Enzyme
A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in flavonoid biosynthesis.
C4H
Enzyme
Cinnamate 4-hydroxylase
Enzyme name
EC:1.14.14.91
Entry
Oxidoreductases;Acting on paired donors, with incorporation or reduction of molecular oxygen;With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Class
trans-cinnamate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
Sysname
trans-cinnamate + [reduced NADPH---hemoprotein reductase] + O2 = 4-hydroxycinnamate + [oxidized NADPH---hemoprotein reductase] + H2O[RN:R02253]
Reaction
4-hydroxycinnamate [CPD:C00811];[oxidized NADPH---hemoprotein reductase] [CPD:C03161];H2O [CPD:C00001]
Product
Species information
Fagopyrum esculentum
Species name
Common buckwheat (Fagopyrum esculentum) is a species of eudicot in the family Polygonaceae (buckwheat family).
Species info
Gene sequence info
Fagopyrum_esculentum.C4H.fa
Download
>gene:Fes_sc0000044.1.g000005.aua.1
MDLVLLQKGLYGLFFAISVAIVISKLRGKKYKLPPGPIPVPIFGNWLQVGDDLNHRNLTELAKKYGEIFLLRMGQRNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRHGWESEAQSVVDDVKKNPESATKGIVLRRRLQMMMYNNMYRIMFDTRFDKEDDPLFTKLKALNGERSRLAQSFEYNYGDFIPILRPFLRGYLKICKEVKERRLKLFKDYFVDERKKLGSTRPSSNNELKCAIDHILEAQQKGEISEDNVLYIVENINVAAIETTLWSIEWGIAELVNHPEIQRKLRDELDTVLGKGVQITEPDLPKLPYLQAVVKETLRLRMAIPLLVPHMNLHDAKLGGFDIPAESKILVNAWWLANNPAQWKKPEEFRPERFLEEEAKVDANGNDFRYLPFGVGRRSCPGIILALPILGITIGRLVQNFEMLPPPGENKLDTSEKGGQFSLHILKHSTIVMKPTA
>gene:Fes_sc0000086.1.g000027.aua.1
MDLALLQKGLYGLFVSVTLAIIISKLRGKKYRLPPGPVPVPIFGNWLQVGDDLNHGNLTELAKKFGDIFLLRMGQRNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGDHWRKMRRIMTVPFFTNKVVQQNRLGWEDEAARVVDDIKKNPEAARGGIVLRRRLQLMMYNNLYRLMFNRRFESDEDPLFIKLRALNAERSRLSQSFEYNYGDFIPVLRPFLRGYLKVCKELQERRLNVFKDYFIDERRQLASTKGSSNADVKCAIDHILEAQQKGEINEDNVLYIVENINVAAIETTLWSVEWALGELVNHPNIQAKLRTELDTVLGKGVEVTEPDLQNLPYLMAVVKEALRLRMAIPLLVPHMNLNDAKLAGYDIPAESKILVNAWWLANNPTLWKNPEEFRPERFLEEESKVDANGNDFRYLPFGVGRRSCPGIVLAMPIAGITVGRLVQNFDILPPNGESKIDLTEKPGQFSLQIKNHYTVVLKPRN
>gene:Fes_sc0000454.1.g000008.aua.1
MAFLLSEILYSIFVSVILATLVSILRARKYKLPPGPIPVPIFGNWLQIGDNLNHRKLTELAKTYGHIFLLRMGQRTIVVVSSPELAKDVLQTQGVQFGSHSRNIVMDVLTGKGQDLLYTVYGEHWRKMRRITTTSLFTKKVVQLNRVVWEDEAARMVEDVMKNPKAAREGVVIRKRIRLMIYNNLYMLMYNKRFEREDDELLLRIRELNEKRVMLLQSFKYNYGDFIPFLRPLCSGYLKLCKDVQKRRLNLFKDYFLDERKKVVSTKGSNKCAIDHILEAEQKGEINEDNVLYLLENINVGGIDTILWTCEWAMGEIVNNPRIQKKLRDELDSVVGKGVVVTVPDLEKLPYLNAVIKETLRLKMPNPLLVPHMNICHAKLAGYDIPAESKIYVNAWWLANNPDLWKKPEEFRPERFLEEELNVEPNGEDFRYVPFGAGRRICPGIVLALPIARIIVGTLVHNFELLPPPGQDKIDLTERFGQSSMTMMTYCTIVLKPRSF
>gene:Fes_sc0000454.1.g000003.aua.1
MALLTDFLLCEKVLYSIFVSVILATLVSKLRAKKYRLPPGPIPVPIFGNWLQIGDNLNHRKLTELAKTYGHIFLLRMGQRTIVVVSSPELAKEVLQTQGVEFGSHSRNIVMDVLTGKGQDLLYTVYGEHWRKMRRIATASLFTKKVVQLNRVVWEDEAARMVEDIMKNPKAAREGIVIRKRIRALNEKRVMLLQSFKYNYGDFIPFLRPFCSGYLKLCKDVQKRRLNLFKDYFLDERKKVVSTKGSNKCAIDHILEAEQKGEISEDNVLYLLENINVGGIDTILWTCEWAMGEIVNNPRIQKKLRDELDSVVGKGIGVRVPDLEKLPYLNAVIKETLRLKTVNPLLVPHMNISDAKLAGYDIPAESKIYINAWWLANNPDLWKNPEEFRPERFLEEESKVEPNGEDFRYVPFGAGRRICPGIVLTLPIVGIIVGNLVHNFELLAPPGQDKIDLTERFGQSSMTMMTYCTIVLKPRSF
>gene:Fes_sc0000454.1.g000009.aua.1
MAFLLSEKVLYSILVSVTLAIIVSKLRAKKYRLPPGPIPIPIFGNWLQLGDNLTYRKLTELSKTYGEIFLLRMGQRNLVVVSSPELAKEVLQTQGVEFGSRPRNIVLDVFSGKGKDMLFTVYGEHWRKMRRITTAPFFTKKVVQLNRVGWEDEAARMVEDVRKNPKAAREGIVIRTRIQLMLYNNLYMLMFNKRFESEDDELLLRLRALNDKRARLSQSFKYNYGDFIPVLRPFCSGYLKLCKDVQRRRLNFYKDKFLNERKKVASTKGSKKCGIDHILEAQQKGEINEDNVLYLLENLNLGGVETTLATIEKAIGEVVNNPRIQKKLRDELDSVVGKGVGVTVPDLEKLPYLNAVIKETLRLNTVAPLLVPHMNLHDAKLAGYDIPAESKVFVNAWWLANNPDHWKNPEEFRPERFLEEESEVDTNGNDFRYVPFGVGRRNCPGSVLALPIAGIIIGNLVHNFELLLPPGQDRIDMTELIGQFTSNMMNHYTIVLKPRSF
>gene:Fes_sc0000454.1.g000002.aua.1
MVNNPMKLRDDRAGQCRRKRRPSNGYDIPAESKIPVNAWWLANNPDHWKNPEEFRPERFLEEESEVDPNGEDFRYVLFGIGRRSCPGIVLRNMARLR
>gene:Fes_sc0007020.1.g000001.aua.1
MDLLFLQKGLYGLCLAIVIAIVISKLRGKKYKLPPGPIPVPIFGNWLQNINVAALETTLWSIEWGIAELVNHQEIQTKLRAELDKVLGKGTEITEPDLAKLPYLQAIIKETLRLRMAIPLLVPHMNLNDAKLGGYNIPAESKILVNAWWLANNPAEWKNPEEFRPERFLEEEAKVEANGNDFRYVPFGVGRRSCPGIILALPIVGIVLGRLVQNFELLPPPGEMKVDTSEKGGQFSLHILKHSTIVMKPRI
>gene:Fes_sc0022474.1.g000001.aua.1
YKLPPGPIPVPIFGNWLQVGDDLNHRNLTDLAKKYGEIFLLRMGQRNLVVVSSPKLAKEVLHTQGVEFGSRTRNVVFDIFTGEGQDMVFTVYGDHWRKMRRIMTVPFFTNKVVQQYHRGWEEEIQFVVEEMKGNPEAAKGGVVLRRRLQLMIYNNLYRIMFDRRFESEEDPLFKQLIALNGERSRLAQSFEYNYGDFIPILRPFLRGYLKICKEVKETRLKIFKDYFVDERKKLGSSKSSNSKELKCATDHMLEAQQKGEINEDNVLYIVENINVAEVLLSLDLVRSPPYSVPFHRHPCSNPFHRP
MDLVLLQKGLYGLFFAISVAIVISKLRGKKYKLPPGPIPVPIFGNWLQVGDDLNHRNLTELAKKYGEIFLLRMGQRNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRHGWESEAQSVVDDVKKNPESATKGIVLRRRLQMMMYNNMYRIMFDTRFDKEDDPLFTKLKALNGERSRLAQSFEYNYGDFIPILRPFLRGYLKICKEVKERRLKLFKDYFVDERKKLGSTRPSSNNELKCAIDHILEAQQKGEISEDNVLYIVENINVAAIETTLWSIEWGIAELVNHPEIQRKLRDELDTVLGKGVQITEPDLPKLPYLQAVVKETLRLRMAIPLLVPHMNLHDAKLGGFDIPAESKILVNAWWLANNPAQWKKPEEFRPERFLEEEAKVDANGNDFRYLPFGVGRRSCPGIILALPILGITIGRLVQNFEMLPPPGENKLDTSEKGGQFSLHILKHSTIVMKPTA
>gene:Fes_sc0000086.1.g000027.aua.1
MDLALLQKGLYGLFVSVTLAIIISKLRGKKYRLPPGPVPVPIFGNWLQVGDDLNHGNLTELAKKFGDIFLLRMGQRNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGDHWRKMRRIMTVPFFTNKVVQQNRLGWEDEAARVVDDIKKNPEAARGGIVLRRRLQLMMYNNLYRLMFNRRFESDEDPLFIKLRALNAERSRLSQSFEYNYGDFIPVLRPFLRGYLKVCKELQERRLNVFKDYFIDERRQLASTKGSSNADVKCAIDHILEAQQKGEINEDNVLYIVENINVAAIETTLWSVEWALGELVNHPNIQAKLRTELDTVLGKGVEVTEPDLQNLPYLMAVVKEALRLRMAIPLLVPHMNLNDAKLAGYDIPAESKILVNAWWLANNPTLWKNPEEFRPERFLEEESKVDANGNDFRYLPFGVGRRSCPGIVLAMPIAGITVGRLVQNFDILPPNGESKIDLTEKPGQFSLQIKNHYTVVLKPRN
>gene:Fes_sc0000454.1.g000008.aua.1
MAFLLSEILYSIFVSVILATLVSILRARKYKLPPGPIPVPIFGNWLQIGDNLNHRKLTELAKTYGHIFLLRMGQRTIVVVSSPELAKDVLQTQGVQFGSHSRNIVMDVLTGKGQDLLYTVYGEHWRKMRRITTTSLFTKKVVQLNRVVWEDEAARMVEDVMKNPKAAREGVVIRKRIRLMIYNNLYMLMYNKRFEREDDELLLRIRELNEKRVMLLQSFKYNYGDFIPFLRPLCSGYLKLCKDVQKRRLNLFKDYFLDERKKVVSTKGSNKCAIDHILEAEQKGEINEDNVLYLLENINVGGIDTILWTCEWAMGEIVNNPRIQKKLRDELDSVVGKGVVVTVPDLEKLPYLNAVIKETLRLKMPNPLLVPHMNICHAKLAGYDIPAESKIYVNAWWLANNPDLWKKPEEFRPERFLEEELNVEPNGEDFRYVPFGAGRRICPGIVLALPIARIIVGTLVHNFELLPPPGQDKIDLTERFGQSSMTMMTYCTIVLKPRSF
>gene:Fes_sc0000454.1.g000003.aua.1
MALLTDFLLCEKVLYSIFVSVILATLVSKLRAKKYRLPPGPIPVPIFGNWLQIGDNLNHRKLTELAKTYGHIFLLRMGQRTIVVVSSPELAKEVLQTQGVEFGSHSRNIVMDVLTGKGQDLLYTVYGEHWRKMRRIATASLFTKKVVQLNRVVWEDEAARMVEDIMKNPKAAREGIVIRKRIRALNEKRVMLLQSFKYNYGDFIPFLRPFCSGYLKLCKDVQKRRLNLFKDYFLDERKKVVSTKGSNKCAIDHILEAEQKGEISEDNVLYLLENINVGGIDTILWTCEWAMGEIVNNPRIQKKLRDELDSVVGKGIGVRVPDLEKLPYLNAVIKETLRLKTVNPLLVPHMNISDAKLAGYDIPAESKIYINAWWLANNPDLWKNPEEFRPERFLEEESKVEPNGEDFRYVPFGAGRRICPGIVLTLPIVGIIVGNLVHNFELLAPPGQDKIDLTERFGQSSMTMMTYCTIVLKPRSF
>gene:Fes_sc0000454.1.g000009.aua.1
MAFLLSEKVLYSILVSVTLAIIVSKLRAKKYRLPPGPIPIPIFGNWLQLGDNLTYRKLTELSKTYGEIFLLRMGQRNLVVVSSPELAKEVLQTQGVEFGSRPRNIVLDVFSGKGKDMLFTVYGEHWRKMRRITTAPFFTKKVVQLNRVGWEDEAARMVEDVRKNPKAAREGIVIRTRIQLMLYNNLYMLMFNKRFESEDDELLLRLRALNDKRARLSQSFKYNYGDFIPVLRPFCSGYLKLCKDVQRRRLNFYKDKFLNERKKVASTKGSKKCGIDHILEAQQKGEINEDNVLYLLENLNLGGVETTLATIEKAIGEVVNNPRIQKKLRDELDSVVGKGVGVTVPDLEKLPYLNAVIKETLRLNTVAPLLVPHMNLHDAKLAGYDIPAESKVFVNAWWLANNPDHWKNPEEFRPERFLEEESEVDTNGNDFRYVPFGVGRRNCPGSVLALPIAGIIIGNLVHNFELLLPPGQDRIDMTELIGQFTSNMMNHYTIVLKPRSF
>gene:Fes_sc0000454.1.g000002.aua.1
MVNNPMKLRDDRAGQCRRKRRPSNGYDIPAESKIPVNAWWLANNPDHWKNPEEFRPERFLEEESEVDPNGEDFRYVLFGIGRRSCPGIVLRNMARLR
>gene:Fes_sc0007020.1.g000001.aua.1
MDLLFLQKGLYGLCLAIVIAIVISKLRGKKYKLPPGPIPVPIFGNWLQNINVAALETTLWSIEWGIAELVNHQEIQTKLRAELDKVLGKGTEITEPDLAKLPYLQAIIKETLRLRMAIPLLVPHMNLNDAKLGGYNIPAESKILVNAWWLANNPAEWKNPEEFRPERFLEEEAKVEANGNDFRYVPFGVGRRSCPGIILALPIVGIVLGRLVQNFELLPPPGEMKVDTSEKGGQFSLHILKHSTIVMKPRI
>gene:Fes_sc0022474.1.g000001.aua.1
YKLPPGPIPVPIFGNWLQVGDDLNHRNLTDLAKKYGEIFLLRMGQRNLVVVSSPKLAKEVLHTQGVEFGSRTRNVVFDIFTGEGQDMVFTVYGDHWRKMRRIMTVPFFTNKVVQQYHRGWEEEIQFVVEEMKGNPEAAKGGVVLRRRLQLMIYNNLYRIMFDRRFESEEDPLFKQLIALNGERSRLAQSFEYNYGDFIPILRPFLRGYLKICKEVKETRLKIFKDYFVDERKKLGSSKSSNSKELKCATDHMLEAQQKGEINEDNVLYIVENINVAEVLLSLDLVRSPPYSVPFHRHPCSNPFHRP
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University