Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Euphorbia lathyris
Species name
Euphorbia lathyris is a species of eudicot in the family Euphorbiaceae (spurge family).
Species info
Gene sequence info
Euphorbia_lathyris.CHS.fa
Download
>Casp00351.t1
MSKPETNGSSGHHSAHIRRAPTPGKAAILAVGKAFPSQLIPQDCLVEGYIRDTKCEDVSIKEKLERLCKTTTVKTRYTVMCKDILDKYPELATEGSPTIKQRLDIANPAVVEMAKEASLSCIKQWGRPVEDITHIVYVSSSEIRLPGGDLYLSSELGLRSDVSRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNKARPYDLVGAALFGDGAAAVMIGANPEMDRECPFMELNYAVQQFLPGTQNVIDGRLSEEGINFKLGRDLPQKIEDNIEEFCKKVISKGELSTTDFNKLFWAVHPGGPAILNRLEATLKLNGDKLECSRRALMDYGNVSSNTIFYVIEYMRDALKNKKADGEEWGLALAFGPGITFEGILLRSL
>Casp04045.t1
MVSVEEVRNAQRAQGPATILAIDTATPPNCVYQDTYPDYYFRITNSEHMTDLKLKFKRMCEKSMIKKRYMHLTEEILKENPNICEYMAPSLDARQDIAVVEIPKLGKEAATKAINEWGQPKSKITHLVFCTITGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKDARVLVVCSEITSVTFRGPNDAHIDSLVGQALFGDGAAAIIIGSDPVAQVEKPLFELVSAAQTILPDSHGAVEGHLREVGLTFHLLKDVPELISKNIEKSLIEAFQPLGISDWNSIFWIAHPGGSAILDQVEATLRLKQEKLQATRHVLSEYGNMSSACVLFIFDDMRKKSAKEGMKSTGEGLDWGVLFGGLNMSGADYQLIKLLGFRPSVKRLMMYQQGCFTRGIVLRLAKDPAENNKDACVLVVCSEITAVIFRGPSDTYLDGLVGQALFGDGAAAVTVGSDPVA
>Casp04046.t1
MVSVDEVRNAQRAQGLATILAIGAIPPNCVYQDTYPNYYFRITNSEHMTDLKLKFKRICEKSMIKKRYMHLTEDILKENPNIYEYMAPLLDARQEIVVVEIPKLGKDAGTKAIKEWVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVNFRGPSDAHLDSLIGQAIFGDGAGAIIIGSDQVEKPLFELVSAAQTILSDNHGAIGGHLREAGQTFHLSKDVPGLILKNIEKSLIEAFQPLGISNWNSIFWIVHPGGPAILDQVEATLRLKQEKLRASRHVLSEYGNMSSACVLFILDDMRKKSAEEGMKSTGEGLDWGVLFGFGPEVTVETIVLHSVAI
>Casp04048.t1
MVSVEEVRNAQRAQGPATILAIGTANPENCVDQDTYPDFYFRITNSEHMTDLKQKFKRMYEKSMIKKRYMHLTEEILKENPKICEYMAPSLDARQDIVVVEIPKLGKEAATKAIKEWGQRKSKITHLVFCTTSGVDMPGADYQLIKLLGLRPSVKRFMMYQQGCFASGTVLPLAKDLAENNKDACVLVVYSEITAVTFCGPSDTHLDSLVGQALFGDGAAAIIVGSDPVAHVEKSLFELVLAAQTILPDSHGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLTEAFQPLGISDWNSILWVAHPGGPAILD
>Casp04049.t1
MVSVEEVRNAQRAQGPATILAIGTATPPNCVDQDTYPDYYFRITNSEHMTDLKLKFKRMCEKSMIKKRYMHLTEEILKENPNICEYMAPSLDARQDIVVVEIPKLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPNDAHLDSLVGQALFGDGAAAIIIGSDPLPQVEKPLFELVSAAQTILPDSHGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLIEAFQPLGISDWNSIFWIAHPGGPAILDQVEATLRLKEEKLRATRHVLSEYGNMSSACVLFILDDMRKKSTEEGMKSTGEGLDWGVLFGFGPGLTVETIVLHSIAI
>Casp12276.t1
MGSEGRIAHEGLPKAASPGKATILALGKAFPHQLVMQEFLVDGYFRNTNCDDPDLKQKLARLCKTTTVKTRYVVMSDEILSKYPELAIEGLPTVKQRLDICNDAVTEMAVEASQTCIKNWGRSISSITHVVYVSSSEARLPGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGFKPPSAERPYDLVGVALFGDGAGAMIIGTDPVPETERPLFELHTAIQNFLPDTEKIIDGKLTEEGISFKLSRELPNIIEDNIEGFCKKLIDVVGLTDKDYNKLFWAVHPGGPAILNRMEKRLDLSPEKLNASRRALMDYGNASSNTIVYVLEYMLEESLKMGDTEKSEWGLVLAFGPGITFEGILARNLMV
>Casp12771.t1
MASVSVQEIRNGQRAQGPATILAIGTATPSNCVNQSEYPDYYFRITQSEHMTDLKEKFKRMCEKSMIKKRYMFLDEEILKENKNMCGYWESSLDARQDIVVVQVPKLGKEAATKAIKEWGQPKSKITHLIFCTTSGVDMPGCDYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRMAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAGALIVGADPDTSIERPLFEVVSAAQTILPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLVEAFTPIGIKDWNSIFWVAHPGGPAILDQVEEKLKLKPEKMRATRHVLSEYGNMSSACVLFILDEMRNKSIQQAKPTTGEGLDWGVLFGFGPGLTVETVVLHSVAL
>Casp21055.t1
MEMEGKVGVPKAAKGVATILAVGTANPPNCILQADYPDFYFRITQTQHMTQLKDKFTRICEKSTVKKRYLHLSEEFIKDNPNIAIYKAPSLDARQEILVKEVPKLGKEAALKAIKEWGQPIKKITHLIFCTSAGIAMPGADQELIKLLGLDYSVKRFMMYQSGCFAGAAALRLAKDMAENNPQSRILIVCSENTTNCFHAPSDTHLDILIGSAIFGDGAAALIVGAHPEINIERPLYEVISASQTIIPNSEDGVVGNLCEMGLSYYLSKRVPNYIADNIVDLLVKEENLKEFGIKNWNSLFYIVHPGGPDILDRLEMKLGLTKDKLRATRHVLSEYGNMWSPSVFFVIDEMRRRSAHKGKNTSGEGLDLGLLLAFGPGLTIETLMLRNIPIYY
>Casp21059.t1
MHLSEEIIKNNPNIAIYKSPSLDARQEILVKEVPKLGKEAALKAIKEWGQPIKKITHLIFCTSSGVDMPGADLELIKLLGLNYSVKRLMMYHSGCFAGAAALRLAKDMAENNHQSRILIVCSENMTSFFHAPSDNHLDILIGSAIFADGAAALIVGAHLEINIEHPLFEVISASQTIIPNSEDGIVGHLCEMGLSYYLSKGVPNFIADNIVDLLVKEENLKEFGIKNWNSLFYIVHPGGPVILDRLEMKLGLTKDKLKATRHVLIEYGNMWSPSVFFIIDEMRRRSAQEGKNTTGEGLDLGFLLSFGPGLTVEILMLRSIPIQY
>Casp21060.t1
MEMEGKVGVPKANKGVATILAVRTANPPNCIFQADYPDFYFRITQTQHMTQLKDKFTRICEKSTVKKRYMHLSEEMIKDNPNIAIYKACTSRNSGITMPGADQELIKLLGLDYSVKRFMMYQQENMTACFHAPSDTHLDILIGSAIFADGAAALIVGTHPEIDIEHPLFEVISASQTIIPDSEDGIVGHVCEMGLSYYLSKGVPNFIADNIGGPGILDRLEMKLGLTKDKLRATKHVLSEYGNMWSPSVFFILDEMRRRSVQEGTDTTGEGLDLGLLLAFGPGLTEEEKREAREWKIEDGKAVVRTRGGMEECSGDQLLDCSCDEPTIVTSSVSIRTDREEAEAEAAGTAVADGEYAGSLKPSMGFTMTDENEMGRRRMYKKLSYTAPIYKASCSLVHVAELSATLYAIRLTYNKG
>Casp33357.t1
MPSADYALMKQLGLPPSIKRFMIYQQGCSGGGNVLRLANDVAENNLNARVLVVCSEHVVVSFHAPSHTHLDILVGAAIFSDGAGAVIVGADPDINIERPLFQLISAFQTTIPNSEDAIRGQTLEMGLSYYLSRAIPKIIGDHIVGIMNETCDGIGVKDWNSLFYVAHAGGPSILRGMEEKLGLDKEKLRLDCNCILAPSSFVTDY
MSKPETNGSSGHHSAHIRRAPTPGKAAILAVGKAFPSQLIPQDCLVEGYIRDTKCEDVSIKEKLERLCKTTTVKTRYTVMCKDILDKYPELATEGSPTIKQRLDIANPAVVEMAKEASLSCIKQWGRPVEDITHIVYVSSSEIRLPGGDLYLSSELGLRSDVSRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNKARPYDLVGAALFGDGAAAVMIGANPEMDRECPFMELNYAVQQFLPGTQNVIDGRLSEEGINFKLGRDLPQKIEDNIEEFCKKVISKGELSTTDFNKLFWAVHPGGPAILNRLEATLKLNGDKLECSRRALMDYGNVSSNTIFYVIEYMRDALKNKKADGEEWGLALAFGPGITFEGILLRSL
>Casp04045.t1
MVSVEEVRNAQRAQGPATILAIDTATPPNCVYQDTYPDYYFRITNSEHMTDLKLKFKRMCEKSMIKKRYMHLTEEILKENPNICEYMAPSLDARQDIAVVEIPKLGKEAATKAINEWGQPKSKITHLVFCTITGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKDARVLVVCSEITSVTFRGPNDAHIDSLVGQALFGDGAAAIIIGSDPVAQVEKPLFELVSAAQTILPDSHGAVEGHLREVGLTFHLLKDVPELISKNIEKSLIEAFQPLGISDWNSIFWIAHPGGSAILDQVEATLRLKQEKLQATRHVLSEYGNMSSACVLFIFDDMRKKSAKEGMKSTGEGLDWGVLFGGLNMSGADYQLIKLLGFRPSVKRLMMYQQGCFTRGIVLRLAKDPAENNKDACVLVVCSEITAVIFRGPSDTYLDGLVGQALFGDGAAAVTVGSDPVA
>Casp04046.t1
MVSVDEVRNAQRAQGLATILAIGAIPPNCVYQDTYPNYYFRITNSEHMTDLKLKFKRICEKSMIKKRYMHLTEDILKENPNIYEYMAPLLDARQEIVVVEIPKLGKDAGTKAIKEWVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVNFRGPSDAHLDSLIGQAIFGDGAGAIIIGSDQVEKPLFELVSAAQTILSDNHGAIGGHLREAGQTFHLSKDVPGLILKNIEKSLIEAFQPLGISNWNSIFWIVHPGGPAILDQVEATLRLKQEKLRASRHVLSEYGNMSSACVLFILDDMRKKSAEEGMKSTGEGLDWGVLFGFGPEVTVETIVLHSVAI
>Casp04048.t1
MVSVEEVRNAQRAQGPATILAIGTANPENCVDQDTYPDFYFRITNSEHMTDLKQKFKRMYEKSMIKKRYMHLTEEILKENPKICEYMAPSLDARQDIVVVEIPKLGKEAATKAIKEWGQRKSKITHLVFCTTSGVDMPGADYQLIKLLGLRPSVKRFMMYQQGCFASGTVLPLAKDLAENNKDACVLVVYSEITAVTFCGPSDTHLDSLVGQALFGDGAAAIIVGSDPVAHVEKSLFELVLAAQTILPDSHGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLTEAFQPLGISDWNSILWVAHPGGPAILD
>Casp04049.t1
MVSVEEVRNAQRAQGPATILAIGTATPPNCVDQDTYPDYYFRITNSEHMTDLKLKFKRMCEKSMIKKRYMHLTEEILKENPNICEYMAPSLDARQDIVVVEIPKLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPNDAHLDSLVGQALFGDGAAAIIIGSDPLPQVEKPLFELVSAAQTILPDSHGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLIEAFQPLGISDWNSIFWIAHPGGPAILDQVEATLRLKEEKLRATRHVLSEYGNMSSACVLFILDDMRKKSTEEGMKSTGEGLDWGVLFGFGPGLTVETIVLHSIAI
>Casp12276.t1
MGSEGRIAHEGLPKAASPGKATILALGKAFPHQLVMQEFLVDGYFRNTNCDDPDLKQKLARLCKTTTVKTRYVVMSDEILSKYPELAIEGLPTVKQRLDICNDAVTEMAVEASQTCIKNWGRSISSITHVVYVSSSEARLPGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGFKPPSAERPYDLVGVALFGDGAGAMIIGTDPVPETERPLFELHTAIQNFLPDTEKIIDGKLTEEGISFKLSRELPNIIEDNIEGFCKKLIDVVGLTDKDYNKLFWAVHPGGPAILNRMEKRLDLSPEKLNASRRALMDYGNASSNTIVYVLEYMLEESLKMGDTEKSEWGLVLAFGPGITFEGILARNLMV
>Casp12771.t1
MASVSVQEIRNGQRAQGPATILAIGTATPSNCVNQSEYPDYYFRITQSEHMTDLKEKFKRMCEKSMIKKRYMFLDEEILKENKNMCGYWESSLDARQDIVVVQVPKLGKEAATKAIKEWGQPKSKITHLIFCTTSGVDMPGCDYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRMAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAGALIVGADPDTSIERPLFEVVSAAQTILPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLVEAFTPIGIKDWNSIFWVAHPGGPAILDQVEEKLKLKPEKMRATRHVLSEYGNMSSACVLFILDEMRNKSIQQAKPTTGEGLDWGVLFGFGPGLTVETVVLHSVAL
>Casp21055.t1
MEMEGKVGVPKAAKGVATILAVGTANPPNCILQADYPDFYFRITQTQHMTQLKDKFTRICEKSTVKKRYLHLSEEFIKDNPNIAIYKAPSLDARQEILVKEVPKLGKEAALKAIKEWGQPIKKITHLIFCTSAGIAMPGADQELIKLLGLDYSVKRFMMYQSGCFAGAAALRLAKDMAENNPQSRILIVCSENTTNCFHAPSDTHLDILIGSAIFGDGAAALIVGAHPEINIERPLYEVISASQTIIPNSEDGVVGNLCEMGLSYYLSKRVPNYIADNIVDLLVKEENLKEFGIKNWNSLFYIVHPGGPDILDRLEMKLGLTKDKLRATRHVLSEYGNMWSPSVFFVIDEMRRRSAHKGKNTSGEGLDLGLLLAFGPGLTIETLMLRNIPIYY
>Casp21059.t1
MHLSEEIIKNNPNIAIYKSPSLDARQEILVKEVPKLGKEAALKAIKEWGQPIKKITHLIFCTSSGVDMPGADLELIKLLGLNYSVKRLMMYHSGCFAGAAALRLAKDMAENNHQSRILIVCSENMTSFFHAPSDNHLDILIGSAIFADGAAALIVGAHLEINIEHPLFEVISASQTIIPNSEDGIVGHLCEMGLSYYLSKGVPNFIADNIVDLLVKEENLKEFGIKNWNSLFYIVHPGGPVILDRLEMKLGLTKDKLKATRHVLIEYGNMWSPSVFFIIDEMRRRSAQEGKNTTGEGLDLGFLLSFGPGLTVEILMLRSIPIQY
>Casp21060.t1
MEMEGKVGVPKANKGVATILAVRTANPPNCIFQADYPDFYFRITQTQHMTQLKDKFTRICEKSTVKKRYMHLSEEMIKDNPNIAIYKACTSRNSGITMPGADQELIKLLGLDYSVKRFMMYQQENMTACFHAPSDTHLDILIGSAIFADGAAALIVGTHPEIDIEHPLFEVISASQTIIPDSEDGIVGHVCEMGLSYYLSKGVPNFIADNIGGPGILDRLEMKLGLTKDKLRATKHVLSEYGNMWSPSVFFILDEMRRRSVQEGTDTTGEGLDLGLLLAFGPGLTEEEKREAREWKIEDGKAVVRTRGGMEECSGDQLLDCSCDEPTIVTSSVSIRTDREEAEAEAAGTAVADGEYAGSLKPSMGFTMTDENEMGRRRMYKKLSYTAPIYKASCSLVHVAELSATLYAIRLTYNKG
>Casp33357.t1
MPSADYALMKQLGLPPSIKRFMIYQQGCSGGGNVLRLANDVAENNLNARVLVVCSEHVVVSFHAPSHTHLDILVGAAIFSDGAGAVIVGADPDINIERPLFQLISAFQTTIPNSEDAIRGQTLEMGLSYYLSRAIPKIIGDHIVGIMNETCDGIGVKDWNSLFYVAHAGGPSILRGMEEKLGLDKEKLRLDCNCILAPSSFVTDY
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University