Enzyme

Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.

HIDH

Enzyme

2-hydroxyisoflavanone dehydratase

Enzyme name

EC:4.2.1.105

Entry

Lyases;Carbon-oxygen lyases;Hydro-lyases

Class

2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)

Sysname

(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O

Reaction

daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]

Product

Species information

Alnus glutinosa

Species name

Alnus glutinosa is a species of eudicot in the family Betulaceae (birch family).

Species info

Gene sequence info

Alnus_glutinosa.HIDH.fa

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>Alngl4118S10056
MAVVSLDPRFNLQVGKNNHQHGGAVEEIEGLIRVYIDGHVERPPIVSIVPCTMALECGVTAKDVVIEKCTGLWARVYFPSCPGKLPLLVFFHGGGFCVGSAAWSCYNEFLSRLASKASCVIISVNYRLAPENRLPAAYEDGINTLMWVKQQVLSGSKEHKWWVKHCSLSSVYLAGDSAGANIAYNVATRLGSSGSSESTIIRPLCLKGTILIQPFFGGEARTWSEKHTYQPPNSALTLSVSDAYWRLSLPPGANRDHAWCNPLANGTDKLCDSRLPTTMICISEMDILKDRSLEFCNALTSAGKKVETVMHKGVGHSFQILHNSQLSQPRTHEMMSQIKAFISE
>Alngl1094S00278
MAAISLDPSLSLQHISDHRHQAMIEEIEGLIRVYEDGHVERPQIVPCVTSALSLKLGVTSRDMVIDKFTNIWARFYVPAAVCHGKLPLLVYFHGGGFCVGSAAWSCYHEFLARLSAEAGCLIMSVNYRLAPENPLPAAYEDGLTALIWLKQQSLRGASDHQWWSRLCNFSKIFLAGDSAGANIAHNVATRLGSKNAVEATSLKPLSLKGTILIQPFFGGEARTQSENYMVQPPRSALSLAASDAYWRLALPAGANRDHPWCNPLSNKLEDLKLLPAMVCISEMDILKDRNLEFCSALARAGKRSEYVVYKGVGHAFQVLSRAQVSQTRTLEMVAHIKAFITR
>Alngl4702S04593
MNPVGPGAPSLAGLGCSRLLVTVAENDVLRDRGVFYYNAVKESGWEGEMELIQVEGEDHAFQIIHFGTENAKNLIKSLASFLHK
>Alngl4702S30459
MASSGKEVEVECLPWVRKYKDGSVERLHGSPYVAPTPEDPKTGVATKDIVISKNPAISARLFLPKLDQSRRQKLPIMYYTRGGAFNHESVFCRDHTQFFSSLVAEAQVVGVSVDYRQAPEHFLPIAYEDCWAGLRWIASHAVDDTGIEDKDPWLVNHGNFDRFILGGDSAGANIAHNILMRAGAESLPGGVEISAAYLTHPYFWGSKAIGSEPSVEREKMLPALVWKFAYPGAPGGIDNPMVNPLVPGAPSLAGLGTSRMLVTVAGNDLLRDRGVAYYDAVVESGWKGEAVLLEVEGETHAFHILEFGTQKASDFIKRLAAFLRQLGNACQALSTTMSRRVSSTHISTPLAYHVHMGSIPKEVDTELHPFVRIYKDGSVERLIGSPYVAPSPDQDPETGVSSKDITISHDPSISARLYLPTLDQTAAQNQKLPVLVYFHGGGFCIESAFSSDHQQFLNSLVAQAQVVAVSVEYRLAPEHRLPIAYEDCWAALQWVVSASHSIDNGTVNEEPWLINHGDFKRVFIGGDSAGANIAHNITMRAGDESLHGGVKILGTFLTHPYFWGSKPVGSEPSAGPDEKPLPHVVWNFTYPAAPGGIDNPMINPTGPGAPSLAGLGCSRLLVVVAEKDELRERGVFYYDQVRKSNWEGEVELVQVDGEDHAFHVLKFGSENAKNLIKRLASFLK
>Alngl4702S41537
MPVTAEFLPFFRVYNDGSVERLLGSPIVPPTPEDPETGVSSKDISISQKPSISARLYIPKLTQPNQKFPILVYFHGGAFCVESAFSSDHQQYLNSLVSQGQVLAVSVEYRLAPEHSLPIAFEDSWAAFQWVAAHSIDNGVDKDAEKEPWLANHGDFKLVFTGGDRLTVPEPTLRII
>Alngl6738S05574
MDSLNSEVVHEFRFFRVYKDGRIEKFQSTHKIPPSDDPITGVRSKDVEISSQPAISARIFLPKIHDRTRKLPVLFYCHGGGFCFLSAFSPLLHNYVSALAAEAEAIAVSVEYRLAPEHPIPACYEDSWAAFQWVASHANRNGPEQWLNDHADFQRVFLVGDSAGGNISHNMAVRAGSIQLPGVKLGGAVLVHPYFGGTDDDKMWMYMCPENGGLDDPRLKPAAEDLARLACERVLVFVGEKDHLREVGWRYYEELKKSGWGGNVEIVENEGEDHCFHVDDLTQDKAVALIKRLASFIKEE
>Alngl6738S05575
MDSLNNQVVHEFRFFRVYKNGRIEKFRSTDKIPPSDDQITGVRSKDVVISSQPAISARIFLPKIHDPTRKLPVLFYVHGGGFCFQSAFSSVFHKQVNAVAANANAIAVSVEYGLFPERPLPACYEDSWAGLQWVASHANRNGPEPWLNEYADFDRVFIGGDSGGGNISHTLAVRVGTLGLPGVKVVGLILVHPFFGGTEDDHMWLYMCPTNGGLEDPRLKPAAEDLSRLGCERVLIFIAQNDHLSAKGRLYYEKLKKSGWVGIVEVVEHEGEAHVFHLKKPECENAVDLLNKFAAFINFTSQRL
>Alngl6738S11755
MSLSPCLYLGKFFMPRVPAILPSSARASGLYKSGLFSPINQRKSSLQILVSSSSSSSSSSSLAMDSSNSNEVAYDHSPYLKIFKDGRVERIAGTDIVPPSLDPQTGVESKDVVISPETGVSARLFLPKTSIQTQKKLPLLIYFHGGGFCIETAFSPQYHNYLNALVGEANVVAVSVEYRRAPEHPLPAAYSDSWAALEWVASRVDEWLKSHADFERVFFAGDSAGANIAHHMALRVGAEGLAGVKLQGIALVHPYFWGKEPIGGEPAEAERRAMIENLWRFTCPATSGTDDPYINPASDPKLGSLGCGSVLVCVAEKDLLKARGFYYRELLEKSGWGGAVEVVESPGEDHVFHLNKPVCENSLALLNRIASFFNRGEP
>Alngl6738S34507
MASGTTNEITHDFPPFFKAYNDGRIERYMSHDHVPAGLDPHTRIQSKDVVISPETGLSARIFIPKINGSDHQKLPLLVHYHGGGFCVGSPFDTISHKFLTSLISQANIIVVSVDYRLAPEHPLPIAYDDSWAALQWIGTHSNKQGPEPWLTQHVDFGRVFLAGESAGANIAHHVAVRAGLAGLKIVGVLMVHPFFGGKERDEMYKFLCPTSTGCDDDPKLNPEVDPNLSSMGCDKVLVCVAEKDWLKDRGVAYYGTLGKSGWGGNVEILETKGEDHCFHLFNTEGENAAALMKKLRLGRHAVPELAPPGLDPKTHVQTRDVVVSSESGVSARLFLPKISHPDHKLPLVVHYHGGAFCVGSPFHRAFHNFLVSLAAAANAFVISVDYRLAPEHPLPTGHQDSWAALQWIATHSKGEGPDPWLKEHADFGRVFLAGESAGANIAHYVAVQAGATELVGPNIVGSLILHPYFGGKELDGLYSFMYPTGAGFSDPMLYPKVDPNLSRMAGAKVLVCVADKDWLRDRGVGYCEAVGKSGWGGTVSFYETEGEDHGFFVLNPTSEKVEPLLKPVYSISFSLTTSDAYFGMDSSINQTTHEFPPYFKVHRDGRIERYGVPDYFSTGLDPKTQVQSKDVVVLSESGVSARLFLPKVNGPDRKLPLVVHYHGGGFCIGSPFVETFHNFLLSLASAAHAVVISVDYRLAPEHPLPTAHEDAWAALQWIATHSKGQGPDPWLNEYADFGRVFLAGESAGANIAHYVAVQAGATGLDGPNIIGLLMVHPFFGGKEPSKMYGFMCPTSAGFHDPIMYPAVDPKLPSMAGTKVLVCLAEKDSLRDRGLDYCETLSKSGWGGTVSLYETEGEGHGFFLLNPGSDKVEPLIKAMLGLTMDPNTNSNEVAHDFPPFFRVYKDGRVERLLGTETVPPTTDPLTGVQSKDITISPETALSARLFLPNTTTSAVAHKLPLLIYIHGGAFCVESPFSPIYHNYVSSVAAEANVVAVSIHYRRAPEHPLPIAYEDTWAAMQWVAAHSKGDGPEAWLNDHADFERVFLAGDSAGANIAHSMARRAGVDGLLGFKIVGMAIVHPYFGSGEPGKLIEFIFPTMSGPDDPSIYPAPDPKLRSLGCSRVLVIVAEKDELRDRGWNYYESLRKSGWGGVVEFVETQGENHVKEDIAT
>Alngl6738S34510
MASGDSEIIHKFHFFDVYKDGRVVLHRPFSEKIPPSDDPITGVRSKDVIISTEPPVSARIFLPKSADTTQKLPVLFYVHGGGFCMLSAFSPHYHSFLNNFVAEANVIAVSVEYGLFPTRPIPACYEDSWAGLQWVASHSNGNGPEPWLNDHADFQRVFVGGDSAGGNISHTLAFRVGTIGLPGVKLVGAVLVHPYFGGTEDDQMWLYMCPTNSGLEDPRMNPNAGDLARLGCERVLIFVAEKDHLRDPGKRYYEKLKKSGWVGSVELVENLGEEHCFHLHKPEYEKAVDLFTKFVSFYYSLLLSMASSDSEISHKFPHFDVYKDGRVVLRQPITEKIPPSDDPLTGVRSKDVIISSEPPVSARIFLPKSADTTQKLPLLFYVHGGGFSKQSAFSRKYHNFVNTFVAEANVVAVSVEYGLFPTRPIPACYEDSWVGLQWLASHSNGNGPEPWLNDRADFQRVFVAGDSAGGNIAHNLLVRVGTIGLPGVKVVGAVLVHPYFGGTEIDKMWLYMCPTNSGLEDPRMSPNAEDLARLGCERVLVFVAEDDLMDPGKRYHEELKKSGWVGSVEIVENSGEKHCFHLSNLKYEKAVDLIEKFASFVKQD
>Alngl9722S06502
MAAVSLQVFKNSHQHGGVFEEIEGLLRVYIDGHVERPPIVTIVPCTIALERGVTAKDVVIDKCTGLWARMYLPSCPGKLPLLVFFHGGGFCVGSAAWSCYNEFLSNLASKANCVIISVNYRLAPENRLPAAYEDGLNTLMWVKQQALSGSREHKWWVKHCSLSSVYLAGDSAGANIAYNVATRLGSSGSSESTIIRPLCLKGTILIQPFFGGEARTWSEKHTDQPPSSALTLPVSDAYWRLSLPPGANRDHAWCNPLANGSDKLRDSRLPTTMVCISEMDILKDRNLEFCNALNSAGTKVETVMHKGVGHSFQILHNSQLSQPRTHEMMSQIKAFINE
>Alngl11731S00448
MSIVEEAPGYLQVFSDGSVKRFVPAGIAPASPKPSNGYKSKDVIIDSSKPVTGRLFLPCSDPTTGFSSKLPVVVYFHGGGFCCGSTTWTGYHNFLGDFSAASQSIVLSVDYRLAPEYRLPIAYEDCYSSLDWLGHNVGSEPWLEQADLSRVFLSGDSAGGNIVHHVAVKAIQNNTTCHVRINGLLVIHPYFGSEKRTEKEMAEGAAAAASVASNDMFWRLCIPEGSNRDYYGCNFEKAELSGVEWSRFPAVVVFVAGLDFLKERGVMYAEFLQKKGVEAVRLVEAEEESHAFYMFHPESEATRLLQRQMSEFIKSS
>Alngl11731S00449
MSIVEEAPGYLQVFSDGSVKRFVPAGIAPASPKPSNGYKSKDVIIDSSKPVTGRLFLPCSDPTTGFSSKLPVVVYFHGGGFCCGSTTWTGYHNFLGDFSAASQSIVLSVDYRLAPEYRLPIAYEDCYSSLDWLGHNVGSEPWLEQADLSRVFLSGDSAGGNIVHHVAVKAIQNNTTCHVRINGLLVIHPYFGSEKRTEKEMAEGAAAAASVASNDMFWRLCIPEGSNRDYYGCNFEKAELSGVEWSRFPAVVVFVAGLDFLKERGVMYAEFLQKKGVEAVRLVEAEEESHAFYMFHPESEATRLLQRQMSEFIKSS
>Alngl11731S14463
MSIVEEAPGYLQVFSDGSVKRFVPAGIAPASPKPSNGYKSKDVIIDSTKPVTGRLFLPCSDPTTGFSSKLPVVVYFHGGGFCCGSTTWTGYHNFLGDFSAASQSIVLSVDYRLAPEYRLPIAYEDCYSSLDWLGVIFGKLIARLGLENRFEPVW
>Alngl11731S14464
MSIVEEAPGYLQVFSDGSVKRFVPAGIAPASPKPSNGYKSKDVIIDSTKPVTGRLFLPCSDPTTGFSSKLPVVVYFHGGGFCCGSTTWTGYHNFLGDFSAASQSIVLSVDYRLAPEYRLPIAYEDCYSSLDWLGVIFGKLIARLGLENRFEPVW
>Alngl21663S08529
MSIVEEAPGYLQVFSDGSVKRFVPGIVPASPNPSNGYKSKDVIIDSSKSVTGRLFLPCSAPCPGFSSKLPVVVYSHGGGFCIGSTTWIGYHHFLGDFSVASQSIVLSVDYRLAPEYRLPIAYEDCYSSLDWLGHNVGSEPWLEQADLSRVFLSGDSAGGNIAHHVAVKAIQNNTCHVRINGLLLIHPYFGSEKRTDKEMAEGAAAAESIASNDMFWRLSIPEGSNRDYYGCNFEKAELSGVEWSRFPAIVVFVAGLDFLKERGVMYAEFLQKKGVKVVRLVEAEEESHVFHVFHPESEATRLLQRQMSEFMKSS
>Alngl21663S08530
MSIVEEAPGYLQVFSDGSVKRFVPAGIAPASPKPSNGYKSKDVIIDSSKPVTGRLFLPCSDPTTGFSSKLPVVVYFHGGGFCCGSTTWTGYHNFLGDFSAASQSIVLSVDYRLAPEYRLPIAYEDCYSSLDWLGHSVGSEPWLEQADLSRVFLSGESAGGNIAHHVAVKAIQNNTCHVRINGLLVIHPYYGSEKRTEKEMAEGAAAAETVAMSDMFWRLSIPEGSNRDYYGCNFEKAELSGVEWSRFPAVVVFVAGLDFLKERGVMYAEFLQKKGVGAVRLVETEEESHAFHVFHPESEATRLLQRQMSEFINSS
>Alngl27765S09046
MAVVSLDPRFNLQVGKNNHQHGGAVEEIEGLIRVYIDGHVERPPIVSIVPCTMALECGVTAKDVVIEKCTGLWARVYFPSCPGKLPLLVFFHGGGFCVGSAAWSCYNEFLSRLASKASCVIISVNYRLAPENRLPAAYEDGINTLMWVKQQVLSGSKEHKWWVKHCSLSSVYLAGDSAGANIAYNVATRLGSSGSSESTIIRPLCLKGTILIQPFFGGEARTWSEKHTYQPPNSALTLSVSDAYWRLSLPPGANRDHAWCNPLANGTDKLCDSRLPTTMICISEMDILKDRSLEFCNALTSAGKKVETVMHKGVGHSFQILHNSQLSQPRTHEMMSQIKAFISE
>Alngl34099S24772
MVRETKVVDEVSGWLRVYDDGSVDRTWTGPPEVKFMADPVPPHEEFVDGVAVKDVVINEESGLKARIYLPEKKLDENDKLPILLHFHGGGFCISEADWYMYYHVYTRLARSAGVVCVSAFLRRAPEHRLPAAVDDSYSTLLWLRSLAQGESHEPWLKESADFNRVFLIGDSSGGNLVHEVAARAGKMDLSPLRLAGGIPIHPGFVRLERSKSELEQPQSPFLTLDMLDKFLSFSLPKGCTKDHPITCPMGSAAPPLEKLNLPPFLLCLAETDLIIDTEMEYYQAMKKANKDVELFISHGMSHSFYLNKIAVDMDPNTAAQTENLIAGIKEFINNH
>Alngl41127S26613
MTSLPSSVSIKTSQEGSLAPKLYRPPPILSPESSPKTSQSHPELPCLLASSSPTSPAISAAAHKLPLIYIHNDTFCVESPFFPLYHNYVNSVAAEVNVVAVSIHYKRATKHPLPIVYEDT
>Alngl61958S11560
MSDTVASAATIPPHVVDDCRGVLHVYSDGSIVRSSKPSFNVPVHDDGSVLWKDVVFDAANNLQLRLYKPATFSPSSTSKLPVFYYIHGGGFCIGSRTWPNCQNYCFRLALELQAVVVSPDYRLSPESRLPAAIEDGFLAVKWLQAQAVSSEPDSWLTEVADFGNIFLSGDSAGGNIAHNLAVRLGSGSPELGPVRVRGYVLLAPFFGGTVRTKYEAEGPKEAFLNLELIDRFFFFF
>Alngl76437S05911
MGSLPQIVEDCMGFLQLYSDGTVFRLKDINFNTPVVHDNSVLFKDCVFDEKLNLHLRMYKPTSTKSTTTCNKLPIIVYIHGGGFCFGSCRWPNSHNCCVRLASGLGAVVISPDYRLAPEHRLPAAMDDAVSAVRWLQRQALSQSGGDAWLSGGAVDFGRVFVAGDSSGGNIAHHLAVRFGIGSTEVEPVRVRGYVLLAPFFGGEVRTKSEEGPSEEFLSLEILDR
>Alngl424397S27119
MSLNGKSQNYNSTARHESRRVKKNCHRYVIRVYKDNRVERLEGTDIVPASTDDRTGVTSKDITIIIAQPNFSARLYLPELTKPNQKLPLLVYFHGSAFCVSSPFSSKYHNYLNALVAKSKVVAVSSTLARGRTHTHTLRQMDPSKTEVAVEVFPYLREYKDGTVERIAGTQVVAAGLDPDTGVESKDILIIPETGVSARLYRPNNNYKSDKKLPLVLYFHGGAFCISSVADPVYHNSLNILVADANVIAVSVDYRRAPEHPLPAAYEDAWAAVQWVASQALADHDHQEPWLKDHVDFGKVFLVGDSAGATMAHHVAMKSDPTGNVKLLGIGLINPYFWGEKAIGSEITDPARKAMVDNWWRYVCPSDKGGDDLLINPFADGSPSLSNLACHKILVTVAEKDILRDRGRLYYEELVNSGWTGKAEIVETLGEDHVFHIFDPNCEKAKSLIKRLSSFINQGHL
>Alngl424506S10243
MASSDSEISHKFPHFDVYKDGRVVLRQPITEKIPPSDDPLTGVRSKDVIISSEPPVSARIFLPKSADTTQKLPLLFYVHGGGFSKQSAFSRKYHNFVNTFVAEANVVAVSVEYGLFPTRPIPACYEDSWVGLQWLASHSNGNGPEPWLNDRADFQRVFVAGDSAGGNIAHNLLVRVGTIGLPGVKVVGAVLVHPYFGGTEIDKMWLYMCPTNSGLEDPRMSPNAEDLVRLGCERVLVFVAEEDDLMDPGKRYHEELKKSGWVGSVEIVENSGEKHCFHLSNLKYEKAVDLIEKFASFVKQD
>Alngl424792S28226
MVRETKVVDEVSGWLRVYDDGSVDRTWTGPPEVKFMADPVPPHEEFVDGVAVKDVVINEESGLKARIYLPEKKLDENDKLPILLHFHGGGFCISEADWYMYYHVYTRLARSAGVVCVSAFLRRAPEHRLPAAVDDSYSTLLWLRSLAQGESHEPWLKESADFNRVFLIGDSSGGNLVHEVAARAGKMDLSPLRLAGGIPIHPGFVRLERSKSELEQPQSPFLTLDMLDKFLSFSLPKGCTKDHPITCPMGSAAPPLEKLNLPPFLLCLAETDLIIDTEMEYYQAMKKANKDVELFISHGMSHSFYLNKIAVDMDPNTAAQTENLIAGIKEFINNH

Gene tree

Gene tree

Sheng jun & Dong yang Teams, Yunnan agriculture University