Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Fagus sylvatica
Species name
European beech (Fagus sylvatica) is a species of eudicot in the family Fagaceae (beech family).
Species info
Gene sequence info
Fagus_sylvatica.4CL.fa
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>Bhaga_10.g2239.t1
MMIALAKESVMKKYNLWSLRQVVSGAVPLGRDVMEECAKVIPHADIFQGYGMTEACGIISLGNPKEEPRLSSSTGTLVSGVESQIASTDTLQPLPPNQLGEIWLRGPNINAR
>Bhaga_10.g640.t1
MEKSGYGRDGIYRSMRPPLVVPKDPNLSMVTFLFRNAASYPNKPALIDADTSETLTFSQLKSKVVKLSHALLRLGIKKNDVVLIFAPNSIQFPLCFLSIVAIGAIATTVNPVYTVHELAKQVKDSNPKLVITVSELWDKVKNFNLPTVFLGSKPNLSSDSNIIHFDDLVNQSGSGSESELLNLNINNVKQSDTAALLYSSGTTGTSKGVVLSHGNFIAASLMVTMDQEVSGEKQNVFLCVLPMFHVFGLAVILYSQLQIGNAVVSMTRFELEKILGAVEKYRVTHFWVVPPIILALAKESVVKKFDLSSLKHIGSGAAPLGKDLMEECARNVSHAVVAQGYGMTETCGIVSVENPRVGIRNSGSAGPLAPGVESQIVSVDTLKPLPPTQLGEIWVRGPNMMQGYYNNPQATNLTIDKKGWVHTGDLGYFDGNGHLYVVDRIKELIKYKGFQVAPAELEGLLVSHSEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTEEDVKKFIANQVAPFKRLRSVTFINKVPKSASGKILRRELIEKVRSKM
>Bhaga_10.g2236.t1
MQTSKIWYYSELIKISNRECDLLAKIVTQSDIAALMYSSGTTGMSKGVILTHKNFIANSLMMMADQDRYGDPKNVFFCFLPMFHIYGLSVITDHLLAASEREHGGFDGQVVSGAVPLGRDVMEECAKVIPHADIFQVIWEPYTDDVLSSLPEYCRIGREVWRSVTPLICFQIVEWHLPNRALRQFGMQQDIPQPANTDVKLHDCDLRGKVHENWRHRWRHYISIWDHRREHVVTRDKMVGLMSYHDPYMDWYRRITRRFISRRSGCYEIMTLCNMRICEMFHPEQELDPAKFMELAAEAYQLAFNALEASNELHRLDSVQRVNTDSDTNTHTTVPPTATRRRRPRAQRPPHPRPQRLSPPSDPSSSMSVPPIQLRDATVTETTPMSVAQTTTPIPVAQTTTPISAAQTTTPISSTNTTTPISVAQTTTPISVAQTTTPISVAHTTTPISAAHHEHTISFLAQTFSPLASFSDVTPSSPTQSVGPFSSTQSVGPSSVPQSVVPTLVTQSEDLVQNIEVGDHGRGTGRGRGTKRLEPDMPVVLKRNPPRNKRKPCCGTE
>Bhaga_12.g2345.t1
METYLQNLAQHEEHIFRSRFPAVPVPDITLPEFVLQNAELYANKVAFVEAVTGNEVTYSDVVRDTRRFSKALSSLGIRKGYVVIVVLPNVAEYAIVALGIMAAGGVFSGANPTAHASEIKKQVEAAEAKLIVTNGPNYEKVKGLGLPVIILGEEHIEGSMNWNKLLEAADRAGSSFIKEDVHQTDLCALPFSSGTTGLSKGVMLTHRNLVANLCSTLFSVGPELVGKVTVLGLIPFFHIYGITGICCATLKNKGKVVVMGRFELRTFLNALITQEVTFAPIVPPIILQLVKNPIVGEFDLSKLKLQAIMSAAAPLAPELLTAFENKFPGVLVQEAYGLTEHSCITLTLGDPETGSRIAKKNSVGFILPNLEVKFIDPDTSRSLPKNTPGELCVRSQCVMQGYYNNKEETARTIDKEGWLHTGDIGFIDDEGNVFIVDRIKELIKYKGFQVAPAELEAILLTHPSIEDAAVVPLPDEEAGEIPAASVVMAPGAKESEEEIINYVASNIAHYKKVRVVHFVDTIPKSPSGKIMRRLIREKMIENMQAKLHS
>Bhaga_3.g2748.t1
MISVASSIEPQNSEVITSPTHQNQPSETSINATTTTTTASVFKSKLPDITISNNQPLHTYCFENLSQFSDRPCLIIGSTGKTYTFAETHLICLKIAAGLSNLGIKKGDCVMILLQNCAEFIFSFIAASMIGAVTTTANPFYTSAEVFKQFTASRAKLIITQSLYVEKLREPGENYPKLGDDFIVITVDDPPEKCLHFSVISEANETEIPIVSIDPDDPVALPFSSGTTGLPKGVILTHKSLVTSVAQQVDGENPNLYLKPEDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLLMQKFEIGTLLELIQRHRVSVAAVVPPLVLALAKNPIVEKFDLSSIRVVLSGAAPLGKELEEALRSRVPQAVLGQGYGMTEAGPVLSMCLAFAKQPFPTKSGSCGTVVRNAELKVIDPETGCSLGYNQPGEICIRGSQIMTGYLNDAEATATTIDVEGWLHTGDIGYVDDDDEIFIVDRVKELIKFKGFQVPPAELEALLVSHPSIADAAVVPQKDNVAGEVPVAFVVRSNGNELTEEAVKEFIAKQVVFYKRLHKVYFVHAIPKSPSGKILRKDLRAKLATASPMP
>Bhaga_6.g3646.t1
MESQQDNQEFIFRSKLPDIYIPSHLPLHTYCFENLSQFKDRPCLINGSNGVTYSYAQVELTARKVASGLDKLGIKQGEVILLLLQNCPEFVFAFLGASHIGAIITTANPFYTPAEVAKQAKAANVKLIITQSLYVDKVKDLAKENDVKVMCVDSPPEGYLHFDELTQANENDIPAVKINPDDVVALPYSSGTTGLPKGVMLTHRGLVTSVAQQVDGENPNLYFHKEDVILCVLPLFHIYSLNSVFLCGLRVGAAILIMQKFEIVKLLELVEKFKVTIAPFVPPIVLAIAKSPDMDKYDLSSIRTVMSGAAPMGKELEDTVRAKLPNAKLGQGYGMTEAGPVLAMCLAFAKEPFQIKSGACGTVVRNAEMKIVDPETGASLPRNQAGEICIRGSQIMKGYLNDTEATQRTIDKEGWLLTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLINHPNISDAAVVSMKDEAAGEVPVAFVIKSNGSKISEEDIKQYISRQVVFYKRINRVFFTDSIPKAPSGKILRKDLRARLAAGLVN
>Bhaga_7.g2059.t1
MALQTKQEEFIFRSKLPDIYIPKHLPLHSYCFENISNVGSRPCLINGSTGEVHTYYDVELKARKVASGLNQLGIGKADVVLLLLPNTPEFVFVFLGASHIGAITTAANPFFTPAEIAKQAKGSNAKLIITQASYYDKVKDLASENNGVKIICIDSPPQDCLHFSELTKADEHDIPQVNISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHSEDVILCVLPLFHIYSLNSVLLCGLRVGAAILIMQKFEIVSLLELIQKHKVSVMPIVPPIVLAISKSPDLHKYDLSSIRILKSGGAPLGKELEETVGAKFPNAKFGQGYGMTEAGPVLAMCLAFAKTPFDVKSGACGTVVRNAEMKIVDPETGASLPRNKPGEICIRGDQIMKGYINDPNATAATIDKEGWLHTGDIGLIDVDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPNISDAAVVSMKDDQAGEVPVAFVVRSNGSNITEDEVKQFVSKQLEREFAQRNQEQNSGALDLELDVESPEFVTVDDEPCDAIVADWNFMGRNCKVPLGTQKYVLMLNDDLEGCSWALSGADVVYDQGPAHPFALLLAMWTRAEEASCLGVDLPSDPGLRPRITDYHPNDRDQVRRAYAQRKARQSKEHNFPYKTYGAKDRRFNKGWFTRFDWLEYSIAKDAAFCLYCYLFKRDVGEQAGGDTFVTEGFSNWKCPEKLRIHEGGINSSHNQARRMFDDLLKPNQSIQSFHFKQTDQARIEYRTRLNASIDCIRFLLRQGLAFRGHDESEDSSNQANFHELLRFLADHNEDIKAVTLRNAPENNMMISPAIQKDIVSAAAVETSNAIIMELGDAFFSVLIDESRDISTKEQMAVALRYVDKKGHVVERFLGIEHVTDTTALSLKAAVEDLFCRHGLSLSRLRGQGYDETSNMQAVAKNNNKIATFFNFVANVVNIAGGSCKRLDLLKEKQATRVVESVHNGELPSGQGLNQETSLKRSCDTRWSSHYNTMISLIDMFPSIVDVLDAVAEDGATSELRGQAEHLSHFIQSFGFVFNLHLMRYILGVSNELSQALQRKDQDIVNTMKLVRISKERLQIMRENGWSSLLDEVSTFCGINKILVPNMDDIYVARGRSRRYTDGMTNLHFYRVELFYAIIDMQLQELNNRFTESNTELLLCVSCLSPSDFFATFDKQKLIRLAQFYPEDFSSSELMILSDQLDNYIFDVRSSIEFSKLEGICDLAQKMVETKKNVVYPLVYLLVTLALTLPVATATVERAFSAMKIVKNRLRSRMSDQWMNDSLIVYIEKDIFHSIDNEAIMQRFQNMKTRRNQL
MMIALAKESVMKKYNLWSLRQVVSGAVPLGRDVMEECAKVIPHADIFQGYGMTEACGIISLGNPKEEPRLSSSTGTLVSGVESQIASTDTLQPLPPNQLGEIWLRGPNINAR
>Bhaga_10.g640.t1
MEKSGYGRDGIYRSMRPPLVVPKDPNLSMVTFLFRNAASYPNKPALIDADTSETLTFSQLKSKVVKLSHALLRLGIKKNDVVLIFAPNSIQFPLCFLSIVAIGAIATTVNPVYTVHELAKQVKDSNPKLVITVSELWDKVKNFNLPTVFLGSKPNLSSDSNIIHFDDLVNQSGSGSESELLNLNINNVKQSDTAALLYSSGTTGTSKGVVLSHGNFIAASLMVTMDQEVSGEKQNVFLCVLPMFHVFGLAVILYSQLQIGNAVVSMTRFELEKILGAVEKYRVTHFWVVPPIILALAKESVVKKFDLSSLKHIGSGAAPLGKDLMEECARNVSHAVVAQGYGMTETCGIVSVENPRVGIRNSGSAGPLAPGVESQIVSVDTLKPLPPTQLGEIWVRGPNMMQGYYNNPQATNLTIDKKGWVHTGDLGYFDGNGHLYVVDRIKELIKYKGFQVAPAELEGLLVSHSEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTEEDVKKFIANQVAPFKRLRSVTFINKVPKSASGKILRRELIEKVRSKM
>Bhaga_10.g2236.t1
MQTSKIWYYSELIKISNRECDLLAKIVTQSDIAALMYSSGTTGMSKGVILTHKNFIANSLMMMADQDRYGDPKNVFFCFLPMFHIYGLSVITDHLLAASEREHGGFDGQVVSGAVPLGRDVMEECAKVIPHADIFQVIWEPYTDDVLSSLPEYCRIGREVWRSVTPLICFQIVEWHLPNRALRQFGMQQDIPQPANTDVKLHDCDLRGKVHENWRHRWRHYISIWDHRREHVVTRDKMVGLMSYHDPYMDWYRRITRRFISRRSGCYEIMTLCNMRICEMFHPEQELDPAKFMELAAEAYQLAFNALEASNELHRLDSVQRVNTDSDTNTHTTVPPTATRRRRPRAQRPPHPRPQRLSPPSDPSSSMSVPPIQLRDATVTETTPMSVAQTTTPIPVAQTTTPISAAQTTTPISSTNTTTPISVAQTTTPISVAQTTTPISVAHTTTPISAAHHEHTISFLAQTFSPLASFSDVTPSSPTQSVGPFSSTQSVGPSSVPQSVVPTLVTQSEDLVQNIEVGDHGRGTGRGRGTKRLEPDMPVVLKRNPPRNKRKPCCGTE
>Bhaga_12.g2345.t1
METYLQNLAQHEEHIFRSRFPAVPVPDITLPEFVLQNAELYANKVAFVEAVTGNEVTYSDVVRDTRRFSKALSSLGIRKGYVVIVVLPNVAEYAIVALGIMAAGGVFSGANPTAHASEIKKQVEAAEAKLIVTNGPNYEKVKGLGLPVIILGEEHIEGSMNWNKLLEAADRAGSSFIKEDVHQTDLCALPFSSGTTGLSKGVMLTHRNLVANLCSTLFSVGPELVGKVTVLGLIPFFHIYGITGICCATLKNKGKVVVMGRFELRTFLNALITQEVTFAPIVPPIILQLVKNPIVGEFDLSKLKLQAIMSAAAPLAPELLTAFENKFPGVLVQEAYGLTEHSCITLTLGDPETGSRIAKKNSVGFILPNLEVKFIDPDTSRSLPKNTPGELCVRSQCVMQGYYNNKEETARTIDKEGWLHTGDIGFIDDEGNVFIVDRIKELIKYKGFQVAPAELEAILLTHPSIEDAAVVPLPDEEAGEIPAASVVMAPGAKESEEEIINYVASNIAHYKKVRVVHFVDTIPKSPSGKIMRRLIREKMIENMQAKLHS
>Bhaga_3.g2748.t1
MISVASSIEPQNSEVITSPTHQNQPSETSINATTTTTTASVFKSKLPDITISNNQPLHTYCFENLSQFSDRPCLIIGSTGKTYTFAETHLICLKIAAGLSNLGIKKGDCVMILLQNCAEFIFSFIAASMIGAVTTTANPFYTSAEVFKQFTASRAKLIITQSLYVEKLREPGENYPKLGDDFIVITVDDPPEKCLHFSVISEANETEIPIVSIDPDDPVALPFSSGTTGLPKGVILTHKSLVTSVAQQVDGENPNLYLKPEDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLLMQKFEIGTLLELIQRHRVSVAAVVPPLVLALAKNPIVEKFDLSSIRVVLSGAAPLGKELEEALRSRVPQAVLGQGYGMTEAGPVLSMCLAFAKQPFPTKSGSCGTVVRNAELKVIDPETGCSLGYNQPGEICIRGSQIMTGYLNDAEATATTIDVEGWLHTGDIGYVDDDDEIFIVDRVKELIKFKGFQVPPAELEALLVSHPSIADAAVVPQKDNVAGEVPVAFVVRSNGNELTEEAVKEFIAKQVVFYKRLHKVYFVHAIPKSPSGKILRKDLRAKLATASPMP
>Bhaga_6.g3646.t1
MESQQDNQEFIFRSKLPDIYIPSHLPLHTYCFENLSQFKDRPCLINGSNGVTYSYAQVELTARKVASGLDKLGIKQGEVILLLLQNCPEFVFAFLGASHIGAIITTANPFYTPAEVAKQAKAANVKLIITQSLYVDKVKDLAKENDVKVMCVDSPPEGYLHFDELTQANENDIPAVKINPDDVVALPYSSGTTGLPKGVMLTHRGLVTSVAQQVDGENPNLYFHKEDVILCVLPLFHIYSLNSVFLCGLRVGAAILIMQKFEIVKLLELVEKFKVTIAPFVPPIVLAIAKSPDMDKYDLSSIRTVMSGAAPMGKELEDTVRAKLPNAKLGQGYGMTEAGPVLAMCLAFAKEPFQIKSGACGTVVRNAEMKIVDPETGASLPRNQAGEICIRGSQIMKGYLNDTEATQRTIDKEGWLLTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLINHPNISDAAVVSMKDEAAGEVPVAFVIKSNGSKISEEDIKQYISRQVVFYKRINRVFFTDSIPKAPSGKILRKDLRARLAAGLVN
>Bhaga_7.g2059.t1
MALQTKQEEFIFRSKLPDIYIPKHLPLHSYCFENISNVGSRPCLINGSTGEVHTYYDVELKARKVASGLNQLGIGKADVVLLLLPNTPEFVFVFLGASHIGAITTAANPFFTPAEIAKQAKGSNAKLIITQASYYDKVKDLASENNGVKIICIDSPPQDCLHFSELTKADEHDIPQVNISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHSEDVILCVLPLFHIYSLNSVLLCGLRVGAAILIMQKFEIVSLLELIQKHKVSVMPIVPPIVLAISKSPDLHKYDLSSIRILKSGGAPLGKELEETVGAKFPNAKFGQGYGMTEAGPVLAMCLAFAKTPFDVKSGACGTVVRNAEMKIVDPETGASLPRNKPGEICIRGDQIMKGYINDPNATAATIDKEGWLHTGDIGLIDVDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPNISDAAVVSMKDDQAGEVPVAFVVRSNGSNITEDEVKQFVSKQLEREFAQRNQEQNSGALDLELDVESPEFVTVDDEPCDAIVADWNFMGRNCKVPLGTQKYVLMLNDDLEGCSWALSGADVVYDQGPAHPFALLLAMWTRAEEASCLGVDLPSDPGLRPRITDYHPNDRDQVRRAYAQRKARQSKEHNFPYKTYGAKDRRFNKGWFTRFDWLEYSIAKDAAFCLYCYLFKRDVGEQAGGDTFVTEGFSNWKCPEKLRIHEGGINSSHNQARRMFDDLLKPNQSIQSFHFKQTDQARIEYRTRLNASIDCIRFLLRQGLAFRGHDESEDSSNQANFHELLRFLADHNEDIKAVTLRNAPENNMMISPAIQKDIVSAAAVETSNAIIMELGDAFFSVLIDESRDISTKEQMAVALRYVDKKGHVVERFLGIEHVTDTTALSLKAAVEDLFCRHGLSLSRLRGQGYDETSNMQAVAKNNNKIATFFNFVANVVNIAGGSCKRLDLLKEKQATRVVESVHNGELPSGQGLNQETSLKRSCDTRWSSHYNTMISLIDMFPSIVDVLDAVAEDGATSELRGQAEHLSHFIQSFGFVFNLHLMRYILGVSNELSQALQRKDQDIVNTMKLVRISKERLQIMRENGWSSLLDEVSTFCGINKILVPNMDDIYVARGRSRRYTDGMTNLHFYRVELFYAIIDMQLQELNNRFTESNTELLLCVSCLSPSDFFATFDKQKLIRLAQFYPEDFSSSELMILSDQLDNYIFDVRSSIEFSKLEGICDLAQKMVETKKNVVYPLVYLLVTLALTLPVATATVERAFSAMKIVKNRLRSRMSDQWMNDSLIVYIEKDIFHSIDNEAIMQRFQNMKTRRNQL
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University