Enzyme

4CL

Enzyme

4-coumarate:CoA ligase

Enzyme name

EC:6.2.1.12

Entry

Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases

Class

4-coumarate:CoA ligase (AMP-forming)

Sysname

ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]

Reaction

AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]

Product

Species information

Coptis chinensis

Species name

Coptis chinensis is a species of flowering plant in the family Ranunculaceae (buttercup family).

Species info

Gene sequence info

Coptis_chinensis.4CL.fa

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>rna-gnl|WGS:JADFTS|Cch00027176-RA
MRNPVQEIESAIVRVTQSLRRSKGEPIEVEEKTESSATEKYPLINISDNMLSPEQVPPAELEHLLQSHPEIADVALIPYVFDKFNFAILLFLAYVKMYPDEEAGQIPMAFVVRKPGSNLSAAQVMEFVAKQACLLKTKRFILNAYRGFLLSVYSVLKSLNTMHHHMINYFAS
>rna-gnl|WGS:JADFTS|Cch00015977-RA
MITIASPETKPPQINPQVSTSETENTCPETFVFRSKLPDIPISNHLPLHTYCFERLSEFSDRPCLISGSDGRIYTYAETHLICQRTAVGLSSLGIKKGDVIMILLQNCPEFVFSFMGASMLGAITTTANPFYTSAEIFKQVSASGAKLIITQSLYVDKLQHSNGICCEDFKVVTINDPQKNCIHFSEISNADELKIEPVSIDPNDAVALPYSSGTTGLPKGVMLTHKSLISSVAQQIDGENPNLYLTADDTVLCVLPLFHIYSLNSVLLCSLRRGAGVLLMQKFEIKTLLNLIQKHRVSVAAVVPPLVLALAKDPTVDKFDLSSIRIVLSGAAPLSKELEEALRSRVPQAIFGQGYGMTEAGPVLSMCSGFAKQPFPTKSGSCGTVVRNAELKIIDPESGLSLRRNQPGEICIRGPQIMKGVVANEVNKVKVYGKDFISTRRRNTEFGIGCLENSFLVGGSGVEVVKNFSDGIQGKGVYVKFDNGSSKFGSHFGHSVSTPKKTLLMRAKINTLRMNSTTNEVSSHSTGLHQLDIEMRRIVLEWKFEKEGTDITMSDITNNSKGSQLDPSASIFLGLDDNRICRWDKRDRKDMIQNLASESTSVLNLTQGHQFSRGTNFQCFSIIGGGSIVVGSLDGYLNDADATASTIDLDGWLHTGDIGYVDDDDEVFIVDRVKELIKFKGFQVPPAELEALLVSHPSIADAAVVPQMDAVAGEVPVAFVVRSNDFELTEEAVKEFIAKQVVFYKRLHKVYFIHAIPKSPSGKILRKDLRAKLASSS
>rna-gnl|WGS:JADFTS|Cch00023981-RA
MTIRRRKKGYGMSESTAVGARGLNNGKFSKYMSIGLMVPNMQAKVVNWNFGYVCLQAIVLEKLASPDLWHLSWNKERWYMSETHPFREGEIMFSRSQCRSWKPPTLFREYLGDLYAYNALLREEFIASQSKLDDLSVSSSRLELCLCG
>rna-gnl|WGS:JADFTS|Cch00012589-RA
MNVRVVRVPNVQNFVEFEFEMPEFDCFNRLVSSRPQTAVRPVIHQQDTAAILYSSGTSGVSKGVVLSHGNLIAAVELFVRFEALLHNENFPILENVYLAAIPMFHVYGLSLFALGLLSLGSTIVVMRKFNGDEMVRAIDRYKVTHLPIVPPILMALTRAKALGRCDAGSLKQVSSGAAPLSMKIIHDFLQSFPGVDFIQGYGMSESTAVGTRGLNKGKFRKYTSVGLLAPNMQAKVVNWNSGSCMPPGNSGELWLKGPGVMKGYLKEADATKSAVDKDGWLHTGDIVHFDGDGYLYILDRLKEMIKYKGFQIAPADIEAVLMSHPEILDVAITGYTDDEAGEIPVAFVIKKPGSKLSQEDVMDFAARQVAPHKKVRKVVFTHSIPKSPAGKILRRQLRYKNEASEVTSPTVDTRVPATVITGFLGSGKTTLLNHILTSQHGKRIAVIENEFGEVDIDGSLVASHSSVAEDILMVNNGCLCCTVRGDLVKMLLELGKKKRDQIDHIVIETTGLAKPAPVIETFCTDELVSKYVKLDGVVTLVDCKHSMQRLNEVKPRFVVNEAVEQVAYADRIILNKFSFLCLAYLLPFCPWFDPPILTTLQIDLVTEVELETLRKKITDINGMAHIKEAKFGAVDLDFVLGVGGYDLDRVESEVHVDGNQQHKAGHDHHKHDHSHDSAVSSVSIVCEGALDLEEVDDWLYRVIEEKGEDLYRMKGILSLNDSDERYVFQGVQSTLDGCPGKTWGPDEKRVNKLVFIGRNLDETALKKGLKGCLV
>rna-gnl|WGS:JADFTS|Cch00010654-RA
MASILEPQESIFRSKLPDIYIPNHLPLHTYCFENIAQFSTRPCIINGPTGNTYTYEEVELIARKVASGLNKIGIQQGQVIMLLLPNSPEFVFAFLGASYRGAIITTANPFYTASEIAKQAKASDTRLIITLASYVDKLKELAQDEEVKIMCIDSPPEGCLHFSELSQSDETELPEVKIRPDDIVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHQDDVLLCVLPLFHIYSLNSVLLCGLRAGAAILIMPKFEIKQLMELVEKYKVTIAPFVPPIVLAIAKSPDVEKYDLSSIRILMSGAAPMGKELEDTMRRKLPIAKLGQGYGMTEAGPVLSMCLAFAKEPLDIKSGSCGTVVRNAEMKIIDIENGTSLPRNESGEICIRGDQIMKANTIDRDGWLHTGDVGFIDDDDELFIVDRLKELIKYKGFQVAPAELEALLINHPNISDAAVVPMKDDAAGEVPVAFVVRSNGSQISEEEIKQYISKQVVFYKRINKVFFSETIPKGPSGKILRKELRQILAAGVPS
>rna-gnl|WGS:JADFTS|Cch00013308-RA
MENQMQVEAEEHVFRSQFPAVPVPDMTLPEFVLHNAELYADKVALVETVTGKEYKYGEVIRDTRRFSKALTSLGLRKGKVVVVVLPNVAEYPIIALGIMAAGGVFSGANPQAHASEIKKQVEDSDAKLIVTSGSIYEKVKDLEVPVIVLGEERIEKTISWNDLLDAADHAGTAAINETVDQNDICALPFSSGTTGTSKGVMLTHKNLVANLCSTLFSVTTDLIGQVTTLGLMPFFHIYGIAGICCATLRNKGKVVVMGRFELRTFLNALITHEVTFAPIVPPIMLALVKNPVVGEFDLTRLKLRAIMTAAAPLAPELLSSFESKFPGVQVQEAYGLTEHSCITLTHGDPRHSHGVAKKSSVGFILPNLEIKFIDPDTGRSLPRISLEKSVSEANVSCKEETDRTIDAKGWLHTGDIGYIDDDGDVFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDAAVVPLPDEEAGEIPVAFVVMNKNAKENEEDIMNFVASNVTAYKRVRVVHFVDTIPKSPSGKIMRRYLRDMVEKRKEANNSQSGAHCWNA
>rna-gnl|WGS:JADFTS|Cch00016709-RA
MPVALLFVVPLTHVTRNCLFICFLVFLPTPIIHSMQAYGLTEHSCITLTHGDPRHSHGVAKKSSVGFILPNLEIKFIDPDTGRSLPKNIPGEVCVRSQCVMQGYYNNKEETDRTIDAKGWLHTGDIGYIDDDGDVFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDAAVVPLPDEEAGEIPVAFVVMNKNAKENEEDIMNFVASNVTAYKRVRVVHFVDTIPKSPSGKIMRRYLRDMVEKRKEANNSQSGAHCWNA
>rna-gnl|WGS:JADFTS|Cch00016710-RA
MENQMQVEAEEHVFRSQFPAVPVPDMTLPEFVLHNAELYADKVALVETVTGKEYKYGEVIRDTRRFSKALTSLGLRKGKVVVVVLPNVAEYPIIALGIMAAGGVFSGANPQAHASEIKKQVEDSDAKLIVTSGSIYEKVKDLEVPVIVLGEERIEKTISWNDLLDAADHAGTAAINETVDQNDICALPFSSGTTGTSKGVMLTHKNLVANLCSTLFRICCATLRNKGKVVVMGRFELRTFLNALITHEVTFAPIVPPIMLALVKNPVVGEFDLTRLKLRAIMTAAAPCTRAPILF
>rna-gnl|WGS:JADFTS|Cch00023942-RA
MRNNVQEIESAIVRVTQSLRRSKGELAEVEEKTSLQIPRSYVGDDKGNYFYDGFRWMVKDDNLQVPPAELEHLLQSHPEIADVALILYPDEEVG
>rna-gnl|WGS:JADFTS|Cch00002591-RA
MILFVVVLPAVVVQQNDTAVILYSSGTTGQVKGVEMIHRTFIAFLAAHHSMIQAESIKKKAPHEVGLFTVPLFHIYGFCVHKNSCNGGEWETAVLMGRFDFEGMLKAVETHQVTCMPVSPPLVVAFAKLALVEKYNLSSLLMVESGGAPLGKEVSCKFVSRFPHIQIVQIMEAKLVYANVQGTQFKFDTCWEILKTTPKWNQLMTKNESTNKSKKLRVTIEPNGGDSSSSNPTTPGSTDSCFDPMLVETSTTKERPIGCKAEKDRRKKHADTNRNLSESNAIMKSFTSSLDERLERSEEMQMENLQLKREKMHHIRLMNEKMIMDTKLDDMTSAQREWYQLQQAEILQKWKESSMGGGSSSGGEN
>rna-gnl|WGS:JADFTS|Cch00010885-RA
MSTSTIDSRSGFCSTTKIFHSLRPPVHLPPANIPLSATQYTFALLTKTPSFSPDNTIAFIDYSSGTHLLYSDFLGQVESLAISLRTQFLLEKGDVAFVLSPTSLQIPILYLALLSIGVIVSPANPTSTLSELSRQISLTKPVIAFATSATANKLPSLRHETILLDSSRFFSMLTTQKLDQVELPAVVVQQNDTAVILYSSGTTGQVKGVEMTHRTFIAFLAAQHSMIQAESIKKKAPHEVGLFTVPLFHIYGFYVSIRAVAMGETAILMGRFDFEGMLKAVETHQVTYMPASPPLVVAFAKLALVEKYNLSSLLMVECGGAPLGKEVSCKFVSRFPHIQIVQLQGDEGSVRNLVVLLRRPHSQDLVVPVHCFFVSVVICCNEPHGYGLTEAAGVATMLGPDETKKFGSVGRLSQNIEAKIIDPITCEALPPGKKGELLLRGPTIMKGYVGDDEATANTLNSDGWLKTGDLCYIDSDGFLYVVDRLKELIKYKGYQVPPAELEHLLQSHSEIVDVAVIPLSRFLYENALFMQLCFRYPDEDAGQIPMAFVVAPYKKIRRVAFINSIPKSPAGKILRKQLIDCVLATPSARI
>rna-gnl|WGS:JADFTS|Cch00019352-RA
SVQFILSFFGIVAIGAIATTVNPAYTLTELSKQVKDCCPNLMITVPQLWDKTKDFGLPVVILGSQDSSQIVSNAKITTFSELIKIAAQVLDFPSCSVKQTDTAALLYSSGTTGTSKGVILTHGNFIAAALIATSDQEVQGQMHNVFFCFLPMFHIFGLSIITFAQLQRGNAVISMGRFDIEMVLRSVEKYKVTHLYVVPPVTIALAKQSLVKNYNLSSLKLLLCGAAPLGKDLMEGVAKNIPQAVVIQGYGLTETCGIVAVENAYEGGRHSGATGILVPGVEAKIVSVDKLNALPPAEHGELWVRGPNMMLSTALISTGILVSFHVFFLGISVVKYLKLSYIHIQMAPPFAILKHLQGCLHNPEATKLTIDKQGWVHTGVLGYFDERGQLFVVDRIKELFKYKGFQIAPAELEELLLTHPEIIDAVVIPSPDDEAGEVPIALTLLSLCLISTCLTLICVHSSTTIKPKLPISFPTPQNFQSPPNQMEKSGYGRDGIYRSLRPPLILPRDPNLSLVSFLFRNIHSYSDTPALIDSDTSQTLTFTQLKSTVAKLAHSFLQLGIKKGDVVLIFAPNSIQFPLTFLAVVSIGAIATTVNPLYTVHELAKQVKDSNPKLVITVSELWDKTKGFNLPAVILGTEMVPNNNNNNRKVISYSELIQMAGPVTEFPVSIVKQSDTAALLYSSGTTGTSKGVILTHRNFISASLMVTADQEFGGERNNVFLCFLPMFHIFGLSIITYSQLQRGNTVISMGRFDIEMVLRSVEKYKVTNLFVVPPVMIAFAKLSVVKKYDLSSLKQLGSGAAPLGKDIMEECAKNIPGAAVVQGYGLTESCGIVSLENAYEGSRHSGSTGTLVPGYFNNPQATKLTIDKQGWIHTGDLGYFDERGQLFVVDRIKELIKYKGFQVAPAELEGLLLTHPEILDAVVIPFPDAEAGEVPIAYVVRSPNSSLNEETVQNFIAKQVAPFKRLRRVTFINTVPKSASGKILRRELIEKVRSKV
>rna-gnl|WGS:JADFTS|Cch00003742-RA
MKYMSVGLLVPNIQAEVVNWNAGSYMPLGNSGEIWLKGPDVMKGKKLMKMDFWGRMHMDVHVHDGVGAYIGVKETMLLGSKSQRETLETKAEASFPN

Gene tree

Gene tree

Sheng jun & Dong yang Teams, Yunnan agriculture University