Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Dryas drummondii
Species name
Dryas drummondii is a species of eudicot in the family Rosaceae (rose family).
Species info
Gene sequence info
Dryas_drummondii.4CL.fa
Download
>Drydr2S08079
MLSIASNSVETQKPAEISPNIISEISATTPTQNHGNHQIAAAAAAAATPPPTTTTKTTTQIGHVFRSRLPDIPISNHLPLHTYCFENLSEFSDRPCLINGSTGKTYTFSETHLISQKTGAGLSNLGIKKGDVIMILLQNCAEFVFAFMGASMIGAVSTTANPFYTPAEIFKQFRASNAKLIITQSQYVDKLRQVPTGDQHYPKLGEDFKVVTIDEPPENCLHFSVISEANEKEIPEVVIDPDDPVALPFSSGTTGLPKGVILTHKSLITSVGQQVDGENPNLYLKEDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLLLHKFEIGPLLDLIQRHRVSVAAVVPPLVIALAKNPMVAKFDLSSIRVVLSGAAPLGKELEEALRSRVPQAVLGQGYGMTEAGPVLSMCLAFAKQPFATKSGSCGTVVRNAELKVIDPETGRSLGYNQPGEICIRGSQIMKGYLNDAEATASTVDKDGWLHTGDVGYVDDDDEVFIVDRVKELIKFKGFQVPPAELESLLVSHPSIADAAVVPQKDDVAGEVPVAFVVRSNGLELTEEAVKEFIAKQVVFYKRLHKVYFVHAIPKSPSGKILRKDLRAKLAAATATPNPMA
>Drydr37S21069
MEYKQDNDQFIFRSKLPDIYIPNHLPLHTYCFENISQFRDRPCLINGNTGETYTYAEVELTSRKVAAGLDKLGIQQNDVVMLLLQNCPQFVFAFLGASYVGAVSTTANPFYTPSEVAKQAAASTAKLIITQAAYVDKVKDFAKQNDVKIMCIDHYETLQDDDTTVLNFSDMTAADENDIPAVKINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHAEDVILCVLPLFHIYSLNSVLLCGLRVGAAILIMQKFEINKLLELVEKYKVTIAPFVPPIVLAIAKSPDLHRSDLSSIRTVMSGAAPMGKELENTVRAKLPNAKLGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPDTGASLPRNQAGEICIRGSQIMKGYLNDPEATERTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKFKGFQVAPAELEAMLISHPNLSDAAVVPMKDEAAGEVPVAFVVRSNGSKISEDEIKQYISKQVVFYKRIGRVFFTDKIPKAPSGKILRKDLRARLAAGLPN
>Drydr563S13125
MEVQTTQNDIVFRSKLPDIPIPKHLPLHSYIFQNKSHLASKPCLINGSTGHVYSYADVELTARRVASGLHRLGIRQGDVIMLLLPNSPEFVFAFLGASFRGAMATSANPFFTPAEILKQAKASKAKLIITLSSHYDKVKDLADDDDEEVHVKLMCVDAPPDQKCLHFSELTNSDENDMPDVEIDPNDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNPNLYYSSDDVVLCVLPLFHIYSLNSVLLCGLRAGAAILIMQKFEIVSLLELVQRHRVSVAPIVPPTVLAIAKFPELENYDLSSVRVLKSGGAPLGKELEDTVRAKFPNVTLAQGYGMTEAGPVLTMSLAFAKQPFEVKPGGCGTVIRNAEMKIVDPETGASLPRNQPGEICIRGDQIMKGYLNDPEATRATIDKEGWLHTGDIGFIDDDEELFIVDRLKELIKYKGFQVAPAELEALLITHPTISDAAVVPMKDEAAGEVPVAFVVRSNGSNITEDEIKQFISKQVVYYKRINRVFFIEAIPKSPSGKILRKELRAKLAAGIPN
>Drydr13S15529
MGTFVQSSSQDEEHIFRSRRPAVQVPDNLTLPEFVLKDAELYADNVAFVEAVTGKKITYGEVVRNTRRFAKALRSLGLRKGQVVVVVLPNVAEYAIVALGIMAAGGVFSGANPSGHASEIKKQVEAADAKLIVTNVASYEKVKALGVPVIVLGEELIEGAMNWNNLLEAADRAGNKTNKEEVQQSDLCALPFSSGTTGLSKGVMLTHRNLVANLCSTLFGVTPEMVGKVTVLGLIPFFHIYGITGICCATLRNKGKVVVMGRFELRTFLNALISHEVTFAPIVPPIILNLVKNPIVDEFDLSKLKLQAVMTAAAPLAPDLLTAFENKFPGVQVQEAYGLTEHSCITLTHAELGAKAKKNSVGFILPNMQVKFIHPDTGRSLPRNTPGEVCVLSQCTMKGYYNNEEETARTIDKNGWLHTGDIGFIDDDDNVFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDVAVVPLPDEEAGEIPAACVVMVAGAKESEEEMIKFVASNVAQYKKVRVVHFVDTIPKSPSGKIMRRLIKDTLIEKMKACN
>Drydr270S19071
MCVSVCKVAPAELEGVLLSHPEILDAVVIPCPDAKAGEVPIANVVRAPNSLLTEQDIQKFVEKQVAPFKRLRRVTFINSVPKSAAGNFLRRELIQKLRSKV
>Drydr104S15071
MEKSGYGRDGIFRSLRPPLALPRDPNLSMVSFLFRKSSSYPHKPALIDADSSETLSFTQFKSMVIKVSHGLLHLGIKKNDVVLIFAPNSIQFPICLLGVIAIGAIATTSNPLYTVSELSKQVKDSNPKLVITVPELWEKVKGFNLPSVILGSQSSSSLHIASSSRVVSFHELVKLSGSVSDFPVVDVKQTDTAVLLYSSGTTGLSKGVILTHRNFIASSLMVAMDQELDGDVHRVFLCVLPMFHAFGLAIITYSQLQKGNAVVSMVRFNLEQILMTMEKYKVTHLWVVPPIILALAKHSVVKKYNLSSLKHIGSGAAPLGKELMEKCAKIVPNGVVAQGYGMTETCGIVSVENSLVGNRHTGSTGTLVSGVESQIISVDTLKPLPPNQLGEIWVRGPNMMKGYFNNPQATKMTLDENGWVHTGDLGYFDEDGQLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTEEDVKKFIANQVAPFKRLKKVTFTNSVPKSASGKILRRELIEKVRSKI
>Drydr104S15070
MEKSGYGRDGIFRSLRPPLVLPRDPNLSMVSFLFRNSSSYPHKPALIDADSSETLSFTQFKSMVIKVSHGLLHLGIKKNDVVLIFAPNSIQFPICLVGVIAIGAIATTSNPLYTVSELSKQVKDSNPKLVITVPELWEKVKGFNLPSVILGSQSSSSLHIASSSRVVSFHELVKLSGSVSDFPVVDVKQTDTAVLLYSSGTTGLSKGVILTHRNFIASSLMVTMDQELAGDVHRVFLCVLPMFHVFGLAILTYTQLQKGNAVVSMARFNLEQILMTVEKYKVTHLWVVPPIILALAKHSVVKKYNLSSLKHIGSGAAPLGKELMEECAKIIPDGVVAQGYGMTETCGIVSVENSLVGNRHTGSTGTLVSGVESQIISVDTLKPLPPNQLGEIWVRGPNMMKGYFNNPQATKMTLDKNGWVHTGDLGYFDEDGQLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTEEDVKNFVANQVAPFKRLKKVTFTNSVPKSASGKILRRELIEKVRFAVDLVLELKEEQGVVRKAIKYVGR
>Drydr54S04811
MLLLQNCPQFVFAFLGASYVGTVSTTANSIYTPSKVAKQAAASMTELIITQAAYVDKVKDFAKQNDIKIMCIDHYETSQDDDTTVLNFSNMTRADENDIPAVKINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVA
>Drydr54S04810
MLPLFHIYSLNSVLLCGLRVGAAILIMQKFEINKLLELVEKYKVTIAPFVSSIVLAFAKSPDLHRSDLSSIRTVMSGAAPMGKELEDIVRAKLPNAKLGQSESIVLSIISMPSSANDESPANVEATTCSVMACQTRLTMFGASLPNSIPSVRH
>Drydr54S04809
MLLLQNCPQFVFAFLGTSYVGAVNTTANSFYTLSKVAKQATASTAKLIITQATYVDKVKDFAKQNDIKIINESGQATEKEVYENVELVAPESVKPDNSAAQQVTTVDESSDANVFR
>Drydr54S04808
MLLLQNCPQFVFAFLGTSYVGAVNTTANSFYTPSKLAKQATASTAKLIITQAAYVDKVKDFAKQNDIKIMCIEHYETSQDDDTTVLNFSDMTRADENDIPAVKINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHA
>Drydr54S04805
MLLLQNCPQFVFVFLGASYVGTVSTTANSIYTPSEVAKQAAASTTELIITQAANVDKVKDFAKQNDIKIMCIDHYETSQDDDTTVLNFSNMTRADENDIPAVKINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVA
>Drydr54S04804
MLPLFHIYSLNSVLLCGLRVGAAILIMQKFEINKLLELVEKYKVTIAPFVPSIVLAFAKSPDLHRSDLSSIRTVMSGAAPMGKELEDIVRAKLPNAKLGQSESIVLSIISMPSSANDESPANVEATVSWYQSRHQSKQGFALLVGEQRWDVNVIDVGHEELSKIEEERARGFAQSECIEDFLDWVTDVEQCFEMLEIPKEKIVKVVVERLKGSAYETWKHILKI
MLSIASNSVETQKPAEISPNIISEISATTPTQNHGNHQIAAAAAAAATPPPTTTTKTTTQIGHVFRSRLPDIPISNHLPLHTYCFENLSEFSDRPCLINGSTGKTYTFSETHLISQKTGAGLSNLGIKKGDVIMILLQNCAEFVFAFMGASMIGAVSTTANPFYTPAEIFKQFRASNAKLIITQSQYVDKLRQVPTGDQHYPKLGEDFKVVTIDEPPENCLHFSVISEANEKEIPEVVIDPDDPVALPFSSGTTGLPKGVILTHKSLITSVGQQVDGENPNLYLKEDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLLLHKFEIGPLLDLIQRHRVSVAAVVPPLVIALAKNPMVAKFDLSSIRVVLSGAAPLGKELEEALRSRVPQAVLGQGYGMTEAGPVLSMCLAFAKQPFATKSGSCGTVVRNAELKVIDPETGRSLGYNQPGEICIRGSQIMKGYLNDAEATASTVDKDGWLHTGDVGYVDDDDEVFIVDRVKELIKFKGFQVPPAELESLLVSHPSIADAAVVPQKDDVAGEVPVAFVVRSNGLELTEEAVKEFIAKQVVFYKRLHKVYFVHAIPKSPSGKILRKDLRAKLAAATATPNPMA
>Drydr37S21069
MEYKQDNDQFIFRSKLPDIYIPNHLPLHTYCFENISQFRDRPCLINGNTGETYTYAEVELTSRKVAAGLDKLGIQQNDVVMLLLQNCPQFVFAFLGASYVGAVSTTANPFYTPSEVAKQAAASTAKLIITQAAYVDKVKDFAKQNDVKIMCIDHYETLQDDDTTVLNFSDMTAADENDIPAVKINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHAEDVILCVLPLFHIYSLNSVLLCGLRVGAAILIMQKFEINKLLELVEKYKVTIAPFVPPIVLAIAKSPDLHRSDLSSIRTVMSGAAPMGKELENTVRAKLPNAKLGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPDTGASLPRNQAGEICIRGSQIMKGYLNDPEATERTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKFKGFQVAPAELEAMLISHPNLSDAAVVPMKDEAAGEVPVAFVVRSNGSKISEDEIKQYISKQVVFYKRIGRVFFTDKIPKAPSGKILRKDLRARLAAGLPN
>Drydr563S13125
MEVQTTQNDIVFRSKLPDIPIPKHLPLHSYIFQNKSHLASKPCLINGSTGHVYSYADVELTARRVASGLHRLGIRQGDVIMLLLPNSPEFVFAFLGASFRGAMATSANPFFTPAEILKQAKASKAKLIITLSSHYDKVKDLADDDDEEVHVKLMCVDAPPDQKCLHFSELTNSDENDMPDVEIDPNDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNPNLYYSSDDVVLCVLPLFHIYSLNSVLLCGLRAGAAILIMQKFEIVSLLELVQRHRVSVAPIVPPTVLAIAKFPELENYDLSSVRVLKSGGAPLGKELEDTVRAKFPNVTLAQGYGMTEAGPVLTMSLAFAKQPFEVKPGGCGTVIRNAEMKIVDPETGASLPRNQPGEICIRGDQIMKGYLNDPEATRATIDKEGWLHTGDIGFIDDDEELFIVDRLKELIKYKGFQVAPAELEALLITHPTISDAAVVPMKDEAAGEVPVAFVVRSNGSNITEDEIKQFISKQVVYYKRINRVFFIEAIPKSPSGKILRKELRAKLAAGIPN
>Drydr13S15529
MGTFVQSSSQDEEHIFRSRRPAVQVPDNLTLPEFVLKDAELYADNVAFVEAVTGKKITYGEVVRNTRRFAKALRSLGLRKGQVVVVVLPNVAEYAIVALGIMAAGGVFSGANPSGHASEIKKQVEAADAKLIVTNVASYEKVKALGVPVIVLGEELIEGAMNWNNLLEAADRAGNKTNKEEVQQSDLCALPFSSGTTGLSKGVMLTHRNLVANLCSTLFGVTPEMVGKVTVLGLIPFFHIYGITGICCATLRNKGKVVVMGRFELRTFLNALISHEVTFAPIVPPIILNLVKNPIVDEFDLSKLKLQAVMTAAAPLAPDLLTAFENKFPGVQVQEAYGLTEHSCITLTHAELGAKAKKNSVGFILPNMQVKFIHPDTGRSLPRNTPGEVCVLSQCTMKGYYNNEEETARTIDKNGWLHTGDIGFIDDDDNVFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDVAVVPLPDEEAGEIPAACVVMVAGAKESEEEMIKFVASNVAQYKKVRVVHFVDTIPKSPSGKIMRRLIKDTLIEKMKACN
>Drydr270S19071
MCVSVCKVAPAELEGVLLSHPEILDAVVIPCPDAKAGEVPIANVVRAPNSLLTEQDIQKFVEKQVAPFKRLRRVTFINSVPKSAAGNFLRRELIQKLRSKV
>Drydr104S15071
MEKSGYGRDGIFRSLRPPLALPRDPNLSMVSFLFRKSSSYPHKPALIDADSSETLSFTQFKSMVIKVSHGLLHLGIKKNDVVLIFAPNSIQFPICLLGVIAIGAIATTSNPLYTVSELSKQVKDSNPKLVITVPELWEKVKGFNLPSVILGSQSSSSLHIASSSRVVSFHELVKLSGSVSDFPVVDVKQTDTAVLLYSSGTTGLSKGVILTHRNFIASSLMVAMDQELDGDVHRVFLCVLPMFHAFGLAIITYSQLQKGNAVVSMVRFNLEQILMTMEKYKVTHLWVVPPIILALAKHSVVKKYNLSSLKHIGSGAAPLGKELMEKCAKIVPNGVVAQGYGMTETCGIVSVENSLVGNRHTGSTGTLVSGVESQIISVDTLKPLPPNQLGEIWVRGPNMMKGYFNNPQATKMTLDENGWVHTGDLGYFDEDGQLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTEEDVKKFIANQVAPFKRLKKVTFTNSVPKSASGKILRRELIEKVRSKI
>Drydr104S15070
MEKSGYGRDGIFRSLRPPLVLPRDPNLSMVSFLFRNSSSYPHKPALIDADSSETLSFTQFKSMVIKVSHGLLHLGIKKNDVVLIFAPNSIQFPICLVGVIAIGAIATTSNPLYTVSELSKQVKDSNPKLVITVPELWEKVKGFNLPSVILGSQSSSSLHIASSSRVVSFHELVKLSGSVSDFPVVDVKQTDTAVLLYSSGTTGLSKGVILTHRNFIASSLMVTMDQELAGDVHRVFLCVLPMFHVFGLAILTYTQLQKGNAVVSMARFNLEQILMTVEKYKVTHLWVVPPIILALAKHSVVKKYNLSSLKHIGSGAAPLGKELMEECAKIIPDGVVAQGYGMTETCGIVSVENSLVGNRHTGSTGTLVSGVESQIISVDTLKPLPPNQLGEIWVRGPNMMKGYFNNPQATKMTLDKNGWVHTGDLGYFDEDGQLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTEEDVKNFVANQVAPFKRLKKVTFTNSVPKSASGKILRRELIEKVRFAVDLVLELKEEQGVVRKAIKYVGR
>Drydr54S04811
MLLLQNCPQFVFAFLGASYVGTVSTTANSIYTPSKVAKQAAASMTELIITQAAYVDKVKDFAKQNDIKIMCIDHYETSQDDDTTVLNFSNMTRADENDIPAVKINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVA
>Drydr54S04810
MLPLFHIYSLNSVLLCGLRVGAAILIMQKFEINKLLELVEKYKVTIAPFVSSIVLAFAKSPDLHRSDLSSIRTVMSGAAPMGKELEDIVRAKLPNAKLGQSESIVLSIISMPSSANDESPANVEATTCSVMACQTRLTMFGASLPNSIPSVRH
>Drydr54S04809
MLLLQNCPQFVFAFLGTSYVGAVNTTANSFYTLSKVAKQATASTAKLIITQATYVDKVKDFAKQNDIKIINESGQATEKEVYENVELVAPESVKPDNSAAQQVTTVDESSDANVFR
>Drydr54S04808
MLLLQNCPQFVFAFLGTSYVGAVNTTANSFYTPSKLAKQATASTAKLIITQAAYVDKVKDFAKQNDIKIMCIEHYETSQDDDTTVLNFSDMTRADENDIPAVKINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHA
>Drydr54S04805
MLLLQNCPQFVFVFLGASYVGTVSTTANSIYTPSEVAKQAAASTTELIITQAANVDKVKDFAKQNDIKIMCIDHYETSQDDDTTVLNFSNMTRADENDIPAVKINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVA
>Drydr54S04804
MLPLFHIYSLNSVLLCGLRVGAAILIMQKFEINKLLELVEKYKVTIAPFVPSIVLAFAKSPDLHRSDLSSIRTVMSGAAPMGKELEDIVRAKLPNAKLGQSESIVLSIISMPSSANDESPANVEATVSWYQSRHQSKQGFALLVGEQRWDVNVIDVGHEELSKIEEERARGFAQSECIEDFLDWVTDVEQCFEMLEIPKEKIVKVVVERLKGSAYETWKHILKI
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University