Enzyme
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
HIDH
Enzyme
2-hydroxyisoflavanone dehydratase
Enzyme name
EC:4.2.1.105
Entry
Lyases;Carbon-oxygen lyases;Hydro-lyases
Class
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Sysname
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
Reaction
daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]
Product
Species information
Cucurbita pepo
Species name
Cucurbita pepo is a species of eudicot in the family Cucurbitaceae (cucumber family).
Species info
Gene sequence info
Cucurbita_pepo.HIDH.fa
Download
>rna-XM_023672284.1
MRRKRMPINLDQIPSFEEHGNGFDQHSVLVEEIEGLIRVYGNGYVERPQIVPSVSNALPPELGVTSWDVVVDKLNNIWARFYIPTQCQEKLPLLVYFHGGGFCVGSATWSCYHEFLAKLSAKADCIIMSVNYRLAPENPLPAPYEDGLKTLQWLKQVAINGAKQNWWSRYCDFTKIYLGGDSAGGNIAFNVAARLGGKTTASGAVVMKPLVIKGNILIQPFFGGESRTMSEKFLVQPPHSPLTTAVSDTYWRLALPSRTNRDHPWCNPSANGVFEVEDLRVLPSLICISEMDILKDRNLEFCSALHRVGKLINYVVYEGVGHAFQVLNKSQLSQTRTLEMMDHIKDFLSL
>rna-XM_023667597.1
MIFKRMAAMYVDPRLKLQMAKPHLQNGGTSEEIEGLIRVYADGHVERPPIIPNVACSTTASDKGVTAKDVLIDIFTNTWARIYIPNSQRNLPLLVYFHGGGFCVGSAAWSCYHEFLLNLASKAKCVILSINYRLSPENRLPAAYDDGFNALMWLKQQAITNPIEHKWWSGNCNPSKLFLAGDSAGANIVYNTATRLGHNESTLLKPLTLKGIILIQPFFGGESRTKSEKLAATPSSTSALTLSASDTYWRLSLPPTANRDHPWSNPLVNGGAKLKETKLPPLMVCISELDILLDRNLEFCAAMAGAGKKVDRVILKGVGHGFQILNKDQISTQRTQELMGSIRAFIHQQ
>rna-XM_023669803.1
MVAPDSNNPELELELELLPYLRVYKNGVVERLVGTRVTPPGLDSLTGVDSKDITIVPETGITARLYRPTAVEPPRKLPLVVYFHGGAFLITSSAEPIYHNNCLIPLAAATESVVLSVNYRLAPEHPLPAAYEDSWAALQWVAEQSKTSGDEAGQEPWLKQLVDFEKVFLLGDSAGGNIAHHMALRAQNSNLAGKFKIRGIALIQPYFWGEEPIGSEITEPEKKALVDSWWNFVCPSDRGNDDLLINPFADGSPSVEGLVGEKVVVIVAEKDILRDRGMIYYENLAKSNWKGKVDIFETEGEDHAFHLLDPTSEKAKRLVNRLALFVNED
>rna-XM_023676358.1
MDSTAGEEVVFQFLSVFRVFKSGRVERLVPADTVPPSTDSRTGVQSKDVLIDPHTKLSVRIYLPKVSTSAKKLPLLIYIHGGAFSIGSVASSIYHSHLISLAAEANAVAVSVEYRLAPENPLPAAYDDAWKAVEWVASHSNRDGAEMWLNEHADFDRVFIVGDSAGANISYNVVGRASENDNGPEGLKIIGLGLVHPFFMIDKPDKLIEYIFPTSTGLEDPRMNPWANPGLGRFRCNRVLIIAAEHDFLNDRARGFHAALRESGWKGSVEMVENEGEDHVFHLFNPDCEKAVALVKKVASFIQSDSNEAEMGTRPSSL
>rna-XM_023678307.1
MATSSPFEVDECRGVLRVYSDGSIVRSSNPSFNVPVLDDGSVLWKDLLFDPINHLHLRLYKPAVSSSTLPVFFYIHGGGFCIGSRTWPNCQNYCFRLALELPALVISPDYRLAPENRLPAAIDGGFAAVRWLQAQAQSDHPDPWLADVADFSRVFISGDSAGGNIAHHLAVGLGLGSPALAPVRVRGYVLLAPFFGGTVRTRSEAEGPKDAFLNLELIDRFWRLSIPIGSSTDHPLVNVLGQSSQDLEAVEVDPILVVVGGADLLKDRAVEYAETLKKQGKKIELVEFEGKQHGFFTIDPNSEASNQLMLLLKQFVARHSG
>rna-XM_023678869.1
MASDEIALNAAPWFIIYKDRRIDRLIGNDIDPPGLDPKTGVESKDVVISQEDSVAVRIYRPKSAAGAGKGDQKLPLLVYFHGGGFCIETAFSPFYHQHLNPWVAQANIVAVSVNYRRAPEHQLPIPFEDSWTALKWIAAHSNGTGPDEWLNEIADLNQVYLAGDSAGGNIAHRMTLRMATEGLAGVKIKGLQLIHPHFWGGKLIGEEKEWDPKSIYVVENLWYWVSKDIKDLDDPIVNPEHEPALGRLAAEKVAIYVAEKDNLKERGRHYAECLRKSGWGGTVDVVETDGEGHVFHLFNPTCDSAADLVGQLAAFISGKCGC
>rna-XM_023680498.1
MCSTSYSIFRARMALIGEAPGFLEVYSDGSVRRLIPEVVVSTDNQSSKNYKFKDVVIDPKKPVTGRLFLPNVTGNHVAKLPILVYFHGGGFCIGSTTWMGYHHFLGGLAVASNCVILSIDYRLAPENRLPAAYEDCYSSLEWLAHQASCFEPWLQNADLSRVFLSGDSAGGNIVHHVAVKTMKTNISNMTLKGLMLIHPYFGSEKRTEKEKAEGVEGFVEMNDMFWRLSIPKGSNRDYFGCNYENNTQEMSKEEWSKFPNVVVFVAGLDFLKERGELYVNFLQQKRVKVVKLIEAVDESHVFHVFRPESESTRLLQMQMTQFMNTFN
>rna-XM_023686596.1
MPTINLGQIPSFEEHVNGSDQHDVLVEEIEGLIRVYGNGYVERAQIVPCVSNALPPELDVTSWDVVVNKLSNIWARFYIPKQCQGKLPLLVYFHGGGFCVGSAAWSCYHEFLAKVSAKAECIIMSVNYRLAPENPLPAPYEDGLKAISWLKQVALNGGKQNWWSRYCDFTRIYLGGDSAGGNIAFNVAARLGGKTTASGAVVLKPLVIRGNILIQPFFGGESRTKSEKFLVQPPRSALTMAVSDTYWRLALPSGANRDHPWCNPSAKGLFKVENLRVLPSLVCISELDILKDRNLEFCSALHREGKLINYVVHEGVGHAFQVLNKSQLSQTRTLEMIGHIKAFLCV
>rna-XM_023691534.1
MTNGKSVILDVSGWLRLFDDGSVDRTWTGPPEVKFVAESVPPHDDFIDGVAVRDLVIDRESGLCVRIYLPEVKCSGGGEKLPVVVHFHGGGFCISEADWFMYYHTYTDLVKSAEAICVSVYLRRAPEHRLPAAVDDGFSALRWLQSVALGHEIEPWITENADFNRVFLIGDSSGGNLVHSVAALAGEADLAPVKLAGGIPIHPGFVRAERSKSEIENPQSPFLTLDMVDKFLSLALPEGSTKDHPITCPMGANAPPLETLNLPPFLLCIAEKDLIIDTEMEYYKAMKAANKEVEILMSKGMGHSFYLNKIALKMDPETAAASDHLFAGIARFIKQH
>rna-XM_023690573.1
MHNLSLMTLYGLTKPFARPWYPSSMESGEPETAFELLPLLRVHKNGRIERLIGTDFVPPGTDPLTGVTSKDVTIFPESGVSARLFLPNLTHSTQRLPLVVYFHGGCFCTQSPFTAKYHNYLNALTAEAKVLAVSVNYRKAPEHPVPAAYEDSWAALQWAISHCEGKGPEIWLNKHADFRRLFLAGASAGANIAHNLAMLAGEPDYGENMELVGVALEHPYFWSSARTAKEAEDPMRTRLFERLWGFICPARPENDDPWVNPVAGGAARLAGMGSGRVLVCVAEKDVLRDRGRHYYEALAGSGWLGVAEIVETEDEDHLFHLNDLEGQKAKDLIRRLGAFFNRDMPHSLLR
>rna-XM_023656314.1
MASSTNDVADEFFPFLRIYKDGRIQRLQVTSDIVPACADDPKSAFRAKDVTISVDSALSVRIFIPSAVDLNQKLPLLLYVHGGAFCFESAFNLQYHSHVGSLAAKANAVAVSVEYRLAPENPIPACYDDCWDALRWIAAHVNRDGPEPWLNQHADLDRICLAGDSAGANICHHLAVRAGSSAEQLGRVKVVALALIHPFFGDGAGDRLWKYLCSDTTWLRPTAQDLATLPCRRVKIFLAEKDSLKFGGWNYDEDLKSSGWNGAVETVEHGGEDHVFHLKMPECEKAVDLMEKLACFINLD
>rna-XM_023657201.1
MDSDEISFNAVPYFVIYKDGRIDRLLGEDFDPPGVDPKTGVESKDVVVSPEDSVAVRIYRPKSVAKQARKLPLLVYFHGGGFCVGTAFSSLFHQHINAWVAKANIAAVSVNYRRAPEYQLPIPFEDSWTAMKWVAAHSGGAGPDEWLNEIADLNRVYLAGDSAGGNIAHRMALRVATEGLAGVKIKGLQLVHPHFWGEKLIGEEKEWDPKDIFVVKNLWFVVSKDIKELDDPIVNPEYDPDLGRLPAEKVAVYVAEKDNLKERGRHYAECLRKSGWGGTVEVVETVGEGHVFHLFNPNSDSTVELVRQLAAFTNSDCRG
>rna-XM_023656928.1
MDSTEIAHNFSPLFIVYKDGTVHRLLGNDAIPPSPDPVTGVDSKDVVISPETAVSVRIYRPKPATATAQPQKLPVLVYVHGGGFCIESAFSPFYDRHVKSLVAEANVVAVSVDYRLAPEHPLPIAYEDSWAALKWVAAHSDGNGPEEWLNGIVDLDRVYFAGDSAGANIVHHLAVRVGSEGIGGLNLKGLILVHPYFWGGKLVGDEEKLRAEERHFMEKLWYVTCPTISGLDDPIVNPEYDPKLGQLAAERVVVYVAEKDALKNRGWFYSECLKKSGWGGTVEVVETKGEGHVFHLFNPTTDVALDFVRKLAAFINGNGGRRE
>rna-XM_023656115.1
MASDEIALNAVPYFVVYKDGRIDRLIGNDFDPPGVDPKTGVESKDVVVSPEDSVSVRIYRPKSAAEQAQKLPLLVYFHGGGFCIETAFSPFYHQHINAWVAKANIAAVSVNYRRAPEYQLPIPFEDSWTAMKWVAAHSGGAGPDEWLNEIADLNRVYLAGDSAGGNIAHRMALRVATEGLAGVKIKGLQLIHPHFWGGKLIGEEKEWDPKDIFVVENLWYVVSKDIKELDHPIVNPEHDPDLARLPAEKVAVYVAEKDNLKERGRHYAECLRKSGWGSAVEVVETDGEGHVFHLFNPTCDSAAELVEQLAAFTSSDCRD
>rna-XM_023666726.1
MDSTEIAHNFSPLFIVYKDGTVHRLLGNDAIPPSPDPVTGVDSKDVVISPETAVSVRIYRPKPATATAQPQKLPVLVYVHGGGFCIESAFSPFYDRHVKSLVAEANVVAVSVDYRLAPEHPLPIAYEDSWAALKWVAAHSDGNGPEEWLNGIVDLDRVYFAGDSAGANIVHHLAVRVGSEGIGGLNLKGLILVHPYFWGGKLVGDEEKLRAEERHFMEKLWYVTCPTISGLDDPIVNPEYDPKLGQLAAERVVVYVAEKDALKNRGWFYSECLKKSGWGGTVEVVETKGEGHVFHLFNPTTDVALDFVRKLAAFINGNGGRRE
MRRKRMPINLDQIPSFEEHGNGFDQHSVLVEEIEGLIRVYGNGYVERPQIVPSVSNALPPELGVTSWDVVVDKLNNIWARFYIPTQCQEKLPLLVYFHGGGFCVGSATWSCYHEFLAKLSAKADCIIMSVNYRLAPENPLPAPYEDGLKTLQWLKQVAINGAKQNWWSRYCDFTKIYLGGDSAGGNIAFNVAARLGGKTTASGAVVMKPLVIKGNILIQPFFGGESRTMSEKFLVQPPHSPLTTAVSDTYWRLALPSRTNRDHPWCNPSANGVFEVEDLRVLPSLICISEMDILKDRNLEFCSALHRVGKLINYVVYEGVGHAFQVLNKSQLSQTRTLEMMDHIKDFLSL
>rna-XM_023667597.1
MIFKRMAAMYVDPRLKLQMAKPHLQNGGTSEEIEGLIRVYADGHVERPPIIPNVACSTTASDKGVTAKDVLIDIFTNTWARIYIPNSQRNLPLLVYFHGGGFCVGSAAWSCYHEFLLNLASKAKCVILSINYRLSPENRLPAAYDDGFNALMWLKQQAITNPIEHKWWSGNCNPSKLFLAGDSAGANIVYNTATRLGHNESTLLKPLTLKGIILIQPFFGGESRTKSEKLAATPSSTSALTLSASDTYWRLSLPPTANRDHPWSNPLVNGGAKLKETKLPPLMVCISELDILLDRNLEFCAAMAGAGKKVDRVILKGVGHGFQILNKDQISTQRTQELMGSIRAFIHQQ
>rna-XM_023669803.1
MVAPDSNNPELELELELLPYLRVYKNGVVERLVGTRVTPPGLDSLTGVDSKDITIVPETGITARLYRPTAVEPPRKLPLVVYFHGGAFLITSSAEPIYHNNCLIPLAAATESVVLSVNYRLAPEHPLPAAYEDSWAALQWVAEQSKTSGDEAGQEPWLKQLVDFEKVFLLGDSAGGNIAHHMALRAQNSNLAGKFKIRGIALIQPYFWGEEPIGSEITEPEKKALVDSWWNFVCPSDRGNDDLLINPFADGSPSVEGLVGEKVVVIVAEKDILRDRGMIYYENLAKSNWKGKVDIFETEGEDHAFHLLDPTSEKAKRLVNRLALFVNED
>rna-XM_023676358.1
MDSTAGEEVVFQFLSVFRVFKSGRVERLVPADTVPPSTDSRTGVQSKDVLIDPHTKLSVRIYLPKVSTSAKKLPLLIYIHGGAFSIGSVASSIYHSHLISLAAEANAVAVSVEYRLAPENPLPAAYDDAWKAVEWVASHSNRDGAEMWLNEHADFDRVFIVGDSAGANISYNVVGRASENDNGPEGLKIIGLGLVHPFFMIDKPDKLIEYIFPTSTGLEDPRMNPWANPGLGRFRCNRVLIIAAEHDFLNDRARGFHAALRESGWKGSVEMVENEGEDHVFHLFNPDCEKAVALVKKVASFIQSDSNEAEMGTRPSSL
>rna-XM_023678307.1
MATSSPFEVDECRGVLRVYSDGSIVRSSNPSFNVPVLDDGSVLWKDLLFDPINHLHLRLYKPAVSSSTLPVFFYIHGGGFCIGSRTWPNCQNYCFRLALELPALVISPDYRLAPENRLPAAIDGGFAAVRWLQAQAQSDHPDPWLADVADFSRVFISGDSAGGNIAHHLAVGLGLGSPALAPVRVRGYVLLAPFFGGTVRTRSEAEGPKDAFLNLELIDRFWRLSIPIGSSTDHPLVNVLGQSSQDLEAVEVDPILVVVGGADLLKDRAVEYAETLKKQGKKIELVEFEGKQHGFFTIDPNSEASNQLMLLLKQFVARHSG
>rna-XM_023678869.1
MASDEIALNAAPWFIIYKDRRIDRLIGNDIDPPGLDPKTGVESKDVVISQEDSVAVRIYRPKSAAGAGKGDQKLPLLVYFHGGGFCIETAFSPFYHQHLNPWVAQANIVAVSVNYRRAPEHQLPIPFEDSWTALKWIAAHSNGTGPDEWLNEIADLNQVYLAGDSAGGNIAHRMTLRMATEGLAGVKIKGLQLIHPHFWGGKLIGEEKEWDPKSIYVVENLWYWVSKDIKDLDDPIVNPEHEPALGRLAAEKVAIYVAEKDNLKERGRHYAECLRKSGWGGTVDVVETDGEGHVFHLFNPTCDSAADLVGQLAAFISGKCGC
>rna-XM_023680498.1
MCSTSYSIFRARMALIGEAPGFLEVYSDGSVRRLIPEVVVSTDNQSSKNYKFKDVVIDPKKPVTGRLFLPNVTGNHVAKLPILVYFHGGGFCIGSTTWMGYHHFLGGLAVASNCVILSIDYRLAPENRLPAAYEDCYSSLEWLAHQASCFEPWLQNADLSRVFLSGDSAGGNIVHHVAVKTMKTNISNMTLKGLMLIHPYFGSEKRTEKEKAEGVEGFVEMNDMFWRLSIPKGSNRDYFGCNYENNTQEMSKEEWSKFPNVVVFVAGLDFLKERGELYVNFLQQKRVKVVKLIEAVDESHVFHVFRPESESTRLLQMQMTQFMNTFN
>rna-XM_023686596.1
MPTINLGQIPSFEEHVNGSDQHDVLVEEIEGLIRVYGNGYVERAQIVPCVSNALPPELDVTSWDVVVNKLSNIWARFYIPKQCQGKLPLLVYFHGGGFCVGSAAWSCYHEFLAKVSAKAECIIMSVNYRLAPENPLPAPYEDGLKAISWLKQVALNGGKQNWWSRYCDFTRIYLGGDSAGGNIAFNVAARLGGKTTASGAVVLKPLVIRGNILIQPFFGGESRTKSEKFLVQPPRSALTMAVSDTYWRLALPSGANRDHPWCNPSAKGLFKVENLRVLPSLVCISELDILKDRNLEFCSALHREGKLINYVVHEGVGHAFQVLNKSQLSQTRTLEMIGHIKAFLCV
>rna-XM_023691534.1
MTNGKSVILDVSGWLRLFDDGSVDRTWTGPPEVKFVAESVPPHDDFIDGVAVRDLVIDRESGLCVRIYLPEVKCSGGGEKLPVVVHFHGGGFCISEADWFMYYHTYTDLVKSAEAICVSVYLRRAPEHRLPAAVDDGFSALRWLQSVALGHEIEPWITENADFNRVFLIGDSSGGNLVHSVAALAGEADLAPVKLAGGIPIHPGFVRAERSKSEIENPQSPFLTLDMVDKFLSLALPEGSTKDHPITCPMGANAPPLETLNLPPFLLCIAEKDLIIDTEMEYYKAMKAANKEVEILMSKGMGHSFYLNKIALKMDPETAAASDHLFAGIARFIKQH
>rna-XM_023690573.1
MHNLSLMTLYGLTKPFARPWYPSSMESGEPETAFELLPLLRVHKNGRIERLIGTDFVPPGTDPLTGVTSKDVTIFPESGVSARLFLPNLTHSTQRLPLVVYFHGGCFCTQSPFTAKYHNYLNALTAEAKVLAVSVNYRKAPEHPVPAAYEDSWAALQWAISHCEGKGPEIWLNKHADFRRLFLAGASAGANIAHNLAMLAGEPDYGENMELVGVALEHPYFWSSARTAKEAEDPMRTRLFERLWGFICPARPENDDPWVNPVAGGAARLAGMGSGRVLVCVAEKDVLRDRGRHYYEALAGSGWLGVAEIVETEDEDHLFHLNDLEGQKAKDLIRRLGAFFNRDMPHSLLR
>rna-XM_023656314.1
MASSTNDVADEFFPFLRIYKDGRIQRLQVTSDIVPACADDPKSAFRAKDVTISVDSALSVRIFIPSAVDLNQKLPLLLYVHGGAFCFESAFNLQYHSHVGSLAAKANAVAVSVEYRLAPENPIPACYDDCWDALRWIAAHVNRDGPEPWLNQHADLDRICLAGDSAGANICHHLAVRAGSSAEQLGRVKVVALALIHPFFGDGAGDRLWKYLCSDTTWLRPTAQDLATLPCRRVKIFLAEKDSLKFGGWNYDEDLKSSGWNGAVETVEHGGEDHVFHLKMPECEKAVDLMEKLACFINLD
>rna-XM_023657201.1
MDSDEISFNAVPYFVIYKDGRIDRLLGEDFDPPGVDPKTGVESKDVVVSPEDSVAVRIYRPKSVAKQARKLPLLVYFHGGGFCVGTAFSSLFHQHINAWVAKANIAAVSVNYRRAPEYQLPIPFEDSWTAMKWVAAHSGGAGPDEWLNEIADLNRVYLAGDSAGGNIAHRMALRVATEGLAGVKIKGLQLVHPHFWGEKLIGEEKEWDPKDIFVVKNLWFVVSKDIKELDDPIVNPEYDPDLGRLPAEKVAVYVAEKDNLKERGRHYAECLRKSGWGGTVEVVETVGEGHVFHLFNPNSDSTVELVRQLAAFTNSDCRG
>rna-XM_023656928.1
MDSTEIAHNFSPLFIVYKDGTVHRLLGNDAIPPSPDPVTGVDSKDVVISPETAVSVRIYRPKPATATAQPQKLPVLVYVHGGGFCIESAFSPFYDRHVKSLVAEANVVAVSVDYRLAPEHPLPIAYEDSWAALKWVAAHSDGNGPEEWLNGIVDLDRVYFAGDSAGANIVHHLAVRVGSEGIGGLNLKGLILVHPYFWGGKLVGDEEKLRAEERHFMEKLWYVTCPTISGLDDPIVNPEYDPKLGQLAAERVVVYVAEKDALKNRGWFYSECLKKSGWGGTVEVVETKGEGHVFHLFNPTTDVALDFVRKLAAFINGNGGRRE
>rna-XM_023656115.1
MASDEIALNAVPYFVVYKDGRIDRLIGNDFDPPGVDPKTGVESKDVVVSPEDSVSVRIYRPKSAAEQAQKLPLLVYFHGGGFCIETAFSPFYHQHINAWVAKANIAAVSVNYRRAPEYQLPIPFEDSWTAMKWVAAHSGGAGPDEWLNEIADLNRVYLAGDSAGGNIAHRMALRVATEGLAGVKIKGLQLIHPHFWGGKLIGEEKEWDPKDIFVVENLWYVVSKDIKELDHPIVNPEHDPDLARLPAEKVAVYVAEKDNLKERGRHYAECLRKSGWGSAVEVVETDGEGHVFHLFNPTCDSAAELVEQLAAFTSSDCRD
>rna-XM_023666726.1
MDSTEIAHNFSPLFIVYKDGTVHRLLGNDAIPPSPDPVTGVDSKDVVISPETAVSVRIYRPKPATATAQPQKLPVLVYVHGGGFCIESAFSPFYDRHVKSLVAEANVVAVSVDYRLAPEHPLPIAYEDSWAALKWVAAHSDGNGPEEWLNGIVDLDRVYFAGDSAGANIVHHLAVRVGSEGIGGLNLKGLILVHPYFWGGKLVGDEEKLRAEERHFMEKLWYVTCPTISGLDDPIVNPEYDPKLGQLAAERVVVYVAEKDALKNRGWFYSECLKKSGWGGTVEVVETKGEGHVFHLFNPTTDVALDFVRKLAAFINGNGGRRE
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University