Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Erythranthe guttata
Species name
Spotted monkey flower (Erythranthe guttata) is a species of eudicot in the family Phrymaceae.
Species info
Gene sequence info
Erythranthe_guttata.4CL.fa
Download
>rna-XM_012988609.1
MLSVASAETQNPELSSPIITQKQSSPEKSHVFKSKLPTIPISNHLPLHTYCFENFSHYPDRKCLLVGNGTGKSYTYAETHLICRKVAAGLSNLGIKKGDVVLVLLQNCAEFVFTFMGASMIGAVTTAANPFCTANEIFKQFRASNSRMIITQAQYVDKLREGGDDSPKFGEDFSVITVDDPPEGCLHFSVLSEANENDAPAAVEIDSDDAVSLPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLYLKPDDVVLCVLPLFHIYSLNSVMLCSLRAGAAVLLMQKFEIGSLLELIQRHRVSVAAVVPPLVLALAKNPMVDQFDLSSIRMVLSGAAPLGKELEAALLSRLPQAVFGQGYGMTEAGPVLSMSPSFAKQPLPTKSGSCGNVVRNAELKVVDPETGFSIPRNQPGEICIRGPQIMKGYLNDAEATARTIDVEGWLHTGDIGYVDDDDDVFIVDRVKELIKFKGFQVPPAELEALLVSHPSIADAAVVPQKDEAAGEVPVAFVVRSNGFELTEEAVKDFISKQVVFYKRLHKVYFVHAIPKSPAGKILRKDLRAKLAAAS
>rna-XM_012975856.1
MEPKSEKEHIFRSKLPDIYIPNHLPTHIYCFQNLPNHRSRPALIDGATGNVFTHAEVELTARRAAVGFRKLGIRKNDVVMLLLHNSPDFAFAFLAAFFAGAVATTANPLYTAAEITAQARVSKPKLIVTHACYVEKVKRFAVEEEERGGGAVVIIATIDPPPSPEIVRFADLKNSDERLLPEVEIDADDTAALPFSSGTTGLPKGVMLSHKNIVTCISQKVDGENPAYHIDSRDLMLCLLPLFHVYCLVSVLLTSLRVGAAILIVPKFEINQLMELIQKHRVTIAPLVPPILLAISKSPAAAVRFDLSSVRRVTCGAAPMDSQLECSVKAKLPNATIGQGYGMTEAGVLSMCLGFAKKPFKFKPGSCGNVIRNSEMKIVNPLTGASLPRNQTGEICIRGDSVMKGYYNDPEATKRTIDKDGWLHTGDIGYVDSDDEVFILDRLKELIKYKGLQIAPAELEALLIAHPSVSEAAVVPMKDEVAGEVPVAFVVRVNGSNISEQEIKQYISEQVVSYKRINRVFFTNEIPKAPSGKILRKILRAKI
>rna-XM_012985137.1
MATIAQTLNEDVEIIFKSKCPPVHVPDNVTLPEFVLSGAEPYLDKVAVVDSTTGKSYTYGEVKRDVDRFSKALRSLGLRRGRVVVVLLPNVAEYATIALGIMAAGGVFSGANPSGHSSEIKKQVEAADAKLIVTDGSTYHKVKDLGLPVIIQGEDCVEGTINWDELLEAADKANTDPIYEKVLQTDLCALPFSSGTTGLSKGVMLTHRNLVANLCSTLFSVGPELIGQVTILGLIPFFHIYGLTGICCATIKNKGKVVVMQRYELRLFLGALITHEVTFAPIVPPIILGLVKNPIVDEFDLSKLKLRSIMTAAAPLAPEILNEFEKKFPGVEVQEAYGMTEHSCITLTHGDPSKGHCIAKRNSVGFILPNLEVKFVDPEKGNSLPENTPGEICVRSQCVMNGYHKNEYETSLTIDKDGWLHTGDIGYIDDDGDLFLVDRIKELIKYKGFQVAPAELEAILLTHPSVEDAAVVGLPDEEAGEIPAACVVINSKAKESEEDIMEYISSNVASYKKVRLLQFVDVIPKSPSGKIMRRLIKDNMVKKL
>rna-XM_012997309.1
MVTDQKKQDDDVIIFRSKLPDIYIPKHLPLHSYCFENISQFSERPCLINGATGEVYTYAEVELTSRKVAAGLSNLGLRHGDTVMLLLPNSPEFVFAFLGASRIGAVSTMANPFFTAAEVVKQAKASAVKAIITQACHVEKVAAYAAEHGGVKVVCVDAPPPAAADCVAFSELTSADEADLPAVKISPEDVVALPYSSGTTGLPKGVMLTHKGLVTDVAQQVDGENPNLYIHCNDVVLCVLPFFHIYSLSILLLGLRVGSAILIMQKFDVVPFMELIQKYKVTIGPFVPPIVLAIAKSPVVDKYDLSSVRTVMSGAAPLGKELEDAVRKKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPLEIKSGACGTVVRNAEMKIIDTDNGASLGRNQPGEICIRGDQIMKGYLNDPEATKRTIDKQGWLHTGDIGLIDDDDELFIVDRIKEIIKYKGFQVAPAELEALLINHPYISDAAVVSMKDEQAGELPVAFVVKTKGSTITEDEIKQFVSKQVIFYKRINRVFFIDAIPKSPSGKILRKDLRAKLADEHL
>rna-XM_013001250.1
MENIVAKQDDDIIFRSKLPDIYIPKHLPLHTYCFENISKFSTRPCLINGATNEVFTYEEVELTARKVATGLSKLGIQQGDTIMLLLPNSPEFVFSFLGASYIGAISTMANPYFTPAEVIKQAKASGAKVIVTQASYVDKVRDYALEKRVRVVCTDAPPNCDDYCVAFSELSSADEKEMPAVKINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYIHGGDVVICVLPLFHIYSLNSVLLCGLRVGAAILIMQRFEIDPFLELIQRYKVTIGPFVPPIVLAIVKSPLVGKYDLSSVRTVMSGAAPLGKELEDAVRVKFPNAKLGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPETGASLSRNLAGEICIRGDQIMKGYLNDQESTERTIDKQGWLHTGDIGFIDADDELFIVDRLKEIIKYKGFQVAPAEIEALLLNHPYISDAAVVSMIDEQAGEVPVAFVVRSNGSTITEDEVKQFISKQVIFYKRINRVFFIDVIPKSPAGKILRKDLRAKLAAGVAN
>rna-XM_013002881.1
MLSVASVETTQNPELSSSLAALPQQNQASETHVFVSKLPTIPISNHLPLHTYCFENLSQYPDRTCLLVGSTGKSYSFAETHLLCRRVAAGLSKLGIGKGDVVMALLQNCAEFVFTFMAASMIGAVTTTANPFCTANEIFKQFNASKSKVIVTHAQYVDKLRDAGDNNYPVFGEDFAVVTIDGPPEGCLHFSVLSEANEDDAPAVEIDPSDAVALPFSSGTTGLPKGVVLTHRSLITSVAQQVDGENPNLHLKSDDVVLCVLPLFHIYSLNSVLLCSLRAGAGILLMPKFEIGSLLELIQKHRVTVAAVVPPLVLALAKNPMVDKFDLSSIRMVLSGAAPLGKDLEAALLSRVPQAVFGQGYGMTEAGPVLSMSPSFAKQPLPTKSGSCGNVVRNAELKVVDPETGCSLPRNQPGEICIRGPQIMKGYLNDDEATARTIDVDGWLHTGDIGFVDDDDDVFIVDRVKELIKFKGFQVPPAELEALLISHPNIADAAVVPQKDEAAGEVPVAFVVPSNGFELTEETVKEFVSKQVVFYKRLHKVYFVHAIPKSPAGKILRKDLRAKLAAPTSSSS
>rna-XM_012972384.1
MEKSGYGRDGVYRSLRPPFFPPKDPNISMVSFLFRNISSFSDKRALVDSHTGETLNFAQFKSMVNKVAQGLLQLGVKKNDVVLIFSPNSIQFPLCFLGIVAVGAIATTVNPLYTVSELSKQVHDSKSKLIITVEELIPKVKDFGLPVIILNTDKKWDSVSPIGKIPSITSFSELVDNDGSVNLDGAVKQDDTAALLYSSGTTGISKGVVLTHRNFIASSLMITTDQESVSETNGVFLCVLPMFHVFGLAVIMYAQLQRGSAVVSMSKFDLEMILKAVDKYGITHMWVVPPIILGLAKNSIVKKYSLSSLKQIASGAAPLGRELMQECANNFPQAVVCQGYGMTETCGIVSIENPYSGPRHSGSAGMLVPGVECQIVSVDKSTPLPPGQLGEIWVRGPNMMQGYFNNPVATKLTIDKQRWVHTGDLGYFDEDGQLFVVDRIKELIKYKGYQVAPAELEGLLVSHPEISDAVVIPFPDAEAGEVPAAYVVRAPNSSLSEEDIKKFIAEQVAPFKRLRRVTFITSVPKSAAGKILRRELIEKVRSKI
MLSVASAETQNPELSSPIITQKQSSPEKSHVFKSKLPTIPISNHLPLHTYCFENFSHYPDRKCLLVGNGTGKSYTYAETHLICRKVAAGLSNLGIKKGDVVLVLLQNCAEFVFTFMGASMIGAVTTAANPFCTANEIFKQFRASNSRMIITQAQYVDKLREGGDDSPKFGEDFSVITVDDPPEGCLHFSVLSEANENDAPAAVEIDSDDAVSLPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLYLKPDDVVLCVLPLFHIYSLNSVMLCSLRAGAAVLLMQKFEIGSLLELIQRHRVSVAAVVPPLVLALAKNPMVDQFDLSSIRMVLSGAAPLGKELEAALLSRLPQAVFGQGYGMTEAGPVLSMSPSFAKQPLPTKSGSCGNVVRNAELKVVDPETGFSIPRNQPGEICIRGPQIMKGYLNDAEATARTIDVEGWLHTGDIGYVDDDDDVFIVDRVKELIKFKGFQVPPAELEALLVSHPSIADAAVVPQKDEAAGEVPVAFVVRSNGFELTEEAVKDFISKQVVFYKRLHKVYFVHAIPKSPAGKILRKDLRAKLAAAS
>rna-XM_012975856.1
MEPKSEKEHIFRSKLPDIYIPNHLPTHIYCFQNLPNHRSRPALIDGATGNVFTHAEVELTARRAAVGFRKLGIRKNDVVMLLLHNSPDFAFAFLAAFFAGAVATTANPLYTAAEITAQARVSKPKLIVTHACYVEKVKRFAVEEEERGGGAVVIIATIDPPPSPEIVRFADLKNSDERLLPEVEIDADDTAALPFSSGTTGLPKGVMLSHKNIVTCISQKVDGENPAYHIDSRDLMLCLLPLFHVYCLVSVLLTSLRVGAAILIVPKFEINQLMELIQKHRVTIAPLVPPILLAISKSPAAAVRFDLSSVRRVTCGAAPMDSQLECSVKAKLPNATIGQGYGMTEAGVLSMCLGFAKKPFKFKPGSCGNVIRNSEMKIVNPLTGASLPRNQTGEICIRGDSVMKGYYNDPEATKRTIDKDGWLHTGDIGYVDSDDEVFILDRLKELIKYKGLQIAPAELEALLIAHPSVSEAAVVPMKDEVAGEVPVAFVVRVNGSNISEQEIKQYISEQVVSYKRINRVFFTNEIPKAPSGKILRKILRAKI
>rna-XM_012985137.1
MATIAQTLNEDVEIIFKSKCPPVHVPDNVTLPEFVLSGAEPYLDKVAVVDSTTGKSYTYGEVKRDVDRFSKALRSLGLRRGRVVVVLLPNVAEYATIALGIMAAGGVFSGANPSGHSSEIKKQVEAADAKLIVTDGSTYHKVKDLGLPVIIQGEDCVEGTINWDELLEAADKANTDPIYEKVLQTDLCALPFSSGTTGLSKGVMLTHRNLVANLCSTLFSVGPELIGQVTILGLIPFFHIYGLTGICCATIKNKGKVVVMQRYELRLFLGALITHEVTFAPIVPPIILGLVKNPIVDEFDLSKLKLRSIMTAAAPLAPEILNEFEKKFPGVEVQEAYGMTEHSCITLTHGDPSKGHCIAKRNSVGFILPNLEVKFVDPEKGNSLPENTPGEICVRSQCVMNGYHKNEYETSLTIDKDGWLHTGDIGYIDDDGDLFLVDRIKELIKYKGFQVAPAELEAILLTHPSVEDAAVVGLPDEEAGEIPAACVVINSKAKESEEDIMEYISSNVASYKKVRLLQFVDVIPKSPSGKIMRRLIKDNMVKKL
>rna-XM_012997309.1
MVTDQKKQDDDVIIFRSKLPDIYIPKHLPLHSYCFENISQFSERPCLINGATGEVYTYAEVELTSRKVAAGLSNLGLRHGDTVMLLLPNSPEFVFAFLGASRIGAVSTMANPFFTAAEVVKQAKASAVKAIITQACHVEKVAAYAAEHGGVKVVCVDAPPPAAADCVAFSELTSADEADLPAVKISPEDVVALPYSSGTTGLPKGVMLTHKGLVTDVAQQVDGENPNLYIHCNDVVLCVLPFFHIYSLSILLLGLRVGSAILIMQKFDVVPFMELIQKYKVTIGPFVPPIVLAIAKSPVVDKYDLSSVRTVMSGAAPLGKELEDAVRKKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPLEIKSGACGTVVRNAEMKIIDTDNGASLGRNQPGEICIRGDQIMKGYLNDPEATKRTIDKQGWLHTGDIGLIDDDDELFIVDRIKEIIKYKGFQVAPAELEALLINHPYISDAAVVSMKDEQAGELPVAFVVKTKGSTITEDEIKQFVSKQVIFYKRINRVFFIDAIPKSPSGKILRKDLRAKLADEHL
>rna-XM_013001250.1
MENIVAKQDDDIIFRSKLPDIYIPKHLPLHTYCFENISKFSTRPCLINGATNEVFTYEEVELTARKVATGLSKLGIQQGDTIMLLLPNSPEFVFSFLGASYIGAISTMANPYFTPAEVIKQAKASGAKVIVTQASYVDKVRDYALEKRVRVVCTDAPPNCDDYCVAFSELSSADEKEMPAVKINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYIHGGDVVICVLPLFHIYSLNSVLLCGLRVGAAILIMQRFEIDPFLELIQRYKVTIGPFVPPIVLAIVKSPLVGKYDLSSVRTVMSGAAPLGKELEDAVRVKFPNAKLGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPETGASLSRNLAGEICIRGDQIMKGYLNDQESTERTIDKQGWLHTGDIGFIDADDELFIVDRLKEIIKYKGFQVAPAEIEALLLNHPYISDAAVVSMIDEQAGEVPVAFVVRSNGSTITEDEVKQFISKQVIFYKRINRVFFIDVIPKSPAGKILRKDLRAKLAAGVAN
>rna-XM_013002881.1
MLSVASVETTQNPELSSSLAALPQQNQASETHVFVSKLPTIPISNHLPLHTYCFENLSQYPDRTCLLVGSTGKSYSFAETHLLCRRVAAGLSKLGIGKGDVVMALLQNCAEFVFTFMAASMIGAVTTTANPFCTANEIFKQFNASKSKVIVTHAQYVDKLRDAGDNNYPVFGEDFAVVTIDGPPEGCLHFSVLSEANEDDAPAVEIDPSDAVALPFSSGTTGLPKGVVLTHRSLITSVAQQVDGENPNLHLKSDDVVLCVLPLFHIYSLNSVLLCSLRAGAGILLMPKFEIGSLLELIQKHRVTVAAVVPPLVLALAKNPMVDKFDLSSIRMVLSGAAPLGKDLEAALLSRVPQAVFGQGYGMTEAGPVLSMSPSFAKQPLPTKSGSCGNVVRNAELKVVDPETGCSLPRNQPGEICIRGPQIMKGYLNDDEATARTIDVDGWLHTGDIGFVDDDDDVFIVDRVKELIKFKGFQVPPAELEALLISHPNIADAAVVPQKDEAAGEVPVAFVVPSNGFELTEETVKEFVSKQVVFYKRLHKVYFVHAIPKSPAGKILRKDLRAKLAAPTSSSS
>rna-XM_012972384.1
MEKSGYGRDGVYRSLRPPFFPPKDPNISMVSFLFRNISSFSDKRALVDSHTGETLNFAQFKSMVNKVAQGLLQLGVKKNDVVLIFSPNSIQFPLCFLGIVAVGAIATTVNPLYTVSELSKQVHDSKSKLIITVEELIPKVKDFGLPVIILNTDKKWDSVSPIGKIPSITSFSELVDNDGSVNLDGAVKQDDTAALLYSSGTTGISKGVVLTHRNFIASSLMITTDQESVSETNGVFLCVLPMFHVFGLAVIMYAQLQRGSAVVSMSKFDLEMILKAVDKYGITHMWVVPPIILGLAKNSIVKKYSLSSLKQIASGAAPLGRELMQECANNFPQAVVCQGYGMTETCGIVSIENPYSGPRHSGSAGMLVPGVECQIVSVDKSTPLPPGQLGEIWVRGPNMMQGYFNNPVATKLTIDKQRWVHTGDLGYFDEDGQLFVVDRIKELIKYKGYQVAPAELEGLLVSHPEISDAVVIPFPDAEAGEVPAAYVVRAPNSSLSEEDIKKFIAEQVAPFKRLRRVTFITSVPKSAAGKILRRELIEKVRSKI
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University