Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Coffea canephora
Species name
Robusta coffee (Coffea canephora) is a species of eudicot in the family Rubiaceae (madder family).
Species info
Gene sequence info
Coffea_canephora.CHS.fa
Download
>gene-GSCOC_T00028842001
MSQFNKNGTSRRIPTPGKATVLSIGKAFPRQVVPQDCLVEGYVRDTKCVDPAIKEKLERLCKTTTVKTRYTVMSREILDQYPELTTEGSPTIKQRLEIANPAVVEMAKEASLACIKEWGRPADDITHVVYVSSSEIRLPGGDLYLATELGLRSDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLATSETTILGFRPPSKARPYDLVGAALFGDGAAAVIIGADPIIGTESPFMELNYAVQQFLPGTNNVIDGRLSEEGINFRLGRDLPQKIEDNIEAFCKKLMAKAGLGDFNDLFWAVHPGGPAILNRLESTLKLKPGKLECSRRTLMDFGNVSSNTILYVMEYMREELQKEGGEEWGLALAFGPGITFEGILVRSL
>gene-GSCOC_T00014154001
MGIEDAVHGSTTVTPGKATILALGKAFPPQLVMQEFLVDGYFRNTNCDDPDLKQKLTRLCKTTTVKTRYVVMSEEILNQYPELVVEGLPTVKQRLDICNPAVTEMAIEAAQSCIKNWGRPISDITHLVYVSSSEVRLPGGDLYLAKGLGLRPETQRVMLNFSGCSGGVAGIRVAKDIAENNPGSRVLLATSETTIIGFRPPSAERPYDLVGVALFGDGAGAMIVGSSPEPSIERPLFELHTSMQHFLPDTEKIIDGRLTEEGISFKLGRELPQIIEDNIEGFCARLMDVAGYSEKDYNKMFWAVHPGGPAILNRMEKKLDLLPEKLNASRRALADFGNASSNTIVYVLEYMLEENKIARKEDQKGNEEWGLILAFGPGITFEGILTRTLAV
>rna-GSCOC_T00026577001
MVTVEEVRRAQRAEGPATIMAIGTATPPNCVEQSTYPDYYFRITDSEHKTELKEKFKRMCKYI
>gene-GSCOC_T00001294001
MYFFFLGQNVINCYIYLTEEILKENPNICAYIAPSLDASLDAKFIDFNRKKHPKSKSRYGITHLVFCTTSGEDMPGADFPKHIWVRLNPNPYNSVLSQTQANPAHSAHFATSTDNNKNAGVLVVQSEITTVTFCGPSDTHLDCLVAQALLGDGTGALITGADPVVGVDRPFF
>gene-GSCOC_T00001293001
MRLGFHLIFSRMFPDLSRRTKFFFYYYVLPPQKLIKNNIQKYIREEIKKLHLRTQLELFQIEFSCNSQLPNLSSLQELCQVLAKTRKSMRYTLIDRLIRVLSEHGYVSNTCVLFILDDMRKASVNEGLEWGVFIGFGTGVIVETLILHSVTI
>rna-GSCOC_T00001295001
MIKKRYMYLTEEILKENPNICAYMAPSLDARQDMVVVEVPKLGKEAAQKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFGGGTVLRLAKDLAENNKGARVLVVCSEITAVTFHGPSDAHLDSLVGQALFGDGAAAIIIGADPVPEVERPLFELVTAAQTILPDSHGAIDGQLREVGLTFHLLKDVPGLISKNTEKSLKEAFEPLGISDWNSLFWIAHPGGPAILDQVEQKLALKPEKLRATRHVLSEYGNMSSACVLFILDEMRKASAKDGFNTTGEGLDWGVLFGFGPGITVETVVLHSVTIQK
>rna-GSCOC_T00008801001
MIKKRYMYLTEEILKENPNICAYMAPSLDARQDMVVVEVPKLGKEAAQKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDSHLDSLVGQALFGDGAAAIIIGADPVPEVERPLFELVTAAQTILPDSHGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLKEAFEPLGISDWNSLFWIAHPGGPAILDQVEQKLALKPEKLRATRHVLSEYGNMSSACVVFILDEMRKASAKDGFNTTGEGLDWGVLFGFGPGLTVETVVLHSATIQK
MSQFNKNGTSRRIPTPGKATVLSIGKAFPRQVVPQDCLVEGYVRDTKCVDPAIKEKLERLCKTTTVKTRYTVMSREILDQYPELTTEGSPTIKQRLEIANPAVVEMAKEASLACIKEWGRPADDITHVVYVSSSEIRLPGGDLYLATELGLRSDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLATSETTILGFRPPSKARPYDLVGAALFGDGAAAVIIGADPIIGTESPFMELNYAVQQFLPGTNNVIDGRLSEEGINFRLGRDLPQKIEDNIEAFCKKLMAKAGLGDFNDLFWAVHPGGPAILNRLESTLKLKPGKLECSRRTLMDFGNVSSNTILYVMEYMREELQKEGGEEWGLALAFGPGITFEGILVRSL
>gene-GSCOC_T00014154001
MGIEDAVHGSTTVTPGKATILALGKAFPPQLVMQEFLVDGYFRNTNCDDPDLKQKLTRLCKTTTVKTRYVVMSEEILNQYPELVVEGLPTVKQRLDICNPAVTEMAIEAAQSCIKNWGRPISDITHLVYVSSSEVRLPGGDLYLAKGLGLRPETQRVMLNFSGCSGGVAGIRVAKDIAENNPGSRVLLATSETTIIGFRPPSAERPYDLVGVALFGDGAGAMIVGSSPEPSIERPLFELHTSMQHFLPDTEKIIDGRLTEEGISFKLGRELPQIIEDNIEGFCARLMDVAGYSEKDYNKMFWAVHPGGPAILNRMEKKLDLLPEKLNASRRALADFGNASSNTIVYVLEYMLEENKIARKEDQKGNEEWGLILAFGPGITFEGILTRTLAV
>rna-GSCOC_T00026577001
MVTVEEVRRAQRAEGPATIMAIGTATPPNCVEQSTYPDYYFRITDSEHKTELKEKFKRMCKYI
>gene-GSCOC_T00001294001
MYFFFLGQNVINCYIYLTEEILKENPNICAYIAPSLDASLDAKFIDFNRKKHPKSKSRYGITHLVFCTTSGEDMPGADFPKHIWVRLNPNPYNSVLSQTQANPAHSAHFATSTDNNKNAGVLVVQSEITTVTFCGPSDTHLDCLVAQALLGDGTGALITGADPVVGVDRPFF
>gene-GSCOC_T00001293001
MRLGFHLIFSRMFPDLSRRTKFFFYYYVLPPQKLIKNNIQKYIREEIKKLHLRTQLELFQIEFSCNSQLPNLSSLQELCQVLAKTRKSMRYTLIDRLIRVLSEHGYVSNTCVLFILDDMRKASVNEGLEWGVFIGFGTGVIVETLILHSVTI
>rna-GSCOC_T00001295001
MIKKRYMYLTEEILKENPNICAYMAPSLDARQDMVVVEVPKLGKEAAQKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFGGGTVLRLAKDLAENNKGARVLVVCSEITAVTFHGPSDAHLDSLVGQALFGDGAAAIIIGADPVPEVERPLFELVTAAQTILPDSHGAIDGQLREVGLTFHLLKDVPGLISKNTEKSLKEAFEPLGISDWNSLFWIAHPGGPAILDQVEQKLALKPEKLRATRHVLSEYGNMSSACVLFILDEMRKASAKDGFNTTGEGLDWGVLFGFGPGITVETVVLHSVTIQK
>rna-GSCOC_T00008801001
MIKKRYMYLTEEILKENPNICAYMAPSLDARQDMVVVEVPKLGKEAAQKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDSHLDSLVGQALFGDGAAAIIIGADPVPEVERPLFELVTAAQTILPDSHGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLKEAFEPLGISDWNSLFWIAHPGGPAILDQVEQKLALKPEKLRATRHVLSEYGNMSSACVVFILDEMRKASAKDGFNTTGEGLDWGVLFGFGPGLTVETVVLHSATIQK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University