Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Allium cepa
Species name
Onion (Allium cepa) is a species of monocot in the family Amaryllidaceae (amaryllis family).
Species info
Gene sequence info
Allium_cepa.COMT.fa
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>g528853.t1
MYKPLGSEQFKQSISHSSFLSHSMLICINDLFEIIVKAGPDAYLSPSEVASQFPAKNNPQARVMIDRMMRLLASYNVLTCKFPWLLSVY
>g20184.t1
MVSIQNYVTPAPQSTDEEACLHAMQLCGYSILPMTLKAAIELDFLKFVKGGSNANLSPSEIVSQLPTENPQASTSEEGKAVRKYEAAPLVNFLTKNEDGLSIAALGLMNQDKVLMESW
>g30773.t1
MTLKAAIEVDLFEIIVKVGSNAYLSPSEIVSQLPTENPQAPVMINRITRLLASYNVLTCMLETSEEGKAVRKYEAASVVKFLTKNEDGVSIAALGLMNQDKVLMESG
>g41530.t1
MGSIQNYVTPAPQSTDEEACFYAMQLCSYSVLPMTLKAAIELDLYEIIVKAGSNAYLSPSEIVSQLPTENPQAPVMIDQIMRLLASYNVLTFMLETNEEGKVVRKYRAAPAVKFLTKNKDGVSIAALGLMNQDKVLMESW
>g44791.t1
MKDFHQMFIEGMSSDARVTNEILVRNCKEVFTGLNSLVDVGSGAGTLALAIAGVFPQIRRSVLELPHVIDGLEDNETVQFVKGDMFDHIPSADAALFKARYTYI
>g54465.t1
MYKQYGFNSELRNSCSSIHRRGSMLIATMQLHRSNAYLSPSEIVSRLHTENPQAHVMIDRITRLLASYNVLTCKLETSEEGKAVRKHGVDLVVKFLTKNEDGVSIAALGLMNQDKVLMESW
>g65988.t1
MYPEPTPIVQTMIHWDHIMLAHFHGGKERTLGEIDALAKNTGFKGTKVVCRYAIFSIVEIYKGHMLQEEKVTNHESLRLETIDNQGGNQRKDDPQAAHPSVPLLEALF
>g65989.t1
MSTIENHATFAPQSAEEEACLHAMQLCSYSVLPMVLKAAIELELLEIIKRAGPNAFVSSAEVASELPT
>g68127.t1
MASIQNYITPAPQSTDEEACLYAMQLCSYSVLLMTLKAAIELELFEVIVKAGSNAYLSPSAIVSELPTENP
>g68126.t1
MIDRITSLLASYNVLTCKLETSEDGKEVRKYGAAPVVKFLTKNENGVSIAALGLMNQDKVLMEIEMMPICVSTVPCSELTQLEYLKLYDFFSLAKFIFNELYGCNINEAIYFSKVLYLWEAIV
>g95742.t1
MGLTQNYVTPAPRSTDEEACLYAMQLCSYSVLPMTLKEAIELDLFEIIVKAGSNAYLSPSEIVSQLHMENPQAPVMIDRITRLLASYNVLTCKLETLISKHARHIASSDGETCQAYNKF
>g154509.t1
MQWILHDWSDEHCAKLLKNCYKALPENGKVILMECILPEYPDANCAAQGVIHVDLIMLAHNPGGKERTAEEFDALAKKAGFKGSKVVCGYASSNILEFYK
>g154507.t1
MSSIENSIAPAPQSTDEEACLYAMQLCSYSVLPMTLKAAIELDLFEIIKKAGPNAHLSPSQIADQLPTENPQAPVMIDRIMRLLASYSVLTCKLETGEDGRVVRKYGAAPVVKFLTKDEDGVSIAALGLMNQDKILMESWYYLKDAVLDGGIPFNKAYGMSAFEYHGTDPRFNKVFNEGMRNHSTITTKKVLDTYKGFENLNTVVDVGGGVGGTIKLIVKKYPHLKGINFDLPHVISEAEPIPGVEHVGGDMFESVPSGDAIFMKWILHDWSDEHCAKLLKNCYKALPENGKVILMECILPEYPDANCAAQGVIHVDLIMLAHNPGGKERTAEEFDALAKKAGFKGSNVVCGYASSNILEFYK
>g167406.t1
MVAARKRWAQWCSTLVLGAASLFDSTLVTSESHGMSRSENDLEIGNYTSPQFYPSLPYPLIPPAYFSSNPNNNHCNSSIHFNKLSSSYTTHKPSHQIIEPLHCNCNRTHIPSSLMMPTPQASSKLHFWNSPDHKKKHLENSFLG*FTNEILVRDCREVFTGLNSLVDVGGGSGTLALAIAGVFPQIRCSVLELPHVIDGLENNETVQFVKGDMFDHIPSADAALFKWIFHDWSDQECVKILRTCKQAIPCKEDGGKVIIIDLVVNTENEDYESTETQYTFDIHMMVHTTGKQRSEKRMENYIY
>g187533.t1
MTAFEYHGTDPRFNKVFNEGMRNHSIITTKKVLETYKGFEEINTLVDVGGGVGGTINMIVKKHPHLKGVNFDLPHVISEAEPIPGVEHVGGDMFESVPSGDAIFMKWILHDWSDEHCAKLLKNCYKALPDNGKVILMECILPVYPEPTSVAQGVIHVDLIMLAHNPGGKERTAQEFDTLAKNAGFKGSKVDRAEIHANARGITFGDEDQISGRPTNGKRGAGKKLLNSQTEVCLDDKPSSPIEGSIEAIRPAGTILAKSKDAVTNLIRRRRNS
>g197884.t1
MSIAFIEEFVDVYCGEEKGMDGVEMLVDVGGSSGACLWMIMEKVMGVCVGVNFDLPEVVQGGMDFASLKLNSVGRFTFVVARLKSGNKAKSSAWKFRTKEIKQLQKSGNTKANASAKYFWK
>g220579.t1
MSSPKKLEVISKRSSLSSQDDLDAILKNCGITGAPAKELSVVDKRIVESLITSSVKIGNRLKLLIPSNLRKHSLLYLGQRNYVTPAPQSTDEEACLYAVQLCSYSALPLTLKAAIELDPFEIIVKAGSNAYLSPSEILETGEEGKAVRKYGAAPMVKFLTKNEDSMSIAALGLMNQDKVLMESW
>g220581.t1
MIAASVALNFGPLDRGCYREEDDEVEGMCFKVGVVSKASCICSSVAGESEMEMRERGSVIVGVCSVSFNKDITFRRVGREIEYGEPRKREKTTANNSTDAKNYVTPAPQSTDEEACLYAVQLCSYSALPLTLKAAIELDPFEIIVKAGSNAYLSPSEILETGEEGKAVRKYGAAPMVKFLTKNEDSMSIAALGLMNQDKVLMESW
>g297222.t1
MASSSSSSSQQKESKKSALLAMMELSNMLSVPMALNAIVKLDIPNILSRSHLPLSPSEILSLTNPNSNPSSSINLHRLLRLLTSHKVFNESVQDGEPRYSLTDVGKTLVDDENGNSFASYVLQHHQEPLVRSWPLVHEAVVDPTGPEPFARANGCPAYEYYGKDEGTNGLMRKAMWGVSIAFIEEFLDVYCGEEKGLDGVETLVDVGGSSGACLWMIMERVKGVCVGVNFDLPEVVQGGIDFPGIIHVGGDMFKHIPQGDAIFMKVLDTTTWTDERMCTNTEKTATMHCQRGVKYCMRASRA
>g335962.t1
MFVYVGGGNGTTSLFLLHVFPSLKCVVYDLPHVVASVPENTQIVAVGGDMFRFIPSADAIFLKDWRDQQCAKMLKNCKKAKPIERGKVIIVDNGEREGWCIRVNGDKSL
>g473651.t1
MGSIQNYITPAPQSTDEEACLYAMQLCSYSVLPMTLKAAIELDLFEIIVKAGPNAYLSPSEIVSQLPTENPQAPVMIDRIMRLLASYNVLTCKLETSEEGKAVRKYGAAPVVKFLTKNEDGVSIAALGLMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNEGMRNHSIITTKKVLETYKGFEEINTLVDVGGGVGGTINMIVKKHPHLKGVNFDLPHVISEAEPIPGVEHVGGDMFESVPSGDAIFMKWILHDWSDEHCAKLLKNCYKALPDNGKVILMECILPVYPEPTSVAQGVIHVDLIMLAHNPGGKERTAQEFDTLAKNAGFKGSKVVCAYASSNIIELYK
>g502754.t1
MTLKAPIELDHFETIVKAGSNAHLSPSEIVSQLPTENPQAPAMIDQITRLLASYNVLTFMLETSEEGKAARKYGAAPVVMFLTKNEDGVSIAALGLMNQDKVCMESW
MYKPLGSEQFKQSISHSSFLSHSMLICINDLFEIIVKAGPDAYLSPSEVASQFPAKNNPQARVMIDRMMRLLASYNVLTCKFPWLLSVY
>g20184.t1
MVSIQNYVTPAPQSTDEEACLHAMQLCGYSILPMTLKAAIELDFLKFVKGGSNANLSPSEIVSQLPTENPQASTSEEGKAVRKYEAAPLVNFLTKNEDGLSIAALGLMNQDKVLMESW
>g30773.t1
MTLKAAIEVDLFEIIVKVGSNAYLSPSEIVSQLPTENPQAPVMINRITRLLASYNVLTCMLETSEEGKAVRKYEAASVVKFLTKNEDGVSIAALGLMNQDKVLMESG
>g41530.t1
MGSIQNYVTPAPQSTDEEACFYAMQLCSYSVLPMTLKAAIELDLYEIIVKAGSNAYLSPSEIVSQLPTENPQAPVMIDQIMRLLASYNVLTFMLETNEEGKVVRKYRAAPAVKFLTKNKDGVSIAALGLMNQDKVLMESW
>g44791.t1
MKDFHQMFIEGMSSDARVTNEILVRNCKEVFTGLNSLVDVGSGAGTLALAIAGVFPQIRRSVLELPHVIDGLEDNETVQFVKGDMFDHIPSADAALFKARYTYI
>g54465.t1
MYKQYGFNSELRNSCSSIHRRGSMLIATMQLHRSNAYLSPSEIVSRLHTENPQAHVMIDRITRLLASYNVLTCKLETSEEGKAVRKHGVDLVVKFLTKNEDGVSIAALGLMNQDKVLMESW
>g65988.t1
MYPEPTPIVQTMIHWDHIMLAHFHGGKERTLGEIDALAKNTGFKGTKVVCRYAIFSIVEIYKGHMLQEEKVTNHESLRLETIDNQGGNQRKDDPQAAHPSVPLLEALF
>g65989.t1
MSTIENHATFAPQSAEEEACLHAMQLCSYSVLPMVLKAAIELELLEIIKRAGPNAFVSSAEVASELPT
>g68127.t1
MASIQNYITPAPQSTDEEACLYAMQLCSYSVLLMTLKAAIELELFEVIVKAGSNAYLSPSAIVSELPTENP
>g68126.t1
MIDRITSLLASYNVLTCKLETSEDGKEVRKYGAAPVVKFLTKNENGVSIAALGLMNQDKVLMEIEMMPICVSTVPCSELTQLEYLKLYDFFSLAKFIFNELYGCNINEAIYFSKVLYLWEAIV
>g95742.t1
MGLTQNYVTPAPRSTDEEACLYAMQLCSYSVLPMTLKEAIELDLFEIIVKAGSNAYLSPSEIVSQLHMENPQAPVMIDRITRLLASYNVLTCKLETLISKHARHIASSDGETCQAYNKF
>g154509.t1
MQWILHDWSDEHCAKLLKNCYKALPENGKVILMECILPEYPDANCAAQGVIHVDLIMLAHNPGGKERTAEEFDALAKKAGFKGSKVVCGYASSNILEFYK
>g154507.t1
MSSIENSIAPAPQSTDEEACLYAMQLCSYSVLPMTLKAAIELDLFEIIKKAGPNAHLSPSQIADQLPTENPQAPVMIDRIMRLLASYSVLTCKLETGEDGRVVRKYGAAPVVKFLTKDEDGVSIAALGLMNQDKILMESWYYLKDAVLDGGIPFNKAYGMSAFEYHGTDPRFNKVFNEGMRNHSTITTKKVLDTYKGFENLNTVVDVGGGVGGTIKLIVKKYPHLKGINFDLPHVISEAEPIPGVEHVGGDMFESVPSGDAIFMKWILHDWSDEHCAKLLKNCYKALPENGKVILMECILPEYPDANCAAQGVIHVDLIMLAHNPGGKERTAEEFDALAKKAGFKGSNVVCGYASSNILEFYK
>g167406.t1
MVAARKRWAQWCSTLVLGAASLFDSTLVTSESHGMSRSENDLEIGNYTSPQFYPSLPYPLIPPAYFSSNPNNNHCNSSIHFNKLSSSYTTHKPSHQIIEPLHCNCNRTHIPSSLMMPTPQASSKLHFWNSPDHKKKHLENSFLG*FTNEILVRDCREVFTGLNSLVDVGGGSGTLALAIAGVFPQIRCSVLELPHVIDGLENNETVQFVKGDMFDHIPSADAALFKWIFHDWSDQECVKILRTCKQAIPCKEDGGKVIIIDLVVNTENEDYESTETQYTFDIHMMVHTTGKQRSEKRMENYIY
>g187533.t1
MTAFEYHGTDPRFNKVFNEGMRNHSIITTKKVLETYKGFEEINTLVDVGGGVGGTINMIVKKHPHLKGVNFDLPHVISEAEPIPGVEHVGGDMFESVPSGDAIFMKWILHDWSDEHCAKLLKNCYKALPDNGKVILMECILPVYPEPTSVAQGVIHVDLIMLAHNPGGKERTAQEFDTLAKNAGFKGSKVDRAEIHANARGITFGDEDQISGRPTNGKRGAGKKLLNSQTEVCLDDKPSSPIEGSIEAIRPAGTILAKSKDAVTNLIRRRRNS
>g197884.t1
MSIAFIEEFVDVYCGEEKGMDGVEMLVDVGGSSGACLWMIMEKVMGVCVGVNFDLPEVVQGGMDFASLKLNSVGRFTFVVARLKSGNKAKSSAWKFRTKEIKQLQKSGNTKANASAKYFWK
>g220579.t1
MSSPKKLEVISKRSSLSSQDDLDAILKNCGITGAPAKELSVVDKRIVESLITSSVKIGNRLKLLIPSNLRKHSLLYLGQRNYVTPAPQSTDEEACLYAVQLCSYSALPLTLKAAIELDPFEIIVKAGSNAYLSPSEILETGEEGKAVRKYGAAPMVKFLTKNEDSMSIAALGLMNQDKVLMESW
>g220581.t1
MIAASVALNFGPLDRGCYREEDDEVEGMCFKVGVVSKASCICSSVAGESEMEMRERGSVIVGVCSVSFNKDITFRRVGREIEYGEPRKREKTTANNSTDAKNYVTPAPQSTDEEACLYAVQLCSYSALPLTLKAAIELDPFEIIVKAGSNAYLSPSEILETGEEGKAVRKYGAAPMVKFLTKNEDSMSIAALGLMNQDKVLMESW
>g297222.t1
MASSSSSSSQQKESKKSALLAMMELSNMLSVPMALNAIVKLDIPNILSRSHLPLSPSEILSLTNPNSNPSSSINLHRLLRLLTSHKVFNESVQDGEPRYSLTDVGKTLVDDENGNSFASYVLQHHQEPLVRSWPLVHEAVVDPTGPEPFARANGCPAYEYYGKDEGTNGLMRKAMWGVSIAFIEEFLDVYCGEEKGLDGVETLVDVGGSSGACLWMIMERVKGVCVGVNFDLPEVVQGGIDFPGIIHVGGDMFKHIPQGDAIFMKVLDTTTWTDERMCTNTEKTATMHCQRGVKYCMRASRA
>g335962.t1
MFVYVGGGNGTTSLFLLHVFPSLKCVVYDLPHVVASVPENTQIVAVGGDMFRFIPSADAIFLKDWRDQQCAKMLKNCKKAKPIERGKVIIVDNGEREGWCIRVNGDKSL
>g473651.t1
MGSIQNYITPAPQSTDEEACLYAMQLCSYSVLPMTLKAAIELDLFEIIVKAGPNAYLSPSEIVSQLPTENPQAPVMIDRIMRLLASYNVLTCKLETSEEGKAVRKYGAAPVVKFLTKNEDGVSIAALGLMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNEGMRNHSIITTKKVLETYKGFEEINTLVDVGGGVGGTINMIVKKHPHLKGVNFDLPHVISEAEPIPGVEHVGGDMFESVPSGDAIFMKWILHDWSDEHCAKLLKNCYKALPDNGKVILMECILPVYPEPTSVAQGVIHVDLIMLAHNPGGKERTAQEFDTLAKNAGFKGSKVVCAYASSNIIELYK
>g502754.t1
MTLKAPIELDHFETIVKAGSNAHLSPSEIVSQLPTENPQAPAMIDQITRLLASYNVLTFMLETSEEGKAARKYGAAPVVMFLTKNEDGVSIAALGLMNQDKVCMESW
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University