Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Clethra arborea
Species name
Folhado (Clethra arborea) is a species of eudicot in the family Clethraceae.
Species info
Gene sequence info
Clethra_arborea.COMT.fa
Download
>carb_00760-RA
MALNAAVQLDLFGVISRDGDGAHLSPLEIASCLAATAARRNPVTAAANLDWMLRLFASHSLLKIYLKDKIVDGANPSILALGTESLFESIEADPIVRGFFDRAMKKFYILTA
>carb_08728-RA
MLSPSEIASHLRSNNPQSPILLDRTLRLLASHSILTCSFLAPTTHNIHNPTADVNSTCRLYGLAPVSKYFIPNQDGLSFAPMLQTIQDKVTVNMWAYGMNAFNYVGKDARCRELFKAFMGDYNPMFMKQILETYNGLEGLDSMVDVGSGDGALLQMIVSKHPSIKGINFDLPLVIEKSPSYPGIEHVAGDMFLSIPKGEAIFLKIGGATKMWILRSWDDEHCLKILKNCYKSLPENGKVIVVDMVVPETPDTSVAVKSDFQFDLFLMNINPGGKERTKGEFESLAKEAGFSSIRVAALWNSTKKCDTPLQVFHLLCLVKGKLCTLL
>carb_16274-RA
MDPSASSYSCNQVREREEEEEEHNCIYAKQLVNSSAVSMVMQAVVELGVLDIIAKAGAGHQLSPSEIASQLMISNPDAPAMLDRMLCLLASHSILTCSNSDDHDHDYFSSPAHEIRRLYGLAPVAKYFVPNQDGVSLAPLMFLLQDKVFMDSWCELKAAVVEGGIPFNRVHGMHAFEYPGKDPRFNEVFNKAMINHTTLVLKNILKSSYKGFEQLKQLVDVGGGLGVTLKLITSKYPHIKAINFDLPHVIKHAPPYTGVEHVGGDMFESVPEGDAIFMKVSHNFLLKNCHRALPENGKVIAVEGILPEIPDTSKATKAIYQLDLVMMTQNPGGKERTQQEYLALATGAGFAGITLQCFASNFWVMEFYK
>carb_18725-RA
MNKETKHHHVVSKNVEEEEDEACAYALHVSLSHTFPVVLNAAVQLELFDIIARAGLGAQISPSEIVSKLPAVRDPKKSALMIDSMLQLLASNSLLTCSVREENGVSGRIYGLTRAGKYFVHGGGGGGNGGYSSLAPFMRLAHHRAPKEAWFHLKDAVIEGDIAFKKAHGMHPFYYMGKDPTFYEVFHKAMAHRSTLFMNKILRSYKGFDGLGSLVDVGGSVGKTLSMILPIYPSIRGINFDLPHVIESAPSYPGIEHVGGDMFSSIPKGDASVLHDWGDEHCMKILKNCHDAVPKNGKVIIIEVVKPELPNTSMAAKYAAEEDNEMLLYTGGKERTXXXXDRERISSTV
>carb_24011-RA
MGSITEDQKTTQLDSEEEEACMFAMQLGSASVLPMVLKSAIELDLLETMAKAGPGAFLSPTELAAQLPTTNPDAAVMLDRILRLLTSYSVLNCTLKNLPGGGVQRLYGLAPVCKFLTRNNDGVSMAPLLLMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNQGMSNHSTITMKKILEIYQGFEGLASVVDVGGGTGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCLKFLTKCYEALPDNGKVIIAECILPVAPDTRLTTKNVIHIDVIMLAHNPGGKERTEKEFEALAKGAGFEGFRVACCAFNTYVMEFLK
>carb_29650-RA
MKILKNCHDAVPKNGKVIIIEVVKPELPNTSMVAKYVSDEDNEMLLYTGGKERTEKEFQALCKGSGFLDYRIVCSAYSLCVVEFYK
MALNAAVQLDLFGVISRDGDGAHLSPLEIASCLAATAARRNPVTAAANLDWMLRLFASHSLLKIYLKDKIVDGANPSILALGTESLFESIEADPIVRGFFDRAMKKFYILTA
>carb_08728-RA
MLSPSEIASHLRSNNPQSPILLDRTLRLLASHSILTCSFLAPTTHNIHNPTADVNSTCRLYGLAPVSKYFIPNQDGLSFAPMLQTIQDKVTVNMWAYGMNAFNYVGKDARCRELFKAFMGDYNPMFMKQILETYNGLEGLDSMVDVGSGDGALLQMIVSKHPSIKGINFDLPLVIEKSPSYPGIEHVAGDMFLSIPKGEAIFLKIGGATKMWILRSWDDEHCLKILKNCYKSLPENGKVIVVDMVVPETPDTSVAVKSDFQFDLFLMNINPGGKERTKGEFESLAKEAGFSSIRVAALWNSTKKCDTPLQVFHLLCLVKGKLCTLL
>carb_16274-RA
MDPSASSYSCNQVREREEEEEEHNCIYAKQLVNSSAVSMVMQAVVELGVLDIIAKAGAGHQLSPSEIASQLMISNPDAPAMLDRMLCLLASHSILTCSNSDDHDHDYFSSPAHEIRRLYGLAPVAKYFVPNQDGVSLAPLMFLLQDKVFMDSWCELKAAVVEGGIPFNRVHGMHAFEYPGKDPRFNEVFNKAMINHTTLVLKNILKSSYKGFEQLKQLVDVGGGLGVTLKLITSKYPHIKAINFDLPHVIKHAPPYTGVEHVGGDMFESVPEGDAIFMKVSHNFLLKNCHRALPENGKVIAVEGILPEIPDTSKATKAIYQLDLVMMTQNPGGKERTQQEYLALATGAGFAGITLQCFASNFWVMEFYK
>carb_18725-RA
MNKETKHHHVVSKNVEEEEDEACAYALHVSLSHTFPVVLNAAVQLELFDIIARAGLGAQISPSEIVSKLPAVRDPKKSALMIDSMLQLLASNSLLTCSVREENGVSGRIYGLTRAGKYFVHGGGGGGNGGYSSLAPFMRLAHHRAPKEAWFHLKDAVIEGDIAFKKAHGMHPFYYMGKDPTFYEVFHKAMAHRSTLFMNKILRSYKGFDGLGSLVDVGGSVGKTLSMILPIYPSIRGINFDLPHVIESAPSYPGIEHVGGDMFSSIPKGDASVLHDWGDEHCMKILKNCHDAVPKNGKVIIIEVVKPELPNTSMAAKYAAEEDNEMLLYTGGKERTXXXXDRERISSTV
>carb_24011-RA
MGSITEDQKTTQLDSEEEEACMFAMQLGSASVLPMVLKSAIELDLLETMAKAGPGAFLSPTELAAQLPTTNPDAAVMLDRILRLLTSYSVLNCTLKNLPGGGVQRLYGLAPVCKFLTRNNDGVSMAPLLLMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNQGMSNHSTITMKKILEIYQGFEGLASVVDVGGGTGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCLKFLTKCYEALPDNGKVIIAECILPVAPDTRLTTKNVIHIDVIMLAHNPGGKERTEKEFEALAKGAGFEGFRVACCAFNTYVMEFLK
>carb_29650-RA
MKILKNCHDAVPKNGKVIIIEVVKPELPNTSMVAKYVSDEDNEMLLYTGGKERTEKEFQALCKGSGFLDYRIVCSAYSLCVVEFYK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University