Enzyme
This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)-dihydromyricetin, although some enzymes may act only on a subset of these compounds. Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4-diol. NAD+ can act instead of NADP+, but more slowly.
DFR
Enzyme
Dihydroflavonol 4-reductase
Enzyme name
EC:1.1.1.219
Entry
Oxidoreductases;Acting on the CH-OH group of donors;With NAD+ or NADP+ as acceptor
Class
(2R,3S,4S)-leucoanthocyanidin:NADP+ 4-oxidoreductase
Sysname
a (2R,3S,4S)-leucoanthocyanidin + NADP+ = a (2R,3R)-dihydroflavonol + NADPH + H+ [RN:R11500]
Reaction
(2R,3R)-dihydroflavonol [CPD:C21417];NADPH [CPD:C00005];H+ [CPD:C00080]
Product
Species information
Diospyros oleifera
Species name
Oily persimmon (Diospyros oleifera) is a species of eudicot in the family Ebenaceae (ebony family).
Species info
Gene sequence info
Diospyros_oleifera.DFR.fa
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>evm.model.fragScaff_scaffold_94.20
MEVSPPPATVCVTKASGFIGSWIVMRLLQRGYTVCATVRKGEADDGNVDTNLTLWKADLGKDRALMRPSKVAPSCFMWQRPWASTQRTLMFDGSASDGGVGDGGRCKR
>evm.model.fragScaff_scaffold_124.250
MATPREEQDRVAICINDRLKRLRSYSSSSGGLSGVHDGLHKVDPHEPVILAVGPRYHGQLRLQEMENQKLRYLNQLLERNNMRGTNEYVKEIRRLEERALKFYKLDDQEATKIRDDLVEMLLIDGCFIVELLRKYNGAQWPGDDPIFQLDQLRFVLRRDLILLENQLPFFVLDHLFSKTRGRGEEDDLIPLALAFLEKIMPNQKLEAFNYNGSHKVKHLLGLVYSSWGHRFVQALRDPNRVSQCDIEDIWEFIESATELKDASVKLKMVKNRSDLFNIQFNKKRGVLEIPELCIGSYTEFPLRSLLAYERDYLKGDDQPKYVGHYLAFINCQVQSPRDVQLLRQKRVIERWSADDAAVYNMLKDVYRFVLISPEIGSEEDKTSGKMTVSAITACTAGRRTHRRCRFEGIDKNLPSVTFSSKKLIGMGFKFKYSLEDMFKGAIGTCRGKDYFPTPLKPQPMTIPPKALPLAPRF
>evm.model.fragScaff_scaffold_124.249
MNSDQFPRGTNMPLALEVSPPPSTVCVTGASGFIGSWLVMRLLQRGYTVRATVRDPGNMKKVKPMMESPNADTNLTLWKANLGEDGNFGETIEGCSGVFHVAAPMGFDSKDPEVRRRGLLEKYDGNHPDLIELAFKFLERILPTKKLVSKLDSDFQHDLRSVVYEGLSWLRLEANNNSNPNNDQDGDDKWNLVKSATELLEFGVEFKVIETDNFIDIKFTDKGVLEIPCILIRYGTASSISMLLEVENNFFYNINNLGQQRWLSHYLWFMNSLLKSPSDVQQLRQKNIIDNLSELRDDTAILKFLKDSYESVTISPRNFSYREICESLNSHCNHRQNRWLAKLKRDYFNSPWAFISFFAASLLLILTIAQTVFSIASYYKDG
>evm.model.fragScaff_scaffold_92.577
MEVSPPPATVCVTRASGFIGSWLVVRLLQRGYTVRATVRNSAYGRRWLVDGGDCLGRRRDCLRRKEGRRQVGPDGADSARGGRGGRRWREVLAAVGETMAEGARDGGGPTAMLTALVGQGRPAASSLSCGGFKGESVWV
>evm.model.fragScaff_scaffold_110.393
MHHRSFRVHRLVARHEASSTRLYYLCNRSRPREHEEGEAEMELPNANTNLMLWRVDLGEDGSFDKAIEGCSDVFHVATPMGFDSKDPEDYPSPVGGMRGIEVRESHGDAAQPHLPKHSLHVKNHSHMYRSCSATVIKLIIRHGHAWQDHDKNKGNEEEEVDLRA
>evm.model.original_scaffold_284.172
MTTENQENSHIDPEIQGFRSALDNWEAGQCSSFYIFLQVLQVKTPARELLIENERSEVKTGNMKKVKPMMESPNVDTNLTLWKPDLGEDGSSDEAIEG
>evm.model.original_scaffold_2151.33
MEDEIAYCVTGATGYIGSWLVRSLLQRGFGVHATARDPAKALHLLPLWGGGDRLRLFRADLQEEGSFDEAVKGCTGVFHVAAPMQFDVPPKEDVEGYVCANIIEPAINGTLNLLKSCLKAASVKRVVFTSSISTITAKDTAGKWTSVVDESCQESVDHVWRTKASGWVYVLSKILTEEAAFQFAKEKVIDLVSVITTTVAGPFLTSTVPSSIKVLLSPITGDPKFFSILSAVNSRMGSIALVHIEDICSAHIFLMEHPRAKGQYMCCAGTCSASELVDHLAKAYPLSDRQRLIEVEQDQEEGGSARPEISSEKLTALGFDFKYNLEDIVSQAVNSCVDCGFLCPTTR
>evm.model.original_scaffold_2717.61
MRAEGATAGCVHGFGGGDSGRRRWRHSISRPRLAGFSPPPATVCVTEASGFIGSWLVIRLLQRGYTVCATVRDPGNMKKVKPMKESPNADTNLTLWKADLGEEGSFDEAIEGCSGVFHVATPMGFDSNDPEVRRWCKRRWCG
>evm.model.original_scaffold_2717.56
MEVSPPPATVCVTEASGFIGSWLVMRLLQRGHTVRATVRDPRNMKKVKPMIESAKCRHQLDAVAGGSGRRRELR
>evm.model.fragScaff_scaffold_27.263
MTIFRLILGNMKKVNPLVELPNAVTNLTLWKADLGEDRSFDEAIEGCSGVFHVATPMGFDSKDPEKEVIDPAINGALSIIRSCAKARTVKRLVFTSSAGTVDVQEPGKPVYDETDWSDLDFIYARKMTGWMYFVSKMLAEKAAWEAAKDSKIEFISIVPTLVVGPFIIPTFPPSLITALSPITGFCFSITISFNSQIQG
>evm.model.fragScaff_scaffold_27.264
MFAAGGAGNEGHLSIIKQGQFVHIDDLCEAHIFLYEHPEAEGRYICSSHEATIYDLAEMMRVNWPEYNVPAEFKGIEKNLPIVTFSSKKLTGMGFEFKYSLEEMFRGAIDSCREKGLLPHSSETSADCHSSECPATGKI
>evm.model.fragScaff_scaffold_27.261
MKNDAPPITPVCVTGAAGFIGSWLVMRLLERGYTVRATVRDPGNSKKVKHLLDLPKADTNLTLWKADLNEEGSFDEAIAGCAGVFHVATPMDFESKDPENEVIKPTINGVLGIIRSCTKAKTVKRLVFTSSAGTVNVHGKQQLSVYDETNWSDLDFIYSKKMTGWMYFVSKTLAEKAAWEAAKENNINFISIIPPLVVGPFIMPTFPPSLITALSPITGNQAHYSIIKQGQFVHLDDLCEAHIFLHEHPEAEGRYICSPYDATIYDLAKMMREKWPEYSVPSEFEGIDKNLPSVTFSSKKLTGMGFKFKYSLEDMFKGAIDTCREKGLLPYSFETPADDHSSQSPATGT
>evm.model.fragScaff_scaffold_27.262
MEVSPPPSTVCVTGASGFIGSWLVMRLLERGYTVRATVREPGTQTSFSSNPLMGRIQAGSKGRRIR
>evm.model.original_scaffold_2002.3
MIGYKLYDISTKTMLISRDVVLHEHIFPFRSVTTSNEVLDPFSEFVLPKSSLDLPCFPLQPNDSMAPSDMPEVPSNITESMAYSDMPEVPSNADPSDMTSNPVHRFEGIGKNLPSVTFSSKKLIGMGFKFKYSLEDMFKGASDTCREKGLLPYSFETLADDHSCRSPATDT
>evm.model.original_scaffold_2002.2
MHHRSFRVHWLVAHHEASSTRLYYPCNRSRPREHEEGEAEIELPNANTNLMLWRVDLGEDGSFDEAIEGCSDVFHVARPMGFDSKDPKGYPSPVGGMRGIEVRESHGDAAQPHLPKHSLHVKNHSHMYRSCSATVIKLIIRHGRAWQNHDKNKGNEEEEVDLRA
MEVSPPPATVCVTKASGFIGSWIVMRLLQRGYTVCATVRKGEADDGNVDTNLTLWKADLGKDRALMRPSKVAPSCFMWQRPWASTQRTLMFDGSASDGGVGDGGRCKR
>evm.model.fragScaff_scaffold_124.250
MATPREEQDRVAICINDRLKRLRSYSSSSGGLSGVHDGLHKVDPHEPVILAVGPRYHGQLRLQEMENQKLRYLNQLLERNNMRGTNEYVKEIRRLEERALKFYKLDDQEATKIRDDLVEMLLIDGCFIVELLRKYNGAQWPGDDPIFQLDQLRFVLRRDLILLENQLPFFVLDHLFSKTRGRGEEDDLIPLALAFLEKIMPNQKLEAFNYNGSHKVKHLLGLVYSSWGHRFVQALRDPNRVSQCDIEDIWEFIESATELKDASVKLKMVKNRSDLFNIQFNKKRGVLEIPELCIGSYTEFPLRSLLAYERDYLKGDDQPKYVGHYLAFINCQVQSPRDVQLLRQKRVIERWSADDAAVYNMLKDVYRFVLISPEIGSEEDKTSGKMTVSAITACTAGRRTHRRCRFEGIDKNLPSVTFSSKKLIGMGFKFKYSLEDMFKGAIGTCRGKDYFPTPLKPQPMTIPPKALPLAPRF
>evm.model.fragScaff_scaffold_124.249
MNSDQFPRGTNMPLALEVSPPPSTVCVTGASGFIGSWLVMRLLQRGYTVRATVRDPGNMKKVKPMMESPNADTNLTLWKANLGEDGNFGETIEGCSGVFHVAAPMGFDSKDPEVRRRGLLEKYDGNHPDLIELAFKFLERILPTKKLVSKLDSDFQHDLRSVVYEGLSWLRLEANNNSNPNNDQDGDDKWNLVKSATELLEFGVEFKVIETDNFIDIKFTDKGVLEIPCILIRYGTASSISMLLEVENNFFYNINNLGQQRWLSHYLWFMNSLLKSPSDVQQLRQKNIIDNLSELRDDTAILKFLKDSYESVTISPRNFSYREICESLNSHCNHRQNRWLAKLKRDYFNSPWAFISFFAASLLLILTIAQTVFSIASYYKDG
>evm.model.fragScaff_scaffold_92.577
MEVSPPPATVCVTRASGFIGSWLVVRLLQRGYTVRATVRNSAYGRRWLVDGGDCLGRRRDCLRRKEGRRQVGPDGADSARGGRGGRRWREVLAAVGETMAEGARDGGGPTAMLTALVGQGRPAASSLSCGGFKGESVWV
>evm.model.fragScaff_scaffold_110.393
MHHRSFRVHRLVARHEASSTRLYYLCNRSRPREHEEGEAEMELPNANTNLMLWRVDLGEDGSFDKAIEGCSDVFHVATPMGFDSKDPEDYPSPVGGMRGIEVRESHGDAAQPHLPKHSLHVKNHSHMYRSCSATVIKLIIRHGHAWQDHDKNKGNEEEEVDLRA
>evm.model.original_scaffold_284.172
MTTENQENSHIDPEIQGFRSALDNWEAGQCSSFYIFLQVLQVKTPARELLIENERSEVKTGNMKKVKPMMESPNVDTNLTLWKPDLGEDGSSDEAIEG
>evm.model.original_scaffold_2151.33
MEDEIAYCVTGATGYIGSWLVRSLLQRGFGVHATARDPAKALHLLPLWGGGDRLRLFRADLQEEGSFDEAVKGCTGVFHVAAPMQFDVPPKEDVEGYVCANIIEPAINGTLNLLKSCLKAASVKRVVFTSSISTITAKDTAGKWTSVVDESCQESVDHVWRTKASGWVYVLSKILTEEAAFQFAKEKVIDLVSVITTTVAGPFLTSTVPSSIKVLLSPITGDPKFFSILSAVNSRMGSIALVHIEDICSAHIFLMEHPRAKGQYMCCAGTCSASELVDHLAKAYPLSDRQRLIEVEQDQEEGGSARPEISSEKLTALGFDFKYNLEDIVSQAVNSCVDCGFLCPTTR
>evm.model.original_scaffold_2717.61
MRAEGATAGCVHGFGGGDSGRRRWRHSISRPRLAGFSPPPATVCVTEASGFIGSWLVIRLLQRGYTVCATVRDPGNMKKVKPMKESPNADTNLTLWKADLGEEGSFDEAIEGCSGVFHVATPMGFDSNDPEVRRWCKRRWCG
>evm.model.original_scaffold_2717.56
MEVSPPPATVCVTEASGFIGSWLVMRLLQRGHTVRATVRDPRNMKKVKPMIESAKCRHQLDAVAGGSGRRRELR
>evm.model.fragScaff_scaffold_27.263
MTIFRLILGNMKKVNPLVELPNAVTNLTLWKADLGEDRSFDEAIEGCSGVFHVATPMGFDSKDPEKEVIDPAINGALSIIRSCAKARTVKRLVFTSSAGTVDVQEPGKPVYDETDWSDLDFIYARKMTGWMYFVSKMLAEKAAWEAAKDSKIEFISIVPTLVVGPFIIPTFPPSLITALSPITGFCFSITISFNSQIQG
>evm.model.fragScaff_scaffold_27.264
MFAAGGAGNEGHLSIIKQGQFVHIDDLCEAHIFLYEHPEAEGRYICSSHEATIYDLAEMMRVNWPEYNVPAEFKGIEKNLPIVTFSSKKLTGMGFEFKYSLEEMFRGAIDSCREKGLLPHSSETSADCHSSECPATGKI
>evm.model.fragScaff_scaffold_27.261
MKNDAPPITPVCVTGAAGFIGSWLVMRLLERGYTVRATVRDPGNSKKVKHLLDLPKADTNLTLWKADLNEEGSFDEAIAGCAGVFHVATPMDFESKDPENEVIKPTINGVLGIIRSCTKAKTVKRLVFTSSAGTVNVHGKQQLSVYDETNWSDLDFIYSKKMTGWMYFVSKTLAEKAAWEAAKENNINFISIIPPLVVGPFIMPTFPPSLITALSPITGNQAHYSIIKQGQFVHLDDLCEAHIFLHEHPEAEGRYICSPYDATIYDLAKMMREKWPEYSVPSEFEGIDKNLPSVTFSSKKLTGMGFKFKYSLEDMFKGAIDTCREKGLLPYSFETPADDHSSQSPATGT
>evm.model.fragScaff_scaffold_27.262
MEVSPPPSTVCVTGASGFIGSWLVMRLLERGYTVRATVREPGTQTSFSSNPLMGRIQAGSKGRRIR
>evm.model.original_scaffold_2002.3
MIGYKLYDISTKTMLISRDVVLHEHIFPFRSVTTSNEVLDPFSEFVLPKSSLDLPCFPLQPNDSMAPSDMPEVPSNITESMAYSDMPEVPSNADPSDMTSNPVHRFEGIGKNLPSVTFSSKKLIGMGFKFKYSLEDMFKGASDTCREKGLLPYSFETLADDHSCRSPATDT
>evm.model.original_scaffold_2002.2
MHHRSFRVHWLVAHHEASSTRLYYPCNRSRPREHEEGEAEIELPNANTNLMLWRVDLGEDGSFDEAIEGCSDVFHVARPMGFDSKDPKGYPSPVGGMRGIEVRESHGDAAQPHLPKHSLHVKNHSHMYRSCSATVIKLIIRHGRAWQNHDKNKGNEEEEVDLRA
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University