Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Euphorbia lathyris
Species name
Euphorbia lathyris is a species of eudicot in the family Euphorbiaceae (spurge family).
Species info
Gene sequence info
Euphorbia_lathyris.COMT.fa
Download
>Casp00902.t1
MDSPAEIHLNHADEEKEENFGYAIQLALSSALPMALHSAIQLGVFEIIANAKLSSSEIAAKMPTTNPDAAMMLDRILRLLASHKVVDCSLNGLDRVYGLNSVSKYFVPNQSGMSLAPLMTLVQDKVFLESWSELKDAVLEGGSPFKRYHKTHAFGYCAMDERFNQVFNSAMFHHTNIVMEKILESYRGFESLKQLVDVGGGLGQTLKAITSKYPYINGINFDLPHVIQNAPACPGVEHVGGDMFESVPKGDAIFMKWILHDWSDEHCLRVLKNCYESVPDDGKVIVVDAVLPVMPNSSAAAKANFQTDVICLTVYEGGKERTEHDFLTLAIKAGFRGIRYECFVCNFWVMEFFKTAQMLT
>Casp13989.t1
MDSKSNNPDEEQACLDAVLFSGSHVFPLVLHTAIELNLFNIISNSGPGAYLSASEIASHLPSTNPDAPSILDRILHLFATHSLLSYAPRPLPDGRTEKTYALTPSSKFFTGTAEDGNISFISKLAFHKATIEVWLNMKDVVLDGGNLFKKIHGVSIFEYMNKDGEFNGVFNQAMVGLSSVIMKGILGEYGGFEDVEVLVDVGGGIGRVLNMIVSKYPSIKGINFDLPHVVQSAPSYPGIEHIGGSMLEAVPKGDAIMIKDTCHNWTDVNVIKVLKNINEALPENGKLIIINALMPEEPETSKASKYVARLDNTMLTQPSGKERTAKEFEILTKAAGFSNFKVACVAHGIWAVMEAFK
>Casp18506.t1
MEMENSESRKSARLAILELAIMISIPMSLNAVIRLNVADAMWQDGANSPLSASEILSRILPSGGGDAENLQRLLRMLTSYSVFSEHIDGDGSQRKYSLTEIGKTLVSDSDGLSCASYVLQHHQDALMRAWPLAHEAVLDPMTEPFVKVNGEAAYDYYGKRPEMVDLMMKAMSVDVSDMDRR
>Casp22610.t1
MTPPRDVSEEEEANLFAMQLASASVLPMVLKSAIELDLLEIMKKAGDGAFLSPSEIAYHLPTTNPDAPVMLDRMLRLLASYSVLNCSLRTLPDGQFLRLYGLAPVCKFLTKNEDGVSIGALCLMNQDKILMESWYHLKEAVLEGGIPFNKAYGMSAFEYHGKDERFNKVFNTGMSDHSTITMKKLLETYKGFEGLNTIVDVGGGTGAVLAMILSKYPSIQAINFDLPHVVHDAPSYPGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCLKLLKNCYKALPSKGKVVVAECVLPVAPDTSLATKSVIHIDCIMLAHNPGGKERTLKEFEALAKGAGFQGFQLMCCAFNTYVMEFLKTPLSL
>Casp31851.t1
MGEHEEEEEEEMGKVAVRLANAAVLPLVLKSAIELNLINIIFKATSDGFSLSPCEIAARIPTKNPDAPFLLDRMLRLLASYDILLVSESVSDGELKRVYSAAPICKFLTWNQSEEGESVAPLFLLHHDEVFMKSWYHLNDVILDGGIPFNRAYGMTNFEYLGTDQRFNKVFNQAMSNHTALIAKKILHVYKGFDGLKVLVDVGGGNGVTLNLITSKYPQIKGINFDLPHVLADAPSFPGVEHVGGDMFISVPKGDAVFMKWILHGWSDEYCLKLLQKCWEAIPSKGKVIVVESVLAVEADKSNSVSTQIVFEQDMFMLAQTSGGMERTLKDYHNLAINSGFTGCQLICSAYNTWVMEFHKQ
>Casp35634.t1
MENENSESRNTARLAILELANMISVPMSLNAVVRLNVADAIWQGGANAPLSASEILSRILPSGGDAENLQRILRMLTSYGVFSEHIDGDGSLRKYSLTEIGKTLVTDADGLSYASYVLQHHQDALMRAWPLVHEAVLDPTTEPFVKANGEAAYDYYGKKPEMNGLMLKAMSGVSVPFMKAVLSSYDGFGGVEKLVDVGGSGGDCLKMILNNYPNIRQAINFDLPEVVAKAPTITGVTHVGGDMFKSIPSADAIFMKWVLTTWTDEECKKIMENCYKAVPVGGKMIACEPVLPKDSDESHRTRALLEGDIFVMTIYRAKGKHRTEAEFKKLGELVGFSSFRAYYIDHFYTVLEFLK
MDSPAEIHLNHADEEKEENFGYAIQLALSSALPMALHSAIQLGVFEIIANAKLSSSEIAAKMPTTNPDAAMMLDRILRLLASHKVVDCSLNGLDRVYGLNSVSKYFVPNQSGMSLAPLMTLVQDKVFLESWSELKDAVLEGGSPFKRYHKTHAFGYCAMDERFNQVFNSAMFHHTNIVMEKILESYRGFESLKQLVDVGGGLGQTLKAITSKYPYINGINFDLPHVIQNAPACPGVEHVGGDMFESVPKGDAIFMKWILHDWSDEHCLRVLKNCYESVPDDGKVIVVDAVLPVMPNSSAAAKANFQTDVICLTVYEGGKERTEHDFLTLAIKAGFRGIRYECFVCNFWVMEFFKTAQMLT
>Casp13989.t1
MDSKSNNPDEEQACLDAVLFSGSHVFPLVLHTAIELNLFNIISNSGPGAYLSASEIASHLPSTNPDAPSILDRILHLFATHSLLSYAPRPLPDGRTEKTYALTPSSKFFTGTAEDGNISFISKLAFHKATIEVWLNMKDVVLDGGNLFKKIHGVSIFEYMNKDGEFNGVFNQAMVGLSSVIMKGILGEYGGFEDVEVLVDVGGGIGRVLNMIVSKYPSIKGINFDLPHVVQSAPSYPGIEHIGGSMLEAVPKGDAIMIKDTCHNWTDVNVIKVLKNINEALPENGKLIIINALMPEEPETSKASKYVARLDNTMLTQPSGKERTAKEFEILTKAAGFSNFKVACVAHGIWAVMEAFK
>Casp18506.t1
MEMENSESRKSARLAILELAIMISIPMSLNAVIRLNVADAMWQDGANSPLSASEILSRILPSGGGDAENLQRLLRMLTSYSVFSEHIDGDGSQRKYSLTEIGKTLVSDSDGLSCASYVLQHHQDALMRAWPLAHEAVLDPMTEPFVKVNGEAAYDYYGKRPEMVDLMMKAMSVDVSDMDRR
>Casp22610.t1
MTPPRDVSEEEEANLFAMQLASASVLPMVLKSAIELDLLEIMKKAGDGAFLSPSEIAYHLPTTNPDAPVMLDRMLRLLASYSVLNCSLRTLPDGQFLRLYGLAPVCKFLTKNEDGVSIGALCLMNQDKILMESWYHLKEAVLEGGIPFNKAYGMSAFEYHGKDERFNKVFNTGMSDHSTITMKKLLETYKGFEGLNTIVDVGGGTGAVLAMILSKYPSIQAINFDLPHVVHDAPSYPGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCLKLLKNCYKALPSKGKVVVAECVLPVAPDTSLATKSVIHIDCIMLAHNPGGKERTLKEFEALAKGAGFQGFQLMCCAFNTYVMEFLKTPLSL
>Casp31851.t1
MGEHEEEEEEEMGKVAVRLANAAVLPLVLKSAIELNLINIIFKATSDGFSLSPCEIAARIPTKNPDAPFLLDRMLRLLASYDILLVSESVSDGELKRVYSAAPICKFLTWNQSEEGESVAPLFLLHHDEVFMKSWYHLNDVILDGGIPFNRAYGMTNFEYLGTDQRFNKVFNQAMSNHTALIAKKILHVYKGFDGLKVLVDVGGGNGVTLNLITSKYPQIKGINFDLPHVLADAPSFPGVEHVGGDMFISVPKGDAVFMKWILHGWSDEYCLKLLQKCWEAIPSKGKVIVVESVLAVEADKSNSVSTQIVFEQDMFMLAQTSGGMERTLKDYHNLAINSGFTGCQLICSAYNTWVMEFHKQ
>Casp35634.t1
MENENSESRNTARLAILELANMISVPMSLNAVVRLNVADAIWQGGANAPLSASEILSRILPSGGDAENLQRILRMLTSYGVFSEHIDGDGSLRKYSLTEIGKTLVTDADGLSYASYVLQHHQDALMRAWPLVHEAVLDPTTEPFVKANGEAAYDYYGKKPEMNGLMLKAMSGVSVPFMKAVLSSYDGFGGVEKLVDVGGSGGDCLKMILNNYPNIRQAINFDLPEVVAKAPTITGVTHVGGDMFKSIPSADAIFMKWVLTTWTDEECKKIMENCYKAVPVGGKMIACEPVLPKDSDESHRTRALLEGDIFVMTIYRAKGKHRTEAEFKKLGELVGFSSFRAYYIDHFYTVLEFLK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University