Enzyme
The enzyme participates in the flavonoid biosynthesis pathway found in plants. It catalyses the double reduction of anthocyanidins, producing (2R,3R)-flavan-3-ol monomers required for the formation of proanthocyanidins. While the enzyme from the legume Medicago truncatula (MtANR) can use both NADPH and NADH as reductant, that from the crucifer Arabidopsis thaliana (AtANR) uses only NADPH. Also, while the substrate preference of MtANR is cyanidin>pelargonidin>delphinidin, the reverse preference is found with AtANR. cf. EC 1.3.1.112, anthocyanidin reductase [(2S)-flavan-3-ol-forming].
ANR
Enzyme
Anthocyanidin reductase
Enzyme name
EC:1.3.1.77
Entry
Oxidoreductases;Acting on the CH-CH group of donors;With NAD+ or NADP+ as acceptor
Class
(2R,3R)-flavan-3-ol:NAD(P)+ 3,4-oxidoreductase
Sysname
a (2R,3R)-flavan-3-ol + 2 NAD(P)+ = an anthocyanidin with a 3-hydroxy group + 2 NAD(P)H + H+ [RN:R07351 R07352]
Reaction
anthocyanidin with a 3-hydroxy group [CPD:C21381];NADH [CPD:C00004];NADPH [CPD:C00005];H+ [CPD:C00080]
Product
Species information
Faidherbia albida
Species name
Faidherbia albida is a species of eudicot in the family Fabaceae (pea family).
Species info
Gene sequence info
Faidherbia_albida.ANR.fa
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>Faial60S20400_FAIAL
MAAATKVCVTGAGGFLASWLVKLLLSKRFFVHGTVRQPGHQKYDHLLKFEGASDNLKLFKAELLDYESLSSAIVGCRAVFHVACPVPSTTVEMIGPSVTGTTNVLKACLEAKVERVVFVSSEAAVSVNPNLPKDKLVDESCWSDKEYCRRTKNWYCYSKTEAELQALEFARNNGLSVVTICPTVVWGPILQASAVNASSLILLKLFKGLESLENKQRWVVDVRDVADAILMAYEKSEAEGRYLCTAHSIMTDDLVDKLRRIYPNYSYPKNFIEVDHCIKLSSEKLQKLGWRYRPLEETLVDSVESYKKYDHLLKFEGASENLKLFRADLLDYESLSSAIAGCRAVFHVACPVPSTTVPNPEAQMIEPSVTGTNNVLKACLEAKVELVVFVSSLGAVSRNPNWPKDKVMDESCWSDKEYCRRTKNWYCYSKTEAELQALDFARNSGLSVITICPTVVWGPILQAFKVNSSSLILLKLFKGGIESLENKQRWIVDVRDVADAVLMAYEKPEAEGRYLCTAHSIMTDDLVEKLRRLYPNYSYTKNFVEVDDCIKLSSEKLQRLGWRYRPLEETLVDSVESYKVAGLLESK
>Faial272S13072_FAIAL
MNVEYIDPALKGTLNVLKSCVKASSVKQVVITSSVAAGWSGYILSKTLAEEAAWKFVKENNIDMVAINPSMTFPNGVFGFVNVTDVANAHIQAFGTPSANGRYVLAERVAHYSDVIKILHDLYPTLQLAQKCADDKPLVPKFQISKEKAKTLGIKFISLEVSLREIVESLKEKKFVEF
>Faial478S18119_FAIAL
MGQRAYLYSVEFLKSINMYGLPNHQTELIDLAVMGTLNLLKSCKIVISETSCLILTSSMAVVLCNGQPKTLEVVVDETWFSKPEFCMEVKTGLIDLAVKGTLNLLKSCEIVISETSCLILTPSIAVVFCKGQPKTLEIVVDETWISKP
>Faial647S20939_FAIAL
MDQIRRKKKVCVIRGIAGCELVFHVATPVNFASEDPENDMMKPEIQGVMNVLRACARAKAVKRVIWTSSAAAISINAVEGRDLVMDENNWTDVDFLSTTRPPPWVIIQ
>Faial1136S01504_FAIAL
MEGSKGRVCVTGGTGFIGSWIIKRLLEDGYSVNTTIRSHPEHKKDVSFLTNLPGASQRLQILNADLNEPESFKEAIEGCMGVLHVATPVDFDEKEPEEIVTKRSIDGALGILKACLTSKTVKRVVYTSSAAAVTHRDKEVEVVDEGSWTDVDSLRTSKPFAWSYAISKTLTEKAVLEFGRQHGLDVVTVIPTYVVGPFICPKLPGSVGSTLYFLLGKKGQFNYLQAPMVHVDDVARAHVFLLEHPNPKGRYNCSKCLATIEEVTQIISLETWVIPRMEESKGRVCVTGGTGFIGSWIIKRLLEDGYSVNTTIRSHPEHKKDVSFLTNLPGASQRLQILNADLNEPESFKEAIEGCMGVFHVATPMDFEEKEPEELVTKRSIDGALGILKACLTSKTVKRVVYTSSAAAVTHRDKEVEVVDESSWTDVDTLRTSKPFAWSYAISKTLTEKAVLEFGRQHGLDVVTVIPTYVVGPFICSKLPFSVGSTLYFLLGKKGQFTYLQATMVHVDDVARAHVFLLEHPNPKGRYNCSKCLATIEEVTQIVSAKYPELQMPTIESLRESTCLKLPDLSSKKLIDAGFEYKYGLEEMLVDAIECCKEKGYIRKRKICVTGGTGFIASWIIKRLVEDGYSVNATIRSSPVKHNPVGYLQTPMVHVDDLARAHIFVFENPNVKGRKMSSHKFHNLSSNKLLDVGFEFRHGIEEMLADAIECCM
>Faial757S22769_FAIAL
MVSVSETVCVTGAAGFIGSWLVMRLLERGYTVRATVRDPVIKPTINGLLDIMKSCIKAKTVRRLIFTSSAGTVNMVEHKKPVFDETCWSDTELCRRVKMTGWMYFVSKTLAEQEAWKFAKQHNMDFITVIPTLVVGPFLMDSMPPSLITALSPITGNEAHYSILKQVQFVHLDDLCMSHIFLLEHPEAQGRYICSSHDATIHDVARLLNQKYPEYNVPTKFKNIPDELEIVSFSSKKIRDLGFQFKYSLEDMFTGAVDTCREKGLLPKSSETRRESWVLTLRLFVSPALPDSSAHGSSCGSWSAATPLGPQSATLNEVIKPTINGLLSIMKGCLKAKVRRLIFTSSAGTVDATEHQKPVFDETCWSDVEFCRRVKMTGWMYFVSKTLAEQEAWKFAKEHNMDFISIIPPLVVGPFLMDSMPPSLITGLSLITGNEAHYSIIKQGQFVHLDDLCMGHIFLLEHPEAEGRYMCSSHDATIHDVAKMLSQKYPAYNIPTKFKNIPDELEIIRFSSKKIKDLGFQFKYSLEDMFTGAVDTCKQKGLLPNPPAAETPVFLLPETPVKGTTDQK
>Faial1404S04417_FAIAL
MGSDGGERKVVCVTGASGYIASWIVKFLLLRGYTVKGTVRDPNDSRKVDHLLKLDGANERLRFIKADLEEEGSFDEAVEGCVGVFHTASPCYFDPKDPQTELIDPAVKGTLNVLRSCVKSSTVKRVVLTSSFAAVSHTGKPLTPDVVVDETWFSSPDICRDKKRWYHVSKILAEEAAWKFAKENGIDLVVLNPAFVIGTLLQPSLNETCALILNLIKDHFFGLKMLVENHVHLTEKPSNKLLLCSSSITCLFDAAQTYPNYSAGWVNVKDVANAHIQAFEIPTANGRYIVVERVEHYSEHVKILRELFPTLQLPEKCADDKPFMPKYQVSNEKAKTLGIEFIPLEVSCKARDYLEDRENMGSNVGQGKVVCVTGASGYIASWLVKFLLLRGYTVKGTVRDPNDSRKVDHLLKLDGAKERLRLIKADLEEEGSFDEAVEGSEGVFHTASPCYFDPIDPQTELIDPAVKGTLNVLKSCAKSSSVKRVILTSSFAAVLYNGKPLTLDVVIDETWFSSPDICRDMKRWYGVSKILAEEAAWKFVKENNIDLVVLNPAFVIGPLLQPSLNETSAMILKLIKGQTYPNYRAGWVNVKDVANAHIQAFEIPSAGGRYNLVERVAHYSEHVKILHELFPTLQLPEKCADDQPWSKYQVSKEKAKTLGIEFIPLEEERRTMESNTGKGKVVCVTGASGFIASWIVKLLLLRGYEVKGTVRDPNDSVKVDHLLKLDGAKERLQLIKANLLEEGSFDESVEGCEAVFHTASPVAFNVEYPQTELIDPAVKGTLNVLKSCAKSPSVKRVILTSSAAAVVYYGKPLTPEVVVDETWFSKPDICREQKVWYALSKTLAEDAAWKFAKENNIDMVALNPAVVIGPLLQPLLNESSAAISRLINGAQTFPNISVGWIHVKDVANAHIQALEVSSTSGRYCLFGTIAHYSDIVKILHKLYPTLQLPQRCEDDKPFMPVYQVSQEKARTLGTEFIPLEVSIRDTVESLKEKNLINFKCGDDKPFMSKYQVSKEKAKTLGIESIPLMLQMLIFRPLRFSLASGRYNLVKRVSHYSEQPWTKYQVYKEKAKTLGIEFIPLKEERRRMESNTGKGKVVCVTGASGFIASWIVKLLLLRGYTVKGTVRDPNDSVKVDHLLKLDGAKERLQLIKANLLEEGSFDEAVEGCEAVFHTASPVALNVEEPQTELIDPAVKGTLNVLKSCAKSPSVKRVILTSSTAAVVYNGKPLTPEVVVDETWFSNPDICREHKIWYTLSKTLAEDAAWKFAKENNIDMVALNPAVVIGPLLQPSLNESSATISKLINGAQTFPNFSVGWIHVKDVANAHIQALEISSASGRYCLFGTVAHYSDIVKILHKLYPTLQLPERCEDDKPFMPVYQVCQEKARTLGIEFIPLEVSIRDTVESLKEKNLINF
MAAATKVCVTGAGGFLASWLVKLLLSKRFFVHGTVRQPGHQKYDHLLKFEGASDNLKLFKAELLDYESLSSAIVGCRAVFHVACPVPSTTVEMIGPSVTGTTNVLKACLEAKVERVVFVSSEAAVSVNPNLPKDKLVDESCWSDKEYCRRTKNWYCYSKTEAELQALEFARNNGLSVVTICPTVVWGPILQASAVNASSLILLKLFKGLESLENKQRWVVDVRDVADAILMAYEKSEAEGRYLCTAHSIMTDDLVDKLRRIYPNYSYPKNFIEVDHCIKLSSEKLQKLGWRYRPLEETLVDSVESYKKYDHLLKFEGASENLKLFRADLLDYESLSSAIAGCRAVFHVACPVPSTTVPNPEAQMIEPSVTGTNNVLKACLEAKVELVVFVSSLGAVSRNPNWPKDKVMDESCWSDKEYCRRTKNWYCYSKTEAELQALDFARNSGLSVITICPTVVWGPILQAFKVNSSSLILLKLFKGGIESLENKQRWIVDVRDVADAVLMAYEKPEAEGRYLCTAHSIMTDDLVEKLRRLYPNYSYTKNFVEVDDCIKLSSEKLQRLGWRYRPLEETLVDSVESYKVAGLLESK
>Faial272S13072_FAIAL
MNVEYIDPALKGTLNVLKSCVKASSVKQVVITSSVAAGWSGYILSKTLAEEAAWKFVKENNIDMVAINPSMTFPNGVFGFVNVTDVANAHIQAFGTPSANGRYVLAERVAHYSDVIKILHDLYPTLQLAQKCADDKPLVPKFQISKEKAKTLGIKFISLEVSLREIVESLKEKKFVEF
>Faial478S18119_FAIAL
MGQRAYLYSVEFLKSINMYGLPNHQTELIDLAVMGTLNLLKSCKIVISETSCLILTSSMAVVLCNGQPKTLEVVVDETWFSKPEFCMEVKTGLIDLAVKGTLNLLKSCEIVISETSCLILTPSIAVVFCKGQPKTLEIVVDETWISKP
>Faial647S20939_FAIAL
MDQIRRKKKVCVIRGIAGCELVFHVATPVNFASEDPENDMMKPEIQGVMNVLRACARAKAVKRVIWTSSAAAISINAVEGRDLVMDENNWTDVDFLSTTRPPPWVIIQ
>Faial1136S01504_FAIAL
MEGSKGRVCVTGGTGFIGSWIIKRLLEDGYSVNTTIRSHPEHKKDVSFLTNLPGASQRLQILNADLNEPESFKEAIEGCMGVLHVATPVDFDEKEPEEIVTKRSIDGALGILKACLTSKTVKRVVYTSSAAAVTHRDKEVEVVDEGSWTDVDSLRTSKPFAWSYAISKTLTEKAVLEFGRQHGLDVVTVIPTYVVGPFICPKLPGSVGSTLYFLLGKKGQFNYLQAPMVHVDDVARAHVFLLEHPNPKGRYNCSKCLATIEEVTQIISLETWVIPRMEESKGRVCVTGGTGFIGSWIIKRLLEDGYSVNTTIRSHPEHKKDVSFLTNLPGASQRLQILNADLNEPESFKEAIEGCMGVFHVATPMDFEEKEPEELVTKRSIDGALGILKACLTSKTVKRVVYTSSAAAVTHRDKEVEVVDESSWTDVDTLRTSKPFAWSYAISKTLTEKAVLEFGRQHGLDVVTVIPTYVVGPFICSKLPFSVGSTLYFLLGKKGQFTYLQATMVHVDDVARAHVFLLEHPNPKGRYNCSKCLATIEEVTQIVSAKYPELQMPTIESLRESTCLKLPDLSSKKLIDAGFEYKYGLEEMLVDAIECCKEKGYIRKRKICVTGGTGFIASWIIKRLVEDGYSVNATIRSSPVKHNPVGYLQTPMVHVDDLARAHIFVFENPNVKGRKMSSHKFHNLSSNKLLDVGFEFRHGIEEMLADAIECCM
>Faial757S22769_FAIAL
MVSVSETVCVTGAAGFIGSWLVMRLLERGYTVRATVRDPVIKPTINGLLDIMKSCIKAKTVRRLIFTSSAGTVNMVEHKKPVFDETCWSDTELCRRVKMTGWMYFVSKTLAEQEAWKFAKQHNMDFITVIPTLVVGPFLMDSMPPSLITALSPITGNEAHYSILKQVQFVHLDDLCMSHIFLLEHPEAQGRYICSSHDATIHDVARLLNQKYPEYNVPTKFKNIPDELEIVSFSSKKIRDLGFQFKYSLEDMFTGAVDTCREKGLLPKSSETRRESWVLTLRLFVSPALPDSSAHGSSCGSWSAATPLGPQSATLNEVIKPTINGLLSIMKGCLKAKVRRLIFTSSAGTVDATEHQKPVFDETCWSDVEFCRRVKMTGWMYFVSKTLAEQEAWKFAKEHNMDFISIIPPLVVGPFLMDSMPPSLITGLSLITGNEAHYSIIKQGQFVHLDDLCMGHIFLLEHPEAEGRYMCSSHDATIHDVAKMLSQKYPAYNIPTKFKNIPDELEIIRFSSKKIKDLGFQFKYSLEDMFTGAVDTCKQKGLLPNPPAAETPVFLLPETPVKGTTDQK
>Faial1404S04417_FAIAL
MGSDGGERKVVCVTGASGYIASWIVKFLLLRGYTVKGTVRDPNDSRKVDHLLKLDGANERLRFIKADLEEEGSFDEAVEGCVGVFHTASPCYFDPKDPQTELIDPAVKGTLNVLRSCVKSSTVKRVVLTSSFAAVSHTGKPLTPDVVVDETWFSSPDICRDKKRWYHVSKILAEEAAWKFAKENGIDLVVLNPAFVIGTLLQPSLNETCALILNLIKDHFFGLKMLVENHVHLTEKPSNKLLLCSSSITCLFDAAQTYPNYSAGWVNVKDVANAHIQAFEIPTANGRYIVVERVEHYSEHVKILRELFPTLQLPEKCADDKPFMPKYQVSNEKAKTLGIEFIPLEVSCKARDYLEDRENMGSNVGQGKVVCVTGASGYIASWLVKFLLLRGYTVKGTVRDPNDSRKVDHLLKLDGAKERLRLIKADLEEEGSFDEAVEGSEGVFHTASPCYFDPIDPQTELIDPAVKGTLNVLKSCAKSSSVKRVILTSSFAAVLYNGKPLTLDVVIDETWFSSPDICRDMKRWYGVSKILAEEAAWKFVKENNIDLVVLNPAFVIGPLLQPSLNETSAMILKLIKGQTYPNYRAGWVNVKDVANAHIQAFEIPSAGGRYNLVERVAHYSEHVKILHELFPTLQLPEKCADDQPWSKYQVSKEKAKTLGIEFIPLEEERRTMESNTGKGKVVCVTGASGFIASWIVKLLLLRGYEVKGTVRDPNDSVKVDHLLKLDGAKERLQLIKANLLEEGSFDESVEGCEAVFHTASPVAFNVEYPQTELIDPAVKGTLNVLKSCAKSPSVKRVILTSSAAAVVYYGKPLTPEVVVDETWFSKPDICREQKVWYALSKTLAEDAAWKFAKENNIDMVALNPAVVIGPLLQPLLNESSAAISRLINGAQTFPNISVGWIHVKDVANAHIQALEVSSTSGRYCLFGTIAHYSDIVKILHKLYPTLQLPQRCEDDKPFMPVYQVSQEKARTLGTEFIPLEVSIRDTVESLKEKNLINFKCGDDKPFMSKYQVSKEKAKTLGIESIPLMLQMLIFRPLRFSLASGRYNLVKRVSHYSEQPWTKYQVYKEKAKTLGIEFIPLKEERRRMESNTGKGKVVCVTGASGFIASWIVKLLLLRGYTVKGTVRDPNDSVKVDHLLKLDGAKERLQLIKANLLEEGSFDEAVEGCEAVFHTASPVALNVEEPQTELIDPAVKGTLNVLKSCAKSPSVKRVILTSSTAAVVYNGKPLTPEVVVDETWFSNPDICREHKIWYTLSKTLAEDAAWKFAKENNIDMVALNPAVVIGPLLQPSLNESSATISKLINGAQTFPNFSVGWIHVKDVANAHIQALEISSASGRYCLFGTVAHYSDIVKILHKLYPTLQLPERCEDDKPFMPVYQVCQEKARTLGIEFIPLEVSIRDTVESLKEKNLINF
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University