Enzyme
A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in flavonoid biosynthesis.
C4H
Enzyme
Cinnamate 4-hydroxylase
Enzyme name
EC:1.14.14.91
Entry
Oxidoreductases;Acting on paired donors, with incorporation or reduction of molecular oxygen;With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Class
trans-cinnamate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
Sysname
trans-cinnamate + [reduced NADPH---hemoprotein reductase] + O2 = 4-hydroxycinnamate + [oxidized NADPH---hemoprotein reductase] + H2O[RN:R02253]
Reaction
4-hydroxycinnamate [CPD:C00811];[oxidized NADPH---hemoprotein reductase] [CPD:C03161];H2O [CPD:C00001]
Product
Species information
Allium cepa
Species name
Onion (Allium cepa) is a species of monocot in the family Amaryllidaceae (amaryllis family).
Species info
Gene sequence info
Allium_cepa.C4H.fa
Download
>g227658.t1
MKRKQNPPNVSANQIFTYHHHSVNLHPQPSPTPPFSPITPFINILHPSLFPPFSSTNFKYRNMELLLLEKTLISLFFAITLAIVISKLRGKKFKLPPGPLPVPIFGNWLQVGDDLNHRNLANFAKKFGDVFLLRMGQRNLVVVSSPDLARDVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVNQYRYGWEDEAGRVVEDVKKDAKAATEGIVLRKRLQLMMYNNMYRIMFDRRFESENDPLFLKLKALNGERSRLAQSFEYNYGDFIPILRPFLRGYLKICKEVKERRIQLFKDYFLEERKKLSSTKPTDNAGLKCAIDHILDAEKKGEINEDNVLYIVENINVAAIETTLWSIEWGIAELVNHPEIQRKLQHELDTVLGPGTQITEPDTHRLPYLQAVIKETLRLRMAIPLLVPHMNLHDAKLGGYDIPAESKILVNAWWLANNPAHWKDPEEFRPERFLEEEAKVEANGNDFRYIPFGVGRRSCPGIILALPILGITIGRLVQNFDLMPPPGMDKIDTTEKGGQFSLHILNHSTIVAKPRVF
>g81470.t1
MRAGGAGSEQLINRPERFLEEKAKVEANENDFRYIRFGVGRRRLLPIYIEIKNEEVGYLGFRVKEAREVKLIKEKGGTS
>g152545.t1
MKAGGAGSEQLINRPERFLEQKAKVEADENDFRYIPFGVRRKRPLPIYFGIKNGEIVYLGFRVKAAREVKLIKEKGGTP
>g26860.t1
MSKATDNACLKCVIDYILDCEKKEEINKDNVLYIMENINVAELEKEFSFNQMAYAAMKPSKPGMEEPLENLHRIRITLSSKKCQLKPFALLLGRLPVVKTITICCRINCSMIYRGNGTLNPVVAFFFGRRFLFAFYVFYMF
>g77483.t1
MNLHDSELGGYDNSMKSIFLVNAWYIPFGIGRRNCPAIILLLPIYFGIEDLPQVIWNKEVCDLGFRVREN
>g103845.t1
MIISLQYSSQVWKFIPMEIQSLFFKRNKELGELIWSFRKEWVWLELEKSNQGKGGKLVVESRLVLAIDVVNHEGRRCSEQLINKPERFQEEKAKVEADENDFKYTPFGVVRRRLLPIYFGIKNGEIGYLGFRVKEARGVKLVKEKGGTP
>g174754.t1
MRAGSVGRWRKAVRTTSTLFVTLVVDYSEQLINRPERFLKEKAKVEADENDFRYIPFGLGRKRLLPIYFGIKNGEIAKSTVEAADEGEAPGHGVVIRSRPSKVELESGSCAISIGWCGPRFEEAGAREHLEGRRDLAVAIPGGACWRCRCGAMGFICVVSKMELESGSCAISIDGVGRDRRSRRSRASRRDAIWLSRFLEARAGDVMWGNGLSAL
>g196313.t1
MGQRNLVVVSSPDLARDVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMIVPFFTNKVVNQYRESVEDVKKDANAATEGIVLRKRLQLMMYNNMYRIMFDRRFESENDPLFLKLQALNGKRSRLAQSFEYNYGDFIPILRPFLRGYLKIFKEVKERRIQLFKDYFLEERKKLSSTKPTDNAGLKCAVDNYWMLRRKEKSTKTTSFTFSSNVPLLATLISTSTMDPFATLLHLYTMFVASSISRQQLPLTSASSILPPFHRPLQLRLVYPIRLYGQQHVLTPHKLKLCCRVMEPSKSKIMKQRSGDERGSSRE
>g218050.t1
MKAGGAGSEQLINRPERFLEEKTKVEADENDFRYIPFGVGRKRPLPIYFGIKNGEIVYLGFRVKEAREVKLIKEKGGTP
>g286990.t1
MLRRFAYAAVCSTSSTFLAIVAVSIKGRPHLRWPAMMATCSLLDPVVALSPPSTLVVENLVGVGGRGREIMREGGAGRSERFLEEKAKVEANENDFRYIPFGVGMRRLLPIYFEIKNGEAHESGGAQAHASVLARGKVGVRVKSEACAMMEAMLGQLAIDWEEARVGGGARWI
>g286996.t1
MLRRFACAVVSSTSSTFLAVVAVSIKGRPHLRWPAMMATCSLLDPVVALSPPSTLVVENRLVLAVEVVNHEGRRCGPERFLEEKAKVEANENDFRYIPFGVGMRRLLPIYFEIKNGEVSYLGFRVKEARGVKLIKEKGDTP
>g287009.t1
MRAGGAGRPERFLEEKAKVEANENDFRYIPFGVGMRRPLPIYFEIKNGEVSYLGFRVKEARGVKLIKEKGDTP
>g287011.t1
MATAMTTFQSPTTSSGECDLTTDRHKTGDCVISNGQRSITISNRQECNNDHDSRPERFLEEKAKVEANENDFRYIPFGVGMKRPLPIYFEIKNGEVSYLGFRVKEARGVKLIKEKGDTP
>g329809.t1
MNLNKLSNKKDWQNDKVPAASMKAQLERECDDALTSIRNRCSRSTMSRAAPGRESEESQIAPALGRDLPYITRTIGRERPSKCSTIIVSPTLVRERPTKSRVVLLFHRLGRSTIPDRKLRPNHNCEVGVCDLEWWSDLGGGRARQRDFWSRPRDGAVWGSSLSRPEAARLMVERERRLRMEGKGGRLVAESLLVLAVEAVNHEGKRCRPKRFLEEKAKVEANENDFRYIPFGMGRRRLLLIYFEIKNGEVGYLGFRVKEARGVKLIKEKGDMP
>g395755.t1
MISHPLPNMPSSPKKITICGKSKDGSSNLCKNNSNLISFINNQNMDLVLLEKTLICIFLTTVVAILVSKLRGKKLKLPPGPAPIPIFGNWLQVGDDLNHSNLTALAKKFGDVLLLKMGQRNLVVVSSPELARDVLQTQGVRFASRTRNVVFDIFTGKGQDMVFTVYGDHWRKMRRIMTVPFFTTKVVNQYRTGWEEEAHQAVEDIRKNPKAATEGIVLRRRLQLMMYNNMFRIMFDRRFESEEDPLYVKLKALNAERSRLSQSFEYNYGDFIPVLRPFLRGYLKVCKEIKQKRLQLFNDYFVEERKKVSNTRVSENGNLKCAMDHILDAEKNGEINKDNVLYIVENINVAAIETTLWSIEWGIAELINHPEIQQKLRNEIDTVLGTSHQVTEPDLQKLPYLQAVVKETLRLRMAIPLLVPHMNLNEEKIRDYDIPAESKILINAWWLANNPESWKNADEFRPERFLEEEANVEANGNDFRFIPFGVGRRSCPGIILALPILGITIGRLVQNFELLPPPGEMKIDTSEKAGQFSLQILKHSTVVARPRVF
>g410184.t1
MGQRNLVVVSSPDLAKDVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVNQYRESVEDVKKDAKAATEGIVLRKRLQLMMYNNMYMIMFDRRFESENDPLFLKLKALNGERSRLAQSFEYNYGDFIPILRPFLRGYYLKIFKEVKERRIQLFKDYFLEERKYVNFYTHNLCIPMWLPGNQVEELRSY
>g445984.t1
MMYNNMYRIMFDRRFESENDPLFLKLKALNGERSRLAQSFERIQLFKDYFLEERKKLSSTKPTDNAGLKCAIDHILDAEKKGEIDEDNVLYIVENINVAGV
>g465558.t1
MRAGDASRPERFLEEKAKVEANENDFRYIPFGVGMRRLLPIYFEIKNGEVSYLGFRVKEARGVKLIKEKGDTP
MKRKQNPPNVSANQIFTYHHHSVNLHPQPSPTPPFSPITPFINILHPSLFPPFSSTNFKYRNMELLLLEKTLISLFFAITLAIVISKLRGKKFKLPPGPLPVPIFGNWLQVGDDLNHRNLANFAKKFGDVFLLRMGQRNLVVVSSPDLARDVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVNQYRYGWEDEAGRVVEDVKKDAKAATEGIVLRKRLQLMMYNNMYRIMFDRRFESENDPLFLKLKALNGERSRLAQSFEYNYGDFIPILRPFLRGYLKICKEVKERRIQLFKDYFLEERKKLSSTKPTDNAGLKCAIDHILDAEKKGEINEDNVLYIVENINVAAIETTLWSIEWGIAELVNHPEIQRKLQHELDTVLGPGTQITEPDTHRLPYLQAVIKETLRLRMAIPLLVPHMNLHDAKLGGYDIPAESKILVNAWWLANNPAHWKDPEEFRPERFLEEEAKVEANGNDFRYIPFGVGRRSCPGIILALPILGITIGRLVQNFDLMPPPGMDKIDTTEKGGQFSLHILNHSTIVAKPRVF
>g81470.t1
MRAGGAGSEQLINRPERFLEEKAKVEANENDFRYIRFGVGRRRLLPIYIEIKNEEVGYLGFRVKEAREVKLIKEKGGTS
>g152545.t1
MKAGGAGSEQLINRPERFLEQKAKVEADENDFRYIPFGVRRKRPLPIYFGIKNGEIVYLGFRVKAAREVKLIKEKGGTP
>g26860.t1
MSKATDNACLKCVIDYILDCEKKEEINKDNVLYIMENINVAELEKEFSFNQMAYAAMKPSKPGMEEPLENLHRIRITLSSKKCQLKPFALLLGRLPVVKTITICCRINCSMIYRGNGTLNPVVAFFFGRRFLFAFYVFYMF
>g77483.t1
MNLHDSELGGYDNSMKSIFLVNAWYIPFGIGRRNCPAIILLLPIYFGIEDLPQVIWNKEVCDLGFRVREN
>g103845.t1
MIISLQYSSQVWKFIPMEIQSLFFKRNKELGELIWSFRKEWVWLELEKSNQGKGGKLVVESRLVLAIDVVNHEGRRCSEQLINKPERFQEEKAKVEADENDFKYTPFGVVRRRLLPIYFGIKNGEIGYLGFRVKEARGVKLVKEKGGTP
>g174754.t1
MRAGSVGRWRKAVRTTSTLFVTLVVDYSEQLINRPERFLKEKAKVEADENDFRYIPFGLGRKRLLPIYFGIKNGEIAKSTVEAADEGEAPGHGVVIRSRPSKVELESGSCAISIGWCGPRFEEAGAREHLEGRRDLAVAIPGGACWRCRCGAMGFICVVSKMELESGSCAISIDGVGRDRRSRRSRASRRDAIWLSRFLEARAGDVMWGNGLSAL
>g196313.t1
MGQRNLVVVSSPDLARDVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMIVPFFTNKVVNQYRESVEDVKKDANAATEGIVLRKRLQLMMYNNMYRIMFDRRFESENDPLFLKLQALNGKRSRLAQSFEYNYGDFIPILRPFLRGYLKIFKEVKERRIQLFKDYFLEERKKLSSTKPTDNAGLKCAVDNYWMLRRKEKSTKTTSFTFSSNVPLLATLISTSTMDPFATLLHLYTMFVASSISRQQLPLTSASSILPPFHRPLQLRLVYPIRLYGQQHVLTPHKLKLCCRVMEPSKSKIMKQRSGDERGSSRE
>g218050.t1
MKAGGAGSEQLINRPERFLEEKTKVEADENDFRYIPFGVGRKRPLPIYFGIKNGEIVYLGFRVKEAREVKLIKEKGGTP
>g286990.t1
MLRRFAYAAVCSTSSTFLAIVAVSIKGRPHLRWPAMMATCSLLDPVVALSPPSTLVVENLVGVGGRGREIMREGGAGRSERFLEEKAKVEANENDFRYIPFGVGMRRLLPIYFEIKNGEAHESGGAQAHASVLARGKVGVRVKSEACAMMEAMLGQLAIDWEEARVGGGARWI
>g286996.t1
MLRRFACAVVSSTSSTFLAVVAVSIKGRPHLRWPAMMATCSLLDPVVALSPPSTLVVENRLVLAVEVVNHEGRRCGPERFLEEKAKVEANENDFRYIPFGVGMRRLLPIYFEIKNGEVSYLGFRVKEARGVKLIKEKGDTP
>g287009.t1
MRAGGAGRPERFLEEKAKVEANENDFRYIPFGVGMRRPLPIYFEIKNGEVSYLGFRVKEARGVKLIKEKGDTP
>g287011.t1
MATAMTTFQSPTTSSGECDLTTDRHKTGDCVISNGQRSITISNRQECNNDHDSRPERFLEEKAKVEANENDFRYIPFGVGMKRPLPIYFEIKNGEVSYLGFRVKEARGVKLIKEKGDTP
>g329809.t1
MNLNKLSNKKDWQNDKVPAASMKAQLERECDDALTSIRNRCSRSTMSRAAPGRESEESQIAPALGRDLPYITRTIGRERPSKCSTIIVSPTLVRERPTKSRVVLLFHRLGRSTIPDRKLRPNHNCEVGVCDLEWWSDLGGGRARQRDFWSRPRDGAVWGSSLSRPEAARLMVERERRLRMEGKGGRLVAESLLVLAVEAVNHEGKRCRPKRFLEEKAKVEANENDFRYIPFGMGRRRLLLIYFEIKNGEVGYLGFRVKEARGVKLIKEKGDMP
>g395755.t1
MISHPLPNMPSSPKKITICGKSKDGSSNLCKNNSNLISFINNQNMDLVLLEKTLICIFLTTVVAILVSKLRGKKLKLPPGPAPIPIFGNWLQVGDDLNHSNLTALAKKFGDVLLLKMGQRNLVVVSSPELARDVLQTQGVRFASRTRNVVFDIFTGKGQDMVFTVYGDHWRKMRRIMTVPFFTTKVVNQYRTGWEEEAHQAVEDIRKNPKAATEGIVLRRRLQLMMYNNMFRIMFDRRFESEEDPLYVKLKALNAERSRLSQSFEYNYGDFIPVLRPFLRGYLKVCKEIKQKRLQLFNDYFVEERKKVSNTRVSENGNLKCAMDHILDAEKNGEINKDNVLYIVENINVAAIETTLWSIEWGIAELINHPEIQQKLRNEIDTVLGTSHQVTEPDLQKLPYLQAVVKETLRLRMAIPLLVPHMNLNEEKIRDYDIPAESKILINAWWLANNPESWKNADEFRPERFLEEEANVEANGNDFRFIPFGVGRRSCPGIILALPILGITIGRLVQNFELLPPPGEMKIDTSEKAGQFSLQILKHSTVVARPRVF
>g410184.t1
MGQRNLVVVSSPDLAKDVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVNQYRESVEDVKKDAKAATEGIVLRKRLQLMMYNNMYMIMFDRRFESENDPLFLKLKALNGERSRLAQSFEYNYGDFIPILRPFLRGYYLKIFKEVKERRIQLFKDYFLEERKYVNFYTHNLCIPMWLPGNQVEELRSY
>g445984.t1
MMYNNMYRIMFDRRFESENDPLFLKLKALNGERSRLAQSFERIQLFKDYFLEERKKLSSTKPTDNAGLKCAIDHILDAEKKGEIDEDNVLYIVENINVAGV
>g465558.t1
MRAGDASRPERFLEEKAKVEANENDFRYIPFGVGMRRLLPIYFEIKNGEVSYLGFRVKEARGVKLIKEKGDTP
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University