Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Cynara cardunculus
Species name
Cardoon (Cynara cardunculus) is a species of eudicot in the family Asteraceae (daisy family).
Species info
Gene sequence info
Cynara_cardunculus.4CL.fa
Download
>rna-XM_025113645.1
MEPEKESEIIFRSKLPDIYIPKHLTLHSYCFENISDFSDRPCLIDGATGQVYTYAEVELTSRKVASALHKLGIGKGDVIMILLQNSFEFVYSFLGASYLGAISTMANPFFTAAEIIKQAKASSAKIIITQSSHVPKVKEFASDNSIKVVCIDSAPEGCLHYSELTSGNETELPEVEISSDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLWIHKEDVLMCVLPLFHIYSLNSILLCGLRAGAAILIMQKFEIVPFLQLIEKYKVTIGPFVPPIVLTIANNEEVVDKYDLSSIRTVMSGAAPLGKELEDTVRIKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFDIKSGACGTVVRNAEMKIVDPDSGASLPRNQRGEICIRGDQIMKGYVNDLEATKATIDSKGWLHTGDVGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPDISDAAVVPMKDEAAGEVPVAFVVKSNVDVTEDDIKQFISKQVVFYKRIKRVFFIEAIPKSPSGKILRKELRAKLAAGVPN
>rna-XM_025120662.1
MEAKSETIFRSRLPDIYIPKHLSLHSYCFENISAFSDRPCLIDGATGDVYTYADVELTSRKVGSALHKHGINKGDVIMILLPNSPEFVYSFLGASFIGAVSTMANPFFTSAEIIKQAKASAAKIIITQSEHAAKVKDFASENSIKLVCIDSAPEECLHFSELISGDEEELPEVEISSDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLWIHSEDVLMCVLPLFHIYSLNSILLCGLRAGAAILIMQKFHIVPFLELIQKYKVTIGPVVPPIVLTIAKNEEVVDKYDLTSIRTVMSGAAPLGKELENTVRMKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPDTGVSLPRNQRGEICIRGDQIMKGYLNDPEATKSTIVDGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPDISDAAVVPMKHEDAGEVPVAFVVKSNGTTVTEVEVKQFISKQVVFYKKLYRVFFIDKVPKSPSGKILRKDLRAKLAAGVPN
>rna-XM_025127976.1
MADLTPYNPTTGIYTSTRPPISLPRSPTTSIIDFLFRNLPAYSNRPALIDPHSHEIITFSQLKQKVSDLAHALHYTHNISNGDVVLIFSPNSILFPVAFFAVASIGAIVTTANPVYTVNELSHQIADSKPKLIITVDQLYSKVNEFNLPIVDLENYLDLIEKSRNQPVISFSVSQNDVAAILYSSGTTGLSKGVVLTHRAIMATALMVTSDQEFYGEGRSVFLCVVPLFHIMGLITFSYSQIQRGNAVVVMQRFELEKALDAMEKYKVTHLYTAPPVVVAMAKQPAVVRRYDTSSLKEIGSGAAPLGKDVMDECSKVFPQAKILQGYGMTETGGIISIENTRVGSGLSGSSGVLCPGMESKIIHIETLKPLPPNQLGEIWVRGPNLMQQYFHNKEATQQTIDKEGWLHTGDLGYFDEGGRIFVVDRLKELIKYKGYQVAPAELEGLLVKHPEIMDAAVIPYPDEEAGEIPMAYIVRKVGSSITGEELQSFIARQVAPFKRIRKVAFIDIIPKAASGKILRRELRQKLKSRL
>rna-XM_025131332.1
MEKSGYGRDGIFRSLRPPLVIPADPNTSMTSFLFRNVSSYPNRPALIDSDSGETLTFSELRTTVAKISYALNTQLGIKKNDVVLIFAPNSIQYPICLYSIIALGAIATTVNPQYTVRELSKQIKDSNPXLIITVQELYQKVENFGLPVVFLGSESSRKGCISYKDLISKSGSVSELPKVSIRGDDTAALLYSSGTTGVSKGVILSHRNFISISQMLASDQRLLGEKGYVFLCFLPMFHIFGLGVVLYSQLQEGNTVVSMGKFDFGGMLKNIEKYRVTHLWVVPPVILALAKQDVVNKFDLSSLKQIGSGAAPLGKELMEECAKKFPSVVVMQGYGMTETSGVVSVESPIMGPRHSGSAGRLIPGVEAQIVSVDTSKLLPPNQMGEIWTRGANMMQGYLNNPQATKLTIDKQGWVHTGDLGYFDDEGQLFVVDRIKELIKYKGFQVAPAELEALLLSHSEILDAAVIPFPDAEAGEVPIGFVVRSPNSSLNEEDVKKFIAELVAPYKRLRRVTFVNSVPKSAAGKLLRRELIEKVRSKM
>rna-XM_025131041.1
MEKSGYGRDGIFRSLRPPLVIPADPNTSMISFLFRNVSSYPNRPALIDSDSGETLTFSELRTTVAKISYALNTQLGIKKNDVVLIFAPNSIQYPICLYSIIALGAIATTVNPQYTVRELSKQIKDSNPKLIITVQELYHKVENFGLPVVFLGSESSRKGCISYKDLISKSGSVSELPKVSIRGDDTAALLYSSGTTGVSKGVILSHRNFISVSQMAVSDQRLMGEKGYVFLCFLPMFHIFGLGVILYSQLQEGNTVVSMGKFDFGEMLKNIEKYRATHLWVVPPVILALAKQDVVKKFDLSSLKQIGSGAAPLGKELMEECAKKFPSAVVMQGYGMTETTGVVSVESPIMGPRHSGSAGRLIPGVEAQIISVDTSKPLPPNQMGEIWARGANMMQGYLNNPQATKLTIDKQGWVHTGDLGYFDDEGQLFVVDRIKELIKYKGFQVAPAELEALLLSHSEILDAAVIPFPDAEAGEVPIAFVVRSPNSSLNEEDVKKFIAEQVAPYKRLRRVTFVNSVPKSAAGKLLRRELIEKVRSKI
>rna-XM_025136207.1
MAKNTQNSTKEDDEEIVFQSRYPSVPIPDDLTLPEFVLKDAESYADNVAFVEAATNKSYTYGQVAKDVKRFSKALRSLGLRTGHVVIVVLPNMAEYAIVALGIMAAGGVFSGANPSSHSSELKKQAELADAKLIVTDDHTYNKVKELGLPVIILGEGRVAGTIWWDELLEAAERASNNGIESVVNQSDLCALPFSSGTTGLSKGVMLTHRNIVANLCSTLFSVGPELIGKVTILGLIPYFHIYGLTGILCATLKNKGKVVVMGRYDLSTVLKALIEHEVTFAPIVPPILLGLVKHPIAEDLEKLKLRSIMTAAAPLAPEIYEEFQKKFPQVEVQEAYGMTEHSCITLTHGDPRKGHHIAKKRSVGYILPNLEVKFVDPDTGRSLPSNTPGEICVRSQCVMKGYYKNEVETAQTIDEHGWLHTGDVGYIDEEGDIFIIDRMKELIKYKGFQVAPAELEGILLGHPSVEDAAVVGLPDEEAGEIPGANVVMCKDAKESEEEMMKYVAHNVAQYKKVRVLHFVDKIPKSPSGKIMRRLIKDAMLDKITKSQSSAVAQ
>rna-XM_025106000.1
MLSIEAQKPETPPPPPLVTSSSSASTCNNNINHTHNHNVDDDSSRHVVFRSKLPDLPNIPNHIPLHTYCFENLSRFSDRPCLVVGSTGTTYSFSQTHFLSRKIAAGLSTLGITKGDVIMLLLQNCAEFALTFMAASMIGAITTAANPLYTAGEIFKQFNSSNSKMIITQAQYVDKLRDPGEHNPKMGQDFPVITVDEPPEKCLHFSVLWKTDENNIPSVTIDPDDAVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLYLKQDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVVLMPKFEIRSLLDLIQRYRVTVAAVVPPLVLALAKNPMVGSYDLSSIRVVLSGAAPLGKELEDGLRSRVPQAIFGQGYGMTEAGPVLSMSAAFAKQPLATKSGSCGSVVRNAELKVIDLDTHYSLGYNQPGEICIRGPQIMKGYLNDAKSTAATIDEQGWLHTGDIGYVDHDDEVFIVDRVKELIKFKGFQVPPAELEALLVSHPCIADAAVVPQKDDAAGEVPVAFVVLLNGMQELTEEAVKDYIAKQMKIEEGACWQVVFYKKLHKVYFVTSIPKSPSGKILRKDLRAKLPST
MEPEKESEIIFRSKLPDIYIPKHLTLHSYCFENISDFSDRPCLIDGATGQVYTYAEVELTSRKVASALHKLGIGKGDVIMILLQNSFEFVYSFLGASYLGAISTMANPFFTAAEIIKQAKASSAKIIITQSSHVPKVKEFASDNSIKVVCIDSAPEGCLHYSELTSGNETELPEVEISSDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLWIHKEDVLMCVLPLFHIYSLNSILLCGLRAGAAILIMQKFEIVPFLQLIEKYKVTIGPFVPPIVLTIANNEEVVDKYDLSSIRTVMSGAAPLGKELEDTVRIKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFDIKSGACGTVVRNAEMKIVDPDSGASLPRNQRGEICIRGDQIMKGYVNDLEATKATIDSKGWLHTGDVGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPDISDAAVVPMKDEAAGEVPVAFVVKSNVDVTEDDIKQFISKQVVFYKRIKRVFFIEAIPKSPSGKILRKELRAKLAAGVPN
>rna-XM_025120662.1
MEAKSETIFRSRLPDIYIPKHLSLHSYCFENISAFSDRPCLIDGATGDVYTYADVELTSRKVGSALHKHGINKGDVIMILLPNSPEFVYSFLGASFIGAVSTMANPFFTSAEIIKQAKASAAKIIITQSEHAAKVKDFASENSIKLVCIDSAPEECLHFSELISGDEEELPEVEISSDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLWIHSEDVLMCVLPLFHIYSLNSILLCGLRAGAAILIMQKFHIVPFLELIQKYKVTIGPVVPPIVLTIAKNEEVVDKYDLTSIRTVMSGAAPLGKELENTVRMKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPDTGVSLPRNQRGEICIRGDQIMKGYLNDPEATKSTIVDGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPDISDAAVVPMKHEDAGEVPVAFVVKSNGTTVTEVEVKQFISKQVVFYKKLYRVFFIDKVPKSPSGKILRKDLRAKLAAGVPN
>rna-XM_025127976.1
MADLTPYNPTTGIYTSTRPPISLPRSPTTSIIDFLFRNLPAYSNRPALIDPHSHEIITFSQLKQKVSDLAHALHYTHNISNGDVVLIFSPNSILFPVAFFAVASIGAIVTTANPVYTVNELSHQIADSKPKLIITVDQLYSKVNEFNLPIVDLENYLDLIEKSRNQPVISFSVSQNDVAAILYSSGTTGLSKGVVLTHRAIMATALMVTSDQEFYGEGRSVFLCVVPLFHIMGLITFSYSQIQRGNAVVVMQRFELEKALDAMEKYKVTHLYTAPPVVVAMAKQPAVVRRYDTSSLKEIGSGAAPLGKDVMDECSKVFPQAKILQGYGMTETGGIISIENTRVGSGLSGSSGVLCPGMESKIIHIETLKPLPPNQLGEIWVRGPNLMQQYFHNKEATQQTIDKEGWLHTGDLGYFDEGGRIFVVDRLKELIKYKGYQVAPAELEGLLVKHPEIMDAAVIPYPDEEAGEIPMAYIVRKVGSSITGEELQSFIARQVAPFKRIRKVAFIDIIPKAASGKILRRELRQKLKSRL
>rna-XM_025131332.1
MEKSGYGRDGIFRSLRPPLVIPADPNTSMTSFLFRNVSSYPNRPALIDSDSGETLTFSELRTTVAKISYALNTQLGIKKNDVVLIFAPNSIQYPICLYSIIALGAIATTVNPQYTVRELSKQIKDSNPXLIITVQELYQKVENFGLPVVFLGSESSRKGCISYKDLISKSGSVSELPKVSIRGDDTAALLYSSGTTGVSKGVILSHRNFISISQMLASDQRLLGEKGYVFLCFLPMFHIFGLGVVLYSQLQEGNTVVSMGKFDFGGMLKNIEKYRVTHLWVVPPVILALAKQDVVNKFDLSSLKQIGSGAAPLGKELMEECAKKFPSVVVMQGYGMTETSGVVSVESPIMGPRHSGSAGRLIPGVEAQIVSVDTSKLLPPNQMGEIWTRGANMMQGYLNNPQATKLTIDKQGWVHTGDLGYFDDEGQLFVVDRIKELIKYKGFQVAPAELEALLLSHSEILDAAVIPFPDAEAGEVPIGFVVRSPNSSLNEEDVKKFIAELVAPYKRLRRVTFVNSVPKSAAGKLLRRELIEKVRSKM
>rna-XM_025131041.1
MEKSGYGRDGIFRSLRPPLVIPADPNTSMISFLFRNVSSYPNRPALIDSDSGETLTFSELRTTVAKISYALNTQLGIKKNDVVLIFAPNSIQYPICLYSIIALGAIATTVNPQYTVRELSKQIKDSNPKLIITVQELYHKVENFGLPVVFLGSESSRKGCISYKDLISKSGSVSELPKVSIRGDDTAALLYSSGTTGVSKGVILSHRNFISVSQMAVSDQRLMGEKGYVFLCFLPMFHIFGLGVILYSQLQEGNTVVSMGKFDFGEMLKNIEKYRATHLWVVPPVILALAKQDVVKKFDLSSLKQIGSGAAPLGKELMEECAKKFPSAVVMQGYGMTETTGVVSVESPIMGPRHSGSAGRLIPGVEAQIISVDTSKPLPPNQMGEIWARGANMMQGYLNNPQATKLTIDKQGWVHTGDLGYFDDEGQLFVVDRIKELIKYKGFQVAPAELEALLLSHSEILDAAVIPFPDAEAGEVPIAFVVRSPNSSLNEEDVKKFIAEQVAPYKRLRRVTFVNSVPKSAAGKLLRRELIEKVRSKI
>rna-XM_025136207.1
MAKNTQNSTKEDDEEIVFQSRYPSVPIPDDLTLPEFVLKDAESYADNVAFVEAATNKSYTYGQVAKDVKRFSKALRSLGLRTGHVVIVVLPNMAEYAIVALGIMAAGGVFSGANPSSHSSELKKQAELADAKLIVTDDHTYNKVKELGLPVIILGEGRVAGTIWWDELLEAAERASNNGIESVVNQSDLCALPFSSGTTGLSKGVMLTHRNIVANLCSTLFSVGPELIGKVTILGLIPYFHIYGLTGILCATLKNKGKVVVMGRYDLSTVLKALIEHEVTFAPIVPPILLGLVKHPIAEDLEKLKLRSIMTAAAPLAPEIYEEFQKKFPQVEVQEAYGMTEHSCITLTHGDPRKGHHIAKKRSVGYILPNLEVKFVDPDTGRSLPSNTPGEICVRSQCVMKGYYKNEVETAQTIDEHGWLHTGDVGYIDEEGDIFIIDRMKELIKYKGFQVAPAELEGILLGHPSVEDAAVVGLPDEEAGEIPGANVVMCKDAKESEEEMMKYVAHNVAQYKKVRVLHFVDKIPKSPSGKIMRRLIKDAMLDKITKSQSSAVAQ
>rna-XM_025106000.1
MLSIEAQKPETPPPPPLVTSSSSASTCNNNINHTHNHNVDDDSSRHVVFRSKLPDLPNIPNHIPLHTYCFENLSRFSDRPCLVVGSTGTTYSFSQTHFLSRKIAAGLSTLGITKGDVIMLLLQNCAEFALTFMAASMIGAITTAANPLYTAGEIFKQFNSSNSKMIITQAQYVDKLRDPGEHNPKMGQDFPVITVDEPPEKCLHFSVLWKTDENNIPSVTIDPDDAVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLYLKQDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVVLMPKFEIRSLLDLIQRYRVTVAAVVPPLVLALAKNPMVGSYDLSSIRVVLSGAAPLGKELEDGLRSRVPQAIFGQGYGMTEAGPVLSMSAAFAKQPLATKSGSCGSVVRNAELKVIDLDTHYSLGYNQPGEICIRGPQIMKGYLNDAKSTAATIDEQGWLHTGDIGYVDHDDEVFIVDRVKELIKFKGFQVPPAELEALLVSHPCIADAAVVPQKDDAAGEVPVAFVVLLNGMQELTEEAVKDYIAKQMKIEEGACWQVVFYKKLHKVYFVTSIPKSPSGKILRKDLRAKLPST
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University