Enzyme
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
HIDH
Enzyme
2-hydroxyisoflavanone dehydratase
Enzyme name
EC:4.2.1.105
Entry
Lyases;Carbon-oxygen lyases;Hydro-lyases
Class
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Sysname
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
Reaction
daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]
Product
Species information
Datisca glomerata
Species name
Datisca glomerata is a species of eudicot in the family Datiscaceae.
Species info
Gene sequence info
Datisca_glomerata.HIDH.fa
Download
>Datgl548S11072
MDPKSDELLHDFPPFFRLYKNGRIERLQEKEPVPPSTDPKTGVSSKDVTISPEVSARIFLPHIPDRTQKLPLAIYIHGGAFCIGSAFSPFYHSYVSSLAADANVVALSVEYRLAPEHPLPAAYEDAWAAVQWASKHSSGEGPESWLNDHVDFHRVFLLGDSAGANIAYNMATRFGPQNVIDGVKIIGTVLVHPYFLINDRDKLIEYLFPSSSGVEDPILNPKANPRLSEMASSRAVVFVAGKDWLKDRGWAFYEAVKNSGWEGEIEIEETEEEGHVFHLFNPNTEKARILMKRVASFINKV
>Datgl548S17180
MDSDLNEITHDFPPFFRVFKDGRVERYMVVDHILPCRDPKNAVESKDVRISPETELSVQIFVPEIIGHNRKLPVLVHYHASHSNGQGPEKWLNEHADLRRVFLAGESAGANIAHYVAIQTGTIGSAELKISGVLITKCTSIYAQRVLGGGDDPKLNPEADPSLLKMGCKRVLVCVAENDWLKDRGVAYYQSLGKGGWSGELEFFESKGEDHCFHLFSSNSENVVPLINKMVNFNLI
>Datgl548S11070
MASTASEVAMDFSPLLKIYKDGHVERLIGEDTVPPSTDPATGVDSKDVVISPESGIYARLYLPKTTASPPHKIPLLIYFHGGGFCIETPSSPQYHNHLNALAADSNVVAVSVHYRRAPEHPLPIAYEDSWAVLKWVASHLGGNGPEEWLNSHADLNRLFLAGDSAGANIAHQMAIRVGSDGLDGVKLRGIVLVHPYFWGKEPIGDEINAKPEESVLAEQLWSFVCPTTSGSDDPLINPGKDPKLGKLGCERVLVCVGEKDLLKDRGFYYSEVVKKSGWKGDVEVTEAKGEPHVFHLMNPTCENALGLLKKIASFINHD
>Datgl548S11071
MAADESDILHKFRFFNVHKDGSLNLFFPIHEKVPPSDHPITGVRSKDVIISTEPSISARIFLPKISDPTQKLPLLFYVHGGGFCMLSPFAPHYHNYVCTVAAKANVIAVSVDYGLFPTRPIPACYDDSWAALQWTASHVNGTGPDPWLNGHADFERVFIAGDSAGGNISQTLITRVGSIGLPTGVKVVGAILVHPYFGGTEDDKMWLYMCPNNEGLDDPRLKPSVEDLRKIGCEKVLIFVAEKDHLMGVGKCYYEELKKSGWGGSVEIVENLGEEHCFHLHDLNYDKAVDLLNKFVSFFEQV
>Datgl548S11069
MDSASSNTEIAHDFRPFFRVYKDGRVERYMSIKTVPPSDDPKIGFRCKDVVISSEPAVSARVFTPSITDRNKKLPLLFYVHGGRFSSGSAFLPGYHKFVGSLVGQGNILAVSIEYRLAPEHPIPACYDDSWAALEWVANHANKDGAEPWLNGYTDFGRVFLVGDSSGANICHYLASRVGSIGSPGFRVAGMALVHPFFGGNEEREMLMYMCRENIGLEDPRLSPAVEDLGKLGCERVLVFVAEKDRLRERGRGYVEDLKKSGWKGTVEIVENEGESHVFHLDKPNSEKAYHMKQKLVSFINHDGADI
>Datgl359S09003
MASTIKELERELPGRVRVYKDGSVERLRGSPTVPPSLDDPETGVSSKDITISQNPIITARFYLPKLQPNQNEKLPILAYFHGGAFCLESAFSFLSHRYLNLLVSQSNVIAISVEYRLAPEHPLPAAYEDSWAALQWIASHSTKNPPINTEPWLVNHANLNKLYIGGDSAGANIVHNLAIQAGVDGLINSVKISKAFLGHPYFWGSKPIGSEPIQGHEKSQQASVWNFVYPSAPGGVDNPMLNPTVAEAPSLARIECRRMLVYVAGKDDMRERGVWYYNAVRESGWEGEMELFEMEEEVHCFHVFHIETENAKIMIKRLVCFLLE
>Datgl825S13822
MPSIGLDEISSLEQTATGLNQHGGVIAEIKGLIRVYKDGHVERSQMIRCVTPALSDDLYVISKDVMIDKLSNVWARFYVPKSHGRLKLSLLVYFHGGGFSVGSASWSCYHQFLAKLSAETGCLIMSVNYRLAPENPLPAAYEDGLKALLWLKQEALNGSNQWWSNHCDFNKIFLIGDSAGANIVHHVATNLDFVLKGTILIQPFFGGEGRTNSEKYMVQPPNSALSLAASDTYWRLALPAGTNRDHPWCNPLAKGLGKLEELRVLPTMVFISEMDILRDRNLEFCYDLVKAGKRVEHVVFSGVGHAFQILGKSQLSQVRAYQMMDHIKEFISR
>Datgl426S09936
MADSSEKEIAIDVFPYLKVYRDGTVERTAGTQVVPAGLDPQTGVESKDIMIIPKTGVSARLYRRSNVAKTDQNLPLVVYFHGGGFFISSTADPLYHNSLNLLVAEANIILISVNYRLAPEHPLPAAYEDSWAALEWIASQSSGDEEWLKGYVDFERVFLAGDSAGANISHHLALKFKDSVLTQKLKIIGIALIHPYFWGEVAIGSEVTDQVRKAMVDKWWGYVCPSEKGGDDVLINPFADGAPSVEGLACDKVIVIVAGTDILRDRGKLYFAKLISCEWIGKVEMMETEGEDHVFHIFNPNSEKAKNLIKQLASFINQ
>Datgl534S10825
MSVVAEAPGYLRVFSDGSVKRFEPETIPASTESSSSRGYTSKDVIIDQSKPITGRLFRPNSTPDPQSSFPVIVYFHGGGFCIGSTTWLGYHHFLGDLSVASQSIILSIDYRLAPENRLPVAYDDSYTALDWLRHRNLSDPWLEQADLSQVFLSGDSAGANIAHNIAIKAIRNKILNITIDGLLLIHPYFGSEKRTEKETSEEEEGGESVAMNDMFWRLSIPEGSNRDYYGCNYEKAEVSRGEWGEFPRVVVYVAELDFLKERGEMYAEFLEKKGVKAVKVVEAEGESHVFHVFDPQSESTRLLQKHMSEFIKSY
>Datgl298S07772
MAAISFDPRLGLYSRNHHQHGVAEEINGLIRVYKNGHVERPPIIPTVPCTIAFDNSVTSKDVVVDKHAYMWARIYVTNSTNKSLPLLFYFHGGGFCVGSAAWSCYHEFLSNLASKAKCVIISVNYRLSPENRLPAAYEDAFNTLTWLKQQLVSDPSEHKWWSNRVNPSRMFLVGDSAGANIAYNLATRIGSGEYSFLKPLSLKGIILIQPFFGGEARTASEKYASQPPNSALTLSVSDTYWRLSLPLGANRDHPWCNPLTNGVAKLRDTKLPTAMVCISETDILKDRNSEFCAALVSAGNKVERVVYKGVGHAFQVLHNSPLSGPRTEEMRSDIKVFIHQ
>Datgl692S12408
MSIEKQIIDEVSGWLRVFNDGSVDRTWTGPPEVKFMAEPVPPHEKFLDGVATRDVLVDTKSDLRVRIYLPELVAGDEITKLPIMVHFHGGGFCISQADWYMYYNTYTQLARLAKAICVSVYLRRAPEHRLPAAIEDGYSALLWLNTLALGQSHEPWLNNYADFNRVFLIGDSSGGNIVHEVAARVGKEDLRPLRVAGGIPIHPGFVKAKRSKSELEQPESPFLTLEMVDKFLGLALPVGSNKDHPITCPMGDQAEPMESLVLPPFLLCIADKDLVLDTEMEYYEAMKIANKEVEIFVSKGMGHSFYLNKIAVDMDPDTAYQTQKLFEGITEFIKKH
>Datgl183S23157
MSNTAVSSAPPYQVEECRGVLRVYSDGSIVRSAKPSFDVPVHDDGSVLWKDVVFHPVNNLQLRLYKPAGCSSSGSKLPVFFYIHGGGFCIGSRTWPNCQNYCFRLTLELQAVVVSPDYRLAPENRLPDAIDDGFAAVKWLQAQSVAEEPDAWLTEVADFSRVIISGDSAGGNIAHNLAVRLGAGSPELSPVRVRGYVLLAPFFGGTVRSRSEAEGPKDAFLNLELIDRFWRLSIPIGDTTDHPLINPFGPKSRDLEPLDLDPILVVVGGSDLLKDRAEDYAKRLQHWGKKIEYVEFEGKHHGFFTIHPNSDAANELMLLIKRVISEYGL
>Datgl1412S20635
MGSIPNDTAIAAAADTTTATVKLEVLPFFRVYSDGSVERLLGSSPVSPTLKDEETGVSSKDITISENPSISARLYLPKLNDVNHKLPILVYYHGGGFCIESAFSFDHHRYVNSLVSLSHVVAVSVEYRLAPEHPLPIAYEDSWEALQWVASHITENCRNKEEWLTNHGNFERVFLGGDSAGANIVHNVAMRAGKETLHGGLKLTGAFLTHPFFWGSIPIGTEPVEEHELRLPFKLWATVYPSAPSGVDNPVMNPMGSDAPSLAGLGCSRLFVSVAENDELRNRGVFYFEAVKKSGWKGELEELVEVKGEGHAFQILNFEKDSAKDLTKQVASFLLK
MDPKSDELLHDFPPFFRLYKNGRIERLQEKEPVPPSTDPKTGVSSKDVTISPEVSARIFLPHIPDRTQKLPLAIYIHGGAFCIGSAFSPFYHSYVSSLAADANVVALSVEYRLAPEHPLPAAYEDAWAAVQWASKHSSGEGPESWLNDHVDFHRVFLLGDSAGANIAYNMATRFGPQNVIDGVKIIGTVLVHPYFLINDRDKLIEYLFPSSSGVEDPILNPKANPRLSEMASSRAVVFVAGKDWLKDRGWAFYEAVKNSGWEGEIEIEETEEEGHVFHLFNPNTEKARILMKRVASFINKV
>Datgl548S17180
MDSDLNEITHDFPPFFRVFKDGRVERYMVVDHILPCRDPKNAVESKDVRISPETELSVQIFVPEIIGHNRKLPVLVHYHASHSNGQGPEKWLNEHADLRRVFLAGESAGANIAHYVAIQTGTIGSAELKISGVLITKCTSIYAQRVLGGGDDPKLNPEADPSLLKMGCKRVLVCVAENDWLKDRGVAYYQSLGKGGWSGELEFFESKGEDHCFHLFSSNSENVVPLINKMVNFNLI
>Datgl548S11070
MASTASEVAMDFSPLLKIYKDGHVERLIGEDTVPPSTDPATGVDSKDVVISPESGIYARLYLPKTTASPPHKIPLLIYFHGGGFCIETPSSPQYHNHLNALAADSNVVAVSVHYRRAPEHPLPIAYEDSWAVLKWVASHLGGNGPEEWLNSHADLNRLFLAGDSAGANIAHQMAIRVGSDGLDGVKLRGIVLVHPYFWGKEPIGDEINAKPEESVLAEQLWSFVCPTTSGSDDPLINPGKDPKLGKLGCERVLVCVGEKDLLKDRGFYYSEVVKKSGWKGDVEVTEAKGEPHVFHLMNPTCENALGLLKKIASFINHD
>Datgl548S11071
MAADESDILHKFRFFNVHKDGSLNLFFPIHEKVPPSDHPITGVRSKDVIISTEPSISARIFLPKISDPTQKLPLLFYVHGGGFCMLSPFAPHYHNYVCTVAAKANVIAVSVDYGLFPTRPIPACYDDSWAALQWTASHVNGTGPDPWLNGHADFERVFIAGDSAGGNISQTLITRVGSIGLPTGVKVVGAILVHPYFGGTEDDKMWLYMCPNNEGLDDPRLKPSVEDLRKIGCEKVLIFVAEKDHLMGVGKCYYEELKKSGWGGSVEIVENLGEEHCFHLHDLNYDKAVDLLNKFVSFFEQV
>Datgl548S11069
MDSASSNTEIAHDFRPFFRVYKDGRVERYMSIKTVPPSDDPKIGFRCKDVVISSEPAVSARVFTPSITDRNKKLPLLFYVHGGRFSSGSAFLPGYHKFVGSLVGQGNILAVSIEYRLAPEHPIPACYDDSWAALEWVANHANKDGAEPWLNGYTDFGRVFLVGDSSGANICHYLASRVGSIGSPGFRVAGMALVHPFFGGNEEREMLMYMCRENIGLEDPRLSPAVEDLGKLGCERVLVFVAEKDRLRERGRGYVEDLKKSGWKGTVEIVENEGESHVFHLDKPNSEKAYHMKQKLVSFINHDGADI
>Datgl359S09003
MASTIKELERELPGRVRVYKDGSVERLRGSPTVPPSLDDPETGVSSKDITISQNPIITARFYLPKLQPNQNEKLPILAYFHGGAFCLESAFSFLSHRYLNLLVSQSNVIAISVEYRLAPEHPLPAAYEDSWAALQWIASHSTKNPPINTEPWLVNHANLNKLYIGGDSAGANIVHNLAIQAGVDGLINSVKISKAFLGHPYFWGSKPIGSEPIQGHEKSQQASVWNFVYPSAPGGVDNPMLNPTVAEAPSLARIECRRMLVYVAGKDDMRERGVWYYNAVRESGWEGEMELFEMEEEVHCFHVFHIETENAKIMIKRLVCFLLE
>Datgl825S13822
MPSIGLDEISSLEQTATGLNQHGGVIAEIKGLIRVYKDGHVERSQMIRCVTPALSDDLYVISKDVMIDKLSNVWARFYVPKSHGRLKLSLLVYFHGGGFSVGSASWSCYHQFLAKLSAETGCLIMSVNYRLAPENPLPAAYEDGLKALLWLKQEALNGSNQWWSNHCDFNKIFLIGDSAGANIVHHVATNLDFVLKGTILIQPFFGGEGRTNSEKYMVQPPNSALSLAASDTYWRLALPAGTNRDHPWCNPLAKGLGKLEELRVLPTMVFISEMDILRDRNLEFCYDLVKAGKRVEHVVFSGVGHAFQILGKSQLSQVRAYQMMDHIKEFISR
>Datgl426S09936
MADSSEKEIAIDVFPYLKVYRDGTVERTAGTQVVPAGLDPQTGVESKDIMIIPKTGVSARLYRRSNVAKTDQNLPLVVYFHGGGFFISSTADPLYHNSLNLLVAEANIILISVNYRLAPEHPLPAAYEDSWAALEWIASQSSGDEEWLKGYVDFERVFLAGDSAGANISHHLALKFKDSVLTQKLKIIGIALIHPYFWGEVAIGSEVTDQVRKAMVDKWWGYVCPSEKGGDDVLINPFADGAPSVEGLACDKVIVIVAGTDILRDRGKLYFAKLISCEWIGKVEMMETEGEDHVFHIFNPNSEKAKNLIKQLASFINQ
>Datgl534S10825
MSVVAEAPGYLRVFSDGSVKRFEPETIPASTESSSSRGYTSKDVIIDQSKPITGRLFRPNSTPDPQSSFPVIVYFHGGGFCIGSTTWLGYHHFLGDLSVASQSIILSIDYRLAPENRLPVAYDDSYTALDWLRHRNLSDPWLEQADLSQVFLSGDSAGANIAHNIAIKAIRNKILNITIDGLLLIHPYFGSEKRTEKETSEEEEGGESVAMNDMFWRLSIPEGSNRDYYGCNYEKAEVSRGEWGEFPRVVVYVAELDFLKERGEMYAEFLEKKGVKAVKVVEAEGESHVFHVFDPQSESTRLLQKHMSEFIKSY
>Datgl298S07772
MAAISFDPRLGLYSRNHHQHGVAEEINGLIRVYKNGHVERPPIIPTVPCTIAFDNSVTSKDVVVDKHAYMWARIYVTNSTNKSLPLLFYFHGGGFCVGSAAWSCYHEFLSNLASKAKCVIISVNYRLSPENRLPAAYEDAFNTLTWLKQQLVSDPSEHKWWSNRVNPSRMFLVGDSAGANIAYNLATRIGSGEYSFLKPLSLKGIILIQPFFGGEARTASEKYASQPPNSALTLSVSDTYWRLSLPLGANRDHPWCNPLTNGVAKLRDTKLPTAMVCISETDILKDRNSEFCAALVSAGNKVERVVYKGVGHAFQVLHNSPLSGPRTEEMRSDIKVFIHQ
>Datgl692S12408
MSIEKQIIDEVSGWLRVFNDGSVDRTWTGPPEVKFMAEPVPPHEKFLDGVATRDVLVDTKSDLRVRIYLPELVAGDEITKLPIMVHFHGGGFCISQADWYMYYNTYTQLARLAKAICVSVYLRRAPEHRLPAAIEDGYSALLWLNTLALGQSHEPWLNNYADFNRVFLIGDSSGGNIVHEVAARVGKEDLRPLRVAGGIPIHPGFVKAKRSKSELEQPESPFLTLEMVDKFLGLALPVGSNKDHPITCPMGDQAEPMESLVLPPFLLCIADKDLVLDTEMEYYEAMKIANKEVEIFVSKGMGHSFYLNKIAVDMDPDTAYQTQKLFEGITEFIKKH
>Datgl183S23157
MSNTAVSSAPPYQVEECRGVLRVYSDGSIVRSAKPSFDVPVHDDGSVLWKDVVFHPVNNLQLRLYKPAGCSSSGSKLPVFFYIHGGGFCIGSRTWPNCQNYCFRLTLELQAVVVSPDYRLAPENRLPDAIDDGFAAVKWLQAQSVAEEPDAWLTEVADFSRVIISGDSAGGNIAHNLAVRLGAGSPELSPVRVRGYVLLAPFFGGTVRSRSEAEGPKDAFLNLELIDRFWRLSIPIGDTTDHPLINPFGPKSRDLEPLDLDPILVVVGGSDLLKDRAEDYAKRLQHWGKKIEYVEFEGKHHGFFTIHPNSDAANELMLLIKRVISEYGL
>Datgl1412S20635
MGSIPNDTAIAAAADTTTATVKLEVLPFFRVYSDGSVERLLGSSPVSPTLKDEETGVSSKDITISENPSISARLYLPKLNDVNHKLPILVYYHGGGFCIESAFSFDHHRYVNSLVSLSHVVAVSVEYRLAPEHPLPIAYEDSWEALQWVASHITENCRNKEEWLTNHGNFERVFLGGDSAGANIVHNVAMRAGKETLHGGLKLTGAFLTHPFFWGSIPIGTEPVEEHELRLPFKLWATVYPSAPSGVDNPVMNPMGSDAPSLAGLGCSRLFVSVAENDELRNRGVFYFEAVKKSGWKGELEELVEVKGEGHAFQILNFEKDSAKDLTKQVASFLLK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University