Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Cucurbita pepo
Species name
Cucurbita pepo is a species of eudicot in the family Cucurbitaceae (cucumber family).
Species info
Gene sequence info
Cucurbita_pepo.COMT.fa
Download
>rna-XM_023684718.1
MGSTAEEQSTIVSSISDDGQQHQHFAYAMQLVTSSVLPMTLQAAFELGLFEILAKAGNGAELSPTEITAKLTTSNPDAASMIDRILRLLAAHSVVGCSVIIDENGNQQRLYSLTPVAKYFLLDEDGVSLGALLSMIQDKVFLESWSELKNGVIEGGIPFNRTHGGVHAFEYPRLDQRFNQVFNNGMINHTTMVIKVVVESYNGFANLKQLVDVGGGLGVTLKIITSAYPSIKGINFDLPHVIQDAPSYPGVEHVGGDMFEKVPKGDAIFMKWILHDWSDEHCVKLLKNCYAAIPDDGKVIVMEGVVPTVPETTAAAKAIGQGDMLMMTQNPGGKERTRDEFKALATKAGFKHVKFVCFICNFWIIEFLK
>rna-XM_023684713.1
MASTAKEQSTIASSNSDDGQEQQHYAYAAQLVTSSVLPMTLQAAFELGLFEILAKAGDGAELSPTEIAAKITTSNPDAASLIDRILRLLAAHSVVGCSVIIDENGNQQRLYSLTPVAKYFVLNEDGLSLGPILSMIQDKVILHSWSELKNVVIEGGVPFNRAHDGLHLFEYNGLDQRFNQVFNNAMINHTTMVIKIAVESYNGFANLKQLVDVGGGLGVTLKIITSAYPSIKGINFDLPHVIQDAPSYPRVEHVGGDMFEKIPNGDAIFVKWILHDWSDDHCVKLLKNCYVAIPDDGKVIVMEGVAPTVPETTAAAKVVIQGDVLMMTQSIEGKERTRDEFKALATKAGFKHIKFVCFLSNYWIIEFSK
>rna-XM_023684586.1
MVVGKENPPMEKESANTVAGSESHKRARLAILELANMISVPMSLNAVVRLNIADAIWQGGSNFPLSASEILARVVPSGGDADNLERILRMLTSYGVFEEHLNPNSSDRRYSLTDVGKTLVTDSDGLSYASYVLQHHQDALMRAWPRVHEAAIDASTEPFVRANGEAAYSYYGKNEEMNLLMQRAMAGVSVPFMKAVLDGYDGFGGVEKLVDVGGSAGDCLRMILQKHPHIKEGINFDLPEVVARAPSIPGVTHVGGDMFKSVPTGDAIFMKWVLSTWTDDECKMILENCCKSLPAGGKLIACEPTVPEKTDDSHRTRALLANDVFIMTIYSAKSKQRTEDQFRQLGLSVGFSAMRSFHVDYFYCVLEFEK
>rna-XM_023684716.1
MASTAKERSTVASSNSDDGQEQQHYSYAAQLVTSSVLPMTLQAAFELGLFEILAKAGDGAELSPTEIATKITTSNPDAASMIDRILRLMAAHAVVGCSVIIDENGNQQRLYSLAPVAKYFVPNEDGVSLGPIVSMIQDKVFLHSWSELKNAVIEGGVPFNRAHGGVHAFEYPRLDQRFNQVFNNAMINYSTTAIKAVVKCYNGFANLKQLVDVGGGLGVTLKIITSAYPSIKGINFDLPHVIQDAPSYPGVEHVGGDMFEKVPEGDAIFIKWILHDWSDEHCVKLLKNCYAAIPDDGKVIVMEGVLPTVPETSEAAKGIIQGDVLMMTQNPGGKERTRDEFEALATKAGFKHVKFVCFLSNHWIIEFLK
>rna-XM_023686550.1
MGSSGQGCEVQITPTTQVSDEEAQLFAMQLASASVLPMVLKAAIELDVLEIIAAAGEGALLSPSQIASHLSFSGAKTPNPEAGVVLDRMLRLLASYSILTYSLNTLPDGSLQRLYGLAPVAKFLVKNQDGVSIAPLCLMNQDKVLMESWYHLKDTVLEGGIPFNKAYGMTAFEYHGTDPRFNRVFNRGMSDHSTITMKKILETYKGFEGLNSVVDVGGGTGAVLNMIVSKYPSIRGINFDLPHVIQDALAYPGVQHVGGDMFVSVPKGDAIFMKWICHDWSDQHCLKLLKNCHDSLPEHGKVIVAECILPVAPDSSLATKGVIHIDVIMLAHNPGGKERTEQEFHALAKAAGFQGFKVHSCAFNTYIMEFLKTL
MGSTAEEQSTIVSSISDDGQQHQHFAYAMQLVTSSVLPMTLQAAFELGLFEILAKAGNGAELSPTEITAKLTTSNPDAASMIDRILRLLAAHSVVGCSVIIDENGNQQRLYSLTPVAKYFLLDEDGVSLGALLSMIQDKVFLESWSELKNGVIEGGIPFNRTHGGVHAFEYPRLDQRFNQVFNNGMINHTTMVIKVVVESYNGFANLKQLVDVGGGLGVTLKIITSAYPSIKGINFDLPHVIQDAPSYPGVEHVGGDMFEKVPKGDAIFMKWILHDWSDEHCVKLLKNCYAAIPDDGKVIVMEGVVPTVPETTAAAKAIGQGDMLMMTQNPGGKERTRDEFKALATKAGFKHVKFVCFICNFWIIEFLK
>rna-XM_023684713.1
MASTAKEQSTIASSNSDDGQEQQHYAYAAQLVTSSVLPMTLQAAFELGLFEILAKAGDGAELSPTEIAAKITTSNPDAASLIDRILRLLAAHSVVGCSVIIDENGNQQRLYSLTPVAKYFVLNEDGLSLGPILSMIQDKVILHSWSELKNVVIEGGVPFNRAHDGLHLFEYNGLDQRFNQVFNNAMINHTTMVIKIAVESYNGFANLKQLVDVGGGLGVTLKIITSAYPSIKGINFDLPHVIQDAPSYPRVEHVGGDMFEKIPNGDAIFVKWILHDWSDDHCVKLLKNCYVAIPDDGKVIVMEGVAPTVPETTAAAKVVIQGDVLMMTQSIEGKERTRDEFKALATKAGFKHIKFVCFLSNYWIIEFSK
>rna-XM_023684586.1
MVVGKENPPMEKESANTVAGSESHKRARLAILELANMISVPMSLNAVVRLNIADAIWQGGSNFPLSASEILARVVPSGGDADNLERILRMLTSYGVFEEHLNPNSSDRRYSLTDVGKTLVTDSDGLSYASYVLQHHQDALMRAWPRVHEAAIDASTEPFVRANGEAAYSYYGKNEEMNLLMQRAMAGVSVPFMKAVLDGYDGFGGVEKLVDVGGSAGDCLRMILQKHPHIKEGINFDLPEVVARAPSIPGVTHVGGDMFKSVPTGDAIFMKWVLSTWTDDECKMILENCCKSLPAGGKLIACEPTVPEKTDDSHRTRALLANDVFIMTIYSAKSKQRTEDQFRQLGLSVGFSAMRSFHVDYFYCVLEFEK
>rna-XM_023684716.1
MASTAKERSTVASSNSDDGQEQQHYSYAAQLVTSSVLPMTLQAAFELGLFEILAKAGDGAELSPTEIATKITTSNPDAASMIDRILRLMAAHAVVGCSVIIDENGNQQRLYSLAPVAKYFVPNEDGVSLGPIVSMIQDKVFLHSWSELKNAVIEGGVPFNRAHGGVHAFEYPRLDQRFNQVFNNAMINYSTTAIKAVVKCYNGFANLKQLVDVGGGLGVTLKIITSAYPSIKGINFDLPHVIQDAPSYPGVEHVGGDMFEKVPEGDAIFIKWILHDWSDEHCVKLLKNCYAAIPDDGKVIVMEGVLPTVPETSEAAKGIIQGDVLMMTQNPGGKERTRDEFEALATKAGFKHVKFVCFLSNHWIIEFLK
>rna-XM_023686550.1
MGSSGQGCEVQITPTTQVSDEEAQLFAMQLASASVLPMVLKAAIELDVLEIIAAAGEGALLSPSQIASHLSFSGAKTPNPEAGVVLDRMLRLLASYSILTYSLNTLPDGSLQRLYGLAPVAKFLVKNQDGVSIAPLCLMNQDKVLMESWYHLKDTVLEGGIPFNKAYGMTAFEYHGTDPRFNRVFNRGMSDHSTITMKKILETYKGFEGLNSVVDVGGGTGAVLNMIVSKYPSIRGINFDLPHVIQDALAYPGVQHVGGDMFVSVPKGDAIFMKWICHDWSDQHCLKLLKNCHDSLPEHGKVIVAECILPVAPDSSLATKGVIHIDVIMLAHNPGGKERTEQEFHALAKAAGFQGFKVHSCAFNTYIMEFLKTL
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University