSVSTDELDHVKVLRLYGLAPVGKYFIRDEDGGSLATILNFCHDKVNTDSWYHLTDAVLEGGLPFSKAYGMSAVEYNAKDARYGEIFRNSMKEFNAVLMKEILESYKGFEGLRTLVDAGGGDGTILNMIISKYPTVKGINYDMAPVIEKSPSYPGIEQIAGDIFENIPKGDAIFMKWMLHQYDDKRCLTILKNCYEALPNHGKVIVVDMVIPEAPETTTSAKSLFQFDMFMMNMNTTGNERTEKELGSLGKQAGFNTIQVACSAFNFSVVELFKNM
MESHGSLENHISAWGLSTSVTIQMTLRAAIELDVFNIIAKAGSGAHLTSKQIVSQIPTTNPKAAVENLERMLRYLSVHSLLSTSQTPNPNDPTIKDTSYGLTEDTLCLVPNEDGVSFAPFLIWKTEMHSLKSLSMLKYTVLEPESSPFLKAHGETPIYEYMSKKPGLPSLFDEVMKLHSYICYERKVFEEYKGFEEVKELMDVGGGDGSAIAKIVSVYPHIQGINFNLPSGVARAPEYPGVKHVNGDMFETIPYTQAIMLKLILHNWDDDHCKKILRNCSNALPNNGKVIVVEYCVLPEVIENTLETKTMLLPADIAMMTLCNGKERTISEYDALAKSVGFVQTKAFPICHGTYVIEFLK
>rna-XM_011463713.1
MHTFKSLQMLKYTVLEPESTPFQKAHGETMYEYMSKKPELCQLFDKAETTYYEQKVFEKYKGFEEVKKLMDVGGGDGSAIAKIVSLYPHIQAINFNLSSVVARAPSYRGVKHVNGDMLETIPDTQAIMLKWVLHNWDDDHCKKI
>rna-XM_004295476.1
MESHGSLENHISAWGVSTSLTIQMTLKAAIELDVFNIIAKAGSGAHLTSKQIVSHIPTTKPNSAIENLERILRFLSFHSLLSTSQTPNPNDLTIKETSYRLTKDALCLVPNENGVSFAPFLIWCSEMHTFKSLSMLKYTVLEPKSTPFLKAHGETMYEYMSKKPELCQLFDKVMRLHSHIYYEQKVFEEYKGFGEVKELMDVGGGDGSAIAKIVSVYPHIQGINFNLPSVVARAPEYQGQYTNIS
>rna-XM_011470049.1
MATPVSLENDISAYYLGSSICIQMAQRAAIELDVFNIIAKSGPEAHLTSKEIVSEIPTTDPNAAAENLERILNLLSAVKSLLSTYLKQRHNDKTPQRAYGLTKEVLLCLVPNEDGVSFTSEIISGSEMHIIQSLCMLKHPVLEPGSVPFCKAHGVSFYEFMSERPEMISWFNKHMRTASYLHFDLKVLKVYEGFEEVKELMDAGGGDGSSLAKIVSMYPHIHGINFDISSVIVQAPNYQAGVKHVSGDV
>rna-XM_011470169.1
MEGHGSLSNHSSAWGLANSITVQMTLRAAIELNVVNIIAKSVVLWGSEMLVMNSYSMLKYTVLEPGSSPFLKGHGESMYEYMSKKPELCQLFDKVMGVISYLYFDHKVFEVYKGFEEVKELMDVGGGDGTAIAKIVSMYGVEHLSGDMFELIPKTQSVMLMLILHNWNDDHFENTPDIKLVLYIDIVMMAMFQGAKERTTAEYDTLAKSVGFVETKIFPLPHGRSYILEFLKGGSVESIVG
>rna-XM_004304282.2
MEDANRIKEASNEARIAILELANMISVPMSLNAVVRLNVADAIWQKGSNTPLSASQILERVLPTGSGDAENLQRILRMLTSYGVFSEHFNADGSERKFSLTEVGQTLVTNQDGLSYGDYVLQHHQDVLMGAWPLVHEAVIDPSVEPFVKANGEPAYQYYGKRPEMNGLMQKAMSGVSVPFIKAVLDGYDGFQGVTRLVDVGGSAGDCLKMIMDRYPNVREGINFDLPEVVAKAPTIAGVTHVGGDMFKSIPSADVIFMKWILSTWTDCECKLILENCYKALPAGGKLIACEPVVPRKSDDSHRTRALLENDIFVMTIYRTKGKNRTEEELRQLGHSAGFSHFRPIYIDYFYTVLEFQK
>rna-XM_011470584.1
MASTKEEEESFCYAMQLVTSTVLSMSMQSAVELGVFDIIAKAGVGPGLSSPEIAAQIGTKNPEAPVMLDRILRLLASHSVLNCTVVNANDDDHGDGPNFLRVYSLAPVSRYFVKSAGDGVSLGTLMALIQDKVFLDS*FQLKGAVLEGGIPFNRVYGTHAFEYPGLDPRFNQVFNTAMFNHTTIVIKKILDLYKGFEHLEKLVDVGGGLGVTLSLITSRYPHIKGINFDLPHVIKDAPSYIGVEHVGGDMFASVPSGDAIFMKWILHDWSDEHCLKLLKNCYNAIPDNGKVIVVEALLPVVPETSTAVKSTSQIDVLMMTQNPGGKERTEQEFIALATGAGFRGIRYECFVCNFWVMEFFK
>rna-XM_004307851.2
MGSTGETQMTPTQVSDEEANLFAMQLASASVLPMVLKAAIELDLLEIMAKAGPGSFLSPNDLASQLPTENPEAPVMLDRMLRLLASYSILTYSLRTLPDGKVERLYGLGPVCKFLTKNEDGVSIAALCLMNQDKVLVESWYHLKDAVLDGGIPFNKAYGMTAFDYHGTDPRFNKVFNKGMADHSTITMKKILETYKGFEGLKSIVDVGGGTGAVVNMIVAKYPSIKGINFDLPHVIEDAPQYPGVQHVGGDMFVSVPKGDAIFMKWICHDWSDEHCIKFLKNCYAALPDDGKVILGECILPVAPDTSLATKGVVHIDVIMLAHNPGGKERTEQEFEALAKGSGFQGIRVCCDAFNTYVIEFLKKI
>rna-XM_011472572.1
MESHSQYAMQLVSASLAPMVLKAAIELGVLEIIHRAGPGAQLSPSEIASQLHSNNNPDAPAVLDRMLRLLSAHSILTCSVSTDELDHVKVLRLYGLAPVGKYFIRDEDGGSLATILNFCHDKVNTDSWYHLTDAVLEGGLPFSKAYGMSAVEYNAKDARYGEIFRNSMKEFNAVLMKEILESYKGFEGLRTLVDAGGGDGTILNMIISKYPTVKGINYDMAPVIEKSPSYPGIEQIAGDIFENIPKGDAIFMKWMLHQYDDKRCLTILKNCYEALPNHGKVIVVDMVIPEAPETTTSAKSLFQFDMFMMNMNTTGNERTEKELGSLGKQAGFNTIQVACSAFNFSVVELFKNM
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University