Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Cuscuta australis
Species name
Cuscuta australis is a species of eudicot in the family Convolvulaceae (morning-glory family).
Species info
Gene sequence info
Cuscuta_australis.CHS.fa
Download
>C002N0353E0.1
MKIEKNGGGTWRVQRADGPANILAIGTATPSHWVDQSEYPDFYFRVTNSEHLEDLKDKFRRICGRTMIKKRHMLLNEEILKENPNLCTFSEPSLNTRQDILISEIPKLGKEAALNAIVEWGESRTKITHLIFCTRSGLDMPGADYQLIKLLGLSPTTQRFMMYQQGCFAGGTVLRLAKDIAENNKDSRILAVCTESSAIGFRGPSPDHIDNLVAQSLFGDGAAALIIGSDPKPNIEKPIFEIFSAAQTFVPNGDYHLALHLRESGLSFHGTKFVPSTIAKNAESCLIRAFDGLGISDWNSLFWALHPGGSAIVDQVESKLGLEPDKLRATRSILRDYGNLSSACVMFILDEVRKKSIRDGLMTTGDGLEFGVLLSFGPGLTIETVVLRSMPI
>C026N0280M0.1
MVTVEEVRKAQRAEGPATILAIGTATPPNCVDQSTYPDYYFRVTNSDHMTDLKQKFKRIYKLYIYPAYPAKRFLGEKSMINKRYLYLTEELLKDKPNMCEYMAPSLDARQDIVVVEVPKLGKEAAQKALTEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLTPSVKRLMMYQQGCFAGGTVLRLAENNCGARVLVVCSEITAIIFRGPSDTNLDCLVGQALFGDGAAALIIGSDPLPSLERPLFELVTAAQTLLPDSHGAIDLHLREVGLTFHLRKDVPEIISKNIEKSLKEAFQPLGISEWNSLFWIAHPGGPAILDQVEAKLGLRPEKLRATRHVLSEYGNLTSACVLFILDEMRKASVKDGLSTTGEGLEWGVLFGFGPGLTVETVVLHSVSTN
>C036N0047E0.1
MGFGEAIMQGGVKKANTGKASIMAIGKAFPHQLVMQEFLVDGYFKNTNCDDPALRQKLTRLCKTTTVKTRYVVMSEEILNKYPELAIEGLPTVKQRLDICNSAVTQMALEASRVCIEKWGRSTSEITHLVYVSSSEARLPGGDLYLAKGLGLCPDTQRVMLYFSGCSGGVAGLRVAKDIAENNPGSRVLLSTSETTIIGFKPPSVDRPYDLVGVALFGDGAGAMIIGSDPVQETERPLFELHTAIQHFVPNTEKIIDGRLTEEGISFKLERELPQIIEDNIGEFCEKLIRVAGYTPEDYNKLFWAVHPGGPAILNRLEKKFELLPEKLSASRRALADYGNASSNTIVYVLEYMLEEKNKKNQPEEEEADWGLILAFGPGITFEGILTRKLTA
>C011N0315E0.1
MNKCERPNQVRNLLKICICRGNRNADGAAIDIHFPGGQLHGEDGDGGGGEKGAARGGSGDNNGHRHRQSACVDQITYPDYYFRITNSDHMTELKAKFKRICEKSMIKKRYMHITEEILKENANMCAYMAPSLDARQKMVAEEVPKLGKEAAQKAIKEWGQPKSKITHLIVCSTTCVDMPGIDYRLINLLGLNPSVKRFMMYQQGCFAGGTVLRLAKDISENNKGSRTLVVCSEMILSTFHGLDETHFDNLVGQSLFGDGASAVIIGAGPIPETERPLFELVSAAQTLLPDSFGAIEGHLREVGLTFHLQKNVPSIISENIGQILKDAFGPLGITDWNSIFCIAHPGGPSILDRVEVQLGLKPKKLQATRRVLSEYGNMSSASVLFILDLMRKASVENGLSTTGEGLEWGVLFGFGPGLTVETLVLHSISTSNCN
>C011N0317G0.1
MVTVEEVRKAQRAEGPATILAIGTATPPNCVDQSTYPDYYFRITNSDHMTDLKEKFKRMCEKSMINKRYMYLTEEVLKDKPSMCEYMAPSLDARQDIVVVEVPKLGKEAAQKAIKEWGEPKSKITHLVFCTTSGVDMPGADYQLTKLLGLKPSVKRLMMYQQGCFAGGTVLRLAKDLAENNRGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAIIIGSDPVPDVERPLFELVTAAQTLLPDSHGAIDGHLREVGLTFHLLKDVPGIISKNIEKSLKEAFQPLGISDWNSLFWIAHPGGPAILDQVEAKLGLKPEKLRATRHVLSEYGNMSSACVLFILDEMRKASAEDGLSTTGEGLEWGVLFGFGPGLTVETVVLHSVSTN
>C035N0275E0.1
MSNLNGKCNNNNSSTITRRVPTKGKAAILAMGKAFPSQLVPQDRLVEGYFRDTKCDDPSIKEKLERLCKTTTVKTRYTVMCKDVLEKYPELATEGTPTIAQRLEIANPAVVEMAKEASLACIHDWGRSAAEITHIVYVSSSEIRLPGGDLYLAAELGLRSDVNRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNMARPYDLVGAALFGDGAAAAIIGADPMAGVENPFMELFFAAQQFLPGTQGVIDGRLSEEGINFKLGRDLPEKIQDNIEEFCAKLAGNVAGGKKPGYNEMFWAVHPGGPAILNRLEGTLGLRKEKLDCSRRALMDYGNVSSNTILYVIEHMRDELKRKKEEEEEEEEEWGVALAFGPGITFEGILLRSI
MKIEKNGGGTWRVQRADGPANILAIGTATPSHWVDQSEYPDFYFRVTNSEHLEDLKDKFRRICGRTMIKKRHMLLNEEILKENPNLCTFSEPSLNTRQDILISEIPKLGKEAALNAIVEWGESRTKITHLIFCTRSGLDMPGADYQLIKLLGLSPTTQRFMMYQQGCFAGGTVLRLAKDIAENNKDSRILAVCTESSAIGFRGPSPDHIDNLVAQSLFGDGAAALIIGSDPKPNIEKPIFEIFSAAQTFVPNGDYHLALHLRESGLSFHGTKFVPSTIAKNAESCLIRAFDGLGISDWNSLFWALHPGGSAIVDQVESKLGLEPDKLRATRSILRDYGNLSSACVMFILDEVRKKSIRDGLMTTGDGLEFGVLLSFGPGLTIETVVLRSMPI
>C026N0280M0.1
MVTVEEVRKAQRAEGPATILAIGTATPPNCVDQSTYPDYYFRVTNSDHMTDLKQKFKRIYKLYIYPAYPAKRFLGEKSMINKRYLYLTEELLKDKPNMCEYMAPSLDARQDIVVVEVPKLGKEAAQKALTEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLTPSVKRLMMYQQGCFAGGTVLRLAENNCGARVLVVCSEITAIIFRGPSDTNLDCLVGQALFGDGAAALIIGSDPLPSLERPLFELVTAAQTLLPDSHGAIDLHLREVGLTFHLRKDVPEIISKNIEKSLKEAFQPLGISEWNSLFWIAHPGGPAILDQVEAKLGLRPEKLRATRHVLSEYGNLTSACVLFILDEMRKASVKDGLSTTGEGLEWGVLFGFGPGLTVETVVLHSVSTN
>C036N0047E0.1
MGFGEAIMQGGVKKANTGKASIMAIGKAFPHQLVMQEFLVDGYFKNTNCDDPALRQKLTRLCKTTTVKTRYVVMSEEILNKYPELAIEGLPTVKQRLDICNSAVTQMALEASRVCIEKWGRSTSEITHLVYVSSSEARLPGGDLYLAKGLGLCPDTQRVMLYFSGCSGGVAGLRVAKDIAENNPGSRVLLSTSETTIIGFKPPSVDRPYDLVGVALFGDGAGAMIIGSDPVQETERPLFELHTAIQHFVPNTEKIIDGRLTEEGISFKLERELPQIIEDNIGEFCEKLIRVAGYTPEDYNKLFWAVHPGGPAILNRLEKKFELLPEKLSASRRALADYGNASSNTIVYVLEYMLEEKNKKNQPEEEEADWGLILAFGPGITFEGILTRKLTA
>C011N0315E0.1
MNKCERPNQVRNLLKICICRGNRNADGAAIDIHFPGGQLHGEDGDGGGGEKGAARGGSGDNNGHRHRQSACVDQITYPDYYFRITNSDHMTELKAKFKRICEKSMIKKRYMHITEEILKENANMCAYMAPSLDARQKMVAEEVPKLGKEAAQKAIKEWGQPKSKITHLIVCSTTCVDMPGIDYRLINLLGLNPSVKRFMMYQQGCFAGGTVLRLAKDISENNKGSRTLVVCSEMILSTFHGLDETHFDNLVGQSLFGDGASAVIIGAGPIPETERPLFELVSAAQTLLPDSFGAIEGHLREVGLTFHLQKNVPSIISENIGQILKDAFGPLGITDWNSIFCIAHPGGPSILDRVEVQLGLKPKKLQATRRVLSEYGNMSSASVLFILDLMRKASVENGLSTTGEGLEWGVLFGFGPGLTVETLVLHSISTSNCN
>C011N0317G0.1
MVTVEEVRKAQRAEGPATILAIGTATPPNCVDQSTYPDYYFRITNSDHMTDLKEKFKRMCEKSMINKRYMYLTEEVLKDKPSMCEYMAPSLDARQDIVVVEVPKLGKEAAQKAIKEWGEPKSKITHLVFCTTSGVDMPGADYQLTKLLGLKPSVKRLMMYQQGCFAGGTVLRLAKDLAENNRGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAIIIGSDPVPDVERPLFELVTAAQTLLPDSHGAIDGHLREVGLTFHLLKDVPGIISKNIEKSLKEAFQPLGISDWNSLFWIAHPGGPAILDQVEAKLGLKPEKLRATRHVLSEYGNMSSACVLFILDEMRKASAEDGLSTTGEGLEWGVLFGFGPGLTVETVVLHSVSTN
>C035N0275E0.1
MSNLNGKCNNNNSSTITRRVPTKGKAAILAMGKAFPSQLVPQDRLVEGYFRDTKCDDPSIKEKLERLCKTTTVKTRYTVMCKDVLEKYPELATEGTPTIAQRLEIANPAVVEMAKEASLACIHDWGRSAAEITHIVYVSSSEIRLPGGDLYLAAELGLRSDVNRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNMARPYDLVGAALFGDGAAAAIIGADPMAGVENPFMELFFAAQQFLPGTQGVIDGRLSEEGINFKLGRDLPEKIQDNIEEFCAKLAGNVAGGKKPGYNEMFWAVHPGGPAILNRLEGTLGLRKEKLDCSRRALMDYGNVSSNTILYVIEHMRDELKRKKEEEEEEEEEWGVALAFGPGITFEGILLRSI
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University