Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Dryas drummondii
Species name
Dryas drummondii is a species of eudicot in the family Rosaceae (rose family).
Species info
Gene sequence info
Dryas_drummondii.COMT.fa
Download
>Drydr2S08348
MGSTGETQMTPTQVSDEEANLFAMQLASASVLPMVLKSAIELDLLEIMAKAGPGAFLSPSDIASQLPTKNPDAPVMLDRMLRLLASYSVLTYSLRTLPDGKVERLYGLGPVCKFLTKNEDGVSIAPLCLMNQDKVLVESWYYLKDAVLEGGIPFNKAYGMTAFEYHGTDPRFNKVFNRGMADHSTITMKKILETYKGFEGLTSVVDVGGGTGAVVNMIVSKYPSIKGINFDLPHVIEDAPQYPGVEHVGGDMFVSVPKADAIFMKWICHDWSDEHCLKFLKNCYAALPDNGKVIVAECILPVAPDSSLATKGVVHIDVIMLAHNPGGKERTEKEFEALAKGAGFQGFRVMCSAFNTYVIEFLKNI
>Drydr347S20868
MASSPVETESHSRKKQLEEESLCDALQLALSSALSRSMQSAIELGLFDIMAKVGPGTDGLSSSEIAAQIGTKNPEAPMMLDRILRLLTTHSVLSCSVAAVDQGSNFQRLYSLNPVSKHFVTSQDGVSLGPLMTLVHDKVCVDSWFQLKDAVVEGGIPFNRVHGTNVFEYSGLNPKFNQVFNTAMYSFTTIIIKKILDLYKGFEHITQLVDVGGGLGVTLNLITSRYPHIKGINFDLPHVIKHAPSYPGVEHVGGDMFANVPSGDAIFIKGVLHNWFDEDCIKLLKNCYNAIPDNGKVIVLDPLVPIVPETSAAAKITSQIDLIMMTQTPGGKERSQQELMALATGAGFSGIRFECSVCNFWVMEFFK
>Drydr347S20869
MASSVEKELNHPRIEQSEEEEENFCYATQLSSSSVLSMSMQSAIELGVFDIIAKAGSGHGLSPPEIAAQIGTKNPEAPMMLDRILRLLSSHSVFNCSVVADDHGSFQRLYSLAPVSKYFVTNRDGGSLVPMMALLQDKVFLDSWTQLKDAVLEGGIPFNRVHGTHAFEYPGLDPRFNQVFNTAMINHTTIVVKKILDLYKGFEHIRQLVDVGGGLGVTLNLIISRYPHIKGINFDLPHVIKHASSSPGVEHVGGDMFASVPSGDAIFMKWILHDWSDEHCLKLLKNCYTAIPDNGKVIVVEALLPVKPETSTAAKSTSQIDVLMMTQNPGGKERSQQEFMALATAAGFSGIRFECSVCNFWVMEFFK
>Drydr347S20870
MASSPVETESRSRKKQLEEESFCDAVQLVLSSALSMSMQSAIELGLFDIMTQVGPGTAGLSSSEIAAQIGTKNPEAPMMLDRILRLLTTHSVLSCSVAADDQGSNFQRLYSLNPVSKHFVTSQDGVSLGPVMTLFQDKVFVNSWFQLKDAVVEGGIPFNRVHGTNVFEYSGLNPKFNQVFNTAMYSFTTIIIKKILDLYKGFEHITQLVDVGGGLGVTLNLITSRYPHIKGINFDLPHVIKHALSYPGVEHIGGDMFANVPSGDAIFMKGILHDWFDEDCIKLLKNCYNAIPDNGKVIVLEALVPIVPETSAAAKITSRLDLIMMTQTPGGKERSQQEFMALATSAGFSGIKFECCVSNLWVMEFFK
>Drydr347S03640
MASSPVEAESYSRKKELEEESFCDAVQLVVSSALTMSMHPAIELGVFDIIAKAAGLTSSEIAAQIGTKNPEASMMLDRILRLLTTHSVLNCYVVIADDQGSSFQRLYSLSPACVQAFCAQ
>Drydr191S01630
MVLKSAIELNVIDILWAARDGACLSPSDIAARLPTQNADAPVLLDRMLRLLASYSILKCSVRTGQHGEVERLYCAAPICKFLVKDQHGGAGSVGPLFLLHHDKVFMESWFQLNDAILEGGIPFNRVYGMTAFEYPETDQRFNRVFNQAMSNHTTLILKKILDVYKGFEGLNVLVDVGGGNGVTLNLITTKYPHIKGINFDLPHVLADAPSYTGVEHVGGDMFKSVPEGDAIFMKWILHDWSDEHCLTLLKNCCKALPSHGKVIIVESILPVMPENSVSSNIVFEQDLLMLAQNPGGKERTKNQYEALVVKSGFSGCEPLRWSNQLGPRIPTFTLKLCLAALVYSVWKARNGRVIRTMKIPPLMLLDFPEVLGCVSFGYFSFKVPAELESALRLNTVQYFITKRPWLDLYGINVRPVAPVGSTSRKTCVDPALIHRSLPDELLFEVFARMTPYNLGRASCVCRKWRYTIRNPVFWRNACLKAWQFSGVVENYKILQAKYESSWRKMWLLRPRIRTDGLYVSRNTYIRTGVAEWKITNPVHLVCYYRYMRFFPSGRFLYKNSSQKIKDIAKSMNFRAAKADGVFSGHYTLSDDKVEAAVLYPGTRPTVLRIRLRLRGIVVGANNRMDLLSLVTSGVNDNEVCGPDEDILGVVEGWQDDETHNPDVPAVSHKRGLTPFVFVPFEEVETSFFNLPVEKMDYFVPG
>Drydr270S09429
MEDNNDETSEARNQARLGILELANMISVPMSLNAVVRLNVPDAIWQSGSNAPLSASQILARVLPQGGGDADNLQRILRMLASYGVFSEHLNDASQDGERKFSLTNVGKTLVTDPNGLSYGPYVLQHHQDVLMGAWPLVHEAVVDPTVEPFVKVNGEPAYEYYGKKPEMNGLMQRAMSGVSVPFMKAILDGYDGFEGVQRLVDVGGSAGDCLRMILQKHPTVREGINFDLPEVVAKAPTIAGVTHVGGDMFKSIPAADAIFMKWVLSTWTDSECKLIMENCYKALPAGGKLIACEPVLPKKSDDSRRTRALLENDIFVMTIYRAKGKNRTEEELQQLGLSVGFSHFRSIYIDYFYTVLEFQK
>Drydr346S10888
METFVWKNIICRSFCSRLNINLRFTAPYHPQSNGQVEAINKIIKKTLKTKLDNAKGNWPELLPEVLWSYQTSYRNSTEETPYSLAFGTDAVVPVEMGTPSFRTEHVFGSARLSAAIPGKITSPGSSILAFNAALNAKEWVLHNWDDDQCKKLLRNCSEALPEIGNLIVVEFAIPEVLGNTAELSNIVTIDILMMNFLGGKERTTTEFDNLAKANPPLYTSIIYKNDLNTELRMVKGSEASKDLDGEEYGASTEALWAAYAAREEHIISKLDDLEPCVNVTVANSFSAILAAAGVEPL
MGSTGETQMTPTQVSDEEANLFAMQLASASVLPMVLKSAIELDLLEIMAKAGPGAFLSPSDIASQLPTKNPDAPVMLDRMLRLLASYSVLTYSLRTLPDGKVERLYGLGPVCKFLTKNEDGVSIAPLCLMNQDKVLVESWYYLKDAVLEGGIPFNKAYGMTAFEYHGTDPRFNKVFNRGMADHSTITMKKILETYKGFEGLTSVVDVGGGTGAVVNMIVSKYPSIKGINFDLPHVIEDAPQYPGVEHVGGDMFVSVPKADAIFMKWICHDWSDEHCLKFLKNCYAALPDNGKVIVAECILPVAPDSSLATKGVVHIDVIMLAHNPGGKERTEKEFEALAKGAGFQGFRVMCSAFNTYVIEFLKNI
>Drydr347S20868
MASSPVETESHSRKKQLEEESLCDALQLALSSALSRSMQSAIELGLFDIMAKVGPGTDGLSSSEIAAQIGTKNPEAPMMLDRILRLLTTHSVLSCSVAAVDQGSNFQRLYSLNPVSKHFVTSQDGVSLGPLMTLVHDKVCVDSWFQLKDAVVEGGIPFNRVHGTNVFEYSGLNPKFNQVFNTAMYSFTTIIIKKILDLYKGFEHITQLVDVGGGLGVTLNLITSRYPHIKGINFDLPHVIKHAPSYPGVEHVGGDMFANVPSGDAIFIKGVLHNWFDEDCIKLLKNCYNAIPDNGKVIVLDPLVPIVPETSAAAKITSQIDLIMMTQTPGGKERSQQELMALATGAGFSGIRFECSVCNFWVMEFFK
>Drydr347S20869
MASSVEKELNHPRIEQSEEEEENFCYATQLSSSSVLSMSMQSAIELGVFDIIAKAGSGHGLSPPEIAAQIGTKNPEAPMMLDRILRLLSSHSVFNCSVVADDHGSFQRLYSLAPVSKYFVTNRDGGSLVPMMALLQDKVFLDSWTQLKDAVLEGGIPFNRVHGTHAFEYPGLDPRFNQVFNTAMINHTTIVVKKILDLYKGFEHIRQLVDVGGGLGVTLNLIISRYPHIKGINFDLPHVIKHASSSPGVEHVGGDMFASVPSGDAIFMKWILHDWSDEHCLKLLKNCYTAIPDNGKVIVVEALLPVKPETSTAAKSTSQIDVLMMTQNPGGKERSQQEFMALATAAGFSGIRFECSVCNFWVMEFFK
>Drydr347S20870
MASSPVETESRSRKKQLEEESFCDAVQLVLSSALSMSMQSAIELGLFDIMTQVGPGTAGLSSSEIAAQIGTKNPEAPMMLDRILRLLTTHSVLSCSVAADDQGSNFQRLYSLNPVSKHFVTSQDGVSLGPVMTLFQDKVFVNSWFQLKDAVVEGGIPFNRVHGTNVFEYSGLNPKFNQVFNTAMYSFTTIIIKKILDLYKGFEHITQLVDVGGGLGVTLNLITSRYPHIKGINFDLPHVIKHALSYPGVEHIGGDMFANVPSGDAIFMKGILHDWFDEDCIKLLKNCYNAIPDNGKVIVLEALVPIVPETSAAAKITSRLDLIMMTQTPGGKERSQQEFMALATSAGFSGIKFECCVSNLWVMEFFK
>Drydr347S03640
MASSPVEAESYSRKKELEEESFCDAVQLVVSSALTMSMHPAIELGVFDIIAKAAGLTSSEIAAQIGTKNPEASMMLDRILRLLTTHSVLNCYVVIADDQGSSFQRLYSLSPACVQAFCAQ
>Drydr191S01630
MVLKSAIELNVIDILWAARDGACLSPSDIAARLPTQNADAPVLLDRMLRLLASYSILKCSVRTGQHGEVERLYCAAPICKFLVKDQHGGAGSVGPLFLLHHDKVFMESWFQLNDAILEGGIPFNRVYGMTAFEYPETDQRFNRVFNQAMSNHTTLILKKILDVYKGFEGLNVLVDVGGGNGVTLNLITTKYPHIKGINFDLPHVLADAPSYTGVEHVGGDMFKSVPEGDAIFMKWILHDWSDEHCLTLLKNCCKALPSHGKVIIVESILPVMPENSVSSNIVFEQDLLMLAQNPGGKERTKNQYEALVVKSGFSGCEPLRWSNQLGPRIPTFTLKLCLAALVYSVWKARNGRVIRTMKIPPLMLLDFPEVLGCVSFGYFSFKVPAELESALRLNTVQYFITKRPWLDLYGINVRPVAPVGSTSRKTCVDPALIHRSLPDELLFEVFARMTPYNLGRASCVCRKWRYTIRNPVFWRNACLKAWQFSGVVENYKILQAKYESSWRKMWLLRPRIRTDGLYVSRNTYIRTGVAEWKITNPVHLVCYYRYMRFFPSGRFLYKNSSQKIKDIAKSMNFRAAKADGVFSGHYTLSDDKVEAAVLYPGTRPTVLRIRLRLRGIVVGANNRMDLLSLVTSGVNDNEVCGPDEDILGVVEGWQDDETHNPDVPAVSHKRGLTPFVFVPFEEVETSFFNLPVEKMDYFVPG
>Drydr270S09429
MEDNNDETSEARNQARLGILELANMISVPMSLNAVVRLNVPDAIWQSGSNAPLSASQILARVLPQGGGDADNLQRILRMLASYGVFSEHLNDASQDGERKFSLTNVGKTLVTDPNGLSYGPYVLQHHQDVLMGAWPLVHEAVVDPTVEPFVKVNGEPAYEYYGKKPEMNGLMQRAMSGVSVPFMKAILDGYDGFEGVQRLVDVGGSAGDCLRMILQKHPTVREGINFDLPEVVAKAPTIAGVTHVGGDMFKSIPAADAIFMKWVLSTWTDSECKLIMENCYKALPAGGKLIACEPVLPKKSDDSRRTRALLENDIFVMTIYRAKGKNRTEEELQQLGLSVGFSHFRSIYIDYFYTVLEFQK
>Drydr346S10888
METFVWKNIICRSFCSRLNINLRFTAPYHPQSNGQVEAINKIIKKTLKTKLDNAKGNWPELLPEVLWSYQTSYRNSTEETPYSLAFGTDAVVPVEMGTPSFRTEHVFGSARLSAAIPGKITSPGSSILAFNAALNAKEWVLHNWDDDQCKKLLRNCSEALPEIGNLIVVEFAIPEVLGNTAELSNIVTIDILMMNFLGGKERTTTEFDNLAKANPPLYTSIIYKNDLNTELRMVKGSEASKDLDGEEYGASTEALWAAYAAREEHIISKLDDLEPCVNVTVANSFSAILAAAGVEPL
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University