Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Coptis chinensis
Species name
Coptis chinensis is a species of flowering plant in the family Ranunculaceae (buttercup family).
Species info
Gene sequence info
Coptis_chinensis.CHS.fa
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>rna-gnl|WGS:JADFTS|Cch00014281-RA
MQSVEEIRTAQRAKGPATVLAIGTANPSNCVYQADYPDFYFRITESEHLTDLKRKFQRMCEKSGIKKRYMYLTEEILKENPNIRAYMAPSLDARQDMVVVEVPKLGKEAATKAIKEWGQPKSKITHVVFCTTSGVDMPGADYQLAKLLGLSPTVKRLMMYQQGCFAGGTVLRIAKDLAENNAGARVLVVCSEITAVTFRGPSDAHLDSLVGQALFGDGAAAVIVGADPDTSIERPIFQLVSAFQTILPDSEGAIDGHVREAGLTFHLLRDVPGIISKNIEKSLVGAFKPIGITDWNSLFWIVHPGGPAILDQVEQKVALKEEKMKTTRHVLSEYGNMSSACVLFVMDEMRKKSLEEGKSTTGEGLDWGVLFGFGPGLTIETVVLHSVSTI
>rna-gnl|WGS:JADFTS|Cch00009592-RA
MVSLETTQGCLARTANPGKTTILALGKAFPHQLVMQELLVDGYFRNTKCDDPELKQKLARLCKTTTVKTRYVVMSEEILKEYPELALEGLPTVRQRLEISNKAVTDMAIEASQACIKNWGRPVSDITHLVYVSSSEARLPGGDLYLARGLGLSPEVNRVMLYFMGCSGGVAGLRVAKDIAENNPGSRILLATSETTIIGFKPPNPDRPYDLVGAALFGDGAGAMLLGSNPQPGVERPLFELYTAIQNFLPDTEKTIDGRLTEEGISFKLGRDLPQIIEDNIEAFCAKLMGVVGFNTEYNKLFWAVHPGGPAILNRLEKRLDLLPEKLTASRKALMDYGNASSNTIVYVLENMIEENLKKDKTDDDCEWGLILAFGPGITFEGILARSLV
>rna-gnl|WGS:JADFTS|Cch00005988-RA
MGNNGRLATVLAIGTATPPNCYVQSDYPDFYFRVTKSEKSMVRKRYLHLTESMLEENPNLCAYMAPSLDVRQDIAAIVVQKLSEDAVETALKEWGQPKSKITHLVVHATSGIDIPGLDYQLTKQLGLPLNIKRFMLYHQGCHAGGTVLRLAKDLAENNEGARVLVICCELNGILSFRGPSEDNPSNLVGMAVVADGAAALIVGANPDKLLSELPLFELVSASQTILPVSDNALQAQLRGRAILDRIEAKLGLNEDKLSASRHVLSEYGNMASACVLFILDELRKRAVEKMQVTTGEGFSLGVLLGYGPGLTVETIVLRGLSVEKSN
>rna-gnl|WGS:JADFTS|Cch00004126-RA
MLEENPNLCAYMAPSLNVRQDIAVIGVQKLSEDAVDTALKEWGQPKSKITLSVVHTISGIDIPGLDYQLTKQLGLPLIIKQFMLYHQGCHAGGTILHLAKDLSKNNEAQQDAI
>rna-gnl|WGS:JADFTS|Cch00026363-RA
MSRIDLNGTKNHNANNTHGSPKRTCTPGKATILALGKAFPSQLIPQEHLVEGYCRDTKCEDPAMKEKLERLCKNTTVKTRYTVMSKEILEKYPELVTEGSPTIRQRLEIANQAVVEMALDASLSCIKEWGRPVGEITHLVYVSSSEIRLPGGDLYLSSQLGLRNTVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPSMDRPYDLVGAALFGDGAAAVIIGSDPITGIENPFMELNFAVQQFLPGTQHIIDGRLSEEGINFKLGRDLPQKIEDNIEEFCKTLMEKENLKNFNDLFWAVHPGGPAILNKLERNLKLQAEKLQCSRRALMDFGNVSSNTIFYVLDYIREELKLSGEEWGLALAFGPGITFEGILVRSLQS
>rna-gnl|WGS:JADFTS|Cch00013399-RA
MVSIDEIRRSQRADGTATVMAIGTANPPNCFDQSTYPDYYFRVTKSEQNTRLKDKFKRLCEKTTIKKRYMHVTEDILKENPSMCTYNAPSLNARQDIFISEIPKLGKEAATKAIKEWGQPKSKITHLIFCTTVGADMPGADYQLTELLGLSSSIKRIMMYQQGCFAGGTALRVAKDLAENNKGARVLVVCCEMQSFTFSTPSDTDFEALIRSAIFGDGAAAVIIGADPVIGAENPLFEVVSASQTIVPGSNGAVAGHLREEGLTVHLRRDLPMLVSNNIEKSLEEAFHPLGISDWNSLFWIAHPGGPAILDQVEEKLNLEPEKLGVTRQVLSEYGNMSSASVLFILDQMRKKSVQEELKTTGGGLEWGVLFGFGAGLTVETVVLHSVLI
>rna-gnl|WGS:JADFTS|Cch00018587-RA
AAAKAIEEWGQPKSKITHVVFCSLNGVDMPGADYQLTKLLGLEPTVKRFMFYAQGSDDAILGQMREEEGMTLYLQKDTVPEMIGDNIKKSVEEAFGPLGISDWNSLFWMVHPGGSAVVEQNGVRSLGLDLALQLRLWCSTTACSECVNTQ
>rna-gnl|WGS:JADFTS|Cch00018591-RA
MSGTWKMLKEAGDALYQECRPAAPPLCFSVVQHHTLPMDIERRACILLTCKGKGSLIKKRYMYMNEDILGKNPSMCVYNAPSLNASQKLVVDEIPKLGKEAAAKAIEEWGQPKSKITHVVFCSLNGVDIPGGDYQLTKLLGLEPTVKRFMFYAQGCFRGAMLGKNPSMCVYNAPSLNASQKLVVDEIPKLGQEAAAKVIEEWGQPKSKITHVVFCNLNGVDMPGEDYQLTKLLGLEPTVKRFMFYALSSEITSISNFTCPNPISGIEHPLSELVSASQTILPASNDAILGHMREEEGMTLYLQKDTVPEMTGDNIKKSVEEAFGPLGISDWNSLFWMVHPGGRAVVEQVKDKLNLKPGKLTASRQVMHDYGNMSSATVLFVID
>rna-gnl|WGS:JADFTS|Cch00018589-RA
MQYYSRNEIPICQLKLTTSSSGRGKSRTGDPYGPSKIASTLGKQVASEEPCCYLAENNWGAGQAIQGDGAAAVIVGADPISGIEHPLFELVSASQTILPVHPGGRAVVEQVEDKLNLKPGKLTASRQVMYDYGNMSSATVLYVIDEMRKKSAEERHKTTGEGLEWGALIGFELWIWHYS
>rna-gnl|WGS:JADFTS|Cch00018593-RA
MVSIDEIRRAQRADGPATVMAIGTATPPNCVDQSTYADYYFRITKSEHKTELKEKFKRMCEKSMIKRRYMYLTEDILKESPNLCAFQAPSLDARQDIVVVEVPKLGKEAATRAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRLAKDLAENNRGARVLVVCSEITAVTFRGPSDSHLDSLVGQALFGDGAAAMIIGADPIIGVEKPLFELVSAAQTLLPNSEGAIDGHLREEGLTFHLLKDVPGLISKHIEKSLEEAFAPLGISDWNSLFWIAHPGGPAILDQVEDKLNLEPKKLCATRQVLSEYGNMSSACVIFIMDEMRKKSVQEGFKTTGEGLEWGVLFGFGPGLTVETVVLHSVLT
>rna-gnl|WGS:JADFTS|Cch00006196-RA
MTMVTVEEIRKLQRADGPATVLAIGTATPSNCVYQADYPDYYFRITKSDHMTDLKEKFKRMCDKSTIRKRHMHLSEEILKENPNMCAYMAPSLDARQDIVVHEVPRLGKEAASKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRSSVKRLMMYQQGCFAGGTVIRLAKDLAENNRGARVLVVCSEITAVTFRGPTDTHLDSLVGQALFGDGAGAMIIGADPDMSIERPLFELVSAAQTILPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLVEAFTPLGISDWNSLFWIAHPGGPAILDQVELKLGLKEEKLRATRHILSEYGNMSSACVLFILDEMRKKSVEEGKATTGDGLEWGVLFGFGPGLTVETVVLHSLPATETH
MQSVEEIRTAQRAKGPATVLAIGTANPSNCVYQADYPDFYFRITESEHLTDLKRKFQRMCEKSGIKKRYMYLTEEILKENPNIRAYMAPSLDARQDMVVVEVPKLGKEAATKAIKEWGQPKSKITHVVFCTTSGVDMPGADYQLAKLLGLSPTVKRLMMYQQGCFAGGTVLRIAKDLAENNAGARVLVVCSEITAVTFRGPSDAHLDSLVGQALFGDGAAAVIVGADPDTSIERPIFQLVSAFQTILPDSEGAIDGHVREAGLTFHLLRDVPGIISKNIEKSLVGAFKPIGITDWNSLFWIVHPGGPAILDQVEQKVALKEEKMKTTRHVLSEYGNMSSACVLFVMDEMRKKSLEEGKSTTGEGLDWGVLFGFGPGLTIETVVLHSVSTI
>rna-gnl|WGS:JADFTS|Cch00009592-RA
MVSLETTQGCLARTANPGKTTILALGKAFPHQLVMQELLVDGYFRNTKCDDPELKQKLARLCKTTTVKTRYVVMSEEILKEYPELALEGLPTVRQRLEISNKAVTDMAIEASQACIKNWGRPVSDITHLVYVSSSEARLPGGDLYLARGLGLSPEVNRVMLYFMGCSGGVAGLRVAKDIAENNPGSRILLATSETTIIGFKPPNPDRPYDLVGAALFGDGAGAMLLGSNPQPGVERPLFELYTAIQNFLPDTEKTIDGRLTEEGISFKLGRDLPQIIEDNIEAFCAKLMGVVGFNTEYNKLFWAVHPGGPAILNRLEKRLDLLPEKLTASRKALMDYGNASSNTIVYVLENMIEENLKKDKTDDDCEWGLILAFGPGITFEGILARSLV
>rna-gnl|WGS:JADFTS|Cch00005988-RA
MGNNGRLATVLAIGTATPPNCYVQSDYPDFYFRVTKSEKSMVRKRYLHLTESMLEENPNLCAYMAPSLDVRQDIAAIVVQKLSEDAVETALKEWGQPKSKITHLVVHATSGIDIPGLDYQLTKQLGLPLNIKRFMLYHQGCHAGGTVLRLAKDLAENNEGARVLVICCELNGILSFRGPSEDNPSNLVGMAVVADGAAALIVGANPDKLLSELPLFELVSASQTILPVSDNALQAQLRGRAILDRIEAKLGLNEDKLSASRHVLSEYGNMASACVLFILDELRKRAVEKMQVTTGEGFSLGVLLGYGPGLTVETIVLRGLSVEKSN
>rna-gnl|WGS:JADFTS|Cch00004126-RA
MLEENPNLCAYMAPSLNVRQDIAVIGVQKLSEDAVDTALKEWGQPKSKITLSVVHTISGIDIPGLDYQLTKQLGLPLIIKQFMLYHQGCHAGGTILHLAKDLSKNNEAQQDAI
>rna-gnl|WGS:JADFTS|Cch00026363-RA
MSRIDLNGTKNHNANNTHGSPKRTCTPGKATILALGKAFPSQLIPQEHLVEGYCRDTKCEDPAMKEKLERLCKNTTVKTRYTVMSKEILEKYPELVTEGSPTIRQRLEIANQAVVEMALDASLSCIKEWGRPVGEITHLVYVSSSEIRLPGGDLYLSSQLGLRNTVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPSMDRPYDLVGAALFGDGAAAVIIGSDPITGIENPFMELNFAVQQFLPGTQHIIDGRLSEEGINFKLGRDLPQKIEDNIEEFCKTLMEKENLKNFNDLFWAVHPGGPAILNKLERNLKLQAEKLQCSRRALMDFGNVSSNTIFYVLDYIREELKLSGEEWGLALAFGPGITFEGILVRSLQS
>rna-gnl|WGS:JADFTS|Cch00013399-RA
MVSIDEIRRSQRADGTATVMAIGTANPPNCFDQSTYPDYYFRVTKSEQNTRLKDKFKRLCEKTTIKKRYMHVTEDILKENPSMCTYNAPSLNARQDIFISEIPKLGKEAATKAIKEWGQPKSKITHLIFCTTVGADMPGADYQLTELLGLSSSIKRIMMYQQGCFAGGTALRVAKDLAENNKGARVLVVCCEMQSFTFSTPSDTDFEALIRSAIFGDGAAAVIIGADPVIGAENPLFEVVSASQTIVPGSNGAVAGHLREEGLTVHLRRDLPMLVSNNIEKSLEEAFHPLGISDWNSLFWIAHPGGPAILDQVEEKLNLEPEKLGVTRQVLSEYGNMSSASVLFILDQMRKKSVQEELKTTGGGLEWGVLFGFGAGLTVETVVLHSVLI
>rna-gnl|WGS:JADFTS|Cch00018587-RA
AAAKAIEEWGQPKSKITHVVFCSLNGVDMPGADYQLTKLLGLEPTVKRFMFYAQGSDDAILGQMREEEGMTLYLQKDTVPEMIGDNIKKSVEEAFGPLGISDWNSLFWMVHPGGSAVVEQNGVRSLGLDLALQLRLWCSTTACSECVNTQ
>rna-gnl|WGS:JADFTS|Cch00018591-RA
MSGTWKMLKEAGDALYQECRPAAPPLCFSVVQHHTLPMDIERRACILLTCKGKGSLIKKRYMYMNEDILGKNPSMCVYNAPSLNASQKLVVDEIPKLGKEAAAKAIEEWGQPKSKITHVVFCSLNGVDIPGGDYQLTKLLGLEPTVKRFMFYAQGCFRGAMLGKNPSMCVYNAPSLNASQKLVVDEIPKLGQEAAAKVIEEWGQPKSKITHVVFCNLNGVDMPGEDYQLTKLLGLEPTVKRFMFYALSSEITSISNFTCPNPISGIEHPLSELVSASQTILPASNDAILGHMREEEGMTLYLQKDTVPEMTGDNIKKSVEEAFGPLGISDWNSLFWMVHPGGRAVVEQVKDKLNLKPGKLTASRQVMHDYGNMSSATVLFVID
>rna-gnl|WGS:JADFTS|Cch00018589-RA
MQYYSRNEIPICQLKLTTSSSGRGKSRTGDPYGPSKIASTLGKQVASEEPCCYLAENNWGAGQAIQGDGAAAVIVGADPISGIEHPLFELVSASQTILPVHPGGRAVVEQVEDKLNLKPGKLTASRQVMYDYGNMSSATVLYVIDEMRKKSAEERHKTTGEGLEWGALIGFELWIWHYS
>rna-gnl|WGS:JADFTS|Cch00018593-RA
MVSIDEIRRAQRADGPATVMAIGTATPPNCVDQSTYADYYFRITKSEHKTELKEKFKRMCEKSMIKRRYMYLTEDILKESPNLCAFQAPSLDARQDIVVVEVPKLGKEAATRAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRLAKDLAENNRGARVLVVCSEITAVTFRGPSDSHLDSLVGQALFGDGAAAMIIGADPIIGVEKPLFELVSAAQTLLPNSEGAIDGHLREEGLTFHLLKDVPGLISKHIEKSLEEAFAPLGISDWNSLFWIAHPGGPAILDQVEDKLNLEPKKLCATRQVLSEYGNMSSACVIFIMDEMRKKSVQEGFKTTGEGLEWGVLFGFGPGLTVETVVLHSVLT
>rna-gnl|WGS:JADFTS|Cch00006196-RA
MTMVTVEEIRKLQRADGPATVLAIGTATPSNCVYQADYPDYYFRITKSDHMTDLKEKFKRMCDKSTIRKRHMHLSEEILKENPNMCAYMAPSLDARQDIVVHEVPRLGKEAASKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRSSVKRLMMYQQGCFAGGTVIRLAKDLAENNRGARVLVVCSEITAVTFRGPTDTHLDSLVGQALFGDGAGAMIIGADPDMSIERPLFELVSAAQTILPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLVEAFTPLGISDWNSLFWIAHPGGPAILDQVELKLGLKEEKLRATRHILSEYGNMSSACVLFILDEMRKKSVEEGKATTGDGLEWGVLFGFGPGLTVETVVLHSLPATETH
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University