Enzyme

Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.

HIDH

Enzyme

2-hydroxyisoflavanone dehydratase

Enzyme name

EC:4.2.1.105

Entry

Lyases;Carbon-oxygen lyases;Hydro-lyases

Class

2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)

Sysname

(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O

Reaction

daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]

Product

Species information

Clethra arborea

Species name

Folhado (Clethra arborea) is a species of eudicot in the family Clethraceae.

Species info

Gene sequence info

Clethra_arborea.HIDH.fa

Download
>carb_02732-RA
TSQTMESTTNEIAYEYLPYFRAYKDGRVQRFFGTDVFPTSTDPQSPISTKDVLISPETAVSARLFKPTKTNPTQKLPILLYFHGGAYCFGSPFCAEYHRHLASLAAAASIIALSVDYRLAPENPLPLAYEDSWAALKWVGSHSNGQGPEKWINENADLRRVFVAGDSAGANIAHNTAVRAGEEELVGVNLVGACLVHPDFASREGHVPKSWFFACPGTAGSGDPRINPAVDPRLGRMGCRRVLVCVAEKDEMRERGRFYYETVKESGWSGVVELVETEGEGHVFHLFDPNCDKAVDLALPPQNHQPTSEKASYSRLLTSTAAVFASGPPSPVYHNYVNSLAAEANVVVVVSVNYGRAPEHPLPIAYNDSWAAI
>carb_03981-RA
MASTTDEIVHDFPLLGVRTYKDGRVERLKGTEIVPPSTDPTTGVQSNDVVIDPVTGLSARLYLPKIKNPHQEKLPLLVYFHGGGFCIETAFSPLYHNYLNCLAAEAVAVIVSVDYRRAPEHPLPVAYDDCWAAIKWAAAHCEGGGDEVWLKKYVDFDRVFFAGDSAGGNIAHYMAIRVGLEGLGGASLAGIVLVHAYFWGKEPIGAKHDDVMVNEFVEKLWFFVCPSSSGMDDPLMNPLKDPNFSKLGCNKVLVCVAEKDLLRDWGWHYKGELEKSGWGGVAEAMEAKGEQHVFHLFNPTCDNAVAKLKRVAAFINGDKAYREGQDTYGSGDPRIHPAVDPRSGRIGCRRVLVCGRRRMGGVVWWRFWRLKVKGMCFIICDKAIMEVAGKDHVFHLINPTCDNAVAMLKRLAAFMNE
>carb_07464-RA
MSIVVEAPGFLQVFSDGSVKRFAPEIAPPSSSPTPPPSSNSYKSKDVIIDPSKPITARIFLPNYQSQPPSNQNLLPVIVYFHGGGFCIGSTTWLGYHVFLGNLSNTSQSIILSVDYRLAPQHKLPVAYDNCCSAIEWLIHAKNRDSWLVRADLTRVFLSGDSAGGNIAHQVAITKTRKRDNHMVNVKGLLLIHPYFGSEERTEREMDEGAAGEVAMNDMFWGLSLPDKANRDFYGLTSRTRR
>carb_09747-RA
MDSIAGEIAHEFPPFFRVYKDGRVERFMVSDYVPPTGDETNDVVISPETGVKARIFKPRVNGPDQKLPLLVHYHGGGFCIGSALGTTTQRFLTSLASVAHSIAVSVEYRLAPEHPLPIAYDDSWSAFQWIASHSKGEGPDPWLNKYADFSRVFLVGESAGANIAHHVAVRVGSSGLNGLRVCGAIIVHPFFAESEPDKMIQYLYPGSSGSIDDPRLNPKGDPDLAKMGCSKVLVFVGEKDWLKARGLDYYETLRNSEWGGSGELVENEGEDHCFFLFNPTCENAVLLVQKLAAFINQD
>carb_09993-RA
MESAIDEVTHDFSPFFRVHKDGRIERSRKPEFAPTSDDPEAPVRSKDVVISPETGVSARIYLPTTADPNQKLPLLIYIHGGGFCLGSASSPKFDHFVASLAAKAQIAVVSIDYRLAPEHPLPAAHDDAWDGFRWALSHSDGSGHDPWLNDRVDFQRVFVGGESAGANIANNVAIRAGSDVSKFLGLILVHPFFGGKEEDKMYKFMCPSSSGPEDDPRLNPAADPGLPGMGCRRVLFCVAERDWLRDRGWGYYEALGKSGWGGEREIMETEGEGHGFYLFDPNCEKAGALMTRLASFLNRD
>carb_10013-RA
MRVYKDGTVERLFGYEVAPPGFDPQTGVKSKDTVITPETGVSARLYRPNQAPDIPKLPLVVYFHGGGFFLSSVADPKYHHSLNRLVAKANVVLVSVNYRKAPEHPLPAAYEDSWAALNWVASHMSGGGDEDWLRDKIDFSRVFLAGDSAGASISHHLAIRVGSNPVGVLKLRGIIMIHPYFWGEDPVGSEAKDPGRKAMVDAWWRFVCPSDKGNDDPLINPVADGAPSLSGLACGRVIVCVAEKDILRDRGRLYYESLVKSEWNGEAEIVEIEGEDHVFHIMDPNGEKALYMIECLASFINQE
>carb_10034-RA
MASISLDPSPRLNFQTPKIHHQHGPVIEEVEGIIKVYKDGHVERPPIVPNVSCSAVGPELSVAAKDVSIDKSTNLWARLYIPSSPSGKLPVLVYFHGGGFCVGSPAWSCYHDFLANLASRAGTVILSINYRLAPENRLPAAYEDGLSAVAWLKNQALNWSNDQNWWLSRCDLSSLFLAGDSAGANIAHNVANRLANTKPLRLKGTILIQPFFGGEWRTESENRDAQGSALTLSASDAYWRLSLPAGANRDHNWCNPLAKGGTRVVGDYCAMMVCVSDLDILRDRNLEFCVAKGEEKRVEKVIYGGVGHAFQILNNSQVSRNRTCEMMNDIKAFINK
>carb_11475-RA
MASTTDEIVLEFPRLGVRTYKDGRVERLKGTEIVPPSTDPTTGVQSNDVVIDPVTGLSARLYLPKIKNPHQEKLPLLVYFHGGGFCMETAFSPQYHNYLNCLAAEAVAVIVSVDYRRAPEHPLPVAYDDCWAAIKWAAAHCEGGGDEVRLKKYVDFDRVFFAGDSAGGNIVHNMAIRVGLEGLGGPNLAGIVLAHAFFWGKEPIVAKHDDIMVNELVEKLWLFVCPSSSGMDDPLMNPVKDPNFSKLGCNKVLVCVAEKDLLRDRGWYYKEELEKSGWGGVVEVMEAKGEGHGFHLLNPTSDNAVAKLKRVAAFINGDKA
>carb_11934-RA
SPTQKCQTQLIRIQSQTQKNKKREMGSLPHVIEDCQGILQLYSDGSVVRTTDINFPTQVTDDGSVEWKDYLFDKSHNLHLRLYKPKSPPTTTTTSTSLPIIIFLHGGGFCVGSRTWPNCHNCCLRLSSALRALVVAPDYRLAPEHRLPAAMEDALGALKWVQAQAVSGDRDTWMGDGGADFERVFVVGDSSGGNIAHHLAVRVGSGEEDLGPVRVSGFVLMAPFFGGSVRTISEAVGPPEPMLNLEVLDRFWRLSIPIGETADHPLANPFGPLSPNLEPVTLNPILVIVGGSEMLKDRVEDYAIRLKKMGKKIDYVEFEGKQHGFFTNEPYSEVAYRVLQLVENFMDANSN
>carb_12987-RA
MSTTTTATPSPYEVDECRGVLRVFSDGSIVRSTKPSFDVPVHDDGSVLWKDATFDVTNNLQLRLYKPAAPKAAKLPIFYYIHGGGFCIGSRAWPNCQNYCFQLALQLQAVIVSPDYRLAPENRLPAAIEDGFASVKWLQAQAESEEPDSWLADVADFSRVFISGDSAGGNIAHNLAVRLGAGLAELGPVRVRGYVLLAPFFGGTILMRFWRLSIPVGETTDHPLVNPFGPVSPPLEPLDLDPILVVVGGSDLLKDRAEDYAKKLKGWGKKVEYVEFEGKQHGFFTIDPNSQAASALMLIIKKFITENSS
>carb_14650-RA
MAIHKTPACLSLFLFLFFAMASADCKTAKGGPNLPAQIPKPDVHYKDVKIVDKVCARLYVPKSADPGKKLPLVVHYHGGSFTMFSAFLYPHDNYVYALSKKANVAALSVEYRTAPDDPIPVPYDDSWAAIKWIAAHVDFSRIFLEGDSAGANIAHNMAMRASSEKLEGLQINGIALMHPFFWGSKPVGSEPSDKAGRAVGDGTWLNACASKFGLDDPRVNPLVDPKLSELGAKKVLVAVAGNDTLFRERGLYYYKGLKESGWKGEAELVETPGEGHCFHLTSPNSKNALDLLKRVSSFVNEA
>carb_15802-RA
MSPTNKKVVEEVSHWLRVFEDGTVDRTWTGPPEIEFMTKSVLPHEEFIDGVATRDVTIDPNSGLAVRIYIPERNNAIPDKDKLPLLLHFHGGGFCFTRPDWYLYYHFYTRLVRSARAVCLSVYLRLAPEHRVPAACDDAYSAFLWLGSMARGDSSEPWLESYVDFSRVFLVGDSTGGNLVHEVAARAGTEAITMPVKLAGGIALHPGFIRAEPSKSFLELPESPMLTRDMVNKLLALGLPVGSTKEHPVTCPMGEAATPLCRLRLPPMMVVVAEMDLLRDSELEYCEAMEKGGKQVEVLIEPRMGHSYYLNKIAVDVDKETAASVDHLIAKITSFINKH
>carb_17113-RA
MGSTNLEVSLEVLPYLRVYKDGTIERLAGTQVTPPNSDPRNGVVSKDVVIVPKTSVSARLYHPNPTTAADPKKKLPLVVYFHGGAFCIASVAEPYYHNSLNILVAQSGVVVVSVDYRLVPEHPLSAAYEDSWAALQWVASHSGGGGSGGTEAWLREEVDFDKVFLAGDSAGANIAHHMAIRAGSTRIDGLKFRGIVMIHPYFWGEEPVGMEGEDPRKAMVDSWWRFVSPSEKGADDPLINPFVDGAPKLSGLACERVIVCVAAKDILRERGRLYYEKLMKSGWKGKVEIVETEVSKAIVKNNNVHFMVGLFYIRCLDFYLRLADFISDELIPISGGPILQRADFIYGGLIPVFGGSIFGEVERRY
>carb_17163-RA
MVCQTLSNHIQFSSKKVVDEVSGWLRVFDDGSVDRTWTGPPEVKFMAEPVPAHRDFVDGVATQDVFVDEDSGLQVRLYLPEVENNGDKKLPILLHFHGGGFCISRADWYMYYHMYARLAREAGAICISVFLRLAPEHRLPAPCDDGFSALLWLRSLAQGSRGSHEPWLSDRADFSRVFLVGDSSGGNLVHQVAARAGETDLTPVRLAGAIPIHPGFVRSHRSKSELEQPESPFLTLQMVDKFLSLALPVGATKDHPITCPMGGGAPPIAALNLPPVLLCVAEKDLIKDTEMEYYEALKKGNKDVELMINCGMGHSFYLNKIAVDFDRQTAAETEKLVGGIADFIKRH
>carb_18333-RA
MAAITLDPILNLQINTKTHQHGAVVEEIDGLIRVDKDGHVERTQIVPCVTSSLAPELGVTSGDIVIDKPTNIWARFYVPNKCRGNVPLLVYFHGGGFCVGSAAWSCYHEFLAKLAAKAGCLIMSVNYRLSPENPLPAAYDDGVKALMWVKNQSLFCGGENDWWSKQCNFSSIFLAGDSAGANIAHNVAVRLGSSRATGLKPLTLKGIILIQPFFGGDGRTHSEKYMVVPPRSALSLAASDTYWRLSLPAGSSRDHLWCNPLVRGSSQLAEELGSFPILVCVAEMDILRDRSLEFCAALGRGGKRVEHVVYQGVGHAFQYAHGFDETVI
>carb_21454-RA
SEPRDGHLENMMYRVWKFVYPTAVDGIDNPMINPFALGAPSLAGLGCSKLLVVVGENDKAKDRGIHYCDVVRESGWGGEVELCVVEGANYGFHINTPETELAQNMFTRLASFLQ
>carb_21455-RA
MGSAAKEVATDLHPILHVYKDGTVERLMGSPYVPPSPDPDPTTAVSSKDITISPHVSARLYLPNLAAAAAEKLPILIYFHGGGFCVESAFSLFQHRYLNALVAESKAIAVSVDYRLAPEHPLPAAYEDSWHGDFDRLFIGGDSAGANIAHNIDIRAGTEPLPGSVKILGASLSHPYFLGSTPIGSERPDSINTESLLYKIWTCVSAARGIDDPAINPFAGNAPSLAGIGCGRVLVCVAGKDALRERGVWYFEEVKRSGWRGEIELFEVEGEDHAFHFFGFGSENAKRMITRLASLISQA
>carb_21814-RA
MVSHTKTLASELSPILRVYTDGTVERLLGSPFVPPSLDDPITGVSSKDITISPHVSARLYLPKLSPHPTTTTHDQEKLPILVYFHGGGFCIESAFSFLSQRYVSSLSFQAKVIIVSVEYRLAPEHPLPAAYDDSWTALEWVASHSLNEDNIMNKDPWLTKHGDFGRVYLGGDSSGANIAHNLAARAGGESLIGGVKILGLFLSQPYFCGSTPVGSESVVGHEENLLYRTWNLVYPSAPGGVDNPMINPFASDAPSLSRLGCSRLLVCVAEMDELRERGIRYGDAVRESGWGGELEVVEVEGEGHCFHILNFESESAKCMIKRLASFLQ
>carb_28579-RA
MAIHKTPACLSLFLFLFLFFAMASADCETAKSGPNLPAQIPKPDVHYKDVKIVDGVCARLYVPKSAAPGKKLPLVVHYHGGSFVMFSAFLPPHDDYVYALSKRANAVALSVEYRRPPTAHIPVLYDDSWAAIKWIAAHFAGANIVHNMAMRASSEKLEGIQINGIALMHPYFWGSKPIGTEPSDKAGRAAADWIWLNAGASKFGLDDPRVNPLVDPKLSCLGAKKVLVAIAGNDTMFRQRGLYYYKALKKSGWKGKAKLVETPGEGHCFHLTYPNSKNALDLLGRVSSFVNKA
>carb_28581-RA
MAIHKTPACLSLFLFLFFAMASADCETAKGGSNIPKPDVHFKDVKIVDGVCARLYVPKSATPGKKLPLVVHYHGGAFISYSAFLSPHDDYVYSLSKKANVAALSVEYRMAPNNPIPVPYDDSWAAIKWVTAQARIFLLGDSAGANIAHNMAMRVSSEKLEGIHINGIALMHPFFWGSKPVGTEPSDKDKRAVGDEMWLKAGGSKFGLDDLRINPLEDPKLSGLGAKKVLVAIAGGDTLLRDRGLYYYNALKKSGWKGEAELVETPGEGHCFHLTSPDSKNALDLLERVSSFVNKA
>carb_30004-RA
MESNNPEVAHEFRHFRVYKDGHVERFFWPQQTVTPTADDPTTGVKSKDVVISTDPQISARIFLPRLPDPTRKLPVLLFVHGGGFSFMSALSPIFDRHVRALAAAANAIAVSVEYRLAPEHPIPACYDDSWAALQWIASHANGSGPEPWLNHNADLRRVFVGGDSAGGNISHDLVFRVGSMGLPGTRVVGAILVHPYFGGVELDDKMWLYMCPSASGFDDHRMKPAVEDLGRIGCEKVLVFVAGRDHLCGPGRAYYEDLKRSGWKGTVEIVENEGEEHVFHLRGPTRIASSHPDEPEVNFTFFFKVYKNGTIEKLDKSDVKVPASLDSKAGVQSKDVLISPDGGVSARLYAPNGGAASCGGAPLLVYFHGGGFSTGSAASQAYHRFMNWIVAKAKVVAVSVNYRLAPEHRLPTGYDDSWAAIKWVASHAGGDSSGANFAHNMAMRFGSEKLNGVKLNGIVLIHPYFLLKEPTKSLLAVKETMRNNITKLWSYVCPLSSGLDDPRVNPVADPDLSRLGTKRVLVCLAEMDALKDAGMEYAEKLRGKGGKEVETFGSRGKQHVFHLREPCSPEALALLSRMVSFLKKRSSSYRNDVTVTLL
>carb_30005-RA
MDGIPSKASLPLSHSFSSFMASSTDEIAHDIPSLGIRAYKDGRVERLKGTQIVPPSINPQTGVQSKDTIIDSETGLSARLFIPKITNPQLKKLPLLVYFHGGGFCIESAFFPAYHNYLNSLAAEANVVVVSINYRRAPEHPLPVAYDDSWAAIKWVAAQCKRSGEEVWLKEYVDFDRGIVQVVGLEGLDGVKLVGIVLVHSYFWGKEPIGAEHDDINGKAFIDNLWLFVCPSSSGSDDPLINPVKDPNFSRLRVLVCVAEKDLLRDRGWYYHDELGKRGWGGVVEVMETMGEGHVFHLFNPDCDNAVPMLKRVATFLNEFNLFMQHELGFPLLI
>carb_30006-RA
MGTEIVPPSIMDPLTHVGSRDVVIEPVTGVSARLYKPKPANPSQKLPLLIYFHGGAFFVQTAFSPTYQHFLNSLAAEANVIIVSVDYRRAPEHPLPIGYDDSWAAVEWVVSHSGGNGEEEWLRDFADFERVFFGGDSAGANIAHNMGIRAGSGGLGGGSGKLVGIVLMHPYFWGTDPSGAEDADVDMSAKVEMFWLSACPSSTGFDDPLINPWVDPNLSRLGCAKVLVFVAEKDVLRERGWFYYEGLGKSGWGGVVEIVEAEGEKHVFHLDNPKSEKAQDMRLTGTEIVAASTDPNTGVQSTDVVIDPNTGLSARLYLPKIPNQHQKKLPLLVYFHGGAFCIETAFSPLYHNYLNSLAAEANVVIVSVDYRRAPEHPLPIAYDDCWAAIKWVASHHNGGGNEVWLKEYVDFDRVFFAGDSAGANLSHNMGIRVGTQGLDGVNLVGIVLVHPYFCGKEPVGGEGDNMMGKGLADNMWVLACPSSSGSDDPLINPVLDPDFSKLGCNKVLICVGEKDFLRDRGLYYHGELRKSGWEGAVEVMEAAGEGHVFHLFNPSCDNAVALLKKVAFFINDEVAHDFPPLIRVYKDSRVERLSGTETVPPSIDPQTGVRSKDIVIDPTSGLSARLYIHTIASPHQKNLPVLVYFHGGCFCFETAFSPTYHNYLNSLAAEANVVIVSVNYRRAPEHPLPIAYNDSWAAIEWVASHRKGGGDEVWLKDFVDFDRVFFAGDSAGANIAHQMGIRVGLEGLNGAKLIGIVLIHPYFLGKEPETQLLFVCPSSSGFDDPLINPGLDPRLPSSGCRKVLVCVAEKELLRERGWCYYEELGKSGWGGVVEIMEAIGEDHLFHLYNPNCDEAMVMLKRVASFLNDEERTRVSAPR
>carb_30007-RA
MDGIPSKASLPLSHSFSSFMASSTDEIAHDIPSLGIRAYKDGRVERLKGTQIVPPSINPQTGVQSKDTIIDSETGLSARLFIPKITNPQLKKLPLLVYFHGGGFCIESAFFPAYHNYLNSLAAEANVVVVSINYRRAPEHPLPVAYDDSWAAIKWVAAQCKRSGEEVWLKEYVDFDRGIVQVVGLEGLDGVKLVGIVLVHSYFWGKEPIGAEHDDINGKAFIDNLWLFVCPSSSGSDDPLINPVKDPNFSRLRVLVCVAEKDLLRDRGWYYHDELGKRGWGGVVEVMETMGEGHVFHLFNPDCDNAVPMLKRVATFLNEFNLFMQHELGFPLLI
>carb_30008-RA
MDSSTLELAYDLPPYYRVHKDGKVERLMGTEIVPPSIMDPLTHVGSRDVVIEPVTGVSARLYKPKPANPSQKLPLLIYFHGGAFFVQTAFSPTYQHFLNSLAAEANVIIVSVDYRRAPEHPLPIGYDDSWAAVEWVVSHSGGNGEEEWLRDFADFERVFFGGDSAGANIAHNMGIRAGSGGLGGGSGKLVGIVLMHPYFWGTDPSGAEDADVDMSAKVEMFWLSACPSSTGFDDPLINPWVDPNLSRLGCAKVLVFVAEKDVLRERGWFYYEGLGKSGWGGVVEIVEAEGEKHVFHLDNPKSEKAQDMRLTGTEIVAASTDPNTGVQSTDVVIDPNTGLSARLYLPKIPNQHQKKLPLLVYFHGGAFCIETAFSPLYHNYLNSLAAEANVVIVSVDYRRAPEHPLPIAYDDCWAAIKWVASHHNGGGNEVWLKEYVDFDRVFFAGDSAGANLSHNMGIRVGTQGLDGVNLVGIVLVHPYFCGKEPVGGEGDNMMGKGLADNMWVLACPSSSGSDDPLINPVLDPDFSKLGCNKVLICVGEKDFLRDRGLYYHGELRKSGWEGAVEVMEAAGEGHVFHLFNPSCDNAVALLKKVAFFINDEVAHDFPPLIRVYKDSRVERLSGTETVPPSIDPQTGVRSKDIVIDPTSGLSARLYIHTIASPHQKNLPVLVYFHGGCFCFETAFSPTYHNYLNSLAAEANVVIVSVNYRRAPEHPLPIAYNDSWAAIEWVASHRKGGGDEVWLKDFVDFDRVFFAGDSAGANIAHQMGIRVGLEGLNGAKLIGIVLIHPYFLGKEPETQLLFVCPSSSGFDDPLINPGLDPRLPSSGCRKVLVCVAEKELLRERGWCYYEELGKSGWGGVVEIMEAIGEDHLFHLYNPNCDEAMVMLKRVASFLNDEERTRVSAPR
>carb_30010-RA
MESNNPEVAHEFRHFRVYKDGHVERFFWPQQTVTPTAYDPTTGVKSKDVVISTDPQISARIFLPRLPDPTRKLPVLLFVHGGGFSFMSALSPIFDRHVRALAAAANAIAVSVEYRLAPEHPIPACYDDSWAALQWIASHANGSGPEPWLNHNADLRRVFVGGDSAGGNISHDLVFRVGSMGLPGTRVVGGILVHPYFGGVELDDKMWLYMCPSASGFDDHRMKPAVEDLGRIGCEKVLVFVAGRDHLCGPGRAYYEDLKRSGWKGTVEIVENEGEEHVFHLRGPTRIASSHPDEPEVNFTFFFKVYKNGTIEKLDKSDVKVPASLDSKAGVQSKDVLISPDGSVSARLYAPKGGAASCGGAPLLVYFHGGGFSTGSAASQAYHRFMNWIVAKAKVVAVSVNYRLAPEHRLPAGYDDSWAAIKWVASHAGGDSSGANFAHNMAMRFGSEKLNGVKLNGIVLIHPYFLLKEPTKSLLAVKEPMRNNITKLWSYVCPSSSGLDDPRVNPVADPDLSRLGTKRVLVCLAEMDALKDAGMEYAEKLRGKGGKEVETFGSQGKQHVFHLREPCSPEALALLSRMVSFLKKRSSSYRNDVTVTLL

Gene tree

Gene tree

Sheng jun & Dong yang Teams, Yunnan agriculture University