Enzyme
A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in flavonoid biosynthesis.
C4H
Enzyme
Cinnamate 4-hydroxylase
Enzyme name
EC:1.14.14.91
Entry
Oxidoreductases;Acting on paired donors, with incorporation or reduction of molecular oxygen;With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Class
trans-cinnamate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
Sysname
trans-cinnamate + [reduced NADPH---hemoprotein reductase] + O2 = 4-hydroxycinnamate + [oxidized NADPH---hemoprotein reductase] + H2O[RN:R02253]
Reaction
4-hydroxycinnamate [CPD:C00811];[oxidized NADPH---hemoprotein reductase] [CPD:C03161];H2O [CPD:C00001]
Product
Species information
Cucurbita pepo
Species name
Cucurbita pepo is a species of eudicot in the family Cucurbitaceae (cucumber family).
Species info
Gene sequence info
Cucurbita_pepo.C4H.fa
Download
>rna-XM_023667431.1
MDLLLLEKALLGLFVAMVVAITISKLRGKRFKLPPGPIPIPIFGNWLQVGDDLNHRNLTEMAKKFGDILLLRMGQRNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTDKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQNRLGWEEEASRVVEDLKNDPKASTSGVVLRRRLQLLMYNNMYRIMFDRRFDSMEDPLFNKLKLINAERSRLSQSFEYNYGDFIPILRPFLRGYLNVCKDVKERRLKLFKDNFVDERRRLTSTMSNKEDSVKCAIDHIVEAQENGEITEANVLFIVENINVAAIETTLWSMEWAIAELVNHANIQKKLRDELDSVLGHGVQITEPDIRNLPYLQAVIKETMRLRMAIPLLVPHMNLLDAKLAGYDIPAESKILVNAWWLANNPDHWNKPHEFRPERFLEEEADVEPSGNDFRYLPFGAGRRSCPGIVLALPIVAITLGRLIQNFELLPPPGQSKIDTTEKPGQFSLQILNHSTIVAKPRSF
>rna-XM_023678028.1
MDLLLLEKTLVGLFVAVVLAIAISKLRGKRFKLPPGPLPVPIFGNWLQVGDDLNHRNLTDLAKKFGDIFLLRMGQRNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRYGWEYEAASVVEDVKKNPESATSGIVLRRRLQLMMYNNMYRIMFDRRFESEDDPLFQKLRALNGERSRLAQSFDYNYGDFIPILRPFLRGYLKICKEVKETRLKLFKDYFVEERKKLANTKSTSNEGLKCAIDHILDAQQKGEINEDNVLYIVENINVAAIETTLWSIEWGIAELVNHPEIQRKLRNELDTVLGVDVPITEPDTHKLPYLQAVIKETLRLRMAIPLLVPHMNLHDAKLGGYDIPAESKILVNAWWLANNPANWKDPEVFRPERFLEEESKVEANGNDFRYLPFGVGRRSCPGIILALPILGITIGRLIQNFELLPPPGHSKLDTSEKGGQFSLHILKHSTIVAKPRVF
>rna-XM_023681263.1
MAHSTTKLAFLSLVSLLLLGLLTKFLFISLNILLITLSIAFVFAIILFSNSSNTPPGPLPIPIFGNWLQVGNDLNHRVLASLAQKYGSVFRLKLGYKNLVVVSDVELARQVLHAQGAEFGSRPRNVVFDVFTSNGQDMVFTIYGEHWRKMRRIMTQPLFTNNVVHTYSGTWEEEMDLVVRDLKNNSKVRFEGLVIRKPLQLMMYNIMYRMMFDSKFESQDDPLYIEVTRLNSERMRLAQSSEYNYGDFIPFLKPFLRGYLNKCKELRNERLAFFNVNYVEKRRKIMEANGDEHKTSCAIDHIINAQLKGEISEENVLYIIENINVAAIQTTLRSMEWLIVELVNHPTVQQKIRDELSTVLKEMKVTPSNLHELPYLQAVVKETLRLRIPVPLLVPHMNLKEAKLGGYTIPKESKVMVNAWWLGNNPAWWKNPEEFRPERFLQEESSTEVTVGGNVDFRLVPFGVGRRSCPGIVVAMPILGMFIAKLVTNFEMKPPNGMEKIDVQEKGGPFSLYIANPSTVAFEPISV
>rna-XM_023690003.1
MASTALLSLSTMLIVSLVTKFIFPMSPIALGVTIFLAPLLTYIISSMAFSSKLPPGPLSLPIFGNWLQVGNDLNHRLLASLCNTFGSIFLLKLGSKNLVVVSDAELASQVLHAQGVEFGSRPRNVVFDIFTGNGQDMVFTVYGDHWRKMRRIMTLPFFTNKVVHNYSGMWEDEMDSVVRDLRSNKKFQSEGIVIRKRLQLMLYNIMYRMMFDAKFESQDDPLFIEATRFNSERSRLAQSFEYNYGDFIPLLRPFLRGYLNKCRDLQGRRLDFFNKNYVEKRRKIMAANGDKHKISCAMDHIIDAQLKGEISEENVIYIVENINVAAIETTLWSMEWAIAELVNHPDIQHKIREELKNVLKGKEVSESKLHELPYLQATVKETLRLHTPIPLLVPHMNLEEAKLGGYTIPKESKVVVNAWWLANNPEWWKNPEEFRPERFFEEESGTEAVAAGKVDYRFLPFGVGRRSCPGIVLAMPILGLILAKLVSNFEMKPPSGMEKVDVTEKGGQFSLHIANHSTVVFNPIMA
>rna-XM_023690004.1
MASTALLSLSTMLIVSLVTKFIFPMSPIALGVTIFLAPLLTYIISSMAFSSKLPPGPLSLPIFGNWLQVGNDLNHRLLASLCNTFGSIFLLKLGSKNLVVVSDAELASQVLHAQGVEFGSRPRNVVFDIFTGNGQDMVFTVYGDHWRKMRRIMTLPFFTNKVVHNYSGMWEDEMDSVVRDLRSNKKFQSEGIVIRKRLQLMLYNIMYRMMFDAKFESQDDPLFIEATRFNSERSRLAQSFEYNYGDFIPLLRPFLRGYLNKCRDLQGRRLDFFNKNYVEKRRKIMAANGDKHKISCAMDHIIDAQLKGEISEENVIYIVENINVAAIETTLWSMEWAIAELVNHPDIQHKIREELKNVLKGKEVSESKLHELPYLQATVKETLRLHTPIPLLVPHMNLEEAKLGGYTIPKESKVVVNAWWLANNPEWWKNPEEFRPERFFEEESGTEAVAAGKVDYRFLPFGVGRRSCPGIVLAMPILGLILAKLVSNFEMKPPSGMEKVDVTEKGGQFSLHIANHSTVVFNPIIA
>rna-XM_023657095.1
MDLLLLEKALIGLFIAMVLAIAISKLRGKRFKLPPGPLPVPIFGNWLQVGDDLNHRNLTDLAKKFGDIFMLRMGQRSLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRQGWEDEAASVVEDVKKNPESATTGVVLRRRLQLMMYNNMYRIMFDRRFESEDDPLFLKLRALNGERSRLAQSFDYNYGDFIPILRPFLRGYLKTCKEVKETRLKLFKDYFVDERKKLTNTKKTTNEGLKCAIDHMLDAQQKGEINEDNLLYIVENINVAAIETTLWSIEWGIAELVNHPEIQRKLRNELDTVLGPGVQITEPDAIKLPYLQAVIKETLRLRMAIPLLVPHMNLHNAKLGGYDIPAESKILVNAWWLANNPGNWKNPEEFRPERFLEEESKVEANGNDFRYLPFGVGRRSCPGIILALPILAITIGRLVQNFELLPPPGHSKLDTTEKGGQFSLHILKHSTIVAKPRVF
>rna-XM_023665407.1
MDLLLLEKALLGLFVAMVVAITISKLRGKRFKLPPGPIPIPIFGNWLQVGDDLNHRNLTEMAKKFGDILLLRMGQRNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTDKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQNRLGWEEEASRVVEDLKNDPKASTSGVVLRRRLQLLMYNNMYRIMFDRRFDSMEDPLFNKLKLINAERSRLSQSFEYNYGDFIPILRPFLRGYLNVCKDVKERRLKLFKDNFVDERRRLTSTMSNKEDSVKCAIDHIVEAQENGEITEANVLFIVENINVAAIETTLWSMEWAIAELVNHPNIQKKLKDELDSVLGHGVQITEPDIRNLPYLQAVIKETMRLRMAIPLLVPHMNLLDAKLAGYDIPAESKILVNAWWLANNPDHWNKPHEFRPERFLEEEADVEPSGNDFRYLPFGAGRRSCPGIVLALPIVAITLGRLIQNFELLPPPGQSKIDTTEKPGQFSLQILNHSTIVAKPRSF
>rna-XM_023667186.1
MIKLSNFNRKIMAANGDKHKISCAMDHIIDAQLKGEISEENVIYIVENINVAAIETTLWSMEWAIAELVNHPDIQHKIREELKNVLKGKEVSESKLHELPYLQATVKETLRLHTPIPLLVPHMNLEEAKLGGYTIPKESKVVVNAWWLANNPEWWKNPEEFRPERFFEEESGTEAVAAGKVDYRFLPFGVGRRSCPGIVLAMPILGLILAKLVSNFEMKPPSGMEKVDVTEK
MDLLLLEKALLGLFVAMVVAITISKLRGKRFKLPPGPIPIPIFGNWLQVGDDLNHRNLTEMAKKFGDILLLRMGQRNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTDKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQNRLGWEEEASRVVEDLKNDPKASTSGVVLRRRLQLLMYNNMYRIMFDRRFDSMEDPLFNKLKLINAERSRLSQSFEYNYGDFIPILRPFLRGYLNVCKDVKERRLKLFKDNFVDERRRLTSTMSNKEDSVKCAIDHIVEAQENGEITEANVLFIVENINVAAIETTLWSMEWAIAELVNHANIQKKLRDELDSVLGHGVQITEPDIRNLPYLQAVIKETMRLRMAIPLLVPHMNLLDAKLAGYDIPAESKILVNAWWLANNPDHWNKPHEFRPERFLEEEADVEPSGNDFRYLPFGAGRRSCPGIVLALPIVAITLGRLIQNFELLPPPGQSKIDTTEKPGQFSLQILNHSTIVAKPRSF
>rna-XM_023678028.1
MDLLLLEKTLVGLFVAVVLAIAISKLRGKRFKLPPGPLPVPIFGNWLQVGDDLNHRNLTDLAKKFGDIFLLRMGQRNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRYGWEYEAASVVEDVKKNPESATSGIVLRRRLQLMMYNNMYRIMFDRRFESEDDPLFQKLRALNGERSRLAQSFDYNYGDFIPILRPFLRGYLKICKEVKETRLKLFKDYFVEERKKLANTKSTSNEGLKCAIDHILDAQQKGEINEDNVLYIVENINVAAIETTLWSIEWGIAELVNHPEIQRKLRNELDTVLGVDVPITEPDTHKLPYLQAVIKETLRLRMAIPLLVPHMNLHDAKLGGYDIPAESKILVNAWWLANNPANWKDPEVFRPERFLEEESKVEANGNDFRYLPFGVGRRSCPGIILALPILGITIGRLIQNFELLPPPGHSKLDTSEKGGQFSLHILKHSTIVAKPRVF
>rna-XM_023681263.1
MAHSTTKLAFLSLVSLLLLGLLTKFLFISLNILLITLSIAFVFAIILFSNSSNTPPGPLPIPIFGNWLQVGNDLNHRVLASLAQKYGSVFRLKLGYKNLVVVSDVELARQVLHAQGAEFGSRPRNVVFDVFTSNGQDMVFTIYGEHWRKMRRIMTQPLFTNNVVHTYSGTWEEEMDLVVRDLKNNSKVRFEGLVIRKPLQLMMYNIMYRMMFDSKFESQDDPLYIEVTRLNSERMRLAQSSEYNYGDFIPFLKPFLRGYLNKCKELRNERLAFFNVNYVEKRRKIMEANGDEHKTSCAIDHIINAQLKGEISEENVLYIIENINVAAIQTTLRSMEWLIVELVNHPTVQQKIRDELSTVLKEMKVTPSNLHELPYLQAVVKETLRLRIPVPLLVPHMNLKEAKLGGYTIPKESKVMVNAWWLGNNPAWWKNPEEFRPERFLQEESSTEVTVGGNVDFRLVPFGVGRRSCPGIVVAMPILGMFIAKLVTNFEMKPPNGMEKIDVQEKGGPFSLYIANPSTVAFEPISV
>rna-XM_023690003.1
MASTALLSLSTMLIVSLVTKFIFPMSPIALGVTIFLAPLLTYIISSMAFSSKLPPGPLSLPIFGNWLQVGNDLNHRLLASLCNTFGSIFLLKLGSKNLVVVSDAELASQVLHAQGVEFGSRPRNVVFDIFTGNGQDMVFTVYGDHWRKMRRIMTLPFFTNKVVHNYSGMWEDEMDSVVRDLRSNKKFQSEGIVIRKRLQLMLYNIMYRMMFDAKFESQDDPLFIEATRFNSERSRLAQSFEYNYGDFIPLLRPFLRGYLNKCRDLQGRRLDFFNKNYVEKRRKIMAANGDKHKISCAMDHIIDAQLKGEISEENVIYIVENINVAAIETTLWSMEWAIAELVNHPDIQHKIREELKNVLKGKEVSESKLHELPYLQATVKETLRLHTPIPLLVPHMNLEEAKLGGYTIPKESKVVVNAWWLANNPEWWKNPEEFRPERFFEEESGTEAVAAGKVDYRFLPFGVGRRSCPGIVLAMPILGLILAKLVSNFEMKPPSGMEKVDVTEKGGQFSLHIANHSTVVFNPIMA
>rna-XM_023690004.1
MASTALLSLSTMLIVSLVTKFIFPMSPIALGVTIFLAPLLTYIISSMAFSSKLPPGPLSLPIFGNWLQVGNDLNHRLLASLCNTFGSIFLLKLGSKNLVVVSDAELASQVLHAQGVEFGSRPRNVVFDIFTGNGQDMVFTVYGDHWRKMRRIMTLPFFTNKVVHNYSGMWEDEMDSVVRDLRSNKKFQSEGIVIRKRLQLMLYNIMYRMMFDAKFESQDDPLFIEATRFNSERSRLAQSFEYNYGDFIPLLRPFLRGYLNKCRDLQGRRLDFFNKNYVEKRRKIMAANGDKHKISCAMDHIIDAQLKGEISEENVIYIVENINVAAIETTLWSMEWAIAELVNHPDIQHKIREELKNVLKGKEVSESKLHELPYLQATVKETLRLHTPIPLLVPHMNLEEAKLGGYTIPKESKVVVNAWWLANNPEWWKNPEEFRPERFFEEESGTEAVAAGKVDYRFLPFGVGRRSCPGIVLAMPILGLILAKLVSNFEMKPPSGMEKVDVTEKGGQFSLHIANHSTVVFNPIIA
>rna-XM_023657095.1
MDLLLLEKALIGLFIAMVLAIAISKLRGKRFKLPPGPLPVPIFGNWLQVGDDLNHRNLTDLAKKFGDIFMLRMGQRSLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRQGWEDEAASVVEDVKKNPESATTGVVLRRRLQLMMYNNMYRIMFDRRFESEDDPLFLKLRALNGERSRLAQSFDYNYGDFIPILRPFLRGYLKTCKEVKETRLKLFKDYFVDERKKLTNTKKTTNEGLKCAIDHMLDAQQKGEINEDNLLYIVENINVAAIETTLWSIEWGIAELVNHPEIQRKLRNELDTVLGPGVQITEPDAIKLPYLQAVIKETLRLRMAIPLLVPHMNLHNAKLGGYDIPAESKILVNAWWLANNPGNWKNPEEFRPERFLEEESKVEANGNDFRYLPFGVGRRSCPGIILALPILAITIGRLVQNFELLPPPGHSKLDTTEKGGQFSLHILKHSTIVAKPRVF
>rna-XM_023665407.1
MDLLLLEKALLGLFVAMVVAITISKLRGKRFKLPPGPIPIPIFGNWLQVGDDLNHRNLTEMAKKFGDILLLRMGQRNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTDKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQNRLGWEEEASRVVEDLKNDPKASTSGVVLRRRLQLLMYNNMYRIMFDRRFDSMEDPLFNKLKLINAERSRLSQSFEYNYGDFIPILRPFLRGYLNVCKDVKERRLKLFKDNFVDERRRLTSTMSNKEDSVKCAIDHIVEAQENGEITEANVLFIVENINVAAIETTLWSMEWAIAELVNHPNIQKKLKDELDSVLGHGVQITEPDIRNLPYLQAVIKETMRLRMAIPLLVPHMNLLDAKLAGYDIPAESKILVNAWWLANNPDHWNKPHEFRPERFLEEEADVEPSGNDFRYLPFGAGRRSCPGIVLALPIVAITLGRLIQNFELLPPPGQSKIDTTEKPGQFSLQILNHSTIVAKPRSF
>rna-XM_023667186.1
MIKLSNFNRKIMAANGDKHKISCAMDHIIDAQLKGEISEENVIYIVENINVAAIETTLWSMEWAIAELVNHPDIQHKIREELKNVLKGKEVSESKLHELPYLQATVKETLRLHTPIPLLVPHMNLEEAKLGGYTIPKESKVVVNAWWLANNPEWWKNPEEFRPERFFEEESGTEAVAAGKVDYRFLPFGVGRRSCPGIVLAMPILGLILAKLVSNFEMKPPSGMEKVDVTEK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University