Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Erythranthe guttata
Species name
Spotted monkey flower (Erythranthe guttata) is a species of eudicot in the family Phrymaceae.
Species info
Gene sequence info
Erythranthe_guttata.COMT.fa
Download
>rna-XM_012988071.1
MVLKSAIELDLLELIKKAGPGAFVSPAELAAQLPTTNPDAHVMLDRILRLLASYSILNCSLKTLTGGGGGVERLYALAPVCKYLTKNDDGVSMAPLLLMNHDKILMESWYHLKDTVLEGGIPFNKAYGMSAFEYHGKDTRFNKVFNQGMSNHSTIIMKKILGTYDGFQGLDTVVDVGGGTGATLNMIISKYPSIRGINFDLPHVIEDAPSYPGVEHAGGDMFVSVPKGDAIFMKWICHDWSDEHCVKLLKNCYKSLPENGKVILAECILAEVPDSGLATQITVHVDVIMLAHNPGGKERTEKEFQALANGAGFTKFHKVCCAHGSWIMELLK
>rna-XM_012978202.1
WVLHDWSDEECIVILRKCREAIPEGWGKVIIAEAVIGEKDEVDKYNDVRLALDMVMLAHTEKGKERSIEEWEYVVKSAGFSSFTVKHIHSSIVSVIQAYP
>rna-XM_012982800.1
MEAVNSYKHGEEDEAAVVAMAACGAYMLPMALNAAVELDVFEIIAAAGDGARLSSSDIASRFPTAADGTAVMLESMLHMLAAHSLLICSVENGGGGVRRYGIAPAGKFFVRDESGASMGSHSIVVMKKVVKTYQGFEGLSCLVDVGGGTGSALCTIVSNYPSIHGINFDLPHVIKTAPSYTSIEHIGGDMFLEVPKGDAILLKFILHNWGDEACENLLKCCYKSLPNKGKLIVMDYIMPHTPQTDIHAMYASQMDLGMTTMLAGKERTRDEFEVLAMKAGFAGFKVVCYVYGMWIMEFIKSA
>rna-XM_012984147.1
MNPPTQNDDGQSSYAIQLVNASVLPMALKACIELDVLEIIHRAEPHGPLSSFQIASQIPNCHNPHAASNLLDRMLALLASYSILTCSVSNGSQKLYSLGPVSKYFVANANGVSLAPLFLLNQDKVMMDTWHHMKDAVIEGGLPPFNRAYGMDASEYVVKKNPSYFQLFKNSMSNYNSMFMEKLMDTYGGFEGLESIVDVGGGDGSVLNTIVGKYPNIKAINFDLASVIENNKSIYPGNYNYFFNQLWQFMMQIIKYKSQITVTPEFIPFTETN
>rna-XM_012989169.1
MDCRSEEDAFVFATQLAMAAVFPAALKTAVELDLFELIKKSGSGAAVSARELAAQLPASANPDAHVMLDRILRLLTSYSVLNSSPRNLPGGGGGVDLVYSLAPVCKYLTKNEDGVSVSPFLMLIQDQVLQKSWDNLKDAVLDGGVPFAKAYGMNVFEYGDTDPRFNKVFDQAMSNYSTIVVKKILEIYDGFEGIESVVDVGGGTGAILNMIISKYPSIKGINFDLPHVIQHAPSYPGVEHIGGDMFVSVPKGDAIFMKWIVHDWSDEQCLKLLKNCHNSLQENGKVILAELIMPEEPDKSVATKTVLHSDVLMLTHNPGGRERTEKEFHTLAKAAGFREFRKVCSPHNIWIMELVK
>rna-XM_012989070.1
MEVVNNNYKHGEDDDAAVTALAACGSYILEMVLYAAVELDIFEILSRAGDGARLSTSDIVSRLPTPAADGAAVVLDSMLKLLATHSLLICENIGGTERRYGIAPAGKFFANDDGGASFCQYLLFRPEGASTVPRLKDVIVEGGNLSEKLYGKSYYEHLNCNAEISNKFNEAMRSHSAVLMKKVVKTYRGFEGLSCLVDVGGGTGTALATIISKYPSIRGINFDLPHIVNTAPYYNGIEHIGGDMFVQVPKGDAILLKFILHNWSDEACGKLLKCCYKSLPNKGKLIVMDSIMPNTTQTDIHAMYASQMDFVMTAMFGGKERTHDEFQDLALHSGFGEFKVVSYAYGMWIMEFIK
>rna-XM_012989121.1
MEVVNNNYKHGEDDDAAVTALAACGSYILEMVLYAAVELDIFEILSRAGDGARLSTSDIVSRLPTPAADGAAVVLDSMLKLLATHSLLICENIGGPDRRYGIAPAGKFFANDDGGASFCQYLLFRPEGPSTVPRLKDVIVEGGNLSEKLYGKSYYEHLNSNTEISNKFNEAMRSHSAVLMKKVVKTYRGFEGLSCLVDVGGGTGTALATIISKYPFIRGINFDLPHIVKTAPYYNGIEHIGGDMFVQVPKGDSILLKFILHNWSDEACGKLLKCCYKSLPNKGKLIVMDSIMPNTTQTDIHAMYASQMDFVMTAMFGGKERTQDEFQDLALHSGFGEFKVVSYVYGMWIMEFIK
>rna-XM_012989077.1
MEVVINGNEYKHGEDDEAGVLALAACLSHTFPMALAAAIDLDLFEIISGAGDGARMSASDIAAQLPSAADGAAPVLDAMLQLLASHSLLICSTNVLADGGGGAVERRYGIAPAGKFFVKDESGVSFAQFHSIVRKGGEIGFSLKDAVIEGGNQFEKICAKSFYEFITSNVEATKMFNDGMRAHSSVIIKKVVKTYKGFEGLSCLVDVGGGSGSSLDTIISKYPSIRGVNFDLPHVVETAPTYNGIEHIGGDMFVEVPNGDAILLKFILHNWGDEQCGNLLKNCYKSLPNNGKLIVMDYILPNTHQDDIHAKYASQMNLTMSCFLEGKERTKEEFEGMAKKAGFGEFKVVCYVYGMWVMEFIKLV
>rna-XM_012993973.1
MDYRSEEDAFVFTTQLAMAAVFPAALKTAVELDLFELIKNSSAAVSARELAAQLPAAANPDAHVMLNRILRLLTSYSVLNSNPRNLPGGGVDLVYSLAPCGSIIPSRGLRQGDPLSPYLFIICTEALIAMINKATENGLLDQGIKVAPTAPMVSSLCFADDTLIFCQTSEANARTIKNIVTQYASASGQVINLDKSTMTFCPRTQQWEKDLVHSILGFQIVERHDKYLGLPASIGKTRKQIFGFLRDRTWARIKSWNAKQFSKAGKEILIKAVLQAIPSYVMSCFLLPQGLLVEIEAAIRRFWWGNQNGKPMAWIVWNKLCKPKEAGGIGFRDLRSFNLALIAEQAWRIVTKPELLLSKI
>rna-XM_012971924.1
MNPPTQNDDGQSSYAIHLVNASVLPMALKACIELDVLEIIHRAGPHGPLSSFQIASQIPNCHNPHAASNLLDRMLALLASYSILTCSVSNGPQKLYSLGPVSKYFVANANGVSLAPLFLLNQDKVMMDTWHHMKDAVIEGGLAPFNRAYGMDASEYVVKKNPSYFQLFKNSMSNYNSMFMEKLVDTYRGFEGLESIVDVGGGDGSVLNTIVGKYPNIKGINFDLASVIDNNKSVYPGIEYISGDMFTSIPKGDAMFLKVRFFYFFF
MVLKSAIELDLLELIKKAGPGAFVSPAELAAQLPTTNPDAHVMLDRILRLLASYSILNCSLKTLTGGGGGVERLYALAPVCKYLTKNDDGVSMAPLLLMNHDKILMESWYHLKDTVLEGGIPFNKAYGMSAFEYHGKDTRFNKVFNQGMSNHSTIIMKKILGTYDGFQGLDTVVDVGGGTGATLNMIISKYPSIRGINFDLPHVIEDAPSYPGVEHAGGDMFVSVPKGDAIFMKWICHDWSDEHCVKLLKNCYKSLPENGKVILAECILAEVPDSGLATQITVHVDVIMLAHNPGGKERTEKEFQALANGAGFTKFHKVCCAHGSWIMELLK
>rna-XM_012978202.1
WVLHDWSDEECIVILRKCREAIPEGWGKVIIAEAVIGEKDEVDKYNDVRLALDMVMLAHTEKGKERSIEEWEYVVKSAGFSSFTVKHIHSSIVSVIQAYP
>rna-XM_012982800.1
MEAVNSYKHGEEDEAAVVAMAACGAYMLPMALNAAVELDVFEIIAAAGDGARLSSSDIASRFPTAADGTAVMLESMLHMLAAHSLLICSVENGGGGVRRYGIAPAGKFFVRDESGASMGSHSIVVMKKVVKTYQGFEGLSCLVDVGGGTGSALCTIVSNYPSIHGINFDLPHVIKTAPSYTSIEHIGGDMFLEVPKGDAILLKFILHNWGDEACENLLKCCYKSLPNKGKLIVMDYIMPHTPQTDIHAMYASQMDLGMTTMLAGKERTRDEFEVLAMKAGFAGFKVVCYVYGMWIMEFIKSA
>rna-XM_012984147.1
MNPPTQNDDGQSSYAIQLVNASVLPMALKACIELDVLEIIHRAEPHGPLSSFQIASQIPNCHNPHAASNLLDRMLALLASYSILTCSVSNGSQKLYSLGPVSKYFVANANGVSLAPLFLLNQDKVMMDTWHHMKDAVIEGGLPPFNRAYGMDASEYVVKKNPSYFQLFKNSMSNYNSMFMEKLMDTYGGFEGLESIVDVGGGDGSVLNTIVGKYPNIKAINFDLASVIENNKSIYPGNYNYFFNQLWQFMMQIIKYKSQITVTPEFIPFTETN
>rna-XM_012989169.1
MDCRSEEDAFVFATQLAMAAVFPAALKTAVELDLFELIKKSGSGAAVSARELAAQLPASANPDAHVMLDRILRLLTSYSVLNSSPRNLPGGGGGVDLVYSLAPVCKYLTKNEDGVSVSPFLMLIQDQVLQKSWDNLKDAVLDGGVPFAKAYGMNVFEYGDTDPRFNKVFDQAMSNYSTIVVKKILEIYDGFEGIESVVDVGGGTGAILNMIISKYPSIKGINFDLPHVIQHAPSYPGVEHIGGDMFVSVPKGDAIFMKWIVHDWSDEQCLKLLKNCHNSLQENGKVILAELIMPEEPDKSVATKTVLHSDVLMLTHNPGGRERTEKEFHTLAKAAGFREFRKVCSPHNIWIMELVK
>rna-XM_012989070.1
MEVVNNNYKHGEDDDAAVTALAACGSYILEMVLYAAVELDIFEILSRAGDGARLSTSDIVSRLPTPAADGAAVVLDSMLKLLATHSLLICENIGGTERRYGIAPAGKFFANDDGGASFCQYLLFRPEGASTVPRLKDVIVEGGNLSEKLYGKSYYEHLNCNAEISNKFNEAMRSHSAVLMKKVVKTYRGFEGLSCLVDVGGGTGTALATIISKYPSIRGINFDLPHIVNTAPYYNGIEHIGGDMFVQVPKGDAILLKFILHNWSDEACGKLLKCCYKSLPNKGKLIVMDSIMPNTTQTDIHAMYASQMDFVMTAMFGGKERTHDEFQDLALHSGFGEFKVVSYAYGMWIMEFIK
>rna-XM_012989121.1
MEVVNNNYKHGEDDDAAVTALAACGSYILEMVLYAAVELDIFEILSRAGDGARLSTSDIVSRLPTPAADGAAVVLDSMLKLLATHSLLICENIGGPDRRYGIAPAGKFFANDDGGASFCQYLLFRPEGPSTVPRLKDVIVEGGNLSEKLYGKSYYEHLNSNTEISNKFNEAMRSHSAVLMKKVVKTYRGFEGLSCLVDVGGGTGTALATIISKYPFIRGINFDLPHIVKTAPYYNGIEHIGGDMFVQVPKGDSILLKFILHNWSDEACGKLLKCCYKSLPNKGKLIVMDSIMPNTTQTDIHAMYASQMDFVMTAMFGGKERTQDEFQDLALHSGFGEFKVVSYVYGMWIMEFIK
>rna-XM_012989077.1
MEVVINGNEYKHGEDDEAGVLALAACLSHTFPMALAAAIDLDLFEIISGAGDGARMSASDIAAQLPSAADGAAPVLDAMLQLLASHSLLICSTNVLADGGGGAVERRYGIAPAGKFFVKDESGVSFAQFHSIVRKGGEIGFSLKDAVIEGGNQFEKICAKSFYEFITSNVEATKMFNDGMRAHSSVIIKKVVKTYKGFEGLSCLVDVGGGSGSSLDTIISKYPSIRGVNFDLPHVVETAPTYNGIEHIGGDMFVEVPNGDAILLKFILHNWGDEQCGNLLKNCYKSLPNNGKLIVMDYILPNTHQDDIHAKYASQMNLTMSCFLEGKERTKEEFEGMAKKAGFGEFKVVCYVYGMWVMEFIKLV
>rna-XM_012993973.1
MDYRSEEDAFVFTTQLAMAAVFPAALKTAVELDLFELIKNSSAAVSARELAAQLPAAANPDAHVMLNRILRLLTSYSVLNSNPRNLPGGGVDLVYSLAPCGSIIPSRGLRQGDPLSPYLFIICTEALIAMINKATENGLLDQGIKVAPTAPMVSSLCFADDTLIFCQTSEANARTIKNIVTQYASASGQVINLDKSTMTFCPRTQQWEKDLVHSILGFQIVERHDKYLGLPASIGKTRKQIFGFLRDRTWARIKSWNAKQFSKAGKEILIKAVLQAIPSYVMSCFLLPQGLLVEIEAAIRRFWWGNQNGKPMAWIVWNKLCKPKEAGGIGFRDLRSFNLALIAEQAWRIVTKPELLLSKI
>rna-XM_012971924.1
MNPPTQNDDGQSSYAIHLVNASVLPMALKACIELDVLEIIHRAGPHGPLSSFQIASQIPNCHNPHAASNLLDRMLALLASYSILTCSVSNGPQKLYSLGPVSKYFVANANGVSLAPLFLLNQDKVMMDTWHHMKDAVIEGGLAPFNRAYGMDASEYVVKKNPSYFQLFKNSMSNYNSMFMEKLVDTYRGFEGLESIVDVGGGDGSVLNTIVGKYPNIKGINFDLASVIDNNKSVYPGIEYISGDMFTSIPKGDAMFLKVRFFYFFF
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University